PL2024368T3 - Pochodne 6,7,8,9-tetrahydro-5H-pirymido[4,5-d]azepin-4-ylo]-aminy jako modulatory TRPV1 do leczenia bólu - Google Patents

Pochodne 6,7,8,9-tetrahydro-5H-pirymido[4,5-d]azepin-4-ylo]-aminy jako modulatory TRPV1 do leczenia bólu

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Publication number
PL2024368T3
PL2024368T3 PL07753768T PL07753768T PL2024368T3 PL 2024368 T3 PL2024368 T3 PL 2024368T3 PL 07753768 T PL07753768 T PL 07753768T PL 07753768 T PL07753768 T PL 07753768T PL 2024368 T3 PL2024368 T3 PL 2024368T3
Authority
PL
Poland
Prior art keywords
trpv1
azepin
pyrimido
tetrahydro
modulators
Prior art date
Application number
PL07753768T
Other languages
English (en)
Inventor
Brett D Allison
Bryan James Branstetter
James Guy Breitenbucher
Michael D Hack
Natalie A Hawryluk
Alec D Lebsack
Kelly J Mcclure
Jeffrey E Merit
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PL2024368T3 publication Critical patent/PL2024368T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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PL07753768T 2006-03-21 2007-03-21 Pochodne 6,7,8,9-tetrahydro-5H-pirymido[4,5-d]azepin-4-ylo]-aminy jako modulatory TRPV1 do leczenia bólu PL2024368T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78541506P 2006-03-21 2006-03-21
PCT/US2007/007166 WO2007109355A2 (en) 2006-03-21 2007-03-21 6,7,8, 9 -tetrahydro- 5h- pyrimido [4, 5-d] azepin-4-yl] -amine derivatives as modulators of trpvl for the treatment of pain
EP07753768.6A EP2024368B1 (en) 2006-03-21 2007-03-21 6,7,8,9-tetrahydro-5h-pyrimido[4,5-d]azepin-4-yl]-amine derivatives as modulators of trpv1 for the treatment of pain

Publications (1)

Publication Number Publication Date
PL2024368T3 true PL2024368T3 (pl) 2014-09-30

Family

ID=38353855

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07753768T PL2024368T3 (pl) 2006-03-21 2007-03-21 Pochodne 6,7,8,9-tetrahydro-5H-pirymido[4,5-d]azepin-4-ylo]-aminy jako modulatory TRPV1 do leczenia bólu

Country Status (31)

Country Link
US (3) US8673895B2 (pl)
EP (1) EP2024368B1 (pl)
JP (1) JP5232768B2 (pl)
KR (1) KR101461376B1 (pl)
CN (1) CN101448835B (pl)
AR (1) AR059985A1 (pl)
AU (1) AU2007227203B2 (pl)
BR (1) BRPI0709034B1 (pl)
CA (1) CA2646977C (pl)
CR (1) CR10387A (pl)
DK (1) DK2024368T3 (pl)
EA (1) EA017069B1 (pl)
EC (1) ECSP088807A (pl)
ES (1) ES2474152T3 (pl)
HK (1) HK1129888A1 (pl)
HR (1) HRP20140664T1 (pl)
MX (1) MX2008012163A (pl)
NI (1) NI200800253A (pl)
NO (1) NO341676B1 (pl)
NZ (1) NZ571343A (pl)
PE (1) PE20080145A1 (pl)
PL (1) PL2024368T3 (pl)
PT (1) PT2024368E (pl)
RS (1) RS53436B (pl)
SG (1) SG177176A1 (pl)
SI (1) SI2024368T1 (pl)
TW (1) TWI440639B (pl)
UA (1) UA92636C2 (pl)
UY (1) UY30229A1 (pl)
WO (1) WO2007109355A2 (pl)
ZA (1) ZA200808975B (pl)

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UA101676C2 (uk) * 2008-07-31 2013-04-25 Дженентек, Инк. Піримідинові сполуки, композиції і способи застосування
BRPI0921317A2 (pt) * 2008-11-06 2017-06-06 Astrazeneca Ab composto, composição farmacêutica, e, método para tratar ou prevenir uma patologia relacionada com abeta em um mamífero
CN102480961A (zh) * 2009-06-24 2012-05-30 健泰科生物技术公司 与含氧杂环稠合的嘧啶化合物、组合物和使用方法
JP5572715B2 (ja) * 2009-11-12 2014-08-13 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｎ−７置換プリン及びピラゾロピリミジン化合物、組成物及び使用方法
KR101469334B1 (ko) * 2009-11-12 2014-12-04 에프. 호프만-라 로슈 아게 Ｎ-9-치환된 퓨린 화합물, 조성물 및 사용 방법
EP2585216B1 (en) 2010-06-23 2019-11-20 Johnson Matthey PLC Pi-allylpalladium and pi-allylnickel complexes for use as catalysts in carbon-carbon and carbon-nitrogen coupling reactions
CN102154494B (zh) * 2011-03-14 2013-01-02 中国人民解放军军事医学科学院基础医学研究所 一种用于儿童哮喘检测的标志物
RU2654483C2 (ru) 2013-02-20 2018-05-21 ЭлДжи КЕМ, ЛТД. Агонисты рецептора сфингозин-1-фосфата, способы их получения и фармацевтические композиции, содержащие эти соединения в качестве активного средства
CN103641762A (zh) * 2013-12-18 2014-03-19 中国药科大学 一类trpv1/cox-2双重抑制剂、其制备方法及其制备镇痛药物的用途
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