ATE190058T1 - Tricyclische verbindungen als angiotensin-ii- antagonisten - Google Patents
Tricyclische verbindungen als angiotensin-ii- antagonistenInfo
- Publication number
- ATE190058T1 ATE190058T1 AT92311777T AT92311777T ATE190058T1 AT E190058 T1 ATE190058 T1 AT E190058T1 AT 92311777 T AT92311777 T AT 92311777T AT 92311777 T AT92311777 T AT 92311777T AT E190058 T1 ATE190058 T1 AT E190058T1
- Authority
- AT
- Austria
- Prior art keywords
- chem
- alkyl
- carboxyl
- substituted phenyl
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940123413 Angiotensin II antagonist Drugs 0.000 title 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- -1 cyano, carboxyl Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DBTDEFJAFBUGPP-UHFFFAOYSA-N Methanethial Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 abstract 1
- 101100073357 Streptomyces halstedii sch2 gene Proteins 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 235000019256 formaldehyde Nutrition 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34729491 | 1991-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE190058T1 true ATE190058T1 (de) | 2000-03-15 |
Family
ID=18389240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92311777T ATE190058T1 (de) | 1991-12-27 | 1992-12-24 | Tricyclische verbindungen als angiotensin-ii- antagonisten |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0549352B1 (de) |
| AT (1) | ATE190058T1 (de) |
| DE (1) | DE69230721T2 (de) |
| ES (1) | ES2142817T3 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2716196B1 (fr) * | 1994-02-16 | 1996-04-05 | Synthelabo | Dérivés de 8-[2-(1H-tétrazol-5-yl) phényl] quinoléine, leur préparation et leur application en thérapeutique. |
| US7056911B1 (en) * | 1999-01-26 | 2006-06-06 | Dana-Farber Cancer Institute | Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof |
| TW200400816A (en) | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| CA2496464A1 (en) * | 2002-08-22 | 2004-03-04 | Kyowa Hakko Kogyo Co., Ltd. | Agent for prevention and/or treatment of itching |
| US20060239999A1 (en) * | 2002-08-22 | 2006-10-26 | Mayumi Saki | Preventive and/or therapeutic drugs for asthma |
| KR101126383B1 (ko) * | 2007-02-07 | 2012-04-12 | 교와 핫꼬 기린 가부시키가이샤 | 3환계 화합물 |
| EP2327690A4 (de) * | 2008-08-06 | 2012-03-28 | Kyowa Hakko Kirin Co Ltd | Trizyklische verbindung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| IL95975A (en) * | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
| IL97219A (en) * | 1990-02-19 | 1995-12-08 | Ciba Geigy Ag | Biphenyl substituted aliphatic amino compounds process for their preparation and pharmaceutical compositions containing them |
-
1992
- 1992-12-24 DE DE69230721T patent/DE69230721T2/de not_active Expired - Fee Related
- 1992-12-24 EP EP92311777A patent/EP0549352B1/de not_active Expired - Lifetime
- 1992-12-24 ES ES92311777T patent/ES2142817T3/es not_active Expired - Lifetime
- 1992-12-24 AT AT92311777T patent/ATE190058T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0549352A2 (de) | 1993-06-30 |
| EP0549352A3 (de) | 1993-07-28 |
| DE69230721D1 (de) | 2000-04-06 |
| ES2142817T3 (es) | 2000-05-01 |
| DE69230721T2 (de) | 2000-08-31 |
| EP0549352B1 (de) | 2000-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69331089D1 (de) | Beta-Laktam und Cepham Verbindungen und Ihre Herstellung | |
| AU680704B2 (en) | Cyclic amide derivatives | |
| ATE267814T1 (de) | Substituierte kondensierte heterocyclische verbindungen | |
| DE69408750D1 (de) | 4-Aminopyrimidin Derivate | |
| HUT74182A (en) | Novel imidazole derivatives, process for producing the same and pharmaceutical compositions containing the compounds | |
| ATE190058T1 (de) | Tricyclische verbindungen als angiotensin-ii- antagonisten | |
| FI923774A0 (fi) | 1,7-anellerande 2-(piperazinoalkyl) indolderivat samt foerfaranden och mellanprodukter foer deras framstaellning. | |
| TW197421B (de) | ||
| EP1306369A4 (de) | Neue schwefelverbindungen und intermolekulare verbindungen, die diese als komponente enthalten | |
| CA2089368A1 (en) | Antibacterial penem esters derivatives | |
| DK221490D0 (da) | Beta-carbonyl-carboxyamider af 1,3-thiazolidiner | |
| SE8303913L (sv) | Heterocykliska foreningar | |
| SE8505369D0 (sv) | New thienopyridine derivatives, a process of preparation thereof and therapeutic compositions containing the same | |
| NZ228369A (en) | Heterocyclic substituted 5,7-dihydropyrrolo(3,2-f)-benzoxazol-6-ones, preparation and compositions thereof | |
| ES2096628T3 (es) | Derivados heterociclicos. | |
| PL321309A1 (en) | Novel bis-imide compounds, method of obtaining them and pharmaceutic compositions containing such compounds | |
| DE69427100D1 (de) | Herstellung von Beta-lactamverbindungen und Zwischenprodukte | |
| DE69420362D1 (de) | Makrozyklische Verbindungen und ihre Verwendung als Pharmazeutika | |
| NO872006D0 (no) | Fremgangsmaate for fremstilling av cefalosporinderivater. | |
| ATE148462T1 (de) | Isoxazole derivate als lichtschutzmittel | |
| FI940679A0 (fi) | 4-asyylitioatsetidinonit | |
| ATE109764T1 (de) | Beta-lactamverbindungen und deren herstellung. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |