PL403149A1 - Nowe związki pochodne pirazolilobenzo[d]imidazolu - Google Patents

Nowe związki pochodne pirazolilobenzo[d]imidazolu

Info

Publication number
PL403149A1
PL403149A1 PL403149A PL40314913A PL403149A1 PL 403149 A1 PL403149 A1 PL 403149A1 PL 403149 A PL403149 A PL 403149A PL 40314913 A PL40314913 A PL 40314913A PL 403149 A1 PL403149 A1 PL 403149A1
Authority
PL
Poland
Prior art keywords
pirazolilobenzo
new
imidazole derivatives
absent
compounds
Prior art date
Application number
PL403149A
Other languages
English (en)
Inventor
Daria Zdżalik
Joanna Lipner
Maciej Wieczorek
Karolina Dzwonek
Abdellah Yamani
Krzysztof Dubiel
Monika Lamparska-Przybysz
Original Assignee
Celon Pharma Spółka Akcyjna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celon Pharma Spółka Akcyjna filed Critical Celon Pharma Spółka Akcyjna
Priority to PL403149A priority Critical patent/PL403149A1/pl
Priority to EP14712781.5A priority patent/EP2970210B1/en
Priority to PT147127815T priority patent/PT2970210T/pt
Priority to CN201480008829.4A priority patent/CN105008348B/zh
Priority to CA2900629A priority patent/CA2900629C/en
Priority to JP2015562456A priority patent/JP6594779B2/ja
Priority to BR112015023092-0A priority patent/BR112015023092B1/pt
Priority to EA201591617A priority patent/EA026782B1/ru
Priority to AU2014229401A priority patent/AU2014229401B2/en
Priority to US14/775,240 priority patent/US9776988B2/en
Priority to KR1020157027305A priority patent/KR102266546B1/ko
Priority to HUE14712781A priority patent/HUE031368T2/en
Priority to PL14712781T priority patent/PL2970210T3/pl
Priority to HRP20170190TT priority patent/HRP20170190T1/hr
Priority to SI201430168A priority patent/SI2970210T1/sl
Priority to MX2015012346A priority patent/MX364172B/es
Priority to DK14712781.5T priority patent/DK2970210T3/en
Priority to PCT/IB2014/059515 priority patent/WO2014141015A1/en
Priority to ES14712781.5T priority patent/ES2622376T3/es
Publication of PL403149A1 publication Critical patent/PL403149A1/pl
Priority to IL241234A priority patent/IL241234A0/en
Priority to ZA2015/07548A priority patent/ZA201507548B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Związki będące przedmiotem wynalazku są przedstawione wzorem ogólnym (I), w którym atom wodoru przy pierścieniach pirazolowym i benzimidazolowym jest przyłączony do jednego z atomów azotu pierścienia; R1 oznacza -X-Q-P, gdzie X jest nieobecny lub oznacza -CH2-, -C(O)-, -C(O)NH-(CH2)k-, gdzie k jest 0, 1 lub 2; Q jest wybrany z grupy składającej się z grup Q1, Q2, Q3, Q4 i Q5, które mają znaczenia podane w opisie, przy czym gdy B w Q1 oznacza atom tlenu, to P jest nieobecny; oraz ich sole addycyjne z kwasami. Związki wykazują działanie jako inhibitory kinazy FGFR i mogą znaleźć zastosowanie w leczeniu chorób nowotworowych.
PL403149A 2013-03-14 2013-03-14 Nowe związki pochodne pirazolilobenzo[d]imidazolu PL403149A1 (pl)

Priority Applications (21)

