TW200626560A - HIV inhibiting 5-carbo-or heterocyclic substituted pyrimidines - Google Patents
HIV inhibiting 5-carbo-or heterocyclic substituted pyrimidinesInfo
- Publication number
- TW200626560A TW200626560A TW094134106A TW94134106A TW200626560A TW 200626560 A TW200626560 A TW 200626560A TW 094134106 A TW094134106 A TW 094134106A TW 94134106 A TW94134106 A TW 94134106A TW 200626560 A TW200626560 A TW 200626560A
- Authority
- TW
- Taiwan
- Prior art keywords
- substituted
- 6alkyl
- optionally substituted
- amino
- 6alkyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104814 | 2004-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200626560A true TW200626560A (en) | 2006-08-01 |
Family
ID=34929640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094134106A TW200626560A (en) | 2004-09-30 | 2005-09-29 | HIV inhibiting 5-carbo-or heterocyclic substituted pyrimidines |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7531548B2 (zh) |
| EP (1) | EP1797048B1 (zh) |
| JP (1) | JP5162245B2 (zh) |
| KR (1) | KR20070057798A (zh) |
| CN (1) | CN101031550B (zh) |
| AR (1) | AR050970A1 (zh) |
| AT (1) | ATE520672T1 (zh) |
| AU (1) | AU2005288865B2 (zh) |
| BR (1) | BRPI0515935B8 (zh) |
| CA (1) | CA2573976C (zh) |
| ES (1) | ES2371924T3 (zh) |
| IL (1) | IL180760A (zh) |
| MX (1) | MX2007003798A (zh) |
| RU (1) | RU2403244C2 (zh) |
| TW (1) | TW200626560A (zh) |
| WO (1) | WO2006035068A2 (zh) |
| ZA (1) | ZA200702655B (zh) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1849318B (zh) | 2003-07-30 | 2011-10-12 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物预防和治疗自体免疫疾病的方法 |
| BRPI0516746A (pt) * | 2004-09-30 | 2008-09-23 | Tibotec Pharm Ltd | 5-heterociclil pirimidinas para inibição de hiv |
| RU2410379C2 (ru) * | 2004-09-30 | 2011-01-27 | Тиботек Фармасьютикалз Лтд. | 5-замещенные пиримидины, ингибирующие вич |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| KR101312225B1 (ko) | 2005-06-08 | 2013-09-26 | 리겔 파마슈티칼스, 인크. | Ｊａｋ 경로의 억제를 위한 조성물 및 방법 |
| MX2008012577A (es) * | 2006-03-30 | 2008-10-10 | Tibotec Pharm Ltd | Pirimidinas sustituidas con 5-(hidroximetileno y aminometileno) que inhiben el virus de inmunodeficiencia humana. |
| AU2007233737B2 (en) | 2006-03-30 | 2012-11-29 | Janssen Sciences Ireland Uc | HIV inhibiting 5-amido substituted pyrimidines |
| CN101553483B (zh) | 2006-12-13 | 2013-04-17 | 弗·哈夫曼-拉罗切有限公司 | 作为非核苷逆转录酶抑制剂的2-(哌啶-4-基)-4-苯氧基-或苯基氨基-嘧啶衍生物 |
| DK2114901T3 (da) * | 2006-12-29 | 2014-06-30 | Janssen R & D Ireland | Hiv-inhiberende 6-substituerede pyrimidiner |
| EA020749B1 (ru) * | 2006-12-29 | 2015-01-30 | Тиботек Фармасьютикалз Лтд. | Вич-ингибирующие 5,6-замещенные пиримидины |
| WO2008118823A2 (en) * | 2007-03-26 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| KR20110025224A (ko) * | 2008-06-27 | 2011-03-09 | 아빌라 테라퓨틱스, 인크. | 헤테로아릴 화합물 및 이의 용도 |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| TWI491605B (zh) | 2008-11-24 | 2015-07-11 | Boehringer Ingelheim Int | 新穎化合物 |
| AR074209A1 (es) | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina utiles para el tratamiento del cancer |
| WO2010129053A2 (en) | 2009-05-05 | 2010-11-11 | Dana Farber Cancer Institute | Egfr inhibitors and methods of treating disorders |
| RU2556986C2 (ru) * | 2009-06-22 | 2015-07-20 | Эмкьюар Фармасьютикалз Лимитед | Способ синтеза диарилпиримидинового ненуклеозидного ингибитора обратной транскриптазы |
| CA2807051A1 (en) | 2010-08-10 | 2012-02-16 | Celgene Avilomics Research, Inc. | Besylate salt of a btk inhibitor |
| ES2635713T3 (es) | 2010-11-01 | 2017-10-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
| TWI545115B (zh) | 2010-11-01 | 2016-08-11 | 阿維拉製藥公司 | 雜環化合物及其用途 |
| JP5957003B2 (ja) | 2010-11-10 | 2016-07-27 | セルジーン アヴィロミクス リサーチ， インコーポレイテッド | 変異体選択的ｅｇｆｒ阻害剤およびその使用 |
| EP2770830A4 (en) | 2011-10-28 | 2015-05-27 | Celgene Avilomics Res Inc | METHODS OF TREATING A DISEASE OR DISEASE ASSOCIATED WITH TYROSINE KINASE BTK (BRUTON'S TYROSINE KINASE) |
| JP6317320B2 (ja) | 2012-03-15 | 2018-04-25 | セルジーン シーエーアール エルエルシー | 上皮成長因子受容体キナーゼ阻害剤の塩 |
| CN108658873B (zh) | 2012-03-15 | 2021-09-14 | 西建卡尔有限责任公司 | 表皮生长因子受体激酶抑制剂的固体形式 |
| EP2935226A4 (en) | 2012-12-21 | 2016-11-02 | Celgene Avilomics Res Inc | HETEROARYL COMPOUNDS AND USES THEREOF |
| CN105188371A (zh) | 2013-02-08 | 2015-12-23 | 西建阿维拉米斯研究公司 | Erk抑制剂及其用途 |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| US10005760B2 (en) | 2014-08-13 | 2018-06-26 | Celgene Car Llc | Forms and compositions of an ERK inhibitor |
| PE20230559A1 (es) | 2020-02-19 | 2023-03-31 | Pharmasyntez | Medicamentos antivirales para el tratamiento y prevencion de la infeccion por vih |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| KR20230155351A (ko) * | 2022-05-03 | 2023-11-10 | 한국화학연구원 | 5-클로로-2,4-다이아미노피리미딘을 포함하는 키나아제 억제 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
| NO311614B1 (no) | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| TR200002760T2 (tr) * | 1998-03-27 | 2000-12-21 | Janssen Pharmaceutica N.V. | HIV engelleyici pirimidin türevleri |
| EP0945447A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
| ES2361146T3 (es) * | 1998-03-27 | 2011-06-14 | Janssen Pharmaceutica Nv | Derivados de la piramidina inhibitatoria de vih. |
| CN1214013C (zh) * | 1998-11-10 | 2005-08-10 | 詹森药业有限公司 | 抑制hiv复制的嘧啶类 |
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| ES2542326T3 (es) * | 2000-05-08 | 2015-08-04 | Janssen Pharmaceutica Nv | Inhibidores de la replicación del VIH |
| PL210066B1 (pl) * | 2000-12-21 | 2011-11-30 | Vertex Pharma | Związek pirazolowy, kompozycja zawierająca ten związek i jego zastosowania |
| JO3429B1 (ar) * | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| US7504410B2 (en) * | 2002-11-28 | 2009-03-17 | Schering Aktiengesellschaft | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
-
2005
- 2005-09-29 CN CN200580033118.3A patent/CN101031550B/zh not_active Expired - Fee Related
- 2005-09-29 MX MX2007003798A patent/MX2007003798A/es active IP Right Grant
- 2005-09-29 KR KR1020077003634A patent/KR20070057798A/ko not_active Application Discontinuation
- 2005-09-29 JP JP2007534027A patent/JP5162245B2/ja not_active Expired - Fee Related
- 2005-09-29 AU AU2005288865A patent/AU2005288865B2/en not_active Ceased
- 2005-09-29 TW TW094134106A patent/TW200626560A/zh unknown
- 2005-09-29 CA CA2573976A patent/CA2573976C/en not_active Expired - Fee Related
- 2005-09-29 BR BRPI0515935A patent/BRPI0515935B8/pt not_active IP Right Cessation
- 2005-09-29 WO PCT/EP2005/054931 patent/WO2006035068A2/en active Application Filing
- 2005-09-29 AT AT05803358T patent/ATE520672T1/de not_active IP Right Cessation
- 2005-09-29 ES ES05803358T patent/ES2371924T3/es active Active
- 2005-09-29 US US11/576,068 patent/US7531548B2/en active Active
- 2005-09-29 EP EP05803358A patent/EP1797048B1/en active Active
- 2005-09-29 RU RU2007116161/04A patent/RU2403244C2/ru active
- 2005-09-30 AR ARP050104154A patent/AR050970A1/es not_active Application Discontinuation
-
2007
- 2007-01-17 IL IL180760A patent/IL180760A/en active IP Right Grant
- 2007-03-29 ZA ZA200702655A patent/ZA200702655B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070057798A (ko) | 2007-06-07 |
| IL180760A0 (en) | 2007-06-03 |
| ES2371924T3 (es) | 2012-01-11 |
| BRPI0515935B1 (pt) | 2019-11-19 |
| ZA200702655B (en) | 2008-09-25 |
| RU2007116161A (ru) | 2008-11-10 |
| CN101031550B (zh) | 2015-05-27 |
| BRPI0515935B8 (pt) | 2021-05-25 |
| JP5162245B2 (ja) | 2013-03-13 |
| AU2005288865A1 (en) | 2006-04-06 |
| EP1797048B1 (en) | 2011-08-17 |
| CA2573976A1 (en) | 2006-04-06 |
| WO2006035068A2 (en) | 2006-04-06 |
| CN101031550A (zh) | 2007-09-05 |
| RU2403244C2 (ru) | 2010-11-10 |
| IL180760A (en) | 2013-02-28 |
| ATE520672T1 (de) | 2011-09-15 |
| US20070208022A1 (en) | 2007-09-06 |
| AR050970A1 (es) | 2006-12-06 |
| JP2008514680A (ja) | 2008-05-08 |
| MX2007003798A (es) | 2007-04-23 |
| US7531548B2 (en) | 2009-05-12 |
| CA2573976C (en) | 2014-04-29 |
| WO2006035068A3 (en) | 2006-08-31 |
| BRPI0515935A (pt) | 2008-08-12 |
| AU2005288865B2 (en) | 2012-07-19 |
| EP1797048A2 (en) | 2007-06-20 |
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