MX2015012346A - Derivados de pirazolilbenzo[d]imidazol. - Google Patents
Derivados de pirazolilbenzo[d]imidazol.Info
- Publication number
- MX2015012346A MX2015012346A MX2015012346A MX2015012346A MX2015012346A MX 2015012346 A MX2015012346 A MX 2015012346A MX 2015012346 A MX2015012346 A MX 2015012346A MX 2015012346 A MX2015012346 A MX 2015012346A MX 2015012346 A MX2015012346 A MX 2015012346A
- Authority
- MX
- Mexico
- Prior art keywords
- absent
- alkyl
- attached
- nr2r3
- pyrazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto representado por la Fórmula general (I), en donde los átomos de hidrógeno mostrados como unidos a anillos pirazol y benzimidazol están unidos a uno de los átomos de nitrógeno del anillo pirazol o benzimidazol, respectivamente; R1 representa -X-Q-P, en donde X está ausente o representa -CH2-, -C(O)-, o -C(O)NH-(CH2)k-, en donde k es 0,1 o 2; Q se selecciona del grupo que consiste de Q1, Q2, Q3, Q4 y Q5; P está ausente o representa alquilo de C1-C3 de cadena recta o ramificada, -(CH2)l-NR2R3, o -(CH2)m-C(O)NR2R3, en donde I y m representan independientemente uno del otro 0, 1 o 2, con la condición de que cuando B en Q1 representa un átomo de oxígeno, entonces P está ausente; y R2 y R3 representan independientemente alquilo de C1 o C2, o R2 y R3 junto con el átomo de nitrógeno al cual ambos están unidos forman un anillo heterocíclico saturado de 6 miembros, en donde uno de los átomos de carbono se puede reemplazar con oxígeno, -NH- o -N(C1-C2)alquilo-; y sales de adición ácidas del mismo. El compuesto puede ser útil en el tratamiento de enfermedades del cáncer. (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL403149A PL403149A1 (pl) | 2013-03-14 | 2013-03-14 | Nowe związki pochodne pirazolilobenzo[d]imidazolu |
| PCT/IB2014/059515 WO2014141015A1 (en) | 2013-03-14 | 2014-03-07 | Pyrazolylbenzo[d]imidazole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015012346A true MX2015012346A (es) | 2016-02-03 |
| MX364172B MX364172B (es) | 2019-04-15 |
Family
ID=50382512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015012346A MX364172B (es) | 2013-03-14 | 2014-03-07 | Derivados de pirazolilbenzo[d]imidazol. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9776988B2 (es) |
| EP (1) | EP2970210B1 (es) |
| JP (1) | JP6594779B2 (es) |
| KR (1) | KR102266546B1 (es) |
| CN (1) | CN105008348B (es) |
| AU (1) | AU2014229401B2 (es) |
| BR (1) | BR112015023092B1 (es) |
| CA (1) | CA2900629C (es) |
| DK (1) | DK2970210T3 (es) |
| EA (1) | EA026782B1 (es) |
| ES (1) | ES2622376T3 (es) |
| HR (1) | HRP20170190T1 (es) |
| HU (1) | HUE031368T2 (es) |
| IL (1) | IL241234A0 (es) |
| MX (1) | MX364172B (es) |
| PL (2) | PL403149A1 (es) |
| PT (1) | PT2970210T (es) |
| SI (1) | SI2970210T1 (es) |
| WO (1) | WO2014141015A1 (es) |
| ZA (1) | ZA201507548B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3296297A1 (en) * | 2016-09-15 | 2018-03-21 | Centre National De La Recherche Scientifique | Benzimidazol derivatives for treating filovirus infection |
| CN107698538B (zh) * | 2016-11-30 | 2020-02-14 | 内蒙古京东药业有限公司 | 罗沙替丁醋酸酯盐酸盐的中间体3-(1-哌啶甲基)苯酚的制备方法 |
| CN107163030B (zh) * | 2017-06-20 | 2020-03-24 | 河南工业大学 | 具有吡唑母核的小分子杂环化合物及其用于制备抗菌、抗肿瘤药物的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1200433B1 (en) | 1999-08-02 | 2006-03-22 | Ortho-McNeil Pharmaceutical, Inc. | C-6 RING-SUBSTITUTED PYRIDO[1,2-a]BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS |
| US6897208B2 (en) | 2001-10-26 | 2005-05-24 | Aventis Pharmaceuticals Inc. | Benzimidazoles |
| FR2831536A1 (fr) * | 2001-10-26 | 2003-05-02 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr |
| WO2006033943A2 (en) * | 2004-09-17 | 2006-03-30 | Exelixis, Inc | Pyrazole kinase modulators and methods of use |
| AU2005321091B2 (en) | 2004-12-30 | 2012-04-12 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of CDK, GSK and Aurora kinases |
| EP1968579A1 (en) * | 2005-12-30 | 2008-09-17 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US7737149B2 (en) * | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| MX2010014234A (es) * | 2008-06-19 | 2011-03-25 | Astrazeneca Ab | Compuestos pirazol 436. |
| EP2649062B1 (en) * | 2010-11-30 | 2015-04-08 | Takeda Pharmaceutical Company Limited | Bicyclic compounds as inhibitors of acetyl-coa carboxylase (acc) |
| LT2707385T (lt) * | 2011-05-13 | 2017-12-11 | Glaxosmithkline Biologicals Sa | Iš anksto sulieti rsv f antigenai |
-
2013
- 2013-03-14 PL PL403149A patent/PL403149A1/pl unknown
-
2014
- 2014-03-07 ES ES14712781.5T patent/ES2622376T3/es active Active
- 2014-03-07 EP EP14712781.5A patent/EP2970210B1/en active Active
- 2014-03-07 PL PL14712781T patent/PL2970210T3/pl unknown
- 2014-03-07 MX MX2015012346A patent/MX364172B/es active IP Right Grant
- 2014-03-07 AU AU2014229401A patent/AU2014229401B2/en active Active
- 2014-03-07 EA EA201591617A patent/EA026782B1/ru not_active IP Right Cessation
- 2014-03-07 CA CA2900629A patent/CA2900629C/en active Active
- 2014-03-07 WO PCT/IB2014/059515 patent/WO2014141015A1/en active Application Filing
- 2014-03-07 BR BR112015023092-0A patent/BR112015023092B1/pt active IP Right Grant
- 2014-03-07 PT PT147127815T patent/PT2970210T/pt unknown
- 2014-03-07 CN CN201480008829.4A patent/CN105008348B/zh active Active
- 2014-03-07 KR KR1020157027305A patent/KR102266546B1/ko active IP Right Grant
- 2014-03-07 HU HUE14712781A patent/HUE031368T2/en unknown
- 2014-03-07 SI SI201430168A patent/SI2970210T1/sl unknown
- 2014-03-07 JP JP2015562456A patent/JP6594779B2/ja active Active
- 2014-03-07 DK DK14712781.5T patent/DK2970210T3/en active
- 2014-03-07 US US14/775,240 patent/US9776988B2/en active Active
-
2015
- 2015-09-07 IL IL241234A patent/IL241234A0/en unknown
- 2015-10-12 ZA ZA2015/07548A patent/ZA201507548B/en unknown
-
2017
- 2017-02-06 HR HRP20170190TT patent/HRP20170190T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015023092B1 (pt) | 2021-11-16 |
| KR102266546B1 (ko) | 2021-06-21 |
| CA2900629A1 (en) | 2014-09-18 |
| PL2970210T3 (pl) | 2017-09-29 |
| JP2016516024A (ja) | 2016-06-02 |
| US20160039794A1 (en) | 2016-02-11 |
| AU2014229401A1 (en) | 2015-08-20 |
| MX364172B (es) | 2019-04-15 |
| WO2014141015A1 (en) | 2014-09-18 |
| EA026782B1 (ru) | 2017-05-31 |
| SI2970210T1 (sl) | 2017-05-31 |
| KR20150126893A (ko) | 2015-11-13 |
| EA201591617A1 (ru) | 2016-01-29 |
| BR112015023092A2 (pt) | 2017-07-18 |
| ZA201507548B (en) | 2017-02-22 |
| CN105008348B (zh) | 2018-07-10 |
| PT2970210T (pt) | 2017-04-07 |
| CN105008348A (zh) | 2015-10-28 |
| ES2622376T3 (es) | 2017-07-06 |
| HUE031368T2 (en) | 2017-07-28 |
| DK2970210T3 (en) | 2017-04-10 |
| US9776988B2 (en) | 2017-10-03 |
| AU2014229401B2 (en) | 2018-05-17 |
| PL403149A1 (pl) | 2014-09-15 |
| EP2970210A1 (en) | 2016-01-20 |
| HRP20170190T1 (hr) | 2017-04-07 |
| EP2970210B1 (en) | 2017-01-04 |
| JP6594779B2 (ja) | 2019-10-23 |
| CA2900629C (en) | 2020-12-15 |
| IL241234A0 (en) | 2015-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |