MA29817B1 - Derives de prolinamide utilises comme modulateurs du canal sodium - Google Patents

Derives de prolinamide utilises comme modulateurs du canal sodium

Info

Publication number
MA29817B1
MA29817B1 MA30797A MA30797A MA29817B1 MA 29817 B1 MA29817 B1 MA 29817B1 MA 30797 A MA30797 A MA 30797A MA 30797 A MA30797 A MA 30797A MA 29817 B1 MA29817 B1 MA 29817B1
Authority
MA
Morocco
Prior art keywords
modulators
sodium channel
prolinamide derivatives
prolinamide
derivatives
Prior art date
Application number
MA30797A
Other languages
English (en)
Inventor
Giuseppe Alvaro
Markus Bergauer
Riccardo Giovannini
Roberto Profeta
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0520581A external-priority patent/GB0520581D0/en
Priority claimed from GB0523045A external-priority patent/GB0523045D0/en
Priority claimed from GB0603900A external-priority patent/GB0603900D0/en
Priority claimed from GB0618336A external-priority patent/GB0618336D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA29817B1 publication Critical patent/MA29817B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

L'INVENTION DÉCRIT UN COMPOSÉ DE FORMULE (I), UN DES SES SOLVATES, SELS OU PROMÉDICAMENTS UTILES DANS LE TRAITEMENT DE MALADIES ET DE PATHOLOGIES MÉDIÉES PAR LA MODULATION DE CANAUX SODIUM SENSIBLES AU VOLTAGE.
MA30797A 2005-10-10 2008-03-31 Derives de prolinamide utilises comme modulateurs du canal sodium MA29817B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0520581A GB0520581D0 (en) 2005-10-10 2005-10-10 Novel compounds
GB0523045A GB0523045D0 (en) 2005-11-11 2005-11-11 Novel compounds
GB0603900A GB0603900D0 (en) 2006-02-27 2006-02-27 Novel compounds
GB0618336A GB0618336D0 (en) 2006-09-18 2006-09-18 Novel compounds

Publications (1)

Publication Number Publication Date
MA29817B1 true MA29817B1 (fr) 2008-09-01

Family

ID=37546777

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30797A MA29817B1 (fr) 2005-10-10 2008-03-31 Derives de prolinamide utilises comme modulateurs du canal sodium

Country Status (20)

Country Link
US (2) US7655693B2 (fr)
EP (1) EP1934177B8 (fr)
JP (1) JP5139305B2 (fr)
KR (1) KR101282464B1 (fr)
AR (1) AR056575A1 (fr)
AT (1) ATE556049T1 (fr)
AU (1) AU2006301470B2 (fr)
BR (1) BRPI0616944B8 (fr)
CA (1) CA2625642C (fr)
CR (1) CR9898A (fr)
EA (1) EA015736B1 (fr)
ES (1) ES2387405T3 (fr)
IL (1) IL192627A0 (fr)
MA (1) MA29817B1 (fr)
NO (1) NO20082145L (fr)
NZ (1) NZ567051A (fr)
PE (1) PE20070592A1 (fr)
PL (1) PL1934177T3 (fr)
TW (1) TW200730494A (fr)
WO (1) WO2007042239A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8143306B2 (en) * 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
JP5139307B2 (ja) * 2005-10-10 2013-02-06 グラクソ グループ リミテッド ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体
GB0701365D0 (en) * 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
WO2011015537A1 (fr) 2009-08-05 2011-02-10 Glaxo Group Limited Co-thérapie pour le traitement de l'épilepsie et des troubles associés
WO2011029762A1 (fr) * 2009-09-14 2011-03-17 Convergence Pharmaceuticals Limited Procédé de préparation de dérivés alpha-carboxamides
CA2828456C (fr) 2011-03-03 2021-05-04 Zalicus Pharmaceuticals Ltd. Inhibiteurs n-benzyl-amino-carboxamide du canal sodique
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
CA2936886A1 (fr) 2014-02-27 2015-08-03 Merck Patent Gmbh Composes heterocycliques en tant qu'inhibiteurs du canal nav, et leurs utilisations
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
EP3237379B1 (fr) * 2014-12-23 2022-04-06 Convergence Pharmaceuticals Limited Procédé pour la préparation de dérivés de pyrrolidine alpha-carboxamide
WO2018085521A2 (fr) * 2016-11-02 2018-05-11 Biogen Inc. Nouveau schéma posologique
MA52458A (fr) * 2017-05-19 2021-03-10 Biogen Ma Inc Nouvelles formes cristallines
WO2019071162A2 (fr) * 2017-10-05 2019-04-11 Biogen Inc. Procédé de préparation de dérivés d'alpha-carboxamide de pyrrolidine
AU2018347349A1 (en) 2017-10-10 2020-04-23 Biogen Inc. Process for preparing spiro derivatives
KR20210002472A (ko) * 2018-04-16 2021-01-08 바이오젠 엠에이 인코포레이티드 신경병증성 통증을 치료하는 방법
JP2022527213A (ja) * 2019-04-10 2022-05-31 バイオジェン・エムエイ・インコーポレイテッド アルファ－カルボキサミドピロリジン誘導体を調製するためのプロセス
JP2022526431A (ja) * 2019-04-10 2022-05-24 バイオジェン インコーポレイテッド アルファ－カルボキサミドピロリジン誘導体を調製するためのプロセス
EP4096508A4 (fr) * 2020-01-30 2024-03-27 Mohammad Javed Polythérapies pour le traitement de troubles du système nerveux central

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US6201016B1 (en) 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6136131A (en) * 1998-06-02 2000-10-24 Instrument Specialties Company, Inc. Method of shielding and obtaining access to a component on a printed circuit board
AU782353B2 (en) 1999-03-26 2005-07-21 Euro-Celtique S.A. Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
GB9923748D0 (en) * 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
GB0115517D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Novel antidiabetic agents
TW200404796A (en) * 2002-08-19 2004-04-01 Ono Pharmaceutical Co Nitrogen-containing compound
TWI286132B (en) * 2002-09-20 2007-09-01 Hoffmann La Roche 4-pyrrolidino-phenyl-benzyl ether derivatives
MY142651A (en) 2003-03-18 2010-12-15 Merck Sharp & Dohme Biaryl substituted triazoles as sodium channel blockers
CN101333192A (zh) 2003-04-03 2008-12-31 默克公司 作为钠通道阻滞剂的联芳基取代吡唑
JP2006523701A (ja) * 2003-04-18 2006-10-19 メルク　エンド　カムパニー　インコーポレーテッド ナトリウムチャネルブロッカーとしてのビアリール置換チアゾール、オキサゾール、およびイミダゾール
WO2005000309A2 (fr) * 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Composes chimiques
EP1524265A1 (fr) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Dérivés de prolinamide en tant que bloqueurs du canal sodium et/ou calcium ou inhibiteurs sélectifs de MAO-B
WO2005100334A1 (fr) * 2004-04-14 2005-10-27 Pfizer Products Inc. Inhibiteurs de dipeptidyl peptidase-iv
WO2006119390A1 (fr) 2005-05-04 2006-11-09 Vertex Pharmaceuticals Incorporated Pyridines utiles en tant que modulateurs de canaux ioniques
JP2008540443A (ja) 2005-05-04 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン
EP1888549A2 (fr) 2005-05-19 2008-02-20 Vertex Pharmaceuticals, Inc. Biaryles utiles en tant que modulateurs des canaux ioniques
CA2621564C (fr) * 2005-09-09 2014-06-03 Smithkline Beecham Corporation Derives de pyridine et utilisation de ceux-ci dans le traitement de troubles psychotiques
JP5139307B2 (ja) * 2005-10-10 2013-02-06 グラクソ グループ リミテッド ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体
TW200728258A (en) * 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
EP2117538A1 (fr) 2007-01-24 2009-11-18 Glaxo Group Limited Compositions pharmaceutiques contenant du 2-méthoxy-5- (5-trifluorométhyl-tétrazol-i-yl-benzyl) - (2s-phényl-pipéridin-3s-yl-)
GB0706630D0 (en) 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
PE20070592A1 (es) 2007-06-23
TW200730494A (en) 2007-08-16
IL192627A0 (en) 2011-08-01
EA015736B1 (ru) 2011-10-31
KR101282464B1 (ko) 2013-07-04
US7655693B2 (en) 2010-02-02
ES2387405T3 (es) 2012-09-21
NO20082145L (no) 2008-05-07
ATE556049T1 (de) 2012-05-15
CA2625642A1 (fr) 2007-04-19
EP1934177B1 (fr) 2012-05-02
JP2009511519A (ja) 2009-03-19
EA200801054A1 (ru) 2008-08-29
KR20080059296A (ko) 2008-06-26
CR9898A (es) 2008-07-29
AU2006301470B2 (en) 2012-06-14
AR056575A1 (es) 2007-10-10
BRPI0616944B1 (pt) 2020-04-14
CA2625642C (fr) 2013-12-24
AU2006301470A1 (en) 2007-04-19
PL1934177T3 (pl) 2013-03-29
US8153681B2 (en) 2012-04-10
WO2007042239A1 (fr) 2007-04-19
US20080280969A1 (en) 2008-11-13
NZ567051A (en) 2011-03-31
EP1934177B8 (fr) 2012-09-05
EP1934177A1 (fr) 2008-06-25
BRPI0616944B8 (pt) 2021-05-25
US20100105754A1 (en) 2010-04-29
BRPI0616944A2 (pt) 2011-07-05
JP5139305B2 (ja) 2013-02-06

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