MX2009010932A - Inhibidores no nucleosidos de transcriptasa inversa. - Google Patents

Inhibidores no nucleosidos de transcriptasa inversa.

Info

Publication number
MX2009010932A
MX2009010932A MX2009010932A MX2009010932A MX2009010932A MX 2009010932 A MX2009010932 A MX 2009010932A MX 2009010932 A MX2009010932 A MX 2009010932A MX 2009010932 A MX2009010932 A MX 2009010932A MX 2009010932 A MX2009010932 A MX 2009010932A
Authority
MX
Mexico
Prior art keywords
reverse transcriptase
treatment
transcriptase inhibitors
nucleoside reverse
hiv
Prior art date
Application number
MX2009010932A
Other languages
English (en)
Inventor
Jeffrey Wu
Wylie Solang Palmer
Zachary Kevin Sweeney
Roland J Billedeau
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009010932A publication Critical patent/MX2009010932A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Los compuestos de fórmula I, en donde R1, R2, R3, R4, Ra, X, X1, e Y son como los definidos anteriormente aquí o las sales farmacéuticamente aceptables de los mismos, inhiben la transcriptasa inversa del VIH-1 y proporcionan un método para la prevención y el tratamiento de las infecciones del VIH-1 y el tratamiento del SIDA y/o del ARC. La presente invención se refiere también a composiciones que comprenden compuestos de fórmula I útiles para la prevención y tratamiento de las infecciones del VIH-1 y el tratamiento del SIDA y/o del ARC.
MX2009010932A 2007-04-09 2008-03-31 Inhibidores no nucleosidos de transcriptasa inversa. MX2009010932A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92244907P 2007-04-09 2007-04-09
US96134607P 2007-07-20 2007-07-20
PCT/EP2008/053806 WO2008122534A2 (en) 2007-04-09 2008-03-31 Non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
MX2009010932A true MX2009010932A (es) 2009-10-29

Family

ID=39798124

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010932A MX2009010932A (es) 2007-04-09 2008-03-31 Inhibidores no nucleosidos de transcriptasa inversa.

Country Status (15)

Country Link
US (1) US20080293664A1 (es)
EP (1) EP2134711A2 (es)
JP (1) JP2010523613A (es)
KR (1) KR20100015435A (es)
CN (1) CN101679414A (es)
AR (1) AR066404A1 (es)
AU (1) AU2008235549A1 (es)
BR (1) BRPI0810496A2 (es)
CA (1) CA2683046A1 (es)
CL (1) CL2008000996A1 (es)
IL (1) IL200886A0 (es)
MX (1) MX2009010932A (es)
PE (1) PE20090143A1 (es)
TW (1) TW200906410A (es)
WO (1) WO2008122534A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1838152A2 (en) * 2005-01-21 2007-10-03 Neurogen Corporation Imidazolylmethyl and pyrazolylmethyl heteroaryl derivatives
JP5269087B2 (ja) * 2007-11-16 2013-08-21 ギリアード サイエンシス インコーポレーテッド ヒト免疫不全ウイルス複製のインヒビター
AU2008340422B2 (en) * 2007-12-21 2014-06-19 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
CA2803103A1 (en) 2010-07-15 2012-01-19 Albemarle Corporation Processes for producing 4-bromo-2-methoxybenzaldehyde
US9497234B2 (en) * 2012-12-27 2016-11-15 Facebook, Inc. Implicit social graph connections
TW201613919A (en) 2014-07-02 2016-04-16 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128287D0 (en) * 2001-11-26 2002-01-16 Smithkline Beecham Plc Novel method and compounds
GB0206723D0 (en) * 2002-03-21 2002-05-01 Glaxo Group Ltd Novel compounds
TW200505441A (en) * 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ
EP1608629A1 (en) * 2003-03-24 2005-12-28 F. Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
WO2005090317A1 (en) * 2004-03-23 2005-09-29 F.Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
US7625949B2 (en) * 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
RU2394028C2 (ru) * 2004-07-27 2010-07-10 Ф.Хоффманн-Ля Рош Аг Производные бензилтриазолона в качестве ненуклеозидных ингибиторов обратной транскриптазы
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
ES2360893T3 (es) * 2006-08-16 2011-06-10 F. Hoffmann-La Roche Ag Inhibidores no nucleósidos de la transcriptasa inversa.

Also Published As

Publication number Publication date
EP2134711A2 (en) 2009-12-23
PE20090143A1 (es) 2009-02-26
US20080293664A1 (en) 2008-11-27
IL200886A0 (en) 2010-05-17
BRPI0810496A2 (pt) 2018-11-06
AR066404A1 (es) 2009-08-19
WO2008122534A3 (en) 2009-02-05
CN101679414A (zh) 2010-03-24
JP2010523613A (ja) 2010-07-15
TW200906410A (en) 2009-02-16
KR20100015435A (ko) 2010-02-12
CA2683046A1 (en) 2008-10-16
WO2008122534A2 (en) 2008-10-16
AU2008235549A1 (en) 2008-10-16
CL2008000996A1 (es) 2008-10-10

Similar Documents

Publication Publication Date Title
MX2009009920A (es) Inhibidores no nucleosidos de transcriptasa inversa.
MX2010006397A (es) Compuestos heterociclicos antivirales.
GEP20115320B (en) Non-nucleoside reverse transcriptase inhibitors
MX2009005881A (es) Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida.
GEP20156368B (en) Non-nucleoside reverse transcriptase inhibitors
EP2041159B8 (en) Macrocyclic compounds as antiviral agents
TW200603783A (en) Non-nucleoside reverse transcriptase inhibitors
GEP20186838B (en) 5-phenoxy-3h-pyrimidin-4-one derivatives and their usage as hiv reverse transcriptase inhibitors
UA95955C2 (ru) Ингибиторы обратной транскриптазы вич
MY147390A (en) Substituted isoindoles as bace inhibitors and their use
MX2012007420A (es) Analogos para el tratamiento o prevencion de infecciones de flavivirus.
CR20210608A (es) Pirroles tricíclicos condensados como moduladores de alfa-1 antitripsina
MX2009012168A (es) Derivados de pirrolopiridina y su uso como inhibidores de la enzima que escinde la proteina precursora de amiloide por el sitio beta.
IL180495A (en) Benzyl triazolone compounds as non-nucleotide reverse transcriptase inhibitors
WO2004096128A3 (en) Hiv integrase inhibitors
WO2009146555A8 (en) Hiv integrase inhibitors from pyridoxine
MX2009012418A (es) Derivados de quinazolin-oxima como inhibidores de hsp90.
MY148634A (en) Pyridazinone derivatives
NO20090405L (no) Ikke-nukleoside revers transcriptase inhibitorer
TW200833675A (en) Nicotinamide derivatives
MX2009013804A (es) Inhibidores novedosos de transcriptasa inversa de vih.
EA201991349A1 (ru) Тетрациклические гетероциклические соединения, полезные в качестве ингибиторов интегразы вич
WO2007146230A3 (en) Non-nucleoside reverse transcriptase inhibitors
WO2008054605A3 (en) Non-nucleoside reverse transcriptase inhibitors
JO3067B1 (ar) بيرميدينات بيرازولو امينو كمثبطات ل fak

Legal Events

Date Code Title Description
FA Abandonment or withdrawal