PE20080348A1 - Moduladores tiazolopirimidina de trpv1 - Google Patents

Moduladores tiazolopirimidina de trpv1

Info

Publication number
PE20080348A1
PE20080348A1 PE2007000838A PE2007000838A PE20080348A1 PE 20080348 A1 PE20080348 A1 PE 20080348A1 PE 2007000838 A PE2007000838 A PE 2007000838A PE 2007000838 A PE2007000838 A PE 2007000838A PE 20080348 A1 PE20080348 A1 PE 20080348A1
Authority
PE
Peru
Prior art keywords
phenyl
alkyl
pyrimidin
diamine
trifluoromethyl
Prior art date
Application number
PE2007000838A
Other languages
English (en)
Inventor
Bryan James Branstetter
James Guy Breitenbucher
Alec D Lebsack
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38740251&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080348(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20080348A1 publication Critical patent/PE20080348A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE TIAZOLOPIRIMIDINA DE FORMULA I DONDE R1 ES H, ALQUILO C1-C6, O-(ALQUILO C1-C6), S-(ALQUILO C1-C6), ENTRE OTROS; R2 ES H, ALQUILO C1-C6; R3 ES CICLOALQUILO MONOCICLICO, FENILO, BENCILO, INDANILO, ENTRE OTROS; R4 ES H, ALQUILO C1-C6; R5 ES FENILO, HETEROARILO MONOCICLICO DE 5 MIEMBROS O HETEROARILO MONOCICLICO DE 6 MIEMBROS SUSTITUIDO O NO. SON COMPUESTOS PREFERIDOS: N2-(2,6-DICLORO-FENIL)-N7-(4-TRIFLUOROMETIL-FENIL)-TIAZOLO[5,4-d]PIRIMIDIN-2,7-DIAMINA; N2-o-TOLIL-N7-(4-TRIFLUOROMETIL-FENIL)-TIAZOLO[5,4-d]PIRIMIDIN-2,7-DIAMINA; 5-METIL-N2-(5-METIL-3-FENIL-ISOXAZOL-4-IL)-N7-(6-TRIFLUOROMETIL-PIRIDIN-3-IL)-TIAZOLO[5,4-d]PIRIMIDIN-2,7-DIAMINA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN MODULADOR DE TRPV1 LIGADA A NOCICEPTORES Y ES UTIL EN EL TRATAMIENTO DEL DOLOR, PRURITO, TOS Y OTROS ESTADOS INFLAMATORIOS
PE2007000838A 2006-06-30 2007-07-02 Moduladores tiazolopirimidina de trpv1 PE20080348A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81815306P 2006-06-30 2006-06-30

Publications (1)

Publication Number Publication Date
PE20080348A1 true PE20080348A1 (es) 2008-04-25

Family

ID=38740251

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000838A PE20080348A1 (es) 2006-06-30 2007-07-02 Moduladores tiazolopirimidina de trpv1

Country Status (8)

Country Link
US (1) US20080004253A1 (es)
EP (1) EP2044086A2 (es)
AR (1) AR061761A1 (es)
CL (1) CL2007001921A1 (es)
PE (1) PE20080348A1 (es)
TW (1) TW200821320A (es)
UY (1) UY30454A1 (es)
WO (1) WO2008005303A2 (es)

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US20090156598A1 (en) * 2007-12-17 2009-06-18 Lebsack Alec D Imidazolopyrimidine modulators of TRPV1
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BRPI0907435A8 (pt) * 2008-01-22 2019-01-29 Dow Agrosciences Llc derivados de 5-flúor pirimidina
SG172982A1 (en) * 2009-02-10 2011-08-29 Abbott Lab Agonists and antagonists of the s1p5 receptor, and methods of uses thereof
ES2543216T3 (es) 2009-03-13 2015-08-17 Katholieke Universiteit Leuven, K.U. Leuven R&D Moduladores de tiazolopirimidina como agentes inmunosupresores
SI2448938T1 (sl) 2009-06-29 2014-08-29 Incyte Corporation Experimental Station Pirimidinoni kot zaviralci pi3k
UA106889C2 (uk) * 2009-08-07 2014-10-27 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні n1-ацил-5-фторпіримідинону
UA112284C2 (uk) * 2009-08-07 2016-08-25 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні 5-фторпіримідинону
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DK2462134T3 (da) * 2009-08-07 2014-08-11 Dow Agrosciences Llc N1-sulfonyl-5-fluorpyrimidinonderivater
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
PT2521452E (pt) 2010-01-07 2015-02-24 Dow Agrosciences Llc Tiazolo[5,4-d]pirimidinas e a sua utilização como agroquímicos
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US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
ES2764848T3 (es) 2010-12-20 2020-06-04 Incyte Holdings Corp N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
AR088218A1 (es) 2011-07-19 2014-05-21 Infinity Pharmaceuticals Inc Compuestos heterociclicos utiles como inhibidores de pi3k
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US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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UA117743C2 (uk) 2012-12-28 2018-09-25 Адама Махтешім Лтд. N-(заміщені)-5-фтор-4-іміно-3-метил-2-оксо-3,4-дигідропіримідин-1(2h)-карбоксамідні похідні
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Also Published As

Publication number Publication date
CL2007001921A1 (es) 2008-03-14
UY30454A1 (es) 2008-01-31
WO2008005303A2 (en) 2008-01-10
EP2044086A2 (en) 2009-04-08
AR061761A1 (es) 2008-09-17
US20080004253A1 (en) 2008-01-03
WO2008005303A3 (en) 2008-04-10
TW200821320A (en) 2008-05-16

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