NO20060718L - Substituerte tiofoner og deres anvendelse - Google Patents

Substituerte tiofoner og deres anvendelse

Info

Publication number
NO20060718L
NO20060718L NO20060718A NO20060718A NO20060718L NO 20060718 L NO20060718 L NO 20060718L NO 20060718 A NO20060718 A NO 20060718A NO 20060718 A NO20060718 A NO 20060718A NO 20060718 L NO20060718 L NO 20060718L
Authority
NO
Norway
Prior art keywords
thiophones
substituted
cancer
prevention
compositions
Prior art date
Application number
NO20060718A
Other languages
English (en)
Inventor
Susan Ashwell
Paul Dermot Lyne
Vibha Oza
Mei Su
Dingwei Yu
Thomas Gero
Stophanos Ioannidis
James Janetka
Stephanie Springer
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20060718L publication Critical patent/NO20060718L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Abstract

Foreliggende oppfinnelse omhandler nye forbindelser som har den strukturelle formel (1) og deres farmasøytiske salter, preparater og fremgangsmåter for anvendelse. Disse nye forbindelsene tilveiebringer en behandling eller forebygging av kreft.
NO20060718A 2003-08-15 2006-02-14 Substituerte tiofoner og deres anvendelse NO20060718L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49558003P 2003-08-15 2003-08-15
US57641604P 2004-05-28 2004-05-28
PCT/GB2004/003473 WO2005016909A1 (en) 2003-08-15 2004-08-12 Substituted thiophenes and uses thereof

Publications (1)

Publication Number Publication Date
NO20060718L true NO20060718L (no) 2006-03-01

Family

ID=34198049

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060718A NO20060718L (no) 2003-08-15 2006-02-14 Substituerte tiofoner og deres anvendelse

Country Status (19)

Country Link
US (2) US7423061B2 (no)
EP (1) EP1660474B1 (no)
JP (1) JP2007502308A (no)
KR (1) KR20060080918A (no)
AR (1) AR045459A1 (no)
AT (1) ATE412645T1 (no)
AU (1) AU2004265140A1 (no)
BR (1) BRPI0413585A (no)
CA (1) CA2535652A1 (no)
DE (1) DE602004017478D1 (no)
ES (1) ES2314443T3 (no)
HK (1) HK1091487A1 (no)
IL (1) IL173619A0 (no)
IS (1) IS8344A (no)
MX (1) MXPA06001775A (no)
NO (1) NO20060718L (no)
RU (1) RU2006107782A (no)
TW (1) TW200524894A (no)
WO (1) WO2005016909A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10360369A1 (de) * 2003-12-22 2005-07-14 Bayer Cropscience Ag Amide
JP2007517843A (ja) * 2004-01-05 2007-07-05 アストラゼネカ アクチボラグ Ｃｈｋ１阻害剤であるチオフェン誘導体
DE102005035742A1 (de) * 2005-07-29 2007-02-01 Merck Patent Gmbh Quadratsäurederivate II
DE102005039541A1 (de) * 2005-08-22 2007-03-22 Merck Patent Gmbh 3-Oxo-indazol-quadratsäurederivate
WO2008121592A2 (en) * 2007-03-30 2008-10-09 Takeda Pharmaceutical Company Limited Acetyl coenzyme a carboxylase inhibitors
CN101481380B (zh) * 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
WO2009096198A1 (ja) * 2008-02-01 2009-08-06 Pharma Ip Limited Liability Intermediary Corporations 新規ビアリール誘導体
CN102119156B (zh) * 2008-06-11 2015-01-21 健泰科生物技术公司 取代的吡咯及其使用方法
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
EP4115883A4 (en) * 2020-03-04 2024-04-10 Pharos Ibio Co Ltd USE OF A 2,3,5-SUBSTITUTED THIOPHENE COMPOUND TO PREVENT, MITIGATE OR TREAT OVARIAN CANCER

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1019040B1 (en) 1997-05-23 2004-09-29 Bayer Corporation Aryl ureas for the treatment of inflammatory or immunomodulatory diseases
AU7585598A (en) * 1997-05-23 1998-12-11 Bayer Corporation Raf kinase inhibitors
GB0003154D0 (en) 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
WO2002030353A2 (en) 2000-10-12 2002-04-18 Smithkline Beecham Corporation NF-λB INHIBITORS
UA76977C2 (en) * 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
SE0102616D0 (sv) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
WO2003028731A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
DE60229975D1 (de) 2001-10-04 2009-01-02 Smithkline Beecham Corp Nf-kb-inhibitoren
WO2003029241A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
AU2003249683A1 (en) 2002-06-06 2003-12-22 Smithkline Beecham Corporation Nf-:b inhibitors
AU2003300832A1 (en) 2002-12-06 2004-06-30 Smithkline Beecham Corporation NF-KappaB INHIBITORS
SE0300091D0 (sv) 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
US20050085531A1 (en) 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
JP2007517843A (ja) 2004-01-05 2007-07-05 アストラゼネカ アクチボラグ Ｃｈｋ１阻害剤であるチオフェン誘導体
WO2005105777A1 (en) 2004-05-05 2005-11-10 Pharmacia & Upjohn Company Llc Substituted thiophene amide compounds for the treatment of inflammation
US7612200B2 (en) 2004-12-07 2009-11-03 Locus Pharmaceuticals, Inc. Inhibitors of protein kinases
WO2006062982A2 (en) 2004-12-07 2006-06-15 Locus Pharmaceuticals, Inc. Urea inhibitors of map kinases

Also Published As

Publication number Publication date
AR045459A1 (es) 2005-10-26
AU2004265140A1 (en) 2005-02-24
HK1091487A1 (en) 2007-01-19
DE602004017478D1 (de) 2008-12-11
ATE412645T1 (de) 2008-11-15
BRPI0413585A (pt) 2006-10-17
RU2006107782A (ru) 2006-08-10
EP1660474B1 (en) 2008-10-29
JP2007502308A (ja) 2007-02-08
IS8344A (is) 2006-03-09
US20060281666A1 (en) 2006-12-14
ES2314443T3 (es) 2009-03-16
WO2005016909A1 (en) 2005-02-24
US20090054396A1 (en) 2009-02-26
US7423061B2 (en) 2008-09-09
TW200524894A (en) 2005-08-01
IL173619A0 (en) 2006-07-05
CA2535652A1 (en) 2005-02-24
EP1660474A1 (en) 2006-05-31
KR20060080918A (ko) 2006-07-11
MXPA06001775A (es) 2006-05-17

Similar Documents

Publication Publication Date Title
NO20060718L (no) Substituerte tiofoner og deres anvendelse
NO20063449L (no) Substituerte heterocykler og deres anvendelse
NO20055219L (no) Nye forbindelser
NO20054083L (no) Nye sammenkoblede triazoloner og deres anvendelse
NO20055568L (no) Substituerte 1,4-diazepiner og anvendelser derav
NO20073791L (no) Pyrazolylaminopyridinderivater anvendbare som kinaseinhibitorer
NO20056192L (no) Kapaseinhibitorer og anvendelse derav
NO20070224L (no) 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
NO20070557L (no) Ftalazinderivater som PARP-inhibitorer
NO20050828L (no) lndol-3-svovelderivater
NO20081454L (no) Met-kinaseinhibitorer
NO20054340L (no) Nye sammenkoplede heterocykler og deres anvendelse
BRPI0410630A (pt) antagonista de nk1
ATE433447T1 (de) Pyrimiidinverbindungen
NO20080675L (no) P38-Map kinaseinhibitorer og metoder for deres anvendelse
NO20062021L (no) Omleirede pentanoler, fremgangsmpte for fremstilling av dette, og deres anvendelse som antiflogistika
NO20063468L (no) Triazolforbindelser og deres anvendelse som metabotrofe glutamatreseptorantagonister
NO20055688L (no) Organiske forbindelser
NO20090755L (no) Amino-imidazoloner og deres anvendelse som et medikament for behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerering og demens
NO20050134L (no) Difenylazetidioner substituert med syregrupper, fremgangsmate for fremstilling av disse, medikamenter inneholdende disse forbindelser og deres anvendelse
NO20060195L (no) Kinolylamidderivater som CCR-5-antagonister
NO20054787L (no) Indenderivater som farmasotiske midler
NO20076479L (no) Nye oksadiazolderivater og anvendelse derav som positive allosteriske metabotropiske modulatorer av glutamatreseptorer
NO20071137L (no) Nye piperidinderivater for behandling av depresjon
NO20076638L (no) Nye 8-sulfonylamino-3-aminosubstituerte kroman- eller tetrahydronaftalenderivater som modulerer 5HT6-reseptoren

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application