PE20070592A1 - Derivados de prolinamida como moduladores de canales de sodio - Google Patents

Derivados de prolinamida como moduladores de canales de sodio

Info

Publication number
PE20070592A1
PE20070592A1 PE2006001225A PE2006001225A PE20070592A1 PE 20070592 A1 PE20070592 A1 PE 20070592A1 PE 2006001225 A PE2006001225 A PE 2006001225A PE 2006001225 A PE2006001225 A PE 2006001225A PE 20070592 A1 PE20070592 A1 PE 20070592A1
Authority
PE
Peru
Prior art keywords
prolinamide
sodium channel
channel modulators
fluorophenyl
phenyl
Prior art date
Application number
PE2006001225A
Other languages
English (en)
Inventor
Giuseppe Alvaro
Riccardo Giovannini
Roberto Profeta
Markus Bergauer
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0520581A external-priority patent/GB0520581D0/en
Priority claimed from GB0523045A external-priority patent/GB0523045D0/en
Priority claimed from GB0603900A external-priority patent/GB0603900D0/en
Priority claimed from GB0618336A external-priority patent/GB0618336D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070592A1 publication Critical patent/PE20070592A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE AL COMPUESTO 5-(4-{(2-FLUOROFENIL)METIL OXI}FENIL)PROLINAMIDA DE FORMULA (I), Y SUS DIASTEROISOMEOS SIENDO PREFERIDO (5R)-5-(4-{[(2-FLUOROFENIL)METIL]OXI}FENIL)-L-PROLINAMIDA EN FORMA CRISTALINA. TAMBIEN SE REFIERE A PROCEDIMIENTOS DE PREPARACION Y UNA COMPOSICION FARMACEUTICA QUE LO COMPRENDE. ESTOS COMPUESTOS SON MODULADORES DE LOS CANALES DE SODIO CON APERTURA POR VOLTAJE, POR LO QUE SON UTILES EN EL TRATAMIENTO DE DEPRESION, TRASTORNOS DEL ESTADO EMOCIONAL O TRASTORNO BIPOLAR
PE2006001225A 2005-10-10 2006-10-06 Derivados de prolinamida como moduladores de canales de sodio PE20070592A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0520581A GB0520581D0 (en) 2005-10-10 2005-10-10 Novel compounds
GB0523045A GB0523045D0 (en) 2005-11-11 2005-11-11 Novel compounds
GB0603900A GB0603900D0 (en) 2006-02-27 2006-02-27 Novel compounds
GB0618336A GB0618336D0 (en) 2006-09-18 2006-09-18 Novel compounds

Publications (1)

Publication Number Publication Date
PE20070592A1 true PE20070592A1 (es) 2007-06-23

Family

ID=37546777

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001225A PE20070592A1 (es) 2005-10-10 2006-10-06 Derivados de prolinamida como moduladores de canales de sodio

Country Status (20)

Country Link
US (2) US7655693B2 (es)
EP (1) EP1934177B8 (es)
JP (1) JP5139305B2 (es)
KR (1) KR101282464B1 (es)
AR (1) AR056575A1 (es)
AT (1) ATE556049T1 (es)
AU (1) AU2006301470B2 (es)
BR (1) BRPI0616944B8 (es)
CA (1) CA2625642C (es)
CR (1) CR9898A (es)
EA (1) EA015736B1 (es)
ES (1) ES2387405T3 (es)
IL (1) IL192627A0 (es)
MA (1) MA29817B1 (es)
NO (1) NO20082145L (es)
NZ (1) NZ567051A (es)
PE (1) PE20070592A1 (es)
PL (1) PL1934177T3 (es)
TW (1) TW200730494A (es)
WO (1) WO2007042239A1 (es)

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US8143306B2 (en) * 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
EP1943216B1 (en) * 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
GB0701365D0 (en) * 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
JP2013501026A (ja) * 2009-08-05 2013-01-10 クオンベルゲンセ プハルマセウトイカルス リミテッド てんかん及び関連疾患の治療のための共治療法
PT2477964E (pt) 2009-09-14 2015-06-04 Convergence Pharmaceuticals Processo para a preparação de derivados de alfa-carboxamida
EP3009427B1 (en) 2011-03-03 2019-12-18 Zalicus Pharmaceuticals Ltd. Benzimidazole inhibitors of the sodium channel
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
WO2015130905A1 (en) 2014-02-27 2015-09-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
WO2016102967A1 (en) * 2014-12-23 2016-06-30 Convergence Pharmaceuticals Limited Process for preparing alpha-carboxamide pyrrolidine derivatives
JP2019537601A (ja) * 2016-11-02 2019-12-26 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． 新規投薬レジメン
EP3634400A4 (en) * 2017-05-19 2021-06-09 Biogen MA Inc. NEW CRYSTALLINE SHAPES
KR20200061381A (ko) * 2017-10-05 2020-06-02 바이오젠 인크. 알파-카르복스아미드 피롤리딘 유도체를 제조하기 위한 공정
JP2020536898A (ja) 2017-10-10 2020-12-17 バイオジェン インコーポレイテッド スピロ誘導体を調製するためのプロセス
KR20210002472A (ko) * 2018-04-16 2021-01-08 바이오젠 엠에이 인코포레이티드 신경병증성 통증을 치료하는 방법
EA202192762A1 (ru) * 2019-04-10 2022-03-21 Байоджен Ма Инк. Способ получения производных альфа-карбоксамид пирролидина
JP2022526431A (ja) * 2019-04-10 2022-05-24 バイオジェン インコーポレイテッド アルファ－カルボキサミドピロリジン誘導体を調製するためのプロセス
WO2021154631A1 (en) * 2020-01-30 2021-08-05 Javed Mohammad Combination drug therapies for cns disorders

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US6136131A (en) * 1998-06-02 2000-10-24 Instrument Specialties Company, Inc. Method of shielding and obtaining access to a component on a printed circuit board
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TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
CA2676357A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
JP5139305B2 (ja) 2013-02-06
BRPI0616944A2 (pt) 2011-07-05
NZ567051A (en) 2011-03-31
WO2007042239A1 (en) 2007-04-19
KR101282464B1 (ko) 2013-07-04
EP1934177B8 (en) 2012-09-05
KR20080059296A (ko) 2008-06-26
BRPI0616944B1 (pt) 2020-04-14
ES2387405T3 (es) 2012-09-21
AU2006301470B2 (en) 2012-06-14
ATE556049T1 (de) 2012-05-15
AR056575A1 (es) 2007-10-10
US7655693B2 (en) 2010-02-02
PL1934177T3 (pl) 2013-03-29
CA2625642A1 (en) 2007-04-19
CA2625642C (en) 2013-12-24
EP1934177A1 (en) 2008-06-25
JP2009511519A (ja) 2009-03-19
EA015736B1 (ru) 2011-10-31
US20080280969A1 (en) 2008-11-13
US20100105754A1 (en) 2010-04-29
IL192627A0 (en) 2011-08-01
MA29817B1 (fr) 2008-09-01
BRPI0616944B8 (pt) 2021-05-25
AU2006301470A1 (en) 2007-04-19
EA200801054A1 (ru) 2008-08-29
US8153681B2 (en) 2012-04-10
EP1934177B1 (en) 2012-05-02
CR9898A (es) 2008-07-29
NO20082145L (no) 2008-05-07
TW200730494A (en) 2007-08-16

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed