ES2142817T3 - Compuestos triciclicos como antagonistas de la angiotensina ii. - Google Patents
Compuestos triciclicos como antagonistas de la angiotensina ii.Info
- Publication number
- ES2142817T3 ES2142817T3 ES92311777T ES92311777T ES2142817T3 ES 2142817 T3 ES2142817 T3 ES 2142817T3 ES 92311777 T ES92311777 T ES 92311777T ES 92311777 T ES92311777 T ES 92311777T ES 2142817 T3 ES2142817 T3 ES 2142817T3
- Authority
- ES
- Spain
- Prior art keywords
- chem
- alkyl
- carboxyl
- substituted phenyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE PRESENTAN NUEVOS COMPUESTOS TRICICLICOS Y SALES DE LOS MISMOS QUE SON UTILES COMO ANTAGONISTAS RECEPTORES DE LA AII. ESTOS SON LOS COMPUESTOS DE LA FORMULA I Y SUS SALES: R1 REPRESENTA HIDROGENO, HALOGENO O ALQUIL C1-C6; A REPRESENTA CIANO, CARBOXIL, TETRAZOLIL, FENIL SUSTITUIDO CON CIANO, FENIL SUSTITUIDO CON CARBOXIL O FENIL SUSTITUIDO CON TETRAZOLIL; C REPRESENTA -(CH2)M-, EN DONDE M ES 0, 1 O 2; W REPRESENTA UN GRUPO DE LA FORMULA EN DONDE (ALFA) ES: EN DONDE R2, R3 Y R4 SON CADA UNA HIDROGENO, HALOGENO, ALQUIL C1C6, CICLOALQUIL C2-C6, ALQUIL C1-C6 HALOGENADO, HIDROXIDO, ALCOXIDO C1-C6, AMINO, ALQUILAMINO C1-C6, CARBOXIL O ALCOXICARBONIL C1-C6; Y Q1-Q2-Q3-Q4 REPRESENTAN N=CH-CH=CH, CH=CH-CH=CH O CH2-CH2-CH2-CH2; (BETA) ES: EN DONDE R2, R3 Y R4 SON CADA UNA COMO SE DEFINIERON ANTERIORMENTE GAMMA ES EN DONDE R5 Y R6 REPRESENTAN CADA UNA HIDROGENO, ALQUIL C1-C6 O CICLOALQUIL C3-C5, Y R7 REPRESENTA CARBOXIL, ALCOXICARBONIL C1C6, CARBAMOIL O HIDROXIMETIL; Y (DELTA) ES: EN DONDE R8 Y R9 REPRESENTAN CADA UNA HIDROGENO O ALQUIL C1-C6, Y Q REPRESENTA N O CH; X1-X2-X3 REPRESENTAN UN GRUPO CH=CH, CH-CH2, CH-CH(COOH)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP34729491 | 1991-12-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2142817T3 true ES2142817T3 (es) | 2000-05-01 |
Family
ID=18389240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92311777T Expired - Lifetime ES2142817T3 (es) | 1991-12-27 | 1992-12-24 | Compuestos triciclicos como antagonistas de la angiotensina ii. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0549352B1 (es) |
AT (1) | ATE190058T1 (es) |
DE (1) | DE69230721T2 (es) |
ES (1) | ES2142817T3 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2716196B1 (fr) * | 1994-02-16 | 1996-04-05 | Synthelabo | Dérivés de 8-[2-(1H-tétrazol-5-yl) phényl] quinoléine, leur préparation et leur application en thérapeutique. |
JP2002541144A (ja) * | 1999-01-26 | 2002-12-03 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | 医薬的に活性のある化合物及びその使用方法 |
TW200400816A (en) | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
US20060252679A1 (en) * | 2002-08-22 | 2006-11-09 | Mayumi Saki | Preventive and/or trerapeutic drgs for itch |
WO2004017994A1 (ja) * | 2002-08-22 | 2004-03-04 | Kyowa Hakko Kogyo Co., Ltd. | 喘息の予防および/または治療剤 |
EP1988091B1 (en) * | 2007-02-07 | 2015-06-10 | Kyowa Hakko Kirin Co., Ltd. | Tricyclic compounds |
JP5559689B2 (ja) * | 2008-08-06 | 2014-07-23 | 協和発酵キリン株式会社 | 3環系化合物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
IL95975A (en) * | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
DE59107440D1 (de) * | 1990-02-19 | 1996-04-04 | Ciba Geigy Ag | Acylverbindungen |
-
1992
- 1992-12-24 AT AT92311777T patent/ATE190058T1/de not_active IP Right Cessation
- 1992-12-24 EP EP92311777A patent/EP0549352B1/en not_active Expired - Lifetime
- 1992-12-24 ES ES92311777T patent/ES2142817T3/es not_active Expired - Lifetime
- 1992-12-24 DE DE69230721T patent/DE69230721T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69230721D1 (de) | 2000-04-06 |
ATE190058T1 (de) | 2000-03-15 |
EP0549352A2 (en) | 1993-06-30 |
DE69230721T2 (de) | 2000-08-31 |
EP0549352A3 (en) | 1993-07-28 |
EP0549352B1 (en) | 2000-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU680704B2 (en) | Cyclic amide derivatives | |
EP0152820A3 (en) | Carbamate compounds, compositions and method of making the same | |
FI830776L (fi) | Nya foereningar, foerfarande foer deras framstaellning samt deras anvaendning som laekemedel | |
ATE163647T1 (de) | 4-aminopyrimidin derivate | |
EP0632031A4 (es) | ||
ES2142817T3 (es) | Compuestos triciclicos como antagonistas de la angiotensina ii. | |
DK0459505T3 (da) | Imidazonaphthyridinderivater | |
EP1306369A4 (en) | NEW SULFUR COMPOUNDS AND INTERMOLECULAR COMPOUNDS CONTAINING THEM AS A COMPONENT | |
AU3667589A (en) | Thiophenol derivatives as collagenese inhibitors | |
DK221490D0 (da) | Beta-carbonyl-carboxyamider af 1,3-thiazolidiner | |
SE8303913D0 (sv) | Heterocykliska foreningar | |
SE8505369D0 (sv) | New thienopyridine derivatives, a process of preparation thereof and therapeutic compositions containing the same | |
IE821782L (en) | Sulphimines | |
ES2096628T3 (es) | Derivados heterociclicos. | |
DE69004596D1 (de) | Benzodiazepin-Analoge. | |
DK0481742T3 (da) | Piperazinderivater | |
PL321309A1 (en) | Novel bis-imide compounds, method of obtaining them and pharmaceutic compositions containing such compounds | |
DE69427100D1 (de) | Herstellung von Beta-lactamverbindungen und Zwischenprodukte | |
DE69420362D1 (de) | Makrozyklische Verbindungen und ihre Verwendung als Pharmazeutika | |
NO872006D0 (no) | Fremgangsmaate for fremstilling av cefalosporinderivater. | |
ATE329917T1 (de) | 1h-pyrrolo 1,2-bö 1,2,4ötriazolederivate, zwischenprodukte und verfahren zur herstellung von 1h-1,2,4,-triazol-5-yl essigsäureesterderivate | |
ATE109764T1 (de) | Beta-lactamverbindungen und deren herstellung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 549352 Country of ref document: ES |