NO20032840L - Heterocykloindazol- og azaindazol-forbindelser som 5- hydroksytryptamin-6-ligander - Google Patents
Heterocykloindazol- og azaindazol-forbindelser som 5- hydroksytryptamin-6-ligander Download PDFInfo
- Publication number
- NO20032840L NO20032840L NO20032840A NO20032840A NO20032840L NO 20032840 L NO20032840 L NO 20032840L NO 20032840 A NO20032840 A NO 20032840A NO 20032840 A NO20032840 A NO 20032840A NO 20032840 L NO20032840 L NO 20032840L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- aryl
- alkyl
- heterocycloindazole
- hydroxytryptamine
- Prior art date
Links
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical class C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- -1 cycloheteroalkyl Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (1)
- Forbindelse karakterisert ved formel 1 R2R4)n Q-Rs 10 hvor (1 er S02, CO, CONR24, CSNR25 eller CH2: W er N eller C%; 15 X er N eller CR7; Y er NRa eller CRqRio; n er 0 eller heltallet I eller 2; Z er NR„ eller CR12.R13, med det forbehold at nr n er 1, Q er S02, CO eller CH2, Og W er C%, da m Z vre CR12R13 Og med de ytterligere forbehold at n r Y er 20 NRB, da m Z v re CRUR13 Og minst n av Y og Z m vre N% eller NR,,; Ri, R2 og R7 er hver uavhengig H, halogen, CN, OC02R14, C02R15, CONR2gR3o, CNRjr,NR17Ria. SOmRig, NR20R21, OR22, COR23 eller en CI-C6alkyl-, Cz-Cr,alkenyl-, C2-C6alkynyl-, C3-C6cykloalkyl-, cykloheteroalkyl-, aryl- eller heteroarylgruppe som hver eventuelt er substituert; 25 R3, R4, Rg, Rio, RI 2 og RI 3 er hver uavhengig H eller en eventuelt substituert C,-C6alkylgruppe; R5 er en eventuelt substituert C,-C6alkyl-, aryl- eller heteroarylgruppe; m er 0 eller heltallet 1 eller 2; 1% er H, halogen, eller en eventuelt substituert C,-C6alkyl-, C,-C6alkoksy-, aryl- eller 30 heteroarylgruppe; og RI, er hver uavhengig H, CNR26NR27R28 eller en C,-C6alkyl-, C3-C6cykloalkyl-, cykloheteroalkyl-, aryl- eller heteroarylgruppe som hver eventuelt er substituert;
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25762700P | 2000-12-22 | 2000-12-22 | |
PCT/US2001/047935 WO2002051837A2 (en) | 2000-12-22 | 2001-12-11 | Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20032840D0 NO20032840D0 (no) | 2003-06-20 |
NO20032840L true NO20032840L (no) | 2003-08-20 |
Family
ID=22977057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20032840A NO20032840L (no) | 2000-12-22 | 2003-06-20 | Heterocykloindazol- og azaindazol-forbindelser som 5- hydroksytryptamin-6-ligander |
Country Status (20)
Country | Link |
---|---|
US (3) | US6767912B2 (no) |
EP (1) | EP1355904B1 (no) |
JP (1) | JP4307073B2 (no) |
KR (1) | KR20030062442A (no) |
CN (1) | CN1281605C (no) |
AR (1) | AR034283A1 (no) |
AT (1) | ATE368658T1 (no) |
BR (1) | BR0116323A (no) |
CA (1) | CA2432654A1 (no) |
DE (1) | DE60129746T2 (no) |
DK (1) | DK1355904T3 (no) |
EA (1) | EA200300717A1 (no) |
ES (1) | ES2290187T3 (no) |
HU (1) | HUP0400684A2 (no) |
IL (1) | IL156517A0 (no) |
MX (1) | MXPA03005432A (no) |
NO (1) | NO20032840L (no) |
PL (1) | PL363241A1 (no) |
WO (1) | WO2002051837A2 (no) |
ZA (1) | ZA200305622B (no) |
Families Citing this family (71)
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- 2001-12-11 ES ES01986147T patent/ES2290187T3/es not_active Expired - Lifetime
- 2001-12-11 KR KR10-2003-7008394A patent/KR20030062442A/ko not_active Application Discontinuation
- 2001-12-11 CN CNB018228283A patent/CN1281605C/zh not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
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DE60129746D1 (de) | 2007-09-13 |
MXPA03005432A (es) | 2003-09-10 |
ATE368658T1 (de) | 2007-08-15 |
US6767912B2 (en) | 2004-07-27 |
ES2290187T3 (es) | 2008-02-16 |
BR0116323A (pt) | 2003-10-14 |
NO20032840D0 (no) | 2003-06-20 |
ZA200305622B (en) | 2004-10-21 |
EP1355904A2 (en) | 2003-10-29 |
WO2002051837A2 (en) | 2002-07-04 |
CN1553910A (zh) | 2004-12-08 |
KR20030062442A (ko) | 2003-07-25 |
CA2432654A1 (en) | 2002-07-04 |
IL156517A0 (en) | 2004-01-04 |
US20050124603A1 (en) | 2005-06-09 |
US20020198213A1 (en) | 2002-12-26 |
EA200300717A1 (ru) | 2003-12-25 |
DK1355904T3 (da) | 2007-10-15 |
EP1355904B1 (en) | 2007-08-01 |
HUP0400684A2 (hu) | 2004-07-28 |
WO2002051837A3 (en) | 2003-01-16 |
US20040092526A1 (en) | 2004-05-13 |
JP2004518668A (ja) | 2004-06-24 |
CN1281605C (zh) | 2006-10-25 |
AR034283A1 (es) | 2004-02-18 |
PL363241A1 (en) | 2004-11-15 |
DE60129746T2 (de) | 2008-04-30 |
JP4307073B2 (ja) | 2009-08-05 |
US6903112B2 (en) | 2005-06-07 |
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