Application Number Priority Date Filing Date Title
PL403149A PL403149A1 (pl) 2013-03-14 2013-03-14 Nowe związki pochodne pirazolilobenzo[d]imidazolu
US14/775,240 US9776988B2 (en) 2013-03-14 2014-03-07 Pyrazolylbenzo[d]imidazole derivatives
PL14712781T PL2970210T3 (pl) 2013-03-14 2014-03-07 Pochodne pirazolilobenzo[d]imidazolu
CN201480008829.4A CN105008348B (zh) 2013-03-14 2014-03-07 吡唑基苯并[d]咪唑衍生物
CA2900629A CA2900629C (en) 2013-03-14 2014-03-07 Pyrazolylbenzo[d]imidazole derivatives
JP2015562456A JP6594779B2 (ja) 2013-03-14 2014-03-07 ピラゾリルベンゾ［ｄ］イミダゾール誘導体
BR112015023092-0A BR112015023092B1 (pt) 2013-03-14 2014-03-07 Derivados de pirazolilbenzo[ d] imidazóis
EA201591617A EA026782B1 (ru) 2013-03-14 2014-03-07 ПРОИЗВОДНЫЕ ПИРАЗОЛИЛБЕНЗО[d]ИМИДАЗОЛА
AU2014229401A AU2014229401B2 (en) 2013-03-14 2014-03-07 Pyrazolylbenzo[d]imidazole derivatives
EP14712781.5A EP2970210B1 (en) 2013-03-14 2014-03-07 Pyrazolylbenzo[d]imidazole derivatives
KR1020157027305A KR102266546B1 (ko) 2013-03-14 2014-03-07 피라졸릴벤조[d]이미다졸 유도체
HUE14712781A HUE031368T2 (en) 2013-03-14 2014-03-07 Pirazolilbenzo [d] imidazole derivatives
PT147127815T PT2970210T (pt) 2013-03-14 2014-03-07 Derivados de pirazolilbenzo[d]imidazole
HRP20170190TT HRP20170190T1 (hr) 2013-03-14 2014-03-07 Derivati pirazolilbenzo[d]imidazola
SI201430168A SI2970210T1 (sl) 2013-03-14 2014-03-07 Pirazolilbenzo(d)imidazolni derivati
MX2015012346A MX364172B (es) 2013-03-14 2014-03-07 Derivados de pirazolilbenzo[d]imidazol.
DK14712781.5T DK2970210T3 (en) 2013-03-14 2014-03-07 Pyrazolylbenzo [d] imidazole
PCT/IB2014/059515 WO2014141015A1 (en) 2013-03-14 2014-03-07 Pyrazolylbenzo[d]imidazole derivatives
ES14712781.5T ES2622376T3 (es) 2013-03-14 2014-03-07 Derivados de pirazolilbenzo[d]imidazol
IL241234A IL241234A0 (en) 2013-03-14 2015-09-07 History of pyrazolylbenzo[d]imidazole derivatives
ZA2015/07548A ZA201507548B (en) 2013-03-14 2015-10-12 Pyrazolylbenzo[d]imidazole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL403149A PL403149A1 (pl) 2013-03-14 2013-03-14 Nowe związki pochodne pirazolilobenzo[d]imidazolu

Publications (1)

Publication Number Publication Date
PL403149A1 true PL403149A1 (pl) 2014-09-15

Family

ID=50382512

Family Applications (2)

Application Number Title Priority Date Filing Date
PL403149A PL403149A1 (pl) 2013-03-14 2013-03-14 Nowe związki pochodne pirazolilobenzo[d]imidazolu
PL14712781T PL2970210T3 (pl) 2013-03-14 2014-03-07 Pochodne pirazolilobenzo[d]imidazolu

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL14712781T PL2970210T3 (pl) 2013-03-14 2014-03-07 Pochodne pirazolilobenzo[d]imidazolu

Country Status (20)

Country Link
US (1) US9776988B2 (pl)
EP (1) EP2970210B1 (pl)
JP (1) JP6594779B2 (pl)
KR (1) KR102266546B1 (pl)
CN (1) CN105008348B (pl)
AU (1) AU2014229401B2 (pl)
BR (1) BR112015023092B1 (pl)
CA (1) CA2900629C (pl)
DK (1) DK2970210T3 (pl)
EA (1) EA026782B1 (pl)
ES (1) ES2622376T3 (pl)
HR (1) HRP20170190T1 (pl)
HU (1) HUE031368T2 (pl)
IL (1) IL241234A0 (pl)
MX (1) MX364172B (pl)
PL (2) PL403149A1 (pl)
PT (1) PT2970210T (pl)
SI (1) SI2970210T1 (pl)
WO (1) WO2014141015A1 (pl)
ZA (1) ZA201507548B (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3296297A1 (en) * 2016-09-15 2018-03-21 Centre National De La Recherche Scientifique Benzimidazol derivatives for treating filovirus infection
CN107698538B (zh) * 2016-11-30 2020-02-14 内蒙古京东药业有限公司 罗沙替丁醋酸酯盐酸盐的中间体3-(1-哌啶甲基)苯酚的制备方法
CN107163030B (zh) * 2017-06-20 2020-03-24 河南工业大学 具有吡唑母核的小分子杂环化合物及其用于制备抗菌、抗肿瘤药物的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2260034T3 (es) 1999-08-02 2006-11-01 Ortho-Mcneil Pharmaceutical, Inc. Derivados de pirido (1.2-a) bencimidazol sustituidos en c-6 utiles en el tratamiento de transtornos del sistema nervioso central.
FR2831536A1 (fr) * 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
US6897208B2 (en) 2001-10-26 2005-05-24 Aventis Pharmaceuticals Inc. Benzimidazoles
AU2005287170B2 (en) * 2004-09-17 2012-03-29 Exelixis, Inc Pyrazole kinase modulators and methods of use
EP1833819A1 (en) 2004-12-30 2007-09-19 Astex Therapeutics Limited Pyrazole compounds that modulate the activity of cdk, gsk and aurora kinases
US8399442B2 (en) * 2005-12-30 2013-03-19 Astex Therapeutics Limited Pharmaceutical compounds
US7737149B2 (en) * 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
EA201100030A1 (ru) * 2008-06-19 2011-08-30 Астразенека Аб Пиразольные соединения 436
KR20140001965A (ko) * 2010-11-30 2014-01-07 다케다 야쿠힌 고교 가부시키가이샤 바이시클릭 화합물
SI2707385T1 (en) * 2011-05-13 2018-01-31 Glaxosmithkline Biologicals Sa Pregnant RSV F antigens

Also Published As

Publication number Publication date
BR112015023092A2 (pt) 2017-07-18
AU2014229401B2 (en) 2018-05-17
US9776988B2 (en) 2017-10-03
WO2014141015A1 (en) 2014-09-18
HRP20170190T1 (hr) 2017-04-07
PT2970210T (pt) 2017-04-07
MX2015012346A (es) 2016-02-03
JP2016516024A (ja) 2016-06-02
DK2970210T3 (en) 2017-04-10
HUE031368T2 (en) 2017-07-28
EA201591617A1 (ru) 2016-01-29
SI2970210T1 (sl) 2017-05-31
ES2622376T3 (es) 2017-07-06
CA2900629A1 (en) 2014-09-18
MX364172B (es) 2019-04-15
AU2014229401A1 (en) 2015-08-20
IL241234A0 (en) 2015-11-30
ZA201507548B (en) 2017-02-22
KR102266546B1 (ko) 2021-06-21
PL2970210T3 (pl) 2017-09-29
CN105008348B (zh) 2018-07-10
US20160039794A1 (en) 2016-02-11
JP6594779B2 (ja) 2019-10-23
CN105008348A (zh) 2015-10-28
EP2970210B1 (en) 2017-01-04
EA026782B1 (ru) 2017-05-31
KR20150126893A (ko) 2015-11-13
BR112015023092B1 (pt) 2021-11-16
EP2970210A1 (en) 2016-01-20
CA2900629C (en) 2020-12-15

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