BR9810151A - Composto, composição farmacêutica e método para tratamento ou prevenção de uma desordem tromoboembólica - Google Patents

Composto, composição farmacêutica e método para tratamento ou prevenção de uma desordem tromoboembólica

Info

Publication number
BR9810151A
BR9810151A BR9810151-0A BR9810151A BR9810151A BR 9810151 A BR9810151 A BR 9810151A BR 9810151 A BR9810151 A BR 9810151A BR 9810151 A BR9810151 A BR 9810151A
Authority
BR
Brazil
Prior art keywords
treating
preventing
compound
pharmaceutical composition
thromboembolic disorder
Prior art date
Application number
BR9810151-0A
Other languages
English (en)
Inventor
Robert Anthony Galemmo Jr
Celia Dominguez
John Mathew Fevig
Qi Han
Patrick Yuk-Sun Lam
Donald Joseph Philip Pinto
James Russel Pruitt
Mimi Lifen Quan
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26758382&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9810151(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of BR9810151A publication Critical patent/BR9810151A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA E MéTODO PARA TRATAMENTO OU PREVENçãO DE UMA DESORDEM TROMBOEMBóLICA" A presente invenção descreve inibidores do fator Xa com um grupo de especificidade P1 neutro de fórmula (I) ou suas formas de sais farmaceuticamente aceitáveis, onde R e E podem ser grupos tais como metóxi e halo.
BR9810151-0A 1997-06-19 1998-06-18 Composto, composição farmacêutica e método para tratamento ou prevenção de uma desordem tromoboembólica BR9810151A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87888597A 1997-06-19 1997-06-19
US7669198P 1998-02-27 1998-02-27
PCT/US1998/012681 WO1998057937A2 (en) 1997-06-19 1998-06-18 Inhibitors of factor xa with a neutral p1 specificity group

Publications (1)

Publication Number Publication Date
BR9810151A true BR9810151A (pt) 2000-08-08

Family

ID=26758382

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810151-0A BR9810151A (pt) 1997-06-19 1998-06-18 Composto, composição farmacêutica e método para tratamento ou prevenção de uma desordem tromoboembólica

Country Status (22)

