AR044526A1 - Compuestos triciclicos moduladores de receptor nuclear de hormonas esteroides, composiciones farmaceuticas que los comprenden y su uso para la fabricacion de un medicamento. - Google Patents

Compuestos triciclicos moduladores de receptor nuclear de hormonas esteroides, composiciones farmaceuticas que los comprenden y su uso para la fabricacion de un medicamento.

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Publication number
AR044526A1
AR044526A1 ARP030102283A ARP030102283A AR044526A1 AR 044526 A1 AR044526 A1 AR 044526A1 AR P030102283 A ARP030102283 A AR P030102283A AR P030102283 A ARP030102283 A AR P030102283A AR 044526 A1 AR044526 A1 AR 044526A1
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AR
Argentina
Prior art keywords
alkyl
hydrogen
manufacture
formulas
alkoxy
Prior art date
Application number
ARP030102283A
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English (en)
Original Assignee
Lilly Co Eli
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Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR044526A1 publication Critical patent/AR044526A1/es

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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07C2603/86—Ring systems containing bridged rings containing four rings

Abstract

Compuestos tricíclicos moduladores de receptor nuclear de hormonas esteroides que tienen la fórmula (1), en la que A representa un resto seleccionado del grupo de fórmulas (2); B representa un resto seleccionado del grupo de fórmulas (3); y el resto de fórmula (4) representa un heterociclo benzofusionado que posee un sustituyente que no es hidrógeno en al menos uno de R1 a R3, en donde dicho heterociclo benzofusionado que posee un sustituyente que no es hidrógeno, está dado por un resto del grupo de fórmulas (5); X e Y juntos representan -CH2-CH2-, -CH2-O-, o -O-CH2-; "la línea punto" representa una unión doble; R4 a R7 cada uno independientemente representa hidrógeno, hidroxi, halo, alquilo (C1-6), alcoxi (C1-6); u OR14, en el que R14 representa alquilo (C1-4)-arilo, arilo sustituido con alquilo (C1-4), alquilo (C1-4)-heterociclo, o alquilo (C1-4)-cicloalquilo (C3-7); R8 representa hidrógeno, halo, alquilo (C1-6), hidroximetilo, alquilo (C1-4)-alcoxi (C1-6), o COR12 en donde R12 representa alcoxi (C1-6); cicloalquilo (C3-7), fenilo, o arilo sustituido; o una sal del mismo aceptable para uso farmacéutico. Composición farmacéutica que comprende dichos compuestos y un vehículo aceptable para uso farmacéutico. Su uso para fabricación de un medicamento para tratamiento de paros cardíacos congestivos diastólicos o sistólicos y de hipertensión.
ARP030102283A 2002-06-26 2003-06-25 Compuestos triciclicos moduladores de receptor nuclear de hormonas esteroides, composiciones farmaceuticas que los comprenden y su uso para la fabricacion de un medicamento. AR044526A1 (es)

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