EA201591617A1 - Производные пиразолилбензо[d]имидазола - Google Patents
Производные пиразолилбензо[d]имидазолаInfo
- Publication number
- EA201591617A1 EA201591617A1 EA201591617A EA201591617A EA201591617A1 EA 201591617 A1 EA201591617 A1 EA 201591617A1 EA 201591617 A EA201591617 A EA 201591617A EA 201591617 A EA201591617 A EA 201591617A EA 201591617 A1 EA201591617 A1 EA 201591617A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- absent
- производные
- пиразолилбензо
- имидазола
- nrr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Соединение, представленное общей формулой (I), где атомы водорода, показанные как присоединенные к пиразольному и бензимидазольному кольцам, присоединены к одному из атомов азота пиразольного или бензимидазольного кольца, соответственно; Rпредставляет собой -X-Q-P, где X отсутствует или представляет собой -СН-, -С(О)- или -C(O)NH-(CH)-, где k представляет собой 0, 1 или 2; Q выбран из группы, состоящей из Q1, Q2, Q3, Q4 и Q5; Р отсутствует или представляет собой С1-С3 алкил с прямой или разветвленной цепью, -(CH)-NRRили -(CH)-C(O)-NRR, где I и m независимо друг от друга представляют собой 0, 1 или 2, при условии, что когда В в Q1 представляет собой атом кислорода, то Р отсутствует; и Rи Rнезависимо друг от друга представляют собой С1 или С2 алкил, или Rи Rвместе с атомом азота, к которому они оба присоединены, образуют 6-членное насыщенное гетероциклическое кольцо, при этом один из атомов углерода в указанном гетероциклическом кольце может быть необязательно заменен на -О-, -NH- или -N(C1-C2) алкил; и его соли присоединения кислоты. Соединение может быть применено для лечения раковых заболеваний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL403149A PL403149A1 (pl) | 2013-03-14 | 2013-03-14 | Nowe związki pochodne pirazolilobenzo[d]imidazolu |
PCT/IB2014/059515 WO2014141015A1 (en) | 2013-03-14 | 2014-03-07 | Pyrazolylbenzo[d]imidazole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201591617A1 true EA201591617A1 (ru) | 2016-01-29 |
EA026782B1 EA026782B1 (ru) | 2017-05-31 |
Family
ID=50382512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201591617A EA026782B1 (ru) | 2013-03-14 | 2014-03-07 | ПРОИЗВОДНЫЕ ПИРАЗОЛИЛБЕНЗО[d]ИМИДАЗОЛА |
Country Status (20)
Country | Link |
---|---|
US (1) | US9776988B2 (ru) |
EP (1) | EP2970210B1 (ru) |
JP (1) | JP6594779B2 (ru) |
KR (1) | KR102266546B1 (ru) |
CN (1) | CN105008348B (ru) |
AU (1) | AU2014229401B2 (ru) |
BR (1) | BR112015023092B1 (ru) |
CA (1) | CA2900629C (ru) |
DK (1) | DK2970210T3 (ru) |
EA (1) | EA026782B1 (ru) |
ES (1) | ES2622376T3 (ru) |
HR (1) | HRP20170190T1 (ru) |
HU (1) | HUE031368T2 (ru) |
IL (1) | IL241234A0 (ru) |
MX (1) | MX364172B (ru) |
PL (2) | PL403149A1 (ru) |
PT (1) | PT2970210T (ru) |
SI (1) | SI2970210T1 (ru) |
WO (1) | WO2014141015A1 (ru) |
ZA (1) | ZA201507548B (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3296297A1 (en) * | 2016-09-15 | 2018-03-21 | Centre National De La Recherche Scientifique | Benzimidazol derivatives for treating filovirus infection |
CN107698538B (zh) * | 2016-11-30 | 2020-02-14 | 内蒙古京东药业有限公司 | 罗沙替丁醋酸酯盐酸盐的中间体3-(1-哌啶甲基)苯酚的制备方法 |
CN107163030B (zh) * | 2017-06-20 | 2020-03-24 | 河南工业大学 | 具有吡唑母核的小分子杂环化合物及其用于制备抗菌、抗肿瘤药物的应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU779686B2 (en) | 1999-08-02 | 2005-02-03 | Ortho-Mcneil Pharmaceutical, Inc. | C-6 ring-substituted pyrido(1,2-a)benzimidazole derivatives useful in treating central nervous system disorders |
FR2831536A1 (fr) * | 2001-10-26 | 2003-05-02 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr |
US6897208B2 (en) | 2001-10-26 | 2005-05-24 | Aventis Pharmaceuticals Inc. | Benzimidazoles |
JP5063351B2 (ja) * | 2004-09-17 | 2012-10-31 | エグゼリクシス, インコーポレイテッド | ピラゾールキナーゼモジュレーターおよび使用方法 |
JP5507049B2 (ja) | 2004-12-30 | 2014-05-28 | アステックス、セラピューティックス、リミテッド | 医薬品 |
JP5474354B2 (ja) * | 2005-12-30 | 2014-04-16 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
US7737149B2 (en) * | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
KR20110020904A (ko) * | 2008-06-19 | 2011-03-03 | 아스트라제네카 아베 | 피라졸 화합물 436 |
UY33756A (es) * | 2010-11-30 | 2012-06-29 | Takeda Pharmaceutical | Compuesto biciclico |
ES2651143T3 (es) * | 2011-05-13 | 2018-01-24 | Glaxosmithkline Biologicals Sa | Antígenos de F de prefusión del VRS |
-
2013
- 2013-03-14 PL PL403149A patent/PL403149A1/pl unknown
-
2014
- 2014-03-07 SI SI201430168A patent/SI2970210T1/sl unknown
- 2014-03-07 DK DK14712781.5T patent/DK2970210T3/en active
- 2014-03-07 JP JP2015562456A patent/JP6594779B2/ja active Active
- 2014-03-07 BR BR112015023092-0A patent/BR112015023092B1/pt active IP Right Grant
- 2014-03-07 ES ES14712781.5T patent/ES2622376T3/es active Active
- 2014-03-07 CA CA2900629A patent/CA2900629C/en active Active
- 2014-03-07 CN CN201480008829.4A patent/CN105008348B/zh active Active
- 2014-03-07 PL PL14712781T patent/PL2970210T3/pl unknown
- 2014-03-07 EP EP14712781.5A patent/EP2970210B1/en active Active
- 2014-03-07 MX MX2015012346A patent/MX364172B/es active IP Right Grant
- 2014-03-07 US US14/775,240 patent/US9776988B2/en active Active
- 2014-03-07 WO PCT/IB2014/059515 patent/WO2014141015A1/en active Application Filing
- 2014-03-07 KR KR1020157027305A patent/KR102266546B1/ko active IP Right Grant
- 2014-03-07 PT PT147127815T patent/PT2970210T/pt unknown
- 2014-03-07 AU AU2014229401A patent/AU2014229401B2/en active Active
- 2014-03-07 HU HUE14712781A patent/HUE031368T2/en unknown
- 2014-03-07 EA EA201591617A patent/EA026782B1/ru not_active IP Right Cessation
-
2015
- 2015-09-07 IL IL241234A patent/IL241234A0/en unknown
- 2015-10-12 ZA ZA2015/07548A patent/ZA201507548B/en unknown
-
2017
- 2017-02-06 HR HRP20170190TT patent/HRP20170190T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
HUE031368T2 (en) | 2017-07-28 |
HRP20170190T1 (hr) | 2017-04-07 |
ZA201507548B (en) | 2017-02-22 |
CA2900629A1 (en) | 2014-09-18 |
KR102266546B1 (ko) | 2021-06-21 |
DK2970210T3 (en) | 2017-04-10 |
US9776988B2 (en) | 2017-10-03 |
WO2014141015A1 (en) | 2014-09-18 |
CN105008348A (zh) | 2015-10-28 |
BR112015023092A2 (pt) | 2017-07-18 |
CN105008348B (zh) | 2018-07-10 |
ES2622376T3 (es) | 2017-07-06 |
AU2014229401B2 (en) | 2018-05-17 |
PL2970210T3 (pl) | 2017-09-29 |
AU2014229401A1 (en) | 2015-08-20 |
EA026782B1 (ru) | 2017-05-31 |
PT2970210T (pt) | 2017-04-07 |
BR112015023092B1 (pt) | 2021-11-16 |
US20160039794A1 (en) | 2016-02-11 |
SI2970210T1 (sl) | 2017-05-31 |
MX364172B (es) | 2019-04-15 |
PL403149A1 (pl) | 2014-09-15 |
JP6594779B2 (ja) | 2019-10-23 |
KR20150126893A (ko) | 2015-11-13 |
IL241234A0 (en) | 2015-11-30 |
EP2970210A1 (en) | 2016-01-20 |
EP2970210B1 (en) | 2017-01-04 |
MX2015012346A (es) | 2016-02-03 |
JP2016516024A (ja) | 2016-06-02 |
CA2900629C (en) | 2020-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KG TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): KZ |