MX2009009793A - Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa. - Google Patents
Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa.Info
- Publication number
- MX2009009793A MX2009009793A MX2009009793A MX2009009793A MX2009009793A MX 2009009793 A MX2009009793 A MX 2009009793A MX 2009009793 A MX2009009793 A MX 2009009793A MX 2009009793 A MX2009009793 A MX 2009009793A MX 2009009793 A MX2009009793 A MX 2009009793A
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- pde
- type
- diseases
- pde type
- phosphodiesterase
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se relaciona a inhibidores de fosfodiesterasa (PDE) tipo 4, de fosfodiesterasa (PDE) tipo 7 y de PDE tipo 4/PDE tipo 7 doble. Los compuestos divulgados en la presente que tienen la estructura de la Fórmula 1: pueden ser útiles en el tratamiento, prevención, inhibición o supresión de enfermedades del CNS, por ejemplo, esclerosis múltiple; varias condiciones patológicas tales como enfermedades que afectan el sistema inmune, incluyendo SIDA, rechazo de transplante, desórdenes autoinmunes tales como enfermedades relacionadas con la célula T, por ejemplo, artritis reumatoide; enfermedades inflamatorias tales como enfermedades inflamatorias respiratorias, incluyendo enfermedad pulmonar obstructiva crónica (COPD), asma, bronquitis, rinitis alérgica, síndrome de angustia respiratoria en adulto (ARDS) y otras enfermedades inflamatorias incluyendo, pero no limitadas a, psoriasis, shock, dermatitis atópica, granuloma eosinofílico, conjuntivitis alérgica, osteoartritis; enfermedades de inflamación gastrointestinal tales como enfermedad de Crohn, colitis, pancreatitis así como diferentes tipos de cánceres incluyendo leucemia; especialmente en humanos. Se proporcionan procesos para la preparación de los compuestos divulgados, composiciones farmacéuticas que contienen los compuestos divulgados y su uso como inhibidores de PDE tipo 4, de PDE tipo 7 y de PDE tipo 4/PDE tipo 7 doble.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN550DE2007 | 2007-03-14 | ||
PCT/IB2008/050943 WO2008111010A1 (en) | 2007-03-14 | 2008-03-14 | Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009009793A true MX2009009793A (es) | 2009-10-16 |
Family
ID=39575541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009009793A MX2009009793A (es) | 2007-03-14 | 2008-03-14 | Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa. |
Country Status (22)
Country | Link |
---|---|
US (1) | US8420666B2 (es) |
EP (1) | EP2124944B1 (es) |
JP (1) | JP5671236B2 (es) |
KR (1) | KR101568884B1 (es) |
CN (2) | CN101801376A (es) |
AP (1) | AP2453A (es) |
AT (1) | ATE545417T1 (es) |
AU (1) | AU2008224541B2 (es) |
CA (1) | CA2680625C (es) |
CY (1) | CY1112805T1 (es) |
DK (1) | DK2124944T3 (es) |
EA (1) | EA018670B9 (es) |
ES (1) | ES2382715T3 (es) |
HK (1) | HK1138758A1 (es) |
HR (1) | HRP20120361T1 (es) |
MX (1) | MX2009009793A (es) |
NZ (1) | NZ579645A (es) |
PL (1) | PL2124944T3 (es) |
PT (1) | PT2124944E (es) |
SI (1) | SI2124944T1 (es) |
WO (1) | WO2008111010A1 (es) |
ZA (1) | ZA200906418B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007031838A1 (en) * | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
EP2001880A2 (en) * | 2006-03-07 | 2008-12-17 | Array Biopharma, Inc. | Heterobicyclic pyrazole compounds and methods of use |
US20110053931A1 (en) * | 2006-06-08 | 2011-03-03 | John Gaudino | Quinoline compounds and methods of use |
MX2009001198A (es) * | 2006-08-16 | 2009-02-11 | Hoffmann La Roche | Inhibidores no nucleosidicos de la transcriptasa inversa. |
JP2012502977A (ja) * | 2008-09-19 | 2012-02-02 | ランバクシー ラボラトリーズ リミテッド | ホスホジエステラーゼ阻害薬 |
JP5819846B2 (ja) | 2009-12-08 | 2015-11-24 | バンダービルト ユニバーシティ | 静脈摘出および自家移植のための改善された方法および組成物 |
US10034861B2 (en) * | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
US10246462B2 (en) | 2016-09-09 | 2019-04-02 | Flx Bio, Inc. | Chemokine receptor modulators and uses thereof |
JOP20190126A1 (ar) | 2016-12-22 | 2019-05-28 | H Lundbeck As | بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1 |
EA037544B1 (ru) * | 2017-04-04 | 2021-04-12 | Х. Лундбекк А/С | ПРИМЕНЕНИЕ 1H-ПИРАЗОЛО[4,3-b]ПИРИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ PDE1 |
AR113926A1 (es) | 2017-12-14 | 2020-07-01 | H Lundbeck As | Derivados de 1h-pirazolo[4,3-b]piridinas |
SG11202005361RA (en) | 2017-12-14 | 2020-07-29 | H Lundbeck As | Combination treatments comprising administration of 1h-pyrazolo[4,3-b]pyridines |
US10766893B2 (en) | 2017-12-20 | 2020-09-08 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
US11535611B2 (en) | 2017-12-20 | 2022-12-27 | H. Lundbeck A/S | Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors |
TW201927784A (zh) | 2017-12-20 | 2019-07-16 | 丹麥商H 朗德貝克公司 | 作為pde1抑制劑之大環 |
CN113200997B (zh) * | 2021-05-07 | 2023-10-03 | 上海合全医药有限公司 | 2,5-二氧杂-8-氮杂螺[3.5]壬烷及其盐的合成方法 |
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- 2008-03-14 ES ES08737621T patent/ES2382715T3/es active Active
- 2008-03-14 CA CA2680625A patent/CA2680625C/en not_active Expired - Fee Related
- 2008-03-14 EP EP08737621A patent/EP2124944B1/en not_active Not-in-force
- 2008-03-14 KR KR1020097021120A patent/KR101568884B1/ko not_active IP Right Cessation
- 2008-03-14 SI SI200830590T patent/SI2124944T1/sl unknown
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- 2008-03-14 JP JP2009553263A patent/JP5671236B2/ja not_active Expired - Fee Related
- 2008-03-14 WO PCT/IB2008/050943 patent/WO2008111010A1/en active Application Filing
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- 2008-03-14 CN CN200880014410A patent/CN101801376A/zh active Pending
- 2008-03-14 DK DK08737621.6T patent/DK2124944T3/da active
- 2008-03-14 AT AT08737621T patent/ATE545417T1/de active
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- 2008-03-14 NZ NZ579645A patent/NZ579645A/en not_active IP Right Cessation
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Publication number | Publication date |
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NZ579645A (en) | 2012-01-12 |
EP2124944A1 (en) | 2009-12-02 |
JP2010521451A (ja) | 2010-06-24 |
PT2124944E (pt) | 2012-05-17 |
EA018670B9 (ru) | 2014-01-30 |
EA018670B1 (ru) | 2013-09-30 |
SI2124944T1 (sl) | 2012-05-31 |
KR101568884B1 (ko) | 2015-11-12 |
CY1112805T1 (el) | 2016-02-10 |
ES2382715T3 (es) | 2012-06-12 |
HRP20120361T1 (hr) | 2012-05-31 |
AP2009004977A0 (en) | 2009-10-31 |
CA2680625C (en) | 2016-02-23 |
EP2124944B1 (en) | 2012-02-15 |
CA2680625A1 (en) | 2008-09-18 |
AU2008224541B2 (en) | 2013-08-22 |
ATE545417T1 (de) | 2012-03-15 |
CN101801376A (zh) | 2010-08-11 |
CN103497185A (zh) | 2014-01-08 |
ZA200906418B (en) | 2010-05-26 |
AU2008224541A1 (en) | 2008-09-18 |
PL2124944T3 (pl) | 2012-08-31 |
JP5671236B2 (ja) | 2015-02-18 |
US20100292196A1 (en) | 2010-11-18 |
KR20090120505A (ko) | 2009-11-24 |
HK1138758A1 (en) | 2010-09-03 |
US8420666B2 (en) | 2013-04-16 |
WO2008111010A1 (en) | 2008-09-18 |
EA200970852A1 (ru) | 2010-04-30 |
AP2453A (en) | 2012-08-31 |
DK2124944T3 (da) | 2012-04-23 |
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