EA201370251A1 - Производное камптотецина, способ получения такового, фармацевтическая композиция и ее применение - Google Patents
Производное камптотецина, способ получения такового, фармацевтическая композиция и ее применениеInfo
- Publication number
- EA201370251A1 EA201370251A1 EA201370251A EA201370251A EA201370251A1 EA 201370251 A1 EA201370251 A1 EA 201370251A1 EA 201370251 A EA201370251 A EA 201370251A EA 201370251 A EA201370251 A EA 201370251A EA 201370251 A1 EA201370251 A1 EA 201370251A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- optionally substituted
- derivative
- camptotecine
- obtaining
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 239000010703 silicon Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
- C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение относится к производному камптотецина, которое имеет такую структуру, как представлено формулой (II), в которой Хвыбран из Н, K, Na, Li, Mg, Ca, Zn, Feи иона аммония, где R, R, Rи Rнезависимо представляют собой водород, гидроксильную группу, нитрогруппу, цианогруппу, галоген, карбоксильную группу, необязательно замещенную аминогруппу, кремнийсодержащую группу, моноциклическую арилоксигруппу, необязательно замещенную C-Cалкоксигруппу, необязательно замещенную C-Cалкилкарбонильную группу, необязательно замещенную C-Cалкильную группу или необязательно замещенную C-Cциклоалкильную группу; в качестве альтернативы Rи Rсоединены посредством одного-трех других атомов с образованием гетероциклического кольца; и в другом варианте осуществления R и Rпредставляют собой атомы кислорода и соединены посредством -О-(СН)-О-, образуя кольцо, в котором n=1 или 2. Соединение обладает высокой водорастворимостью, химической стабильностью и высокой активностью при лечении рака.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101814060A CN102850400A (zh) | 2011-06-30 | 2011-06-30 | 喜树碱衍生物及其制备方法、药物组合物与用途 |
PCT/CN2012/000712 WO2013000269A1 (zh) | 2011-06-30 | 2012-05-22 | 喜树碱衍生物及其制备方法、药物组合物与用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201370251A1 true EA201370251A1 (ru) | 2014-04-30 |
EA021814B1 EA021814B1 (ru) | 2015-09-30 |
Family
ID=47397427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201370251A EA021814B1 (ru) | 2011-06-30 | 2012-05-22 | Производное камптотецина, способ его получения, фармацевтическая композиция и ее применение |
Country Status (11)
Country | Link |
---|---|
US (1) | US9266911B2 (ru) |
EP (1) | EP2727927B1 (ru) |
JP (1) | JP5819523B2 (ru) |
KR (1) | KR101606624B1 (ru) |
CN (2) | CN102850400A (ru) |
AU (1) | AU2012276175B2 (ru) |
BR (1) | BR112013033472A2 (ru) |
CA (1) | CA2838875C (ru) |
EA (1) | EA021814B1 (ru) |
WO (1) | WO2013000269A1 (ru) |
ZA (1) | ZA201309559B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3100734A4 (en) * | 2014-01-28 | 2017-08-09 | Zhou, Wenqiang | Use of camptothecin derivative in preparing pharmaceutical used for treating multiple myeloma |
RS63715B1 (sr) * | 2019-03-29 | 2022-11-30 | Medimmune Ltd | Jedinjenja i njihovi konjugati |
US20220242874A1 (en) | 2019-07-11 | 2022-08-04 | Sun Pharma Advanced Research Company Limited | Camptothecin derivatives |
CN114729035B (zh) * | 2019-12-16 | 2024-04-16 | 江苏恒瑞医药股份有限公司 | 抗cea抗体-依喜替康类似物偶联物及其医药用途 |
UY39743A (es) | 2021-04-29 | 2022-11-30 | Abbvie Inc | Conjugados de anticuerpo anti-c-met y fármaco |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62195393A (ja) * | 1986-02-21 | 1987-08-28 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造方法 |
JPS62195394A (ja) * | 1986-02-24 | 1987-08-28 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
WO2007095389A2 (en) * | 2006-02-17 | 2007-08-23 | Novacea, Inc. | Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs |
US20080293648A1 (en) * | 2007-01-05 | 2008-11-27 | Saha Pharmaceuticals, Inc. | Compositions and Methods for Cancer Treatment |
CN102153607B (zh) * | 2010-02-11 | 2015-07-15 | 湖南方盛华美医药科技有限公司 | 水溶性喜树碱衍生物及包含其的药物组合物 |
-
2011
- 2011-06-30 CN CN2011101814060A patent/CN102850400A/zh active Pending
-
2012
- 2012-05-22 AU AU2012276175A patent/AU2012276175B2/en active Active
- 2012-05-22 CN CN201280032341.6A patent/CN103814036B/zh active Active
- 2012-05-22 EP EP12804633.1A patent/EP2727927B1/en active Active
- 2012-05-22 WO PCT/CN2012/000712 patent/WO2013000269A1/zh active Application Filing
- 2012-05-22 EA EA201370251A patent/EA021814B1/ru not_active IP Right Cessation
- 2012-05-22 CA CA2838875A patent/CA2838875C/en active Active
- 2012-05-22 JP JP2014517395A patent/JP5819523B2/ja active Active
- 2012-05-22 KR KR1020137034087A patent/KR101606624B1/ko active IP Right Grant
- 2012-06-25 BR BR112013033472A patent/BR112013033472A2/pt not_active IP Right Cessation
-
2013
- 2013-12-18 ZA ZA2013/09559A patent/ZA201309559B/en unknown
- 2013-12-19 US US14/134,346 patent/US9266911B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2838875C (en) | 2016-06-21 |
JP2014520762A (ja) | 2014-08-25 |
JP5819523B2 (ja) | 2015-11-24 |
EP2727927A4 (en) | 2015-02-11 |
EP2727927A1 (en) | 2014-05-07 |
EP2727927B1 (en) | 2016-07-20 |
BR112013033472A2 (pt) | 2017-03-14 |
ZA201309559B (en) | 2014-08-27 |
EA021814B1 (ru) | 2015-09-30 |
AU2012276175A1 (en) | 2014-01-09 |
CN103814036B (zh) | 2016-05-18 |
CN103814036A (zh) | 2014-05-21 |
WO2013000269A1 (zh) | 2013-01-03 |
KR101606624B1 (ko) | 2016-03-25 |
CN102850400A (zh) | 2013-01-02 |
US9266911B2 (en) | 2016-02-23 |
US20140107342A1 (en) | 2014-04-17 |
KR20140020333A (ko) | 2014-02-18 |
AU2012276175B2 (en) | 2016-08-11 |
CA2838875A1 (en) | 2013-01-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |