DK1004669T3 - Hidtil ukendte differentieringsinhibitor - Google Patents

Hidtil ukendte differentieringsinhibitor

Info

Publication number
DK1004669T3
DK1004669T3 DK98919575T DK98919575T DK1004669T3 DK 1004669 T3 DK1004669 T3 DK 1004669T3 DK 98919575 T DK98919575 T DK 98919575T DK 98919575 T DK98919575 T DK 98919575T DK 1004669 T3 DK1004669 T3 DK 1004669T3
Authority
DK
Denmark
Prior art keywords
inhibitor
newly differentiated
differentiated
newly
differentiated inhibitor
Prior art date
Application number
DK98919575T
Other languages
English (en)
Inventor
Seiji Sakano
Original Assignee
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14876069&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1004669(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind
Application granted granted Critical
Publication of DK1004669T3 publication Critical patent/DK1004669T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK98919575T 1997-05-14 1998-05-13 Hidtil ukendte differentieringsinhibitor DK1004669T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12406497 1997-05-14
PCT/JP1998/002104 WO1998051799A1 (fr) 1997-05-14 1998-05-13 Nouvel inhibiteur de differentiation

Publications (1)

Publication Number Publication Date
DK1004669T3 true DK1004669T3 (da) 2007-08-27

Family

ID=14876069

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98919575T DK1004669T3 (da) 1997-05-14 1998-05-13 Hidtil ukendte differentieringsinhibitor

Country Status (9)

Country Link
US (2) US6664098B1 (da)
EP (1) EP1004669B1 (da)
JP (3) JP4171528B2 (da)
AU (1) AU730782B2 (da)
CA (1) CA2288218C (da)
DE (1) DE69837601T2 (da)
DK (1) DK1004669T3 (da)
ES (1) ES2284205T3 (da)
WO (1) WO1998051799A1 (da)

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US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
JP4171528B2 (ja) * 1997-05-14 2008-10-22 旭化成株式会社 新規な分化抑制剤
CA2333893A1 (en) * 1998-07-13 2000-01-20 Yale University Delta cleavage products and methods based thereon
JP2002523018A (ja) * 1998-07-27 2002-07-30 アムジエン・インコーポレーテツド デルタ関連ポリペプチド
US6703221B1 (en) 1999-08-19 2004-03-09 Chiron Corporation Notch receptor ligands and uses thereof
WO2001012664A2 (en) * 1999-08-19 2001-02-22 Chiron Corporation Notch receptor ligands and uses thereof
BRPI0112205B8 (pt) 2000-07-10 2021-06-22 Asahi Kasei Kuraray Medical Co filtro de processamento de sangue.
US20080194022A1 (en) * 2000-08-03 2008-08-14 Clarke Michael F Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US20040023324A1 (en) * 2000-08-25 2004-02-05 Seiji Sakano Stem cell culture medium and culture method by using the same
GB0118155D0 (en) * 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
US20030119771A1 (en) * 2001-08-22 2003-06-26 Rompaey Luc Van Modulators of bone homeostasis identified in a high-throughput screen
WO2003018799A2 (en) * 2001-08-22 2003-03-06 Galapagos Genomics N.V. Modulators of bone homeostasis identified in a high-throughput screen
EP1639090A4 (en) * 2003-06-09 2008-04-16 Univ Michigan COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER
US7795404B1 (en) 2003-08-08 2010-09-14 Five Prime Therapeutics, Inc. Human soluble notch receptor ligands
US8048418B2 (en) 2004-10-29 2011-11-01 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists
US20060134121A1 (en) * 2004-10-29 2006-06-22 Gavin Thurston DII4 antagonists, assays, and therapeutic methods thereof
US7906116B2 (en) * 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
CA2621226A1 (en) * 2005-09-01 2007-03-08 Vasgene Therapeutics, Inc. Methods for using and identifying modulators of delta-like 4
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
JP2009513708A (ja) 2005-10-31 2009-04-02 オンコメッド ファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
JP5129149B2 (ja) 2005-10-31 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を処置および診断するための組成物および方法
CA2630839C (en) * 2005-12-16 2017-01-17 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with dll4 antagonists
US20080019961A1 (en) * 2006-02-21 2008-01-24 Regents Of The University Of Michigan Hedgehog signaling pathway antagonist cancer treatment
CA2654304A1 (en) * 2006-06-06 2007-12-13 Genentech, Inc. Compositions and methods for modulating vascular development
AU2007319672B2 (en) 2006-06-06 2011-06-30 Genentech, Inc. Anti-DLL4 antibodies and methods using same
PL2066694T3 (pl) 2006-09-29 2016-04-29 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworu
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
WO2008079326A2 (en) * 2006-12-20 2008-07-03 Vasgene Therapeutics, Inc. Methods for using and identifying modulators of delta-like 4
WO2008092002A2 (en) 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
AU2009296246B2 (en) 2008-09-26 2015-07-30 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
DK2356270T3 (da) 2008-11-07 2016-12-12 Fabrus Llc Kombinatoriske antistofbiblioteker og anvendelser deraf
PL3072526T3 (pl) 2009-10-16 2019-04-30 Oncomed Pharm Inc Kombinacja terapeutyczna i zastosowanie przeciwciał antagonistycznych względem DLL4 i środków antyhipertensyjnych
CA2782299A1 (en) * 2009-12-01 2011-06-09 Oncomed Pharmaceuticals, Inc. Methods for treating cancers comprising k-ras mutations
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CN102971337B (zh) 2010-04-01 2016-09-21 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
LT3485903T (lt) 2011-09-23 2023-02-27 Mereo Biopharma 5, Inc. Vegf/ dll4 surišantys agentai ir jų panaudojimas
CA2887711A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
US9599620B2 (en) 2012-10-31 2017-03-21 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a DLL4 antagonist
CN105073195A (zh) 2013-02-04 2015-11-18 昂科梅德制药有限公司 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
AU2015338974B2 (en) 2014-10-31 2021-08-26 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
US10166173B2 (en) * 2014-12-02 2019-01-01 Dow Global Technologies Llc Polyurethane microparticles coated with a zinc salt and methods for the preparation thereof
EP3353204B1 (en) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer
US20220348617A1 (en) * 2019-05-01 2022-11-03 H. Lee Moffitt Cancer Center And Research Institute, Inc Engineering broadly reactive human notch ligands as novel tools for biomedical applications

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04171762A (ja) * 1990-11-02 1992-06-18 Olympus Optical Co Ltd 固体撮像装置及びその製造方法
JPH04171528A (ja) * 1990-11-06 1992-06-18 Nec Corp 送信データ量圧縮通信方式
IL101728A (en) 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
ES2334953T3 (es) 1995-06-28 2010-03-17 Imperial Cancer Research Technology Limited Secuencias de nucleotidos y proteinas de genes delta de vertebrados y metodos basados en los mismos.
JP4283891B2 (ja) * 1995-11-17 2009-06-24 旭化成株式会社 分化抑制ポリペプチド
US6291210B1 (en) * 1996-07-16 2001-09-18 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
EP0972041B2 (en) * 1997-04-04 2017-01-18 Millennium Pharmaceuticals, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
JP4171762B2 (ja) * 1997-05-14 2008-10-29 旭化成株式会社 新規な分化抑制剤
JP4171528B2 (ja) * 1997-05-14 2008-10-22 旭化成株式会社 新規な分化抑制剤
JP3989589B2 (ja) * 1997-05-14 2007-10-10 旭化成株式会社 血管細胞調節剤

Also Published As

Publication number Publication date
AU7236598A (en) 1998-12-08
JP4171528B2 (ja) 2008-10-22
DE69837601T2 (de) 2007-12-27
US6664098B1 (en) 2003-12-16
US20030049788A1 (en) 2003-03-13
WO1998051799A1 (fr) 1998-11-19
EP1004669A1 (en) 2000-05-31
JP4714235B2 (ja) 2011-06-29
JP2008260773A (ja) 2008-10-30
EP1004669B1 (en) 2007-04-18
CA2288218C (en) 2013-03-12
CA2288218A1 (en) 1998-11-19
JP2008260772A (ja) 2008-10-30
DE69837601D1 (de) 2007-05-31
AU730782B2 (en) 2001-03-15
EP1004669A4 (en) 2004-03-31
JP4801695B2 (ja) 2011-10-26
ES2284205T3 (es) 2007-11-01
US7022499B2 (en) 2006-04-04

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