ATE508114T1 - Mit n-alkylhydroxamsäuren substituierte isoindolylverbindungen und deren pharmazeutische verwendung - Google Patents

Mit n-alkylhydroxamsäuren substituierte isoindolylverbindungen und deren pharmazeutische verwendung

Info

Publication number
ATE508114T1
ATE508114T1 AT04720480T AT04720480T ATE508114T1 AT E508114 T1 ATE508114 T1 AT E508114T1 AT 04720480 T AT04720480 T AT 04720480T AT 04720480 T AT04720480 T AT 04720480T AT E508114 T1 ATE508114 T1 AT E508114T1
Authority
AT
Austria
Prior art keywords
pharmaceutical use
compounds substituted
isoindolyl compounds
alkylhydroxamic acids
compounds
Prior art date
Application number
AT04720480T
Other languages
English (en)
Inventor
Hon-Wah Man
George Muller
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Application granted granted Critical
Publication of ATE508114T1 publication Critical patent/ATE508114T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
AT04720480T 2003-03-12 2004-03-12 Mit n-alkylhydroxamsäuren substituierte isoindolylverbindungen und deren pharmazeutische verwendung ATE508114T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45414903P 2003-03-12 2003-03-12
PCT/US2004/007742 WO2004080422A2 (en) 2003-03-12 2004-03-12 N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses

Publications (1)

Publication Number Publication Date
ATE508114T1 true ATE508114T1 (de) 2011-05-15

Family

ID=32990872

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04720480T ATE508114T1 (de) 2003-03-12 2004-03-12 Mit n-alkylhydroxamsäuren substituierte isoindolylverbindungen und deren pharmazeutische verwendung

Country Status (14)

Country Link
US (3) US6911464B2 (de)
EP (1) EP1606256B1 (de)
JP (1) JP4727571B2 (de)
KR (1) KR101138064B1 (de)
AT (1) ATE508114T1 (de)
AU (1) AU2004220456B2 (de)
BR (1) BRPI0408220A (de)
CA (1) CA2518513C (de)
DE (1) DE602004032522D1 (de)
ES (1) ES2362484T3 (de)
MX (1) MXPA05009535A (de)
NZ (1) NZ542670A (de)
WO (1) WO2004080422A2 (de)
ZA (1) ZA200507283B (de)

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US8030343B2 (en) * 2000-06-08 2011-10-04 Celgene Corporation Pharmaceutically active isoindoline derivatives
CN1668296A (zh) 2002-05-17 2005-09-14 细胞基因公司 使用选择性细胞因子抑制性药物用于治疗和控制癌症和其它疾病的方法及组合物
US7842691B2 (en) * 2002-10-15 2010-11-30 Celgene Corporation Method for the treatment of myelodysplastic syndromes using cyclopropanecarboxylic acid {2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-OXO-2,3-dihydro-1 H-isoindol-4-yl}-amide
US7776907B2 (en) * 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
AU2003290652B2 (en) 2002-11-06 2008-06-19 Celgene Corporation Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
AU2003226361B2 (en) * 2002-11-06 2009-01-22 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases
JP2006510617A (ja) * 2002-11-18 2006-03-30 セルジーン・コーポレーション （＋）−３−（３，４−ジメトキシ−フェニル）−３−（１−オキソ−１，３−ジヒドロ−イソインドール−２−イル）−プロピオンアミドの使用方法およびそれを含む組成物
CA2506442A1 (en) * 2002-11-18 2004-07-01 Celgene Corporation Methods of using and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
BR0317885A (pt) 2002-12-30 2005-12-06 Celgene Corp Composto, isÈmeros s e r enantiomericamente puros do mesmo, composição farmacêutica e métodos de inibir pde4 e mmp, de modular a produção de tnf-alfa, de tratar ou prevenir mds, de tratar doença mieloproliferativa, angiogênese indesejada, câncer, uma doença, inflamação dos pulmões, depressão, distúrbio pulmonar obstrutivo crÈnico, doença inflamatória do intestino, dermatite atópica, psorìase, doença de crohn, artrite reumatóide, asma, eslcerose múltipla e doença cardìaca em um mamìfero e de tratar, prevenir ou controlar a sìndrome de dor regional complexa
WO2004080423A2 (en) * 2003-03-12 2004-09-23 Celgene Corporation 7-amino- isoindolyl compounds amd their pharmaceutical uses
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
CA2563207A1 (en) * 2004-04-14 2005-11-24 Celgene Corporation Use of selective cytokine inhibitory drugs in myelodysplastic syndromes
CN1972684A (zh) * 2004-04-23 2007-05-30 细胞基因公司 用于治疗和控制肺高血压的含有pde4调节剂的组合物以及其使用方法
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
EP1833512A1 (de) * 2005-01-06 2007-09-19 GE Healthcare AS Optische bilddarstellung
BRPI0614549A2 (pt) * 2005-08-08 2011-03-29 Genesis Technical Systems Corp rede dsl compartilhada e método de extensão
TW200804347A (en) 2006-01-10 2008-01-16 Janssen Pharmaceutica Nv Urotensin II receptor antagonists
CA2659412A1 (en) 2006-07-31 2008-02-07 Janssen Pharmaceutica N.V. Urotensin ii receptor antagonists
FR2915100B1 (fr) * 2007-04-19 2009-06-05 Sanofi Aventis Sa Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxalide pour le traitement des desordres moteurs lies a la maladie de parkinson
PA8782701A1 (es) * 2007-06-07 2009-01-23 Janssen Pharmaceutica Nv Antagonistas del receptor de urotensina ii
BRPI0705396B1 (pt) * 2007-12-12 2021-10-05 Universidade Estadual De Campinas - Unicamp Compostos derivados ftalimídicos
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US20050203090A1 (en) 2005-09-15
MXPA05009535A (es) 2005-11-16
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EP1606256B1 (de) 2011-05-04
CA2518513C (en) 2014-05-20
WO2004080422A3 (en) 2004-10-28
US20040259873A1 (en) 2004-12-23
KR101138064B1 (ko) 2012-04-23
ZA200507283B (en) 2007-03-28
EP1606256A2 (de) 2005-12-21
JP4727571B2 (ja) 2011-07-20
US6911464B2 (en) 2005-06-28
BRPI0408220A (pt) 2006-02-14
HK1092467A1 (en) 2007-02-09
KR20050111757A (ko) 2005-11-28
DE602004032522D1 (de) 2011-06-16
AU2004220456B2 (en) 2010-10-14
US20100267800A1 (en) 2010-10-21
AU2004220456A1 (en) 2004-09-23
US8076369B2 (en) 2011-12-13
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US7662847B2 (en) 2010-02-16
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ES2362484T3 (es) 2011-07-06

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