NO20080325L - Forbindelser og deres salter som er spesifikke overfor PPAR-reseptorer og EGF-reseptorer samt deres anvendelse innen medisin - Google Patents

Forbindelser og deres salter som er spesifikke overfor PPAR-reseptorer og EGF-reseptorer samt deres anvendelse innen medisin

Info

Publication number
NO20080325L
NO20080325L NO20080325A NO20080325A NO20080325L NO 20080325 L NO20080325 L NO 20080325L NO 20080325 A NO20080325 A NO 20080325A NO 20080325 A NO20080325 A NO 20080325A NO 20080325 L NO20080325 L NO 20080325L
Authority
NO
Norway
Prior art keywords
compounds
ppar
medicine
well
egf receptors
Prior art date
Application number
NO20080325A
Other languages
English (en)
Other versions
NO340680B1 (no
Inventor
Giancarlo Naccari
Sergio Baroni
Original Assignee
Giuliani Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37579831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20080325(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Giuliani Int Ltd filed Critical Giuliani Int Ltd
Publication of NO20080325L publication Critical patent/NO20080325L/no
Publication of NO340680B1 publication Critical patent/NO340680B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser omfattende den generelle formel (I): (I) hvor: R1 og R2, som kan være like eller forskjellige, er valgt fra gruppen omfattende -H eller en lineær eller forgrenet alkylgruppe som har fra 1 til 6 karbonatomer eller sammen danner en aromatisk eller alifatisk ring med 5 eller 6 atomer; Y og Z, som kan være like eller forskjellige, er valgt fra gruppen omfattende -H, -OH, -COOH, -OR3, -CH(OR3)COOH, hvor R3 er valgt fra H, fenyl, benzyl, -CF3 eller -CF2CF3, vinyl, allyl og en lineær eller forgrenet alkylgruppe som har fra 1 til 6 karbonatomer.
NO20080325A 2005-07-22 2008-01-18 Forbindelser og deres salter som er spesifikke overfor PPAR-reseptorer og EGF-reseptorer samt deres anvendelse innen medisin NO340680B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000389A ITRM20050389A1 (it) 2005-07-22 2005-07-22 Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
PCT/IE2006/000078 WO2007010516A2 (en) 2005-07-22 2006-07-24 Compounds and their salts specific to the ppar receptors and the egf receptors and their use in the medical field

Publications (2)

Publication Number Publication Date
NO20080325L true NO20080325L (no) 2008-04-16
NO340680B1 NO340680B1 (no) 2017-05-29

Family

ID=37579831

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080325A NO340680B1 (no) 2005-07-22 2008-01-18 Forbindelser og deres salter som er spesifikke overfor PPAR-reseptorer og EGF-reseptorer samt deres anvendelse innen medisin

Country Status (23)

Country Link
US (6) US8153841B2 (no)
EP (1) EP1910270B3 (no)
JP (1) JP5312026B2 (no)
KR (1) KR101317519B1 (no)
CN (2) CN102020577B (no)
AU (1) AU2006271165C1 (no)
CA (1) CA2616146C (no)
CY (1) CY1114294T1 (no)
DK (1) DK1910270T6 (no)
EA (2) EA014665B3 (no)
ES (1) ES2421260T7 (no)
HR (1) HRP20130549T4 (no)
IL (2) IL188878A (no)
IT (1) ITRM20050389A1 (no)
MX (1) MX366596B (no)
NO (1) NO340680B1 (no)
NZ (2) NZ566045A (no)
PL (1) PL1910270T6 (no)
PT (1) PT1910270E (no)
SI (1) SI1910270T1 (no)
UA (1) UA100359C2 (no)
WO (1) WO2007010516A2 (no)
ZA (2) ZA200801671B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20050390A1 (it) * 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
ITRM20050389A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
IE20070129A1 (en) * 2007-02-28 2008-12-24 Giuliani Int Ltd Ppar-gamma agonists stimulate enteric defensin expression
ITMI20072429A1 (it) 2007-12-24 2009-06-25 Giuliani Int Ltd Composti per il trattamento selettivo della componente immuno-infiammatoria intestinale della malattia celiaca
UA107562C2 (uk) 2008-12-05 2015-01-26 Спосіб лікування псоріазу
HUE032999T2 (hu) 2009-02-16 2017-11-28 Nogra Pharma Ltd Alkilamido vegyületek és azok alkalmazása
US9096531B2 (en) 2010-05-24 2015-08-04 Toa Eiyo Ltd. Fused imidazole derivative
MX364220B (es) * 2012-02-09 2019-04-16 Nogra Pharma Ltd Metodos de tratamientos de fibrosis.
EP2844242A1 (en) 2012-04-18 2015-03-11 Nogra Pharma Limited Methods of treating lactose intolerance
WO2015141851A1 (ja) * 2014-03-20 2015-09-24 京セラ株式会社 ユーザ端末、通信制御方法及び基地局
WO2017093444A1 (en) * 2015-12-01 2017-06-08 Nogra Pharma Limited Compositions for oral administration in the treatment of inflammatory bowel disease
US20220000818A1 (en) 2019-01-25 2022-01-06 Nogra Pharma Limited Compositions for use in preventing acne
KR20210125047A (ko) 2019-02-08 2021-10-15 노그라 파마 리미티드 3-(4'-아미노페닐)-2-메톡시프로피온산, 및 그의 유사체 및 중간체의 제조 방법

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB767788A (en) 1953-12-28 1957-02-06 Schering Corp Polyiodinated phenyl fatty acid compounds and process for their manufacture
US3211610A (en) 1961-09-29 1965-10-12 Merck & Co Inc Benzoic acid ester derivatives for treating coccidiosis and method of using same
US3444232A (en) 1966-05-18 1969-05-13 Squibb & Sons Inc O-alkyl or phenylalkyl benzohydroxamic acids
GB1359560A (en) 1972-02-25 1974-07-10 Merck & Co Inc Preparation of pyrrylsalicylic acid
US4036951A (en) 1973-03-12 1977-07-19 Synergistics, Inc. Ultra-violet filtration with certain aminosalicylic acid esters
FR2440353A1 (fr) * 1978-11-03 1980-05-30 Science Union & Cie Nouveaux arylethanols, leurs procedes d'obtention et leur emploi comme medicament
US4348223A (en) * 1980-12-05 1982-09-07 Ppg Industries, Inc. N-Alkyl-N-[3-(alkoxyalkyl)phenyl]-2-haloacetamide herbicides
EP0055689B1 (de) 1980-12-22 1984-07-04 Schering Aktiengesellschaft In 3-Stellung substituierte 2,4,6-trihalogenierte Benzamide und deren Salze, deren Herstellung und Verwendung als Ersatzstoffe für natürliche Süssstoffe sowie Süssungsmittel auf Basis dieser Verbindungen
JPS58194814A (ja) 1982-05-11 1983-11-12 Nippon Shinyaku Co Ltd 免疫調節作用を有する薬剤
IL69282A (en) 1982-09-02 1988-06-30 Euro Celtique Sa Method for the carboxylation of potassium phenoxide with carbon dioxide
DE3786452T2 (de) * 1987-02-05 1993-10-21 Kureha Chemical Ind Co Ltd Benzylether-Verbindungen und Verfahren zu ihrer Herstellung.
AU1388388A (en) 1987-04-01 1988-10-06 Dak-Laboratoriet A/S Benzoic acid derivatives and use thereof
EP0352826B1 (en) 1988-05-05 1994-10-26 Tillotts Pharma Ag Use of 5-aminosalicylic acid in the treatment of dermatological disorders
US5519014A (en) 1990-10-22 1996-05-21 Borody; Thomas J. Treatment of non-inflammatory and non-infectious bowel disorders
EP0554291B2 (en) 1990-10-22 2010-10-20 Centre For Digestive Diseases Pty Ltd Treatment of non-inflammatory bowel disorders
US5262549A (en) 1991-05-30 1993-11-16 Polaroid Corporation Benzpyrylium dyes, and processes for their preparation and use
US5302751A (en) 1992-01-21 1994-04-12 Ethyl Corporation Profen resolution
WO1994000135A1 (en) 1992-06-30 1994-01-06 Shapiro Howard K Composition containing amine and amine-related derivatives of benzoic acid and uses therefor including treating inflammatory diseases
US5594151A (en) 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
AU698881B2 (en) 1994-05-11 1998-11-12 Howard K. Shapiro Compositions for treatment of chronic inflammatory diseases
US5594015A (en) 1994-06-22 1997-01-14 Regents Of The University Of California Thiazolidine derivatives for the treatment of psoriasis
EP0817631A2 (en) 1995-03-28 1998-01-14 Janssen Pharmaceutica N.V. Low dose ridogrel formulations and their use for the treatment of inflammatory bowel diseases
US5939442A (en) * 1995-06-07 1999-08-17 The Salk Institute For Biological Studies Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof
GB9600464D0 (en) * 1996-01-09 1996-03-13 Smithkline Beecham Plc Novel method
GB9617001D0 (en) 1996-08-13 1996-09-25 Tillotts Pharma Ag Oral composition
DE19647582A1 (de) 1996-11-18 1998-05-20 Hoechst Ag Verfahren zur Herstellung von aromatischen Olefinen mittels Katalyse durch Palladaphosphacyclobutane
WO1998043081A1 (en) 1997-03-26 1998-10-01 Ligand Pharmaceuticals Incorporated Treatment of gastrointestinal disease with ppar modulators
WO1999005161A1 (en) 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
AU9002798A (en) * 1997-09-19 1999-04-12 Ono Pharmaceutical Co. Ltd. Fused or nonfused benzene compounds
FR2773075B1 (fr) 1997-12-31 2000-05-05 Cird Galderma Utilisation d'activateurs de ppar-gamma en dermatologie
US6114382A (en) 1998-11-11 2000-09-05 Moretti; Itagiba G. Methods for treating inflammatory bowel disease
US6326364B1 (en) 1999-02-08 2001-12-04 Cedars-Sinai Medical Center Use of 5-aminosalicylates as antimicrobial agents
FR2791671B1 (fr) 1999-04-01 2001-05-11 Oreal Nouveaux composes derives d'esters d'acide benzoique, composition les comprenant et utilisation
GB9908647D0 (en) 1999-04-15 1999-06-09 Smithkline Beecham Plc Novel compounds
US20040034067A1 (en) 1999-04-15 2004-02-19 Macphee Colin Houston Novel method of treatment
GB9914371D0 (en) 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
CN1939895B (zh) 2000-04-19 2010-05-12 纽若泰克有限公司 预防中枢神经系统急慢性损伤中神经变性的化合物,组合物和方法
US7049342B2 (en) 2000-05-29 2006-05-23 Kyorin Pharmaceutical Co., Ltd. Substituted phenylpropionic acid derivatives
ES2312432T3 (es) * 2000-05-29 2009-03-01 Kyorin Pharmaceutical Co., Ltd. Derivados del acido fenilpropionico sustituidos.
TWI249519B (en) 2000-08-29 2006-02-21 Nobex Corp Immunoregulatory compounds and derivatives and methods of treating diseases therewith
US7176204B2 (en) 2000-12-05 2007-02-13 Kyorin Pahrmaceutical Co., Ltd. Substituted carboxylic acid derivatives
FR2822955B1 (fr) 2001-03-27 2003-10-03 Chru Lille Methode de diagnostic de maladies inflammatoires chroniques de l'intestin
JP2004528329A (ja) 2001-04-18 2004-09-16 メルク　エンド　カムパニー　インコーポレーテッド 炎症を処置するためのＰＰＡＲα〜γのリガンドまたはアゴニスト
CA2354921A1 (en) 2001-05-24 2002-11-24 Yasuo Konishi Drug evolution: drug design at hot spots
PL369655A1 (en) * 2001-10-16 2005-05-02 Dr.Reddy's Laboratories Ltd. Novel-beta-phenyl-alpha-oxysubstituted propionic derivatives, process for its preparation and their use in the preparation of pharmaceutically important compounds
GB0127916D0 (en) 2001-11-21 2002-01-16 Rowett Res Inst Method
UA82835C2 (en) * 2001-12-03 2008-05-26 Reddys Lab Ltd Dr ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon
US20030113815A1 (en) 2001-12-19 2003-06-19 Pfizer Inc. Canine peroxisome proliferator activated receptor gamma
US20030220374A1 (en) 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20040115127A1 (en) 2002-04-12 2004-06-17 Wright Samuel D. Ppar-alpha-gamma ligands or agonists for the treatment of inflammation
US20060159648A1 (en) 2003-02-17 2006-07-20 Davis Adrian F Novel therapeutic method and compositions for topical administration
GB0303609D0 (en) 2003-02-17 2003-03-19 Glaxo Group Ltd Novel therapeutic method and compositions
US20060177444A1 (en) 2003-03-20 2006-08-10 Tatsuo Horizoe Concomitant drug as therapeutic agent for inflammatory bowel disease
JP5198768B2 (ja) 2003-07-21 2013-05-15 メルク セローノ ソシエテ アノニム アルキニルアリールカルボキサミド
JP2007509180A (ja) 2003-10-21 2007-04-12 インスパイアー ファーマシューティカルズ，インコーポレイティド 疼痛を治療するための、非ヌクレオチド組成物および方法
WO2005040102A2 (en) * 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd. Novel compounds and their use as antidiabetic and hypolipidemic agents, process for their preparation and pharmaceutical compositions containing them
US20070086967A1 (en) 2003-12-03 2007-04-19 Brian Macdonald Treatment of psoriasis with rosiglitazone
CA2553775A1 (en) 2004-01-20 2005-08-11 Richard F. Harty Compositions and methods of treatment for inflammatory diseases
WO2005084658A1 (en) 2004-03-04 2005-09-15 Arakis Ltd. Derivatives of actarit and their therapeutic use
US20060286046A1 (en) 2005-01-05 2006-12-21 Haber C Andrew Skin care compositions
US20060270635A1 (en) 2005-05-27 2006-11-30 Wallace John L Derivatives of 4- or 5-aminosalicylic acid
ITRM20050390A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
ITRM20050389A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
DE102005061472A1 (de) 2005-12-22 2007-07-05 Saltigo Gmbh Verfahren zur Herstellung von enantiomerenangereicherten 2-Alkoxy-3-phenylpropionsäuren
WO2007096148A1 (en) 2006-02-23 2007-08-30 Lipid Nutrition B.V. Immunoregulation
US7645801B2 (en) 2007-01-29 2010-01-12 Alaven Pharmaceutical Llc Reduced irritant enema for treatment of inflammatory bowel disease (IBD)
IE20070129A1 (en) 2007-02-28 2008-12-24 Giuliani Int Ltd Ppar-gamma agonists stimulate enteric defensin expression
US20090054312A1 (en) 2007-08-22 2009-02-26 Wolf Dieter A SMIPs: Small molecule inhibitors of p27 depletion in cancers and other proliferative diseases
ITMI20072429A1 (it) 2007-12-24 2009-06-25 Giuliani Int Ltd Composti per il trattamento selettivo della componente immuno-infiammatoria intestinale della malattia celiaca
US8030520B2 (en) 2008-03-31 2011-10-04 Saltigo Gmbh Process for preparing organic compounds by a transition metal-catalysed cross-coupling reaction of an aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide
UA107562C2 (uk) 2008-12-05 2015-01-26 Спосіб лікування псоріазу
HUE032999T2 (hu) 2009-02-16 2017-11-28 Nogra Pharma Ltd Alkilamido vegyületek és azok alkalmazása
EP2298321A1 (en) 2009-08-26 2011-03-23 Nordic Pharma Novel pharmaceutical compositions for treating IBD
CA2841358A1 (en) 2011-07-15 2013-01-24 S.L.A. Pharma Ag Pharmaceutical compositions for rectal administration
WO2013064153A1 (en) 2011-10-31 2013-05-10 Claus Selch Larsen Prodrugs of non- steroid anti - inflammatory agents (nsaids)
MX364220B (es) * 2012-02-09 2019-04-16 Nogra Pharma Ltd Metodos de tratamientos de fibrosis.
EP2844242A1 (en) 2012-04-18 2015-03-11 Nogra Pharma Limited Methods of treating lactose intolerance
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
KR20150016377A (ko) 2012-06-01 2015-02-11 노그라 파마 리미티드 T-세포 반응을 조절할 수 있는 비시클릭 헤테로사이클 및 그의 사용 방법
AU2013314288B2 (en) 2012-09-13 2018-07-05 Nogra Pharma Limited Methods of treating hair related conditions
KR20150053974A (ko) 2012-09-13 2015-05-19 노그라 파마 리미티드 모발 성장 억제 방법
WO2016154730A1 (en) 2015-04-02 2016-10-06 University Health Network Gut anti-inflammatory agents for regulation of high blood glucose levels
EP3307262B1 (en) 2015-06-15 2021-05-19 NMD Pharma A/S Compounds for use in treating neuromuscular disorders

Also Published As

Publication number Publication date
EA014665B3 (ru) 2016-09-30
ES2421260T3 (es) 2013-08-30
IL205992A (en) 2014-05-28
EP1910270B3 (en) 2016-05-11
AU2006271165C1 (en) 2016-11-17
US20150045436A1 (en) 2015-02-12
US20150265563A1 (en) 2015-09-24
WO2007010516A2 (en) 2007-01-25
PT1910270E (pt) 2013-07-17
ZA200801671B (en) 2011-02-23
AU2006271165A1 (en) 2007-01-25
US20090048343A1 (en) 2009-02-19
JP2009502777A (ja) 2009-01-29
NO340680B1 (no) 2017-05-29
CN102020577B (zh) 2013-03-13
US8153841B2 (en) 2012-04-10
US9133099B2 (en) 2015-09-15
CA2616146C (en) 2015-06-30
EA017566B1 (ru) 2013-01-30
WO2007010516A3 (en) 2007-03-29
BRPI0613396A2 (pt) 2011-01-11
IL188878A0 (en) 2008-04-13
JP5312026B2 (ja) 2013-10-09
ES2421260T7 (es) 2016-10-11
CN102020577A (zh) 2011-04-20
DK1910270T6 (en) 2016-08-29
PL1910270T6 (pl) 2017-05-31
US9561202B2 (en) 2017-02-07
HRP20130549T4 (hr) 2016-07-15
MX366596B (es) 2019-07-15
EA014665B1 (ru) 2010-12-30
BRPI0613396A8 (pt) 2017-12-26
KR101317519B1 (ko) 2013-10-15
US8710100B2 (en) 2014-04-29
EA201000708A1 (ru) 2010-10-29
US20170312239A1 (en) 2017-11-02
US10016381B2 (en) 2018-07-10
ITRM20050389A1 (it) 2007-01-23
CN101243039A (zh) 2008-08-13
NZ566045A (en) 2012-04-27
ZA201008268B (en) 2012-04-25
CA2616146A1 (en) 2007-01-25
EP1910270B1 (en) 2013-05-08
UA100359C2 (uk) 2012-12-25
HRP20130549T1 (en) 2013-07-31
KR20080039428A (ko) 2008-05-07
NZ592228A (en) 2012-10-26
DK1910270T3 (da) 2013-07-01
CY1114294T1 (el) 2016-08-31
CN101243039B (zh) 2013-04-03
US20130005813A1 (en) 2013-01-03
US9345680B2 (en) 2016-05-24
EA200800372A1 (ru) 2008-06-30
US20150265562A1 (en) 2015-09-24
AU2006271165B2 (en) 2012-01-19
PL1910270T3 (pl) 2013-09-30
SI1910270T1 (sl) 2013-08-30
IL188878A (en) 2013-04-30
EP1910270A2 (en) 2008-04-16

Similar Documents

Publication Publication Date Title
NO20080325L (no) Forbindelser og deres salter som er spesifikke overfor PPAR-reseptorer og EGF-reseptorer samt deres anvendelse innen medisin
NO20080323L (no) Forbindelser og deres salter som er spesifikke overfor PPAR-reseptorer og EGF-reseptorer og deres anvendlse innen medisinen
PE20061490A1 (es) Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1
RS54260B1 (en) AMINODIHYDROTIAZINE DERIVATIVES AS BACE INHIBITORS FOR ALZHEIMER DISEASE TREATMENT
NO20092770L (no) Nye aminopyrimidinderivater som PLK1-inhibitorer
TW200708605A (en) Aqueous abrasives dispersion medium composition
EA201101089A1 (ru) Производные оксадиазола в качестве агонистов рецептора s1p1
AR052866A1 (es) Fenil-metanonas monociclicas sustituidas
CO5670367A2 (es) Derivados de acido fenoxiacetico
EA201170096A1 (ru) Замещенные производные пиримидона
PE20061303A1 (es) Composicion farmaceutica que comprende oxaprozina
UY29388A1 (es) Derivados del (1,5-difenil-h-pirazol-3-il)oxadiazol, su preparación y su aplicacion en terapéutica.
NO20064599L (no) Substituerte morfolin- og tiomorfolinderivater
PH12015501098A1 (en) Antituberculous composition comprising oxazole compounds
CY1109883T1 (el) Υδατικα συγκεντρωματα δραστικων ουσιων με ζιζανιοκτονα δραση
WO2008136444A1 (ja) 縮合複素環誘導体
EA200700997A1 (ru) 2,5- и 2,6-дизамещенные аналоги бензазола, полезные в качестве ингибиторов протеинкиназ
DE602004009200D1 (de) Tetrahydrochinazolinderivate als cfr-antagonisten
PH12019501391A1 (en) Novel compound and pharmacologically acceptable salt thereof
PE20120692A1 (es) Derivados de 5-fluoro-2-oxopirimidinona-1(2h)-carboxamida substituida-n1
MX2011011281A (es) Compuesto de carbinol que tiene un enlazante heterociclico.
NO20065902L (no) 3-{4-(pyridin-3-yl)fenyl}-5-(1H-,1,2,3-triazol-1-ylmetyl)-1,3-oksazolidin-2-oner som antibakterielle midler
EA200600878A1 (ru) Производные феноксиуксусных кислот, применимые в качестве двойных агонистов активируемого пероксисомным пролифератором рецептора ( ppar )
MY146939A (en) Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics
PE20090513A1 (es) Derivados de benzoil-piperidina como moduladores duales de receptores de 5-ht2a y de d3

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: NOGRA PHARMA LTD, IE