ME01229B - 2-(4-cijanofenil)-6-hidroksilaminopirimidini koji inhibiraju hiv - Google Patents

2-(4-cijanofenil)-6-hidroksilaminopirimidini koji inhibiraju hiv

Info

Publication number
ME01229B
ME01229B MEP-2010-147A MEP14710A ME01229B ME 01229 B ME01229 B ME 01229B ME P14710 A MEP14710 A ME P14710A ME 01229 B ME01229 B ME 01229B
Authority
ME
Montenegro
Prior art keywords
hydroxylaminopyrimidines
cyanophenyl
compounds
hiv inhibiting
hiv
Prior art date
Application number
MEP-2010-147A
Other languages
English (en)
French (fr)
Inventor
Piet Tom Bert Paul Wigerinck
Kock Herman Augustinus De
Original Assignee
Janssen R& D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen R& D Ireland filed Critical Janssen R& D Ireland
Publication of ME01229B publication Critical patent/ME01229B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MEP-2010-147A 2005-03-04 2006-03-02 2-(4-cijanofenil)-6-hidroksilaminopirimidini koji inhibiraju hiv ME01229B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05101707 2005-03-04
PCT/EP2006/060407 WO2006094930A1 (en) 2005-03-04 2006-03-02 Hiv inhibiting 2-(4-cyanophenyl)-6-hydroxylaminopyrimidines

Publications (1)

Publication Number Publication Date
ME01229B true ME01229B (me) 2013-06-20

Family

ID=34938904

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2010-147A ME01229B (me) 2005-03-04 2006-03-02 2-(4-cijanofenil)-6-hidroksilaminopirimidini koji inhibiraju hiv

Country Status (20)

Country Link
US (2) US20080214588A1 (me)
EP (1) EP1858861B1 (me)
JP (1) JP5118978B2 (me)
CN (1) CN101133038B (me)
AT (1) ATE473212T1 (me)
AU (1) AU2006222057B2 (me)
BR (1) BRPI0609291B1 (me)
CY (1) CY1111102T1 (me)
DE (1) DE602006015291D1 (me)
DK (1) DK1858861T3 (me)
ES (1) ES2347815T3 (me)
HR (1) HRP20100504T1 (me)
ME (1) ME01229B (me)
MX (1) MX2007010744A (me)
PL (1) PL1858861T3 (me)
PT (1) PT1858861E (me)
RS (1) RS51435B (me)
RU (1) RU2401261C2 (me)
SI (1) SI1858861T1 (me)
WO (1) WO2006094930A1 (me)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7935711B2 (en) * 2005-02-18 2011-05-03 Tibotec Pharmaceuticals Ltd. HIV inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives
WO2008071587A2 (en) 2006-12-13 2008-06-19 F. Hoffmann-La Roche Ag 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors
UA106972C2 (uk) * 2009-06-22 2014-11-10 Емк'Юр Фармас'Ютікалз Лімітед Спосіб синтезу діарилпіримідинового ненуклеозидного інгібітора зворотної транскриптази
US8153790B2 (en) 2009-07-27 2012-04-10 Krizmanic Irena Process for the preparation and purification of etravirine and intermediates thereof
CN101993419B (zh) * 2009-08-20 2013-01-16 浙江九洲药业股份有限公司 一种4-[(5-溴-4,6-二氯-2-嘧啶基)氨基]苯甲腈的制备方法
GR1007010B (el) 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια
WO2011135578A1 (en) 2010-04-28 2011-11-03 Chetan Balar Composition comprising chitin and tinosporin for use in the treatment of viral diseases
WO2013059572A1 (en) 2011-10-19 2013-04-25 Assia Chemical Industries Ltd. Process for the preparation of etravirine and intermediates in the synthesis thereof
KR20220129043A (ko) 2020-02-19 2022-09-22 조인트 스톡 컴퍼니 “파르마신세즈” Hiv 감염의 치료 및 예방을 위한 항바이러스제로서 피리미딘계 바이사이클

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
SK67298A3 (en) 1995-11-23 1998-11-04 Janssen Pharmaceutica Nv Solid mixtures of cyclodextrins prepared via melt-extrusion
NZ511116A (en) * 1998-11-10 2003-08-29 Janssen Pharmaceutica Nv HIV replication inhibiting pyrimidines
IL148801A0 (en) * 1999-09-24 2002-09-12 Janssen Pharmaceutica Nv Antiviral compositions
US7034019B2 (en) * 2000-05-08 2006-04-25 Janssen Pharmaceutica N.V. Prodrugs of HIV replication inhibiting pyrimidines

Also Published As

Publication number Publication date
CN101133038B (zh) 2012-06-27
RS51435B (en) 2011-04-30
ATE473212T1 (de) 2010-07-15
CY1111102T1 (el) 2015-06-11
AU2006222057A1 (en) 2006-09-14
JP5118978B2 (ja) 2013-01-16
PT1858861E (pt) 2010-09-16
BRPI0609291B1 (pt) 2022-02-08
BRPI0609291A2 (pt) 2010-03-09
CN101133038A (zh) 2008-02-27
HRP20100504T1 (hr) 2010-10-31
JP2008531658A (ja) 2008-08-14
SI1858861T1 (sl) 2010-10-29
ES2347815T3 (es) 2010-11-04
AU2006222057B2 (en) 2012-10-04
US8119801B2 (en) 2012-02-21
RU2007136782A (ru) 2009-04-10
PL1858861T3 (pl) 2010-12-31
DK1858861T3 (da) 2010-11-08
EP1858861B1 (en) 2010-07-07
US20080214588A1 (en) 2008-09-04
RU2401261C2 (ru) 2010-10-10
MX2007010744A (es) 2007-09-12
WO2006094930A1 (en) 2006-09-14
EP1858861A1 (en) 2007-11-28
DE602006015291D1 (de) 2010-08-19
US20100121060A1 (en) 2010-05-13

Similar Documents

Publication Publication Date Title
CY1111102T1 (el) 2-(4-κυανοφαινυλ)-6-υδροξυλαμινοπυριμιδινες που αναστελλουν τον hiv
TW200500346A (en) HIV replication inhibiting indane substituted pyrimidines
MX2022011365A (es) Derivados de biarilo como inhibidores de la interaccion proteina-proteina de yap/taz-tead.
MX2011012628A (es) Derivados amino-propionicos sustituidos como inhibidores de neprilisina.
HRP20040686B1 (hr) Novi heterocikliäśki spojevi koji djeluju kao inhibitori beta-laktamaza
MX2011012627A (es) Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
SE0400284D0 (sv) Novel compounds
TW200736232A (en) Pyrimidine derivatives
MY139506A (en) Hiv replication inhibitors
TW200626561A (en) HIV inhibiting 5-substituted pyrimidines
TW200639156A (en) New compounds
DE602004008959D1 (de) Benzoäbüä1,4üdioxepinderivate
ATE523498T1 (de) Hiv-inhibierende 2-(4- cyanophenylamino)pyrimidinderivate
MXPA05011176A (es) Derivados de carboxamida como agentes antidiabeticos.
SA519410865B1 (ar) مركب حلقي شبيه بكُومارين بوصفه مثبط mek واستخدامه
PH12019502652A1 (en) 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases
MX2009010932A (es) Inhibidores no nucleosidos de transcriptasa inversa.
MX2022012881A (es) Inhibidores de replicacion del virus de inmunodeficiencia humana.
MX2009012704A (es) Inhibidores de transcriptasa inversa de no nucleosidos.
TW200640464A (en) Pharmaceutical composition comprising phenoxazinium compounds as an active ingredient
TW200616614A (en) A pharmaceutical composition for treating spinocerebellar ataxia
MX2009013865A (es) Urea y derivados carbamato como inhibidores no nucleosidicos de la transcriptasa inversa.
EA201290487A1 (ru) 5-амино-4-гидроксипентоиламиды
TN2011000592A1 (en) Substituted aminopropionic derivatives as neprilysin inhibitors
UA81654C2 (ru) Пиримидины и триазины, которые ингибируют репликацию вич