MXPA05009535A - Compuestos de acido n - alquil - hidroxamico - isoindolilo y sus usos farmaceuticos. - Google Patents

Compuestos de acido n - alquil - hidroxamico - isoindolilo y sus usos farmaceuticos.

Info

Publication number
MXPA05009535A
MXPA05009535A MXPA05009535A MXPA05009535A MXPA05009535A MX PA05009535 A MXPA05009535 A MX PA05009535A MX PA05009535 A MXPA05009535 A MX PA05009535A MX PA05009535 A MXPA05009535 A MX PA05009535A MX PA05009535 A MXPA05009535 A MX PA05009535A
Authority
MX
Mexico
Prior art keywords
alkyl
compounds
hydroxamic acid
pharmaceutical uses
isoindolyl compounds
Prior art date
Application number
MXPA05009535A
Other languages
English (en)
Inventor
Man Hon-Wah
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MXPA05009535A publication Critical patent/MXPA05009535A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/08—Antibacterial agents for leprosy
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La invencion abarca nuevos compuestos de acido N-alquil-hidroxamico-isoindolilo, composiciones farmaceuticas de estos compuestos, y metodos de uso de estos compuestos y composiciones para el tratamiento o prevencion de varios padecimientos y desordenes, por ejemplo, padecimientos asociados con PDE4.
MXPA05009535A 2003-03-12 2004-03-12 Compuestos de acido n - alquil - hidroxamico - isoindolilo y sus usos farmaceuticos. MXPA05009535A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45414903P 2003-03-12 2003-03-12
PCT/US2004/007742 WO2004080422A2 (en) 2003-03-12 2004-03-12 N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses

Publications (1)

Publication Number Publication Date
MXPA05009535A true MXPA05009535A (es) 2005-11-16

Family

ID=32990872

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05009535A MXPA05009535A (es) 2003-03-12 2004-03-12 Compuestos de acido n - alquil - hidroxamico - isoindolilo y sus usos farmaceuticos.

Country Status (15)

Country Link
US (3) US6911464B2 (es)
EP (1) EP1606256B1 (es)
JP (1) JP4727571B2 (es)
KR (1) KR101138064B1 (es)
AT (1) ATE508114T1 (es)
AU (1) AU2004220456B2 (es)
BR (1) BRPI0408220A (es)
CA (1) CA2518513C (es)
DE (1) DE602004032522D1 (es)
ES (1) ES2362484T3 (es)
HK (1) HK1092467A1 (es)
MX (1) MXPA05009535A (es)
NZ (1) NZ542670A (es)
WO (1) WO2004080422A2 (es)
ZA (1) ZA200507283B (es)

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BR0316256A (pt) * 2002-11-18 2005-10-04 Celgene Corp Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e composto
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ES2436606T3 (es) * 2003-03-12 2014-01-03 Celgene Corporation Compuestos de 7-amido-isoindolilo y sus usos farmacéuticos
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US20100324107A1 (en) * 2007-12-12 2010-12-23 Universidade Estadual De Campinas - Unicamp USE OF PHTHALIMIDE AND/OR SULPHONAMIDE DERIVATIVES IN THE TREATMENT OF DISEASES WHICH REQUIRE REDUCING THE TNF-alpha LEVELS AND AN EXOGENOUS SOURCE OF NITRIC OXIDE, PHTHALIMIDE DERIVATIVES, SULPHONAMIDE DERIVATIVES, AND A METHOD FOR OBTAINING A SULPHONAMIDE DERIVATIVE
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AP3437A (en) 2009-02-10 2015-10-31 Celgene Corp Methods of using and compositions comprising pde4 modulations for treatment, prevention and management of tuberculosis
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WO2004080422A2 (en) 2004-09-23
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HK1092467A1 (en) 2007-02-09
CA2518513A1 (en) 2004-09-23
AU2004220456A1 (en) 2004-09-23
US8076369B2 (en) 2011-12-13
WO2004080422A3 (en) 2004-10-28
KR101138064B1 (ko) 2012-04-23
EP1606256A2 (en) 2005-12-21
NZ542670A (en) 2008-11-28
US20100267800A1 (en) 2010-10-21
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US7662847B2 (en) 2010-02-16
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JP2006519850A (ja) 2006-08-31
ATE508114T1 (de) 2011-05-15
KR20050111757A (ko) 2005-11-28
US6911464B2 (en) 2005-06-28
DE602004032522D1 (de) 2011-06-16
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AU2004220456B2 (en) 2010-10-14
US20040259873A1 (en) 2004-12-23

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