AR066404A1 - Inhibidores no nucleosidos de transcriptasa inversa - Google Patents
Inhibidores no nucleosidos de transcriptasa inversaInfo
- Publication number
- AR066404A1 AR066404A1 ARP080101433A ARP080101433A AR066404A1 AR 066404 A1 AR066404 A1 AR 066404A1 AR P080101433 A ARP080101433 A AR P080101433A AR P080101433 A ARP080101433 A AR P080101433A AR 066404 A1 AR066404 A1 AR 066404A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- alkyl
- ch2oc
- oar
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de la formula (1) inhiben la transcriptasa inversa del VIH-l y proporcionan un método para la prevencion y el tratamiento de las infecciones del VIH-l y el tratamiento del SIDA y/o del. ARC. La presente invencion se refiere, también a composiciones que contienen compuestos de la formula 1 utiles para la prevencion y tratamiento de las infecciones del VIH-l. Reivindicacion 1: Un compuesto de la formula (1) en la que: X es CH2 o NH; Y es CH2 u O, con la condicion de que por lo menos uno de X e Y sea CH2 y con la condicion adicional de que cuando X1 es CH, entonces o bien (i) R1 es OAr o C(=O)Ar o bien (ii) X es NH; X1 es N o CH; R1 es C(=O)Ar, OAr, fluor o hidrogeno; R2 es OAr, hidrogeno, halogeno, alquilo C1-6, alcoxi C1-6 o halogeno, o cicloalquilo C3-5; R3 y R4 son con independencia hidrogeno, C1-6, alcoxi C1-6 o cicloalquilo C3-5; Ra es hidrogeno, CH2OH, CH2OC(=O) (CH2)nC(=O)OH, en el que n es un numero de 2 a 5, CH2OC(=O)alquilo C1-6, o CH2OC(=O)- CHRbNH2 en el que Rb es fenilo o alquilo inferior C1-6; Ar es fenilo sustituido por 1-3 restos elegidos con independencia entre halogeno, ciano, haloalquilo C1-6 o alquilo C1-6 o sus sales farmacéuticamente aceptables.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92244907P | 2007-04-09 | 2007-04-09 | |
| US96134607P | 2007-07-20 | 2007-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066404A1 true AR066404A1 (es) | 2009-08-19 |
Family
ID=39798124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101433A AR066404A1 (es) | 2007-04-09 | 2008-04-07 | Inhibidores no nucleosidos de transcriptasa inversa |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20080293664A1 (es) |
| EP (1) | EP2134711A2 (es) |
| JP (1) | JP2010523613A (es) |
| KR (1) | KR20100015435A (es) |
| CN (1) | CN101679414A (es) |
| AR (1) | AR066404A1 (es) |
| AU (1) | AU2008235549A1 (es) |
| BR (1) | BRPI0810496A2 (es) |
| CA (1) | CA2683046A1 (es) |
| CL (1) | CL2008000996A1 (es) |
| IL (1) | IL200886A0 (es) |
| MX (1) | MX2009010932A (es) |
| PE (1) | PE20090143A1 (es) |
| TW (1) | TW200906410A (es) |
| WO (1) | WO2008122534A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006078891A2 (en) * | 2005-01-21 | 2006-07-27 | Neurogen Corporation | Imidazolylmethyl and pyrazolylmethyl heteroaryl derivatives |
| CA2705338A1 (en) * | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| RU2495878C2 (ru) * | 2007-12-21 | 2013-10-20 | Ф.Хоффманн-Ля Рош Аг | Гетероциклические антивирусные соединения |
| EP2593419A1 (en) | 2010-07-15 | 2013-05-22 | Albemarle Corporation | Processes for producing 4-bromo-2-methoxybenzaldehyde |
| US9497234B2 (en) * | 2012-12-27 | 2016-11-15 | Facebook, Inc. | Implicit social graph connections |
| TW201613919A (en) * | 2014-07-02 | 2016-04-16 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0128287D0 (en) * | 2001-11-26 | 2002-01-16 | Smithkline Beecham Plc | Novel method and compounds |
| GB0206723D0 (en) * | 2002-03-21 | 2002-05-01 | Glaxo Group Ltd | Novel compounds |
| TW200505441A (en) * | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
| CN100469769C (zh) * | 2003-03-24 | 2009-03-18 | 弗·哈夫曼-拉罗切有限公司 | 作为逆转录酶抑制剂的苄基-哒嗪酮 |
| CN1934092A (zh) * | 2004-03-23 | 2007-03-21 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
| US7166738B2 (en) * | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| US7625949B2 (en) * | 2004-04-23 | 2009-12-01 | Roche Palo Alto Llc | Methods for treating retroviral infections |
| RU2394028C2 (ru) * | 2004-07-27 | 2010-07-10 | Ф.Хоффманн-Ля Рош Аг | Производные бензилтриазолона в качестве ненуклеозидных ингибиторов обратной транскриптазы |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| WO2008019968A1 (en) * | 2006-08-16 | 2008-02-21 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
-
2008
- 2008-03-31 CN CN200880011097A patent/CN101679414A/zh active Pending
- 2008-03-31 JP JP2010502486A patent/JP2010523613A/ja active Pending
- 2008-03-31 CA CA002683046A patent/CA2683046A1/en not_active Abandoned
- 2008-03-31 EP EP08735604A patent/EP2134711A2/en not_active Withdrawn
- 2008-03-31 MX MX2009010932A patent/MX2009010932A/es not_active Application Discontinuation
- 2008-03-31 KR KR1020097021022A patent/KR20100015435A/ko not_active Application Discontinuation
- 2008-03-31 BR BRPI0810496A patent/BRPI0810496A2/pt not_active Application Discontinuation
- 2008-03-31 AU AU2008235549A patent/AU2008235549A1/en not_active Abandoned
- 2008-03-31 WO PCT/EP2008/053806 patent/WO2008122534A2/en active Application Filing
- 2008-04-07 CL CL200800996A patent/CL2008000996A1/es unknown
- 2008-04-07 PE PE2008000622A patent/PE20090143A1/es not_active Application Discontinuation
- 2008-04-07 AR ARP080101433A patent/AR066404A1/es unknown
- 2008-04-08 TW TW097112675A patent/TW200906410A/zh unknown
- 2008-04-08 US US12/082,069 patent/US20080293664A1/en not_active Abandoned
-
2009
- 2009-09-13 IL IL200886A patent/IL200886A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0810496A2 (pt) | 2018-11-06 |
| JP2010523613A (ja) | 2010-07-15 |
| MX2009010932A (es) | 2009-10-29 |
| EP2134711A2 (en) | 2009-12-23 |
| CL2008000996A1 (es) | 2008-10-10 |
| AU2008235549A1 (en) | 2008-10-16 |
| CA2683046A1 (en) | 2008-10-16 |
| IL200886A0 (en) | 2010-05-17 |
| TW200906410A (en) | 2009-02-16 |
| US20080293664A1 (en) | 2008-11-27 |
| WO2008122534A2 (en) | 2008-10-16 |
| PE20090143A1 (es) | 2009-02-26 |
| CN101679414A (zh) | 2010-03-24 |
| KR20100015435A (ko) | 2010-02-12 |
| WO2008122534A3 (en) | 2009-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |