DE69830403D1 - Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifität - Google Patents

Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifität

Info

Publication number
DE69830403D1
DE69830403D1 DE69830403T DE69830403T DE69830403D1 DE 69830403 D1 DE69830403 D1 DE 69830403D1 DE 69830403 T DE69830403 T DE 69830403T DE 69830403 T DE69830403 T DE 69830403T DE 69830403 D1 DE69830403 D1 DE 69830403D1
Authority
DE
Germany
Prior art keywords
specificity
inhibitors
factor
neutral group
neutral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69830403T
Other languages
English (en)
Other versions
DE69830403T2 (de
Inventor
Anthony Galemmo
Celia Dominguez
Matthew Fevig
Qi Han
Yuk-Sun Lam
Joseph Pinto
Russell Pruitt
Lifen Quan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26758382&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69830403(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of DE69830403D1 publication Critical patent/DE69830403D1/de
Publication of DE69830403T2 publication Critical patent/DE69830403T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69830403T 1997-06-19 1998-06-18 Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifität Expired - Lifetime DE69830403T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87888597A 1997-06-19 1997-06-19
US878885 1997-06-19
US7669198P 1998-02-27 1998-02-27
US76691P 1998-02-27
PCT/US1998/012681 WO1998057937A2 (en) 1997-06-19 1998-06-18 Inhibitors of factor xa with a neutral p1 specificity group

Publications (2)

Publication Number Publication Date
DE69830403D1 true DE69830403D1 (de) 2005-07-07
DE69830403T2 DE69830403T2 (de) 2006-02-02

Family

ID=26758382

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69830403T Expired - Lifetime DE69830403T2 (de) 1997-06-19 1998-06-18 Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifität

Country Status (22)

Country Link
EP (1) EP0991625B1 (de)
JP (1) JP2002507968A (de)
KR (1) KR20010013977A (de)
AR (1) AR015906A1 (de)
AT (1) ATE296805T1 (de)
AU (1) AU8150398A (de)
BR (1) BR9810151A (de)
CA (1) CA2290982A1 (de)
DE (1) DE69830403T2 (de)
EA (1) EA200000048A1 (de)
EE (1) EE9900584A (de)
ES (1) ES2239806T3 (de)
HR (1) HRP980334A2 (de)
HU (1) HUP0003906A2 (de)
IL (1) IL133526A0 (de)
LV (1) LV12516B (de)
NO (1) NO996316L (de)
PL (1) PL337831A1 (de)
PT (1) PT991625E (de)
SI (1) SI20208A (de)
SK (1) SK174699A3 (de)
WO (1) WO1998057937A2 (de)

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CN104072431B (zh) * 2014-07-23 2015-11-18 张远强 烷氧基取代的苯基三唑希夫碱结构的化合物及用途
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CN104086497B (zh) * 2014-07-23 2016-03-02 张远强 三唑希夫碱类化合物、其制备方法和用途
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ATE296805T1 (de) 2005-06-15
DE69830403T2 (de) 2006-02-02
SK174699A3 (en) 2000-08-14
IL133526A0 (en) 2001-04-30
ES2239806T3 (es) 2005-10-01
NO996316D0 (no) 1999-12-17
SI20208A (sl) 2000-10-31
CA2290982A1 (en) 1998-12-23
LV12516A (en) 2000-07-20
NO996316L (no) 1999-12-17
AR015906A1 (es) 2001-05-30
AU8150398A (en) 1999-01-04
HUP0003906A2 (hu) 2001-05-28
HRP980334A2 (en) 1999-04-30
PT991625E (pt) 2005-10-31
EP0991625A2 (de) 2000-04-12
PL337831A1 (en) 2000-09-11
BR9810151A (pt) 2000-08-08
LV12516B (en) 2001-03-20
WO1998057937A3 (en) 1999-03-18
EP0991625B1 (de) 2005-06-01
EE9900584A (et) 2000-08-15
JP2002507968A (ja) 2002-03-12
WO1998057937A2 (en) 1998-12-23
EA200000048A1 (ru) 2000-08-28

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