CR20210608A - Pirroles tricíclicos condensados como moduladores de alfa-1 antitripsina - Google Patents

Pirroles tricíclicos condensados como moduladores de alfa-1 antitripsina

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Publication number
CR20210608A
CR20210608A CR20210608A CR20210608A CR20210608A CR 20210608 A CR20210608 A CR 20210608A CR 20210608 A CR20210608 A CR 20210608A CR 20210608 A CR20210608 A CR 20210608A CR 20210608 A CR20210608 A CR 20210608A
Authority
CR
Costa Rica
Prior art keywords
alpha
tryciclic
pyrroles
condensed
compounds
Prior art date
Application number
CR20210608A
Other languages
English (en)
Inventor
Cavan Mckeon Bligh
Samantha Guido
Sarah Carol Hood
Stephen Thomson
Michael John Boyd
Veronique Damagnez
Lev Tyler Dewey Fanning
Robert Francis Fimognari
Sarathy Kesavan
John Patrick Maxwell
Kirk Alan Overhoff
Kathy Stavropoulos
Jinwang Xu
Michael Philip Clark
Kevin James Gagnon
Robert Daniel Giacometti
Simon Giroux
Adam Looker
Ales Medek
Gabrielle Simone Fleming
Dennis James Hurley
Steven M Ronkin
Muna Shrestha
Peter Jones
Diane Boucher
Michael Aaron Brodney
Barrantes Pedro Manuel Garcia
Philippe Marcel Nuhant
Amy Beth Hall
Setu Roday
Rupa Sawant
Marisa Sposato
Upul Keerthi Bandarage
Jr Mac Arthur Johnson
Mei-Hsiu Lai
Brad Maxwell
Rebecca Jane Swett
Mariam Zaky
Kevin Michael Cottrell
Jr Ronald Lee Grey
Siying Liu
Stefanie Roeper
Qing Tang
Timothy Lewis Tapley
Yi Shi
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of CR20210608A publication Critical patent/CR20210608A/es

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    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos
CR20210608A 2019-05-14 2020-05-14 Pirroles tricíclicos condensados como moduladores de alfa-1 antitripsina CR20210608A (es)

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