DE69920888D1 - Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren - Google Patents
Disubstituierte pyrazoline und triazoline als faktor xa inhibitorenInfo
- Publication number
- DE69920888D1 DE69920888D1 DE69920888T DE69920888T DE69920888D1 DE 69920888 D1 DE69920888 D1 DE 69920888D1 DE 69920888 T DE69920888 T DE 69920888T DE 69920888 T DE69920888 T DE 69920888T DE 69920888 D1 DE69920888 D1 DE 69920888D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- factor
- triazoline
- pyrazoline
- disubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Manufacturing Of Printed Wiring (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7972598P | 1998-03-27 | 1998-03-27 | |
US79725P | 1998-03-27 | ||
PCT/US1999/006310 WO1999050255A2 (en) | 1998-03-27 | 1999-03-23 | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69920888D1 true DE69920888D1 (de) | 2004-11-11 |
DE69920888T2 DE69920888T2 (de) | 2006-02-02 |
Family
ID=22152402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69920888T Expired - Fee Related DE69920888T2 (de) | 1998-03-27 | 1999-03-23 | Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren |
Country Status (9)
Country | Link |
---|---|
US (3) | US6191159B1 (de) |
EP (1) | EP1064270B1 (de) |
JP (1) | JP2002509924A (de) |
AT (1) | ATE278673T1 (de) |
AU (1) | AU3110999A (de) |
CA (1) | CA2321538A1 (de) |
DE (1) | DE69920888T2 (de) |
ES (1) | ES2230841T3 (de) |
WO (1) | WO1999050255A2 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE278673T1 (de) * | 1998-03-27 | 2004-10-15 | Bristol Myers Squibb Pharma Co | Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren |
CA2349330C (en) * | 1998-12-23 | 2009-09-29 | Dupont Pharmaceuticals Company | Nitrogen containing heterobicycles as factor xa inhibitors |
US6858616B2 (en) | 1998-12-23 | 2005-02-22 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor Xa inhibitors |
AU4307800A (en) * | 1999-04-30 | 2000-11-17 | Merab Lomia | New indication for use of antiepileptic agents and medicines |
US6329527B1 (en) * | 1999-10-21 | 2001-12-11 | Bristol-Myers Squibb Pharma Company | Synthesis of 1,3,5-trisubstituted pyrazoles |
WO2002000655A1 (en) * | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors |
US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
AU2002247019C1 (en) * | 2001-01-26 | 2017-05-11 | Organon Llc | Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
WO2003026643A2 (en) * | 2001-09-21 | 2003-04-03 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
BRPI0212726B8 (pt) | 2001-09-21 | 2021-05-25 | Bristol Myers Squibb Co | compostos contendo lactamas, e derivados dos mesmos, composição farmacêutica que os compreende e seus usos |
TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
AU2002350217A1 (en) | 2001-12-04 | 2003-06-17 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
AU2003273179A1 (en) | 2002-05-10 | 2003-12-12 | Bristol-Myers Squibb Company | 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors |
US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
CN1867336B (zh) | 2002-06-12 | 2010-05-12 | 凯莫森特里克斯股份有限公司 | 1-芳基-4-取代的哌嗪衍生物及其制药用途 |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
HUE025683T2 (hu) | 2002-12-03 | 2016-04-28 | Pharmacyclics Llc | VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok |
ES2311806T3 (es) * | 2003-03-07 | 2009-02-16 | Schering Corporation | Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
EP1601669B1 (de) * | 2003-03-07 | 2008-12-24 | Schering Corporation | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
US7192944B2 (en) * | 2003-03-07 | 2007-03-20 | Schering Corp. | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
US7235662B2 (en) * | 2003-06-11 | 2007-06-26 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
CN1950082B (zh) * | 2004-03-03 | 2013-02-06 | 凯莫森特里克斯股份有限公司 | 双环和桥连的含氮杂环化物 |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
TWI349666B (en) | 2004-03-12 | 2011-10-01 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivatives |
ES2355951T3 (es) * | 2006-03-24 | 2011-04-01 | EISAI R&D MANAGEMENT CO., LTD. | Derivados de triazolona. |
US7816522B2 (en) | 2006-03-24 | 2010-10-19 | Eisai Co., Ltd. | Triazolone derivatives |
JPWO2009038157A1 (ja) | 2007-09-21 | 2011-01-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 2,3−ジヒドロ−イミノイソインドール誘導体 |
RU2557908C1 (ru) * | 2014-07-04 | 2015-07-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | Способ инкубации куриных яиц |
EP3886854A4 (de) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrol- und pyrazolverbindungen und verfahren zu deren verwendung |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5550147A (en) | 1992-02-05 | 1996-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
WO1995014682A1 (en) * | 1993-11-24 | 1995-06-01 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
ES2154326T3 (es) * | 1993-11-24 | 2001-04-01 | Du Pont Pharm Co | Antagonistas de receptor de fibrinogeno de isoxazolina e isoxazol. |
US5563158A (en) | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5616601A (en) | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
DE69632548T2 (de) * | 1995-12-21 | 2005-06-02 | Bristol-Myers Squibb Pharma Co. | ISOXAZOLIN, ISOTHIAZOLIN UND PYRAZOLIN ALS FAKTOR Xa INHIBITOREN |
AU2056197A (en) * | 1996-02-22 | 1997-09-10 | Du Pont Merck Pharmaceutical Company, The | M-amidino phenyl analogs as factor xa inhibitors |
WO1997047299A1 (en) * | 1996-06-12 | 1997-12-18 | 3-Dimensional Pharmaceuticals, Inc. | Amidino and guanidino heterocyclic protease inhibitors |
HUP0000735A3 (en) * | 1996-12-23 | 2002-03-28 | Bristol Myers Squibb Pharma Co | Nitrogen containing heteroaromatics as factor xa inhibitors |
WO1998057934A1 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS |
ES2239806T3 (es) * | 1997-06-19 | 2005-10-01 | Bristol-Myers Squibb Pharma Company | Inhibidores del factor xa con un grupo de especificidad neutro p1. |
ZA985247B (en) * | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
ATE278673T1 (de) * | 1998-03-27 | 2004-10-15 | Bristol Myers Squibb Pharma Co | Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren |
-
1999
- 1999-03-23 AT AT99912828T patent/ATE278673T1/de not_active IP Right Cessation
- 1999-03-23 JP JP2000541159A patent/JP2002509924A/ja active Pending
- 1999-03-23 AU AU31109/99A patent/AU3110999A/en not_active Abandoned
- 1999-03-23 DE DE69920888T patent/DE69920888T2/de not_active Expired - Fee Related
- 1999-03-23 CA CA002321538A patent/CA2321538A1/en not_active Abandoned
- 1999-03-23 WO PCT/US1999/006310 patent/WO1999050255A2/en active IP Right Grant
- 1999-03-23 EP EP99912828A patent/EP1064270B1/de not_active Expired - Lifetime
- 1999-03-23 ES ES99912828T patent/ES2230841T3/es not_active Expired - Lifetime
- 1999-03-26 US US09/276,960 patent/US6191159B1/en not_active Expired - Lifetime
-
2000
- 2000-12-01 US US09/728,695 patent/US6436985B2/en not_active Expired - Lifetime
-
2002
- 2002-06-26 US US10/180,812 patent/US6630468B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU3110999A (en) | 1999-10-18 |
ES2230841T3 (es) | 2005-05-01 |
EP1064270A2 (de) | 2001-01-03 |
US6630468B2 (en) | 2003-10-07 |
CA2321538A1 (en) | 1999-10-07 |
JP2002509924A (ja) | 2002-04-02 |
DE69920888T2 (de) | 2006-02-02 |
US6191159B1 (en) | 2001-02-20 |
US20030105105A1 (en) | 2003-06-05 |
ATE278673T1 (de) | 2004-10-15 |
US6436985B2 (en) | 2002-08-20 |
WO1999050255A3 (en) | 1999-11-18 |
WO1999050255A2 (en) | 1999-10-07 |
EP1064270B1 (de) | 2004-10-06 |
US20010000179A1 (en) | 2001-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |