MX2009010208A - Derivados de pirimido-[4,5-d]-azepina como agonistas de 5-ht2c. - Google Patents

Derivados de pirimido-[4,5-d]-azepina como agonistas de 5-ht2c.

Info

Publication number
MX2009010208A
MX2009010208A MX2009010208A MX2009010208A MX2009010208A MX 2009010208 A MX2009010208 A MX 2009010208A MX 2009010208 A MX2009010208 A MX 2009010208A MX 2009010208 A MX2009010208 A MX 2009010208A MX 2009010208 A MX2009010208 A MX 2009010208A
Authority
MX
Mexico
Prior art keywords
pyrimido
ht2c agonists
azepine derivatives
ht2c
agonists
Prior art date
Application number
MX2009010208A
Other languages
English (en)
Inventor
Gavin Alistair Whitlock
Julian Blagg
Mark David Andrews
Paul Edward Brennan
Paul Vincent Fish
Lee Richard Roberts
Robert Ian Storer
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of MX2009010208A publication Critical patent/MX2009010208A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se refiere a compuestos de fórmula (I) en donde R1, R2, R3a, R3b, R3c, R3d y R100 son como se define en la especificación; estos compuestos actúan como agonistas de 5-HT2c.
MX2009010208A 2007-03-23 2008-03-14 Derivados de pirimido-[4,5-d]-azepina como agonistas de 5-ht2c. MX2009010208A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89652707P 2007-03-23 2007-03-23
PCT/IB2008/000731 WO2008117169A1 (en) 2007-03-23 2008-03-14 Pyrimido [4, 5-d] azepine derivatives as 5-ht2c agonists

Publications (1)

Publication Number Publication Date
MX2009010208A true MX2009010208A (es) 2009-10-19

Family

ID=39529327

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010208A MX2009010208A (es) 2007-03-23 2008-03-14 Derivados de pirimido-[4,5-d]-azepina como agonistas de 5-ht2c.

Country Status (11)

Country Link
US (1) US7928099B2 (es)
EP (1) EP2139896A1 (es)
JP (1) JP2010522156A (es)
KR (1) KR20090121358A (es)
CN (1) CN101652367A (es)
AU (1) AU2008231543B2 (es)
CA (1) CA2681536A1 (es)
IL (1) IL200442A0 (es)
MX (1) MX2009010208A (es)
WO (1) WO2008117169A1 (es)
ZA (1) ZA200907416B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF
US8829011B2 (en) 2008-10-29 2014-09-09 Janssen Pharmaceutica Nv 2-aminopyrimidine compounds as serotonin receptor modulators
AR074231A1 (es) 2008-11-27 2010-12-29 Boehringer Ingelheim Int Derivados de 6, 7, 8, 9-tetrahidro-5h-1, 4, 7, 10a-tetraaza-ciclohept[f]indeno, composiciones farmacéuticas que contienen estos compuestos, su uso en el agonismo del receptor 5-ht2c y procesos para prepararlos.
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
EP3860996A4 (en) 2018-10-02 2022-08-31 Northwestern University BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C)
WO2021221169A1 (en) * 2020-04-30 2021-11-04 Raqualia Pharma Inc. Pyrimidin-4(3h)-one derivatives as trpv4 antagonists
CN113636977B (zh) * 2021-09-01 2022-12-20 温州大学 2-芳基苯并氮杂卓及其衍生物的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US225275A (en) * 1880-03-09 Seed-planter
US32481A (en) * 1861-06-04 Tent-fixture
US5043443A (en) * 1988-07-29 1991-08-27 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives
JPWO2003104230A1 (ja) * 2002-06-07 2005-10-06 協和醗酵工業株式会社 二環性ピリミジン誘導体
US20040115804A1 (en) * 2002-12-13 2004-06-17 Yu-Show Fu Cell system for generating somatic cells
WO2006044762A2 (en) * 2004-10-15 2006-04-27 Bayer Pharmaceuticals Corporation Tetrahydro-5h-pyrimido[4,5-d]azepine derivatives useful for the treatment of diseases associated with the 5-ht2c receptor
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
WO2007019083A1 (en) 2005-08-04 2007-02-15 Janssen Pharmaceutica N.V. Pyrimidine compounds as serotonin receptor modulators
PE20080145A1 (es) * 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
US20080051387A1 (en) * 2006-06-09 2008-02-28 Yuelian Xu Tetrahydropyrido[3,4-d]pyrimidines and related analogues

Also Published As

Publication number Publication date
CN101652367A (zh) 2010-02-17
EP2139896A1 (en) 2010-01-06
US7928099B2 (en) 2011-04-19
AU2008231543B2 (en) 2011-07-28
AU2008231543A1 (en) 2008-10-02
ZA200907416B (en) 2010-07-28
US20100113422A1 (en) 2010-05-06
WO2008117169A1 (en) 2008-10-02
KR20090121358A (ko) 2009-11-25
IL200442A0 (en) 2010-04-29
JP2010522156A (ja) 2010-07-01
CA2681536A1 (en) 2008-10-02

Similar Documents

Publication Publication Date Title
MX2009010208A (es) Derivados de pirimido-[4,5-d]-azepina como agonistas de 5-ht2c.
HK1251568A1 (zh) 2-氟基-n-甲基-4-[7-(喹啉-6-基甲基)-咪唑[1，2-b][1，2，4]三嗪-2-基]苯甲酰胺鹽和與其製造相關的步驟
MX358682B (es) Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4).
MX2009012144A (es) Derivados de piridopirazina novedosos, procedimientos para su elaboracion y usos de los mismos.
UA99440C2 (uk) Похідні й аналоги n-етилхінолонів і n-етилазахінолонів
EG25765A (en) Pyrido [2,3-B] pyrazine derivatives useful as herbicidal compounds
MY170878A (en) [1,2,3] triazolo [4,5-d] pyrimidine derivatives as agonists of the cannabinoid receptor 2
IL205341A0 (en) IMIDAZO [1, 2 - a] PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
IL205189A0 (en) Derivatives of 6, 7 - dihydro - 5h - imidazo (1, 2 -?? ) imidazole - 3 - carboxylic acid amides
AU2011325479A8 (en) 7-([1,2,3]Triazol-4-yl)-pyrrolo[2,3-b]pyrazine derivatives
WO2010124042A3 (en) Modulators of 5-ht receptors and methods of use thereof
ZA201004823B (en) Novel pyrazolo [3,4-d]pyrimidine derivatives as anti-cancer agents
IL191763A0 (en) Pyrrolo [2,3-b]pyridine derivatives as h3 receptor modulators
PT2024368E (pt) Derivados de 6,7,8,9-tetrahidro-5h-pirimido[4,5-d]azepina-4-il]-amina como moduladores de trpv1 para o tratamento da dor
WO2008116815A3 (en) Compounds
WO2011042860A3 (en) New derivatives of thieno[2,3-b]pyridine and 5,6,7,8-tetrahydrothieno[2,3-b]quinoline in particular useful in the treatment of malaria
ZA201007945B (en) Tricyclic nitrogen containing compounds and their use as antibacterials
RS51912B (en) 1,2,3,4-TETRAHYDROPYROLO (1,2-a) PYRAZINE-6-CARBOXAMIDE AND 2,3,4,5-TETRAHYDROPYROLO (1,2-a) (1,4) -DIAZEPIN-7-CARBOXAMIDE DERIVATIVES THEIR OBTAINING AND THERAPEUTIC APPLICATION
MX347948B (es) Moduladores de los receptores 5-ht y metodos de uso de los mismos.
WO2011161537A3 (en) 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof
ZA201008178B (en) Imidazo [2,1-b]quinazolin-2-one derivatives and their use as platelet anti-aggregative agents
WO2007149728A3 (en) Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
DK2445909T3 (da) Derivater af 6,7-dihydro-5h-imidazo [1,2-a] imidazol-3-carboxylsyre amider
IL195897A0 (en) Novel 4-amino-3-(-azolyl-phenoxymethyl)-thieno[3,2]pyridine-7-carboxylic acid derivatives
HK1162177A1 (en) Novel forms of an indazolo [5,4-a] pyrrolo [3,4-c] carbazole compound

Legal Events

Date Code Title Description
FG Grant or registration