AR034283A1 - Compuestos heterociclilindazol y azaindazol como ligandos de 5-hidroxitriptamina-6, un procedimiento para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamento - Google Patents
Compuestos heterociclilindazol y azaindazol como ligandos de 5-hidroxitriptamina-6, un procedimiento para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamentoInfo
- Publication number
- AR034283A1 AR034283A1 ARP010106001A ARP010106001A AR034283A1 AR 034283 A1 AR034283 A1 AR 034283A1 AR P010106001 A ARP010106001 A AR P010106001A AR P010106001 A ARP010106001 A AR P010106001A AR 034283 A1 AR034283 A1 AR 034283A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- aryl
- independently
- heteroaryl group
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos heterociclilindazol y azaindazol, que comprenden un compuesto de fórmula (1) en la cual Q es SO2, CO, CONR24, CSNR25 o CH2; W es N o CR6; X es N o CR7; Y es NR8 o CR9R10; n es 0 o un número entero de 1 o 2; Z es NR11 o CR12R13 con la condición que cuando n es 1, Q es SO2, CO o CH2, y W es CR6 entonces Z debe ser CR12R13 y con las condiciones adicionales que cuando Y es NR8 entonces Z debe ser CR12R13 y por lo menos uno de Y y Z deben ser NR8 o NR11; R1, R2 y R7 son cada uno independientemente H, halógeno, CN, OCO2R14, CO2R15, CONR29R30, CNR16NR17R18, SOmR19, NR20R21, OR22, COR23 o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido; R3, R4, R9, R10, R12 y R13 son cada uno independientemente H o un grupo alquilo C1-6 opcionalmente sustituido; R5 es un grupo alquilo C1-6, arilo o heteroarilo opcionalmente sustituido; m es 0 un número entero de 1o 2; R6 es H, halógeno, o un grupo alquilo C1-6; alcoxi C1-6, arilo o hereoarilo opcionalmente sustituido; R8 y R11 son cada uno independientemente H, CNR26NR27R28 o un grupo alquilo C1-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido; R14, R15, R22 y R22 son cada uno independientemente H o un grupo alquilo C1-6 alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo opcionalmente sustituido; R16, R17, R18, R20, R21, R26, R27, R28, R29 y R30 son cada uno independientemente H o alquilo C1-4; R19 es un grupo alquilo C1-6, arilo o heteroarilo opcionalmente sustituido. R24 y R25 son cada uno independientemente H o un grupo alquilo, C1-6, arilo o heteroarilo opcionalmente sustituido; y donde la línea punteada representa un enlace simple o un enlace doble; o los estereoisómeros del mismo o sus sales farmacéuticamente aceptables; un procedimiento para su preparación, composición farmacéutica que lo comprende y el uso del mismo para la fabricación de un medicamento para el tratamiento terapéutico de desórdenes relacionados con el sistema nervioso central o afectados por el receptor 5-HT6.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25762700P | 2000-12-22 | 2000-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR034283A1 true AR034283A1 (es) | 2004-02-18 |
Family
ID=22977057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010106001A AR034283A1 (es) | 2000-12-22 | 2001-12-21 | Compuestos heterociclilindazol y azaindazol como ligandos de 5-hidroxitriptamina-6, un procedimiento para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamento |
Country Status (20)
Country | Link |
---|---|
US (3) | US6767912B2 (es) |
EP (1) | EP1355904B1 (es) |
JP (1) | JP4307073B2 (es) |
KR (1) | KR20030062442A (es) |
CN (1) | CN1281605C (es) |
AR (1) | AR034283A1 (es) |
AT (1) | ATE368658T1 (es) |
BR (1) | BR0116323A (es) |
CA (1) | CA2432654A1 (es) |
DE (1) | DE60129746T2 (es) |
DK (1) | DK1355904T3 (es) |
EA (1) | EA200300717A1 (es) |
ES (1) | ES2290187T3 (es) |
HU (1) | HUP0400684A2 (es) |
IL (1) | IL156517A0 (es) |
MX (1) | MXPA03005432A (es) |
NO (1) | NO20032840L (es) |
PL (1) | PL363241A1 (es) |
WO (1) | WO2002051837A2 (es) |
ZA (1) | ZA200305622B (es) |
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-
2001
- 2001-12-11 EA EA200300717A patent/EA200300717A1/ru unknown
- 2001-12-11 KR KR10-2003-7008394A patent/KR20030062442A/ko not_active Application Discontinuation
- 2001-12-11 JP JP2002552932A patent/JP4307073B2/ja not_active Expired - Fee Related
- 2001-12-11 CN CNB018228283A patent/CN1281605C/zh not_active Expired - Fee Related
- 2001-12-11 MX MXPA03005432A patent/MXPA03005432A/es active IP Right Grant
- 2001-12-11 EP EP01986147A patent/EP1355904B1/en not_active Expired - Lifetime
- 2001-12-11 AT AT01986147T patent/ATE368658T1/de not_active IP Right Cessation
- 2001-12-11 ES ES01986147T patent/ES2290187T3/es not_active Expired - Lifetime
- 2001-12-11 CA CA002432654A patent/CA2432654A1/en not_active Abandoned
- 2001-12-11 HU HU0400684A patent/HUP0400684A2/hu unknown
- 2001-12-11 IL IL15651701A patent/IL156517A0/xx unknown
- 2001-12-11 PL PL01363241A patent/PL363241A1/xx unknown
- 2001-12-11 WO PCT/US2001/047935 patent/WO2002051837A2/en active IP Right Grant
- 2001-12-11 DK DK01986147T patent/DK1355904T3/da active
- 2001-12-11 BR BR0116323-0A patent/BR0116323A/pt not_active IP Right Cessation
- 2001-12-11 DE DE60129746T patent/DE60129746T2/de not_active Expired - Lifetime
- 2001-12-20 US US10/028,168 patent/US6767912B2/en not_active Expired - Fee Related
- 2001-12-21 AR ARP010106001A patent/AR034283A1/es unknown
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2003
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- 2003-07-21 ZA ZA200305622A patent/ZA200305622B/en unknown
- 2003-10-23 US US10/691,937 patent/US6903112B2/en not_active Expired - Fee Related
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CN1553910A (zh) | 2004-12-08 |
EP1355904B1 (en) | 2007-08-01 |
WO2002051837A3 (en) | 2003-01-16 |
DE60129746D1 (de) | 2007-09-13 |
CA2432654A1 (en) | 2002-07-04 |
US20020198213A1 (en) | 2002-12-26 |
HUP0400684A2 (hu) | 2004-07-28 |
KR20030062442A (ko) | 2003-07-25 |
US20040092526A1 (en) | 2004-05-13 |
BR0116323A (pt) | 2003-10-14 |
US20050124603A1 (en) | 2005-06-09 |
JP4307073B2 (ja) | 2009-08-05 |
DE60129746T2 (de) | 2008-04-30 |
JP2004518668A (ja) | 2004-06-24 |
NO20032840L (no) | 2003-08-20 |
DK1355904T3 (da) | 2007-10-15 |
US6767912B2 (en) | 2004-07-27 |
NO20032840D0 (no) | 2003-06-20 |
IL156517A0 (en) | 2004-01-04 |
EP1355904A2 (en) | 2003-10-29 |
ES2290187T3 (es) | 2008-02-16 |
CN1281605C (zh) | 2006-10-25 |
ZA200305622B (en) | 2004-10-21 |
US6903112B2 (en) | 2005-06-07 |
WO2002051837A2 (en) | 2002-07-04 |
EA200300717A1 (ru) | 2003-12-25 |
PL363241A1 (en) | 2004-11-15 |
MXPA03005432A (es) | 2003-09-10 |
ATE368658T1 (de) | 2007-08-15 |
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