Country Link
EP (1) EP0991625B1 (pt)
JP (1) JP2002507968A (pt)
KR (1) KR20010013977A (pt)
AR (1) AR015906A1 (pt)
AT (1) ATE296805T1 (pt)
AU (1) AU8150398A (pt)
BR (1) BR9810151A (pt)
CA (1) CA2290982A1 (pt)
DE (1) DE69830403T2 (pt)
EA (1) EA200000048A1 (pt)
EE (1) EE9900584A (pt)
ES (1) ES2239806T3 (pt)
HR (1) HRP980334A2 (pt)
HU (1) HUP0003906A2 (pt)
IL (1) IL133526A0 (pt)
LV (1) LV12516B (pt)
NO (1) NO996316L (pt)
PL (1) PL337831A1 (pt)
PT (1) PT991625E (pt)
SI (1) SI20208A (pt)
SK (1) SK174699A3 (pt)
WO (1) WO1998057937A2 (pt)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052944A1 (en) * 1997-05-19 1998-11-26 Sugen, Inc. Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders
US6271237B1 (en) 1997-12-22 2001-08-07 Dupont Pharmaceuticals Company Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors
IL136637A0 (en) * 1997-12-22 2001-06-14 Du Pont Pharm Co Nitrogen containing heteroaromatics with ortho-substituted pi's as factor xa inhibitors
WO1999041231A1 (fr) 1998-02-17 1999-08-19 Ono Pharmaceutical Co., Ltd. Derives amidino utilises comme ingredients actifs et medicaments les contenant
EP1064270B1 (en) 1998-03-27 2004-10-06 Bristol-Myers Squibb Pharma Company Disubstituted pyrazolines and triazolines as factor xa inhibitors
WO2000006550A1 (fr) * 1998-07-31 2000-02-10 Nippon Soda Co., Ltd. Composes phenylazole, procede de production desdits composes et medicaments pour le traitement de l'hyperlipidemie
AU3127900A (en) 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
US6395897B1 (en) 1999-03-02 2002-05-28 Boehringer Ingelheim Pharmaceuticals, Inc. Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5
ATE241621T1 (de) * 1999-04-02 2003-06-15 Bristol Myers Squibb Pharma Co Arylsulfonyle als faktor xa inhibitoren
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
PT1169038E (pt) 1999-04-15 2012-10-26 Bristol Myers Squibb Co Inibidores cíclicos da proteína tirosina cinase
KR20030011268A (ko) 1999-07-16 2003-02-07 브리스톨-마이어스 스퀴브 파마 컴퍼니 Ｘａ 인자 억제제로서의 질소 함유 헤테로바이사이클
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
WO2001032628A1 (en) * 1999-11-03 2001-05-10 Bristol-Myers Squibb Pharma Company Cyano compounds as factor xa inhibitors
US6407256B1 (en) 1999-11-03 2002-06-18 Bristol Myers Squibb Co Cyano-pyrrole, cyano-imidazole, cyano-pyrazole, and cyano-triazole compounds as factor Xa inhibitors
MY138097A (en) 2000-03-22 2009-04-30 Du Pont Insecticidal anthranilamides
CA2409762A1 (en) 2000-06-23 2002-01-03 Donald J.P. Pinto Heteroaryl-phenyl substituted factor xa inhibitors
CN1439008A (zh) * 2000-06-23 2003-08-27 布里斯托尔-迈尔斯斯奎布药品公司 作为因子xa抑制剂的1－(杂芳环基－苯基)－稠合吡唑衍生物
US6586418B2 (en) 2000-06-29 2003-07-01 Bristol-Myers Squibb Company Thrombin or factor Xa inhibitors
AU2002231235A1 (en) 2000-11-07 2002-05-21 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
EP1332131A2 (en) 2000-11-07 2003-08-06 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
US6906192B2 (en) 2000-11-07 2005-06-14 Bristol Myers Squibb Company Processes for the preparation of acid derivatives useful as serine protease inhibitors
AR036872A1 (es) 2001-08-13 2004-10-13 Du Pont Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados
TWI325302B (en) 2001-08-13 2010-06-01 Du Pont Benzoxazinone compounds
WO2003016304A1 (en) 2001-08-15 2003-02-27 E. I. Du Pont De Nemours And Company Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests
KR100866463B1 (ko) 2001-08-15 2008-10-31 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충 방제용 오르토-치환 아릴 아미드
MXPA04001407A (es) 2001-08-16 2004-05-27 Du Pont Antranilamidas sustituidas para controlar plagas de invertebrados.
TW200724033A (en) 2001-09-21 2007-07-01 Du Pont Anthranilamide arthropodicide treatment
PL204263B1 (pl) 2001-09-21 2009-12-31 Bristol Myers Squibb Co Pochodna 1H-pirazolo[3,4-c]pirydyny i jej zastosowanie oraz kompozycja farmaceutyczna i jej zastosowanie
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials
BR0307178A (pt) 2002-01-22 2004-12-07 Du Pont Composto, composição e método para controle de pragas invertebradas
EP1505966A4 (en) 2002-05-10 2006-08-30 Bristol Myers Squibb Co 1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA HEMMER
US7754738B2 (en) 2002-06-13 2010-07-13 E.I. Du Pont De Nemours And Company Pyrazole and pyrrole carboxamide insecticides
DE10229070A1 (de) * 2002-06-28 2004-01-15 Merck Patent Gmbh Phenylderivate 5
ATE469143T1 (de) 2002-11-15 2010-06-15 Du Pont Neue insektizide vom anthranilamid-typ
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
US7365094B2 (en) 2002-12-23 2008-04-29 4Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
WO2004056746A1 (en) 2002-12-23 2004-07-08 4Sc Ag Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
ATE450498T1 (de) 2002-12-23 2009-12-15 4Sc Ag Cycloalken-dicarbonsäure-verbindungen als entzündungshemmende, immunmodulatorische und antiproliferative mittel
US7247736B2 (en) 2002-12-23 2007-07-24 4Sc Ag Method of identifying inhibitors of DHODH
RU2343151C3 (ru) 2003-01-28 2019-10-01 ЭфЭмСи Корпорейшн Цианоантраниламидные инсектициды
US7122557B2 (en) * 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
CA2525325A1 (en) * 2003-05-01 2004-11-18 Abbott Laboratories Pyrazole-amides and sulfonamides as sodium channel modulators
US20040220170A1 (en) * 2003-05-01 2004-11-04 Atkinson Robert N. Pyrazole-amides and sulfonamides as sodium channel modulators
KR101204247B1 (ko) 2003-07-22 2012-11-22 아스텍스 테라퓨틱스 리미티드 3,4-이치환된 1ｈ-피라졸 화합물 및 그의 시클린 의존성키나제 (ｃｄｋ) 및 글리코겐 합성효소 키나제-3(ｇｓｋ-3) 조정제로서 용도
CN1826121B (zh) * 2003-07-23 2013-05-29 幸讬制药公司 苯基与吡啶基衍生物用于制备调控钙离子释放活化钙离子通道的药物的用途
DK1700856T3 (en) 2003-12-26 2015-12-14 Kyowa Hakko Kirin Co Ltd thiazole
DK1731512T3 (en) 2004-03-05 2015-01-05 Nissan Chemical Ind Ltd Isoxazoline-substituted benzamide AND INSTRUMENTS FOR COMBATING HARMFUL ORGANISMS
AU2005223483B2 (en) 2004-03-18 2009-04-23 Zoetis Llc N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides
GT200500179A (es) 2004-07-01 2006-02-23 Mezclas sinergistas de agentes de antranilamida para el control de plagas de invertebrados
JP2008512364A (ja) * 2004-09-06 2008-04-24 エフ．ホフマン−ラ ロシュ アーゲー ４−アミノメチルベンズアミジン誘導体及び第ＶＩＩａ因子阻害剤としてのその使用
JP5184891B2 (ja) 2005-01-07 2013-04-17 シンタ ファーマシューティカルズ コーポレーション 炎症及び免疫に関連する用途に用いる化合物
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
EP1894930A4 (en) 2005-06-23 2010-06-23 Kyowa Hakko Kirin Co Ltd THIAZOLE DERIVATIVE
KR101083506B1 (ko) * 2005-07-15 2011-11-16 에프. 호프만-라 로슈 아게 신규한 헤테로아릴 융합된 환형 아민
AU2006283181A1 (en) 2005-08-24 2007-03-01 E. I. Du Pont De Nemours And Company Anthranilamides for controlling invertebrate pests
TWI324908B (en) 2006-01-05 2010-05-21 Du Pont Liquid formulations of carboxamide arthropodicides
US7943646B2 (en) * 2006-01-31 2011-05-17 Dong Wha Pharmaceutical Co., Ltd. Benzamidine derivative, process for the preparation thereof and pharmaceutical composition comprising same
EP2051707B1 (en) * 2006-07-31 2013-07-17 Activesite Pharmaceuticals, Inc. Inhibitors of plasma kallikrein
EP1894928A1 (en) 2006-08-29 2008-03-05 PheneX Pharmaceuticals AG Heterocyclic fxr binding compounds
CN101583593A (zh) 2006-11-13 2009-11-18 辉瑞产品公司 二芳基、二吡啶基和芳基-吡啶基衍生物及其用途
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
WO2010059602A2 (en) * 2008-11-19 2010-05-27 Schering Corporation Inhibitors of diacylglycerol acyltransferase
MX2012006723A (es) 2009-12-15 2012-06-28 Bayer Cropscience Ag Procedimiento para la preparacion de derivados de acido 1-alquil-/1-aril-5-pirazolcarboxilico.
EP2512466A4 (en) 2009-12-18 2013-07-03 Activesite Pharmaceuticals Inc PRODRUGS OF INHIBITORS OF PLASMATIC KALLICREIN
EP2630128A1 (en) * 2010-10-20 2013-08-28 Biota Scientific Management Pty Ltd Viral polymerase inhibitors
KR101373185B1 (ko) * 2010-12-17 2014-03-13 주식회사경농 인다졸 유도체 및 이를 함유하는 살충제 조성물
UA110241C2 (en) 2011-03-31 2015-12-10 Bayer Ip Gmbh Herbicides and fungicides active phneylisoxazoline 3-5-carboxamide and 3- phneylisoxazoline -5-thioamides
EP2697196A1 (en) 2011-04-13 2014-02-19 Activesite Pharmaceuticals, Inc. Prodrugs of inhibitors of plasma kallikrein
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
EP2578582A1 (en) 2011-10-03 2013-04-10 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
WO2013050757A1 (en) 2011-10-03 2013-04-11 Respivert Limited 1-pyrazolyl-3- (4- ( (2 -anilinopyrimidin- 4 - yl) oxy) napththalen- 1 - yl) ureas as p38 map kinase inhibitors
MX354745B (es) * 2012-09-25 2018-03-16 Bayer Cropscience Ag 3-fenilisoxazolin-5-carboxamidas 5-oxi-sustituidas y 3-fenilisoxazolin-5-tioamidas 5-oxi-sustituidas herbicidas y fungicidas.
AU2013326600B2 (en) 2012-10-02 2017-03-30 Bayer Cropscience Ag Heterocyclic compounds as pesticides
EP2961746B1 (en) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
EP3828173B1 (en) 2014-03-07 2022-08-31 BioCryst Pharmaceuticals, Inc. Substituted pyrazoles as human plasma kallikrein inhibitors
CN104072432B (zh) * 2014-07-23 2015-12-30 张远强 含苯基取代三唑希夫碱类结构的化合物、其制备方法和用途
CN104086501B (zh) * 2014-07-23 2016-02-17 张远强 一种par-1拮抗剂、其制备方法和用途
CN104086502B (zh) * 2014-07-23 2015-10-14 张远强 卤代四氮唑苯乙酮化合物、其制备方法和用途
CN104072436B (zh) * 2014-07-23 2015-10-14 张远强 对位取代的四氮唑苯乙酮化合物、其制备方法和用途
CN104086492B (zh) * 2014-07-23 2015-12-30 张远强 抗血栓化合物、其制备方法和用途
CN104086493B (zh) * 2014-07-23 2016-05-18 张远强 末端取代的苯基三唑希夫碱结构的化合物及其用途
CN104072435B (zh) * 2014-07-23 2015-11-04 张远强 双烷基取代的四氮唑苯乙酮化合物和用途
CN104086498B (zh) * 2014-07-23 2015-11-18 张远强 末端取代的三唑希夫碱类结构的化合物、其制备方法和用途
CN104086500B (zh) * 2014-07-23 2015-08-26 张远强 一种par-1拮抗剂及其用途
CN104086503B (zh) * 2014-07-23 2015-10-14 张远强 Par-1拮抗剂及其用途
CN104072431B (zh) * 2014-07-23 2015-11-18 张远强 烷氧基取代的苯基三唑希夫碱结构的化合物及用途
CN104072439B (zh) * 2014-07-23 2015-11-04 张远强 卤素取代的四氮唑苯乙酮化合物、其制备方法和用途
CN104086497B (zh) * 2014-07-23 2016-03-02 张远强 三唑希夫碱类化合物、其制备方法和用途
CN104072434B (zh) * 2014-07-23 2015-12-02 张远强 间位取代的四氮唑苯乙酮化合物、其制备方法和用途
CN104072438B (zh) * 2014-07-23 2015-10-14 张远强 二烷氧代四氮唑苯乙酮化合物、其制备方法和用途
CN104072437B (zh) * 2014-07-23 2015-10-14 张远强 双取代的四氮唑苯乙酮化合物、其制备方法和用途
RS58889B1 (sr) 2014-08-29 2019-08-30 Torrent Pharmaceuticals Ltd Jedinjenja indanil uree koja inhibiraju p38 map kinazu
CN104529928A (zh) * 2015-01-13 2015-04-22 佛山市赛维斯医药科技有限公司 一类恶二唑亚砜化合物、其制备方法和用途
CN110770232B (zh) 2017-06-13 2023-08-15 拜耳公司 除草活性的四氢和二氢呋喃羧酸和酯的3-苯基异噁唑啉-5-甲酰胺
AU2018285213B2 (en) 2017-06-13 2022-05-19 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of tetrahydro and dihydrofuran carboxamides
US20200369630A1 (en) 2017-08-17 2020-11-26 Bayer Aktiengesellschaft Herbicidally active 3-phenyl-5-trifluoromethylisoxazoline-5-carboxamides of cyclopentylcarboxylic acids and esters
US20220306591A1 (en) 2018-01-25 2022-09-29 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of cyclopentenylcarboxylic acid derivatives
DK3937637T3 (da) 2019-03-12 2023-07-24 Bayer Ag Herbicidt virksomme 3-phenylisoxazolin-5-carboxamider af s-holdige cyclopentenylcarbonsyreestere
JP2023509452A (ja) 2020-01-03 2023-03-08 バーグ エルエルシー がんを処置するためのｕｂｅ２ｋモジュレータとしての多環式アミド
CA3216863A1 (en) * 2021-05-05 2022-11-10 University College Cardiff Consultants Limited Heteroaryl compounds useful in the treatment of cognitive disorders

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134987A (en) * 1976-01-14 1979-01-16 Huppatz John L Compounds and compositions
ES488768A0 (es) * 1979-02-22 1981-02-16 Monsanto Co Un procedimiento para preparar acido 2-(3-aril-5-isoxazolil)-benzoico
US4226877A (en) * 1979-05-14 1980-10-07 Abbott Laboratories Pyrazoles active in the central nervous system
EP0028489B1 (en) 1979-11-05 1983-10-05 Beecham Group Plc Enzyme derivatives, and their preparation
DE3420985A1 (de) * 1983-10-15 1985-04-25 Bayer Ag, 5090 Leverkusen Substituierte 5-acylamino-1-phenylpyrazole
IL73419A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
DE3540839A1 (de) * 1985-11-18 1987-05-27 Bayer Ag 1-aryl-pyrazole
DE3633840A1 (de) * 1986-10-04 1988-04-14 Hoechst Ag Phenylpyrazolcarbonsaeurederivate, ihre herstellung und verwendung als pflanzenwachstumsregulatoren und safener
DE3706993A1 (de) * 1987-03-05 1988-09-15 Bayer Ag 5-amino-3-halogenalkyl-1-aryl-pyrazole
JPS6425763A (en) * 1987-04-24 1989-01-27 Mitsubishi Chem Ind Pyrazoles and insecticide and acaricide containing said pyrazoles as active ingredient
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
DE3808896A1 (de) * 1988-03-17 1989-09-28 Hoechst Ag Pflanzenschuetzende mittel auf basis von pyrazolcarbonsaeurederivaten
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
DE4013723A1 (de) * 1990-04-28 1991-10-31 Basf Ag 5-(1,2,4-triazol-1-ylmethyl)-isoxazoline
GB9017694D0 (en) 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
ES2245660T3 (es) * 1990-11-30 2006-01-16 Otsuka Pharmaceutical Co., Ltd. Derivados de azol y su utilizacion como inhibidores de los radicales superoxidos.
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
AU672802B2 (en) * 1992-07-24 1996-10-17 Merck Sharp & Dohme Limited Imidazole, triazole and tetrazole derivatives
US5262412A (en) * 1993-03-10 1993-11-16 Merck & Co., Inc. Substituted pyrazoles, compositions and use
ES2120713T3 (es) 1993-11-24 1998-11-01 Du Pont Merck Pharma Compuestos de isoxazolinas utiles como antagonistas de receptores del fibrinogeno.
HUT74690A (en) * 1993-11-24 1997-01-28 Du Pont Merck Pharma Novel isoxazoline and isoxazole fibrinogen receptor antagonists process for producing them and pharmaceutical compositions containing them
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5446056A (en) 1993-11-24 1995-08-29 The Du Pont Merck Pharmaceutical Company Isoxazoline compounds useful as fibrinogen receptor antagonists
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
DE4405207A1 (de) * 1994-02-18 1995-08-24 Bayer Ag N-Pyrazolylaniline und N-Pyrazolylaminopyridine
DK0813525T3 (da) * 1995-03-10 2004-02-16 Berlex Lab Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
IL118007A0 (en) 1995-05-24 1996-08-04 Du Pont Merck Pharma Isoxazoline compounds pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
AU8150398A (en) 1999-01-04
HRP980334A2 (en) 1999-04-30
HUP0003906A2 (hu) 2001-05-28
EE9900584A (et) 2000-08-15
JP2002507968A (ja) 2002-03-12
EP0991625A2 (en) 2000-04-12
ATE296805T1 (de) 2005-06-15
ES2239806T3 (es) 2005-10-01
SK174699A3 (en) 2000-08-14
IL133526A0 (en) 2001-04-30
EA200000048A1 (ru) 2000-08-28
DE69830403D1 (de) 2005-07-07
LV12516B (en) 2001-03-20
DE69830403T2 (de) 2006-02-02
WO1998057937A2 (en) 1998-12-23
NO996316D0 (no) 1999-12-17
AR015906A1 (es) 2001-05-30
NO996316L (no) 1999-12-17
KR20010013977A (ko) 2001-02-26
SI20208A (sl) 2000-10-31
PL337831A1 (en) 2000-09-11
LV12516A (en) 2000-07-20
EP0991625B1 (en) 2005-06-01
PT991625E (pt) 2005-10-31
WO1998057937A3 (en) 1999-03-18
CA2290982A1 (en) 1998-12-23

Similar Documents

Publication Publication Date Title
BR9810151A (pt) Composto, composição farmacêutica e método para tratamento ou prevenção de uma desordem tromoboembólica
BR9810137A (pt) Composto, composição farmacêutica e método de tratamento ou prevenção de uma desordem tromoboembólica
BR9813835A (pt) Composto, composição farmacêutica e método de tratamento ou prevenção de uma desordem tromboembólica
BR9917080A (pt) Composto, composição farmacêutica, uso do composto e método de tratamento ou prevenção de uma disfunção tromboembólica
BRPI0415409A (pt) uso de efetuadores de ciclases de glutaminila e glutamato
NO995349L (no) Multivalent vaksinasjonssammensetning med blandet baerer
BR9709959A (pt) Derivados tricìclicos de fenilamino substituìdo para o tratamento de doenças hiperproliferativas
NZ285846A (en) Arylsulphonamido-substituted hydroxamic acids and preparation and medicaments useful for inhibiting metalloproteinases
NO996269L (no) Kinolin-indol antimikrobielle midler, samt anvendelse og blandinger derav
BR0205890A (pt) Pirazolopirimidinas como agentes terapêuticos
TR199801151T2 (xx) Trombin inhibit�r� �n ila�lar.
DK1129212T3 (da) Screeningsproces for antibakterielle midler
EA200000594A1 (ru) Новые макролиды
WO2002080939A8 (en) Ionene polymers and their use as antimicrobial agents
BR0211305A (pt) Composto, composição farmacêutica, método de tratamento ou prevenção de doenças ou condições e uso de um composto
BR0213154A (pt) Compostos de glicopeptìdeo - cefalosporina de ligação reticulada, composições farmacêuticas de tais compostos, método de fabricação dos mesmos e seus usos
ATE259823T1 (de) Tricyclische erythromycinderivate
MX9708452A (es) Inhibidores de sialidasa bacteriana y metodos para fabricar y usar la misma.
DK1007530T3 (da) 6-O-substituerede erythromycinforbindelser samt fremgangsmåde til fremstilling heraf
ATE328898T1 (de) Chemotaxis hemmendes protein von staphylococcus aureus (chips) und dessen verwendung
PT640098E (pt) Gene de coronavirus canino e suas utilizacoesc
BR9814188A (pt) "agonistas de 5-ht1f"
BR0211737A (pt) Derivados fenìlicos como inibidores do fator xa
BR9915813A (pt) Derivados da higromicina a como agentes antibacterianos
BR9814933A (pt) Composto, composicao farmaceutica e metodo de tratamento de infeccao por hiv.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A, 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1889 DE 20/03/2007.