ATE241621T1 - Arylsulfonyle als faktor xa inhibitoren - Google Patents
Arylsulfonyle als faktor xa inhibitorenInfo
- Publication number
- ATE241621T1 ATE241621T1 AT00923096T AT00923096T ATE241621T1 AT E241621 T1 ATE241621 T1 AT E241621T1 AT 00923096 T AT00923096 T AT 00923096T AT 00923096 T AT00923096 T AT 00923096T AT E241621 T1 ATE241621 T1 AT E241621T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- factor
- arylsulfonyls
- formula
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12763499P | 1999-04-02 | 1999-04-02 | |
| PCT/US2000/008364 WO2000059902A2 (en) | 1999-04-02 | 2000-03-30 | Aryl sulfonyls as factor xa inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE241621T1 true ATE241621T1 (de) | 2003-06-15 |
Family
ID=22431091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00923096T ATE241621T1 (de) | 1999-04-02 | 2000-03-30 | Arylsulfonyle als faktor xa inhibitoren |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6399644B1 (de) |
| EP (1) | EP1175419B1 (de) |
| AT (1) | ATE241621T1 (de) |
| AU (1) | AU4327600A (de) |
| CA (1) | CA2368630A1 (de) |
| DE (1) | DE60003025T2 (de) |
| ES (1) | ES2197092T3 (de) |
| WO (1) | WO2000059902A2 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339099B1 (en) * | 1997-06-20 | 2002-01-15 | Dupont Pharmaceuticals Company | Guanidine mimics as factor Xa inhibitors |
| WO2002000647A1 (en) * | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
| EP2335700A1 (de) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur |
| ATE439360T1 (de) | 2001-09-21 | 2009-08-15 | Bristol Myers Squibb Co | Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer |
| TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
| AU2002350217A1 (en) | 2001-12-04 | 2003-06-17 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
| TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
| AR039241A1 (es) * | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| BR0309551A (pt) | 2002-04-26 | 2005-02-09 | Upjohn Co | Derivados substituìdos de pirazina |
| EP1505966A4 (de) | 2002-05-10 | 2006-08-30 | Bristol Myers Squibb Co | 1,1-disubstituierte cycloalkyl-derivate als faktor xa hemmer |
| EP1537112B1 (de) | 2002-08-06 | 2006-04-19 | Astrazeneca AB | Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität |
| UA80295C2 (en) * | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
| JP2006515838A (ja) | 2002-11-22 | 2006-06-08 | スミスクライン ビーチャム コーポレーション | ファルネソイドｘ受容体アゴニスト |
| PT1569912E (pt) | 2002-12-03 | 2015-09-15 | Pharmacyclics Llc | Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia |
| US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
| JP2006528685A (ja) | 2003-05-06 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | 新規化合物 |
| TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| WO2005012256A1 (en) | 2003-07-22 | 2005-02-10 | Astex Therapeutics Limited | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| ES2431314T3 (es) * | 2004-02-20 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Inhibidores de polimerasa vírica |
| BRPI0508534A (pt) * | 2004-03-08 | 2007-08-14 | Wyeth Corp | moduladores de canais iÈnicos |
| MX2007008008A (es) | 2004-12-30 | 2007-11-12 | Astex Therapeutics Ltd | Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora. |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| MX2007008781A (es) | 2005-01-21 | 2007-09-11 | Astex Therapeutics Ltd | Compuestos farmaceuticos. |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| CA2618682C (en) * | 2005-08-12 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| EP1928866A1 (de) | 2005-09-05 | 2008-06-11 | Ranbaxy Laboratories Limited | Substituierte indazole als inhibitoren von phosphodiesterase typ-iv |
| EP1931668A2 (de) | 2005-09-16 | 2008-06-18 | Ranbaxy Laboratories Limited | Substituierte pyrazolo [3,4-b]pyridine als phosphodiesterase-hemmer |
| WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| US8399442B2 (en) | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
| EP2049119A2 (de) | 2006-06-29 | 2009-04-22 | Astex Therapeutics Limited | Pharmazeutische kombinationen von 1-cyclopropyl-3-[3-(5-morphoolin-4-ylmethyl-1h-benzoimidazol-2-yl)-1h-1-pyrazol-4-yl]-harnstoff |
| MX2009009793A (es) | 2007-03-14 | 2009-10-16 | Ranbaxy Lab Ltd | Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa. |
| CN102066323B (zh) | 2008-04-16 | 2015-05-13 | 卡罗生物股份公司 | 新的雌激素受体配体 |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| US8455499B2 (en) | 2008-12-11 | 2013-06-04 | Amira Pharmaceuticals, Inc. | Alkyne antagonists of lysophosphatidic acid receptors |
| GB2466121B (en) | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
| GB2470833B (en) | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| EP2462128B1 (de) | 2009-08-04 | 2016-09-21 | Amira Pharmaceuticals, Inc. | Verbindungen als lysophosphatidsäure-rezeptorantagonisten |
| GB2474748B (en) | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| JP2014513077A (ja) | 2011-04-05 | 2014-05-29 | アミラ ファーマシューティカルス，インコーポレーテッド | 線維症、疼痛、癌、ならびに呼吸器、アレルギー性、神経系または心血管疾患の治療に有用な３−または５−ビフェニル−４−イルイソキサゾールに基づく化合物 |
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| BR112016020199A8 (pt) * | 2014-03-07 | 2021-07-20 | Biocryst Pharm Inc | composto inibidor de calicreína plasmática de humano, composição farmacêutica compreendendo o referido composto, kit e seu uso |
| JP2019507747A (ja) * | 2016-02-11 | 2019-03-22 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 有害生物防除剤としての置換オキシイミダゾリル−カルボキサミド類 |
| EP3866773A4 (de) * | 2018-10-16 | 2022-10-26 | Georgia State University Research Foundation, Inc. | Kohlenmonoxid-prodrugs zur behandlung von erkrankungen |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3633840A1 (de) | 1986-10-04 | 1988-04-14 | Hoechst Ag | Phenylpyrazolcarbonsaeurederivate, ihre herstellung und verwendung als pflanzenwachstumsregulatoren und safener |
| EP0513387B1 (de) | 1990-11-30 | 2000-03-01 | Otsuka Pharmaceutical Co., Ltd. | Thiazolederivate als inhibitoren von aktivem sauerstoff |
| DE4124942A1 (de) | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| WO1994024095A1 (en) | 1993-04-16 | 1994-10-27 | Abbott Laboratories | Immunosuppressive agents |
| BR9408137A (pt) | 1993-11-24 | 1997-08-12 | Du Pont Merck Pharma | Composto éster de prodroga método de tratamento composição farmacêutica e método de inibição |
| US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| US5563158A (en) | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| US5658909A (en) | 1994-11-17 | 1997-08-19 | Molecular Geriatrics Corporation | Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease |
| US5750550A (en) * | 1995-09-15 | 1998-05-12 | Sanofi | 2-(pyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3 (2H)-One 1, 1-dioxides and compositions and method of use thereof |
| US6372741B1 (en) | 1996-03-08 | 2002-04-16 | Smithkline Beecham Corporation | Use of CSAID™ compounds as inhibitors of angiogenesis |
| WO1997047299A1 (en) | 1996-06-12 | 1997-12-18 | 3-Dimensional Pharmaceuticals, Inc. | Amidino and guanidino heterocyclic protease inhibitors |
| ZA985247B (en) * | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
| BR9810151A (pt) * | 1997-06-19 | 2000-08-08 | Du Pont Pharm Co | Composto, composição farmacêutica e método para tratamento ou prevenção de uma desordem tromoboembólica |
-
2000
- 2000-03-30 WO PCT/US2000/008364 patent/WO2000059902A2/en active IP Right Grant
- 2000-03-30 CA CA002368630A patent/CA2368630A1/en not_active Abandoned
- 2000-03-30 EP EP00923096A patent/EP1175419B1/de not_active Expired - Lifetime
- 2000-03-30 ES ES00923096T patent/ES2197092T3/es not_active Expired - Lifetime
- 2000-03-30 AT AT00923096T patent/ATE241621T1/de not_active IP Right Cessation
- 2000-03-30 DE DE60003025T patent/DE60003025T2/de not_active Expired - Lifetime
- 2000-03-30 AU AU43276/00A patent/AU4327600A/en not_active Abandoned
- 2000-03-31 US US09/540,467 patent/US6399644B1/en not_active Expired - Lifetime
-
2002
- 2002-02-12 US US10/074,301 patent/US6689770B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000059902A3 (en) | 2001-04-26 |
| EP1175419A2 (de) | 2002-01-30 |
| WO2000059902A2 (en) | 2000-10-12 |
| AU4327600A (en) | 2000-10-23 |
| ES2197092T3 (es) | 2004-01-01 |
| DE60003025D1 (en) | 2003-07-03 |
| DE60003025T2 (de) | 2004-03-18 |
| US20030050315A1 (en) | 2003-03-13 |
| US6689770B2 (en) | 2004-02-10 |
| EP1175419B1 (de) | 2003-05-28 |
| US6399644B1 (en) | 2002-06-04 |
| CA2368630A1 (en) | 2000-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |