AR034588A1 - Derivados heterociclilalcoxi-, -alquiltio- y -alquilamino-benzazol como ligandos de 5-hidroxitriptamina-6, un proceso para su preparacion, intermediarios, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos - Google Patents

Derivados heterociclilalcoxi-, -alquiltio- y -alquilamino-benzazol como ligandos de 5-hidroxitriptamina-6, un proceso para su preparacion, intermediarios, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos

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Publication number
AR034588A1
AR034588A1 ARP020101443A ARP020101443A AR034588A1 AR 034588 A1 AR034588 A1 AR 034588A1 AR P020101443 A ARP020101443 A AR P020101443A AR P020101443 A ARP020101443 A AR P020101443A AR 034588 A1 AR034588 A1 AR 034588A1
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AR
Argentina
Prior art keywords
optionally substituted
alkyl
aryl
derivatives
independently
Prior art date
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ARP020101443A
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English (en)
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Wyeth Corp
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Publication date
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Publication of AR034588A1 publication Critical patent/AR034588A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados heterociclilalcoxi-, -alquiltio- y -alquilamino-benzazol, que comprenden un compuesto de fórmula (1) en donde: W es SO2, CO, CONH, CSNH ó (CH2)x; X es O, SOy, ó NR13; Y es CR14 ó N; Z es CR15 ó N, con la condición que cuando Y es N, entonces Z debe ser CR15; m y x son cada uno independientemente 0 ó un entero de 1, 2 ó 3; n y p son cada uno independientemente un entero de 1, 2 ó 3; R1 es halógeno, CN, OR16, CO2R17, CONR18R19, CNR20R21R22, SO2NR23R24, SOwR25, o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, fenilo o un grupo heteroarilo, cada uno opcionalmente sustituido; R2, R3, R5, R6, R7, R8, R9, R10 y R11 son cada uno independientemente H o un grupo alquilo C1-6 opcionalmente sustituido; R4 es H, CNR26NR27R28, o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo, cada uno opcionalmente sustituido; R12 es un grupo arilo, heteroarilo o alquilo C1-6 opcionalmente sustituido; w e y son cada uno 0 ó un entero de 1 ó 2; R13 es H, o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo, cada uno opcionalmente sustituido; R14 y R15 son cada uno de manera independiente H, halógeno, o un grupo alquilo C1-6, arilo, heteroarilo o alcoxi C1-6, cada uno opcionalmente sustituido; R16 es H, COR29, o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo o heteroarilo, cada uno opcionalmente sustituido; R17 y R29 son cada uno de manera independiente H, o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo, cada uno opcionalmente sustituido; R18, R19, R20, R21, R22, R26, R27 y R28 son cada uno de manera independiente H, o un grupo alquilo C1-6 opcionalmente sustituido; R23 y R24 son cada uno de manera independiente H, o un grupo alquilo C1-6, arilo o heteroarilo, cada uno opcionalmente sustituido; y R25 es un grupo arilo, heteroarilo o alquilo C1-6 opcionalmente sustituidos; o los estereoisómeros del mismo o las sales farmacéuticamente aceptables del mismo; un proceso para su preparación, intermediarios, composiciones farmacéuticas y el uso de dichos derivados para la manufactura de medicamentos, para el tratamiento terapéutico de trastornos relacionados con el sistema nervioso central o afectados por el receptor de 5-HT6.
ARP020101443A 2001-04-20 2002-04-19 Derivados heterociclilalcoxi-, -alquiltio- y -alquilamino-benzazol como ligandos de 5-hidroxitriptamina-6, un proceso para su preparacion, intermediarios, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos AR034588A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28564401P 2001-04-20 2001-04-20

Publications (1)

Publication Number Publication Date
AR034588A1 true AR034588A1 (es) 2004-03-03

Family

ID=23095117

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101443A AR034588A1 (es) 2001-04-20 2002-04-19 Derivados heterociclilalcoxi-, -alquiltio- y -alquilamino-benzazol como ligandos de 5-hidroxitriptamina-6, un proceso para su preparacion, intermediarios, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos

Country Status (17)

Country Link
US (2) US6831094B2 (es)
EP (1) EP1392682A2 (es)
JP (1) JP2004526781A (es)
KR (1) KR20030088507A (es)
CN (1) CN1293073C (es)
AR (1) AR034588A1 (es)
AU (1) AU2002309585B2 (es)
BR (1) BR0209047A (es)
CA (1) CA2444036A1 (es)
EA (1) EA200301143A1 (es)
HU (1) HUP0303801A2 (es)
IL (1) IL158448A0 (es)
MX (1) MXPA03009490A (es)
NO (1) NO20034647L (es)
PL (1) PL366639A1 (es)
WO (1) WO2002085853A2 (es)
ZA (1) ZA200309009B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4390698B2 (ja) * 2002-06-05 2009-12-24 エフ.ホフマン−ラ ロシュ アーゲー Cns障害の処置のための5−ht6レセプターモジュレーターとしての1−スルホニル−4−アミノアルコキシインドール誘導体
RU2350602C2 (ru) * 2002-12-03 2009-03-27 Ф.Хоффманн-Ля Рош Аг Аминоалкоксииндолы, как лиганды рецептора 5-нт6, для лечения заболеваний цнс
WO2004074243A2 (en) * 2003-02-14 2004-09-02 Wyeth Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
SE0302760D0 (sv) * 2003-10-20 2003-10-20 Biovitrum Ab New compounds
CA2619309A1 (en) * 2005-08-15 2007-03-22 Wyeth Azinyl-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands
AU2006280091A1 (en) * 2005-08-15 2007-02-22 Wyeth Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands
EP2001865A1 (en) * 2006-04-05 2008-12-17 Wyeth a Corporation of the State of Delaware Sulfonyl-3-heterocyclylindazole derivatives as 5-hydroxytryptamine-6 ligands
WO2007120596A1 (en) * 2006-04-12 2007-10-25 Wyeth DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
CN101432269A (zh) * 2006-06-01 2009-05-13 惠氏公司 作为5-羟色胺-6配体的1-磺酰基吲唑基胺和1-磺酰基吲唑基酰胺衍生物
WO2009006267A2 (en) * 2007-06-28 2009-01-08 Wyeth N'-(2-halobenzylidene)sulfonylhydrazides as intermediates in the manufacture of arylsulfonylindazoles
CN102958927A (zh) 2010-05-12 2013-03-06 Abbvie公司 激酶的吲唑抑制剂
MY170236A (en) 2010-10-06 2019-07-11 Glaxosmithkline Llc Benzimidazole derivatives as pi3 kinase inhibitors
WO2015090233A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
WO2016004882A1 (en) 2014-07-08 2016-01-14 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
CN111032646B (zh) 2017-08-01 2023-01-03 施万生物制药研发Ip有限责任公司 作为jak激酶抑制剂的吡唑并和三唑并双环化合物
JP2022518741A (ja) 2019-01-23 2022-03-16 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー JAKキナーゼ阻害剤としてのイミダゾ[1,5-a]ピリジン、1,2,4-トリアゾロ[4,3-a]ピリジンおよびイミダゾ[1,5-a]ピラジン
US11697648B2 (en) 2019-11-26 2023-07-11 Theravance Biopharma R&D Ip, Llc Fused pyrimidine pyridinone compounds as JAK inhibitors

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Publication number Priority date Publication date Assignee Title
US5274097A (en) * 1988-04-19 1993-12-28 Bayer Aktiengesellschaft 1,3-disubstituted pyrrolidines
DE3835291A1 (de) 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
TW288010B (es) * 1992-03-05 1996-10-11 Pfizer
AU7195694A (en) 1993-07-19 1995-02-20 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives useful as dopamine receptor antagonist, 5-ht receptor agonist or alpha1 receptor antagonist
US5578716A (en) * 1993-12-01 1996-11-26 Mcgill University DNA methyltransferase antisense oligonucleotides
JPH0940646A (ja) 1995-07-27 1997-02-10 Yamanouchi Pharmaceut Co Ltd ベンゼン縮合環誘導体又はその塩
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DK1355904T3 (da) * 2000-12-22 2007-10-15 Wyeth Corp Heterocyclindazol- og -azaindazolforbindelser som 5-hydroxytryptamin-6-ligander
TW593278B (en) * 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
TW200401641A (en) * 2002-07-18 2004-02-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands
WO2004074243A2 (en) * 2003-02-14 2004-09-02 Wyeth Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands

Also Published As

Publication number Publication date
KR20030088507A (ko) 2003-11-19
CA2444036A1 (en) 2002-10-31
BR0209047A (pt) 2004-08-10
WO2002085853A2 (en) 2002-10-31
CN1518548A (zh) 2004-08-04
AU2002309585B2 (en) 2008-01-31
MXPA03009490A (es) 2004-02-12
JP2004526781A (ja) 2004-09-02
US20050065185A1 (en) 2005-03-24
WO2002085853A3 (en) 2002-12-19
EP1392682A2 (en) 2004-03-03
PL366639A1 (en) 2005-02-07
NO20034647L (no) 2003-11-20
ZA200309009B (en) 2005-02-21
NO20034647D0 (no) 2003-10-17
CN1293073C (zh) 2007-01-03
IL158448A0 (en) 2004-05-12
US6831094B2 (en) 2004-12-14
US20030078286A1 (en) 2003-04-24
EA200301143A1 (ru) 2004-02-26
HUP0303801A2 (hu) 2004-03-01

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