DE602005027707D1 - Isoindolin-verbindungen und deren verwendungen - Google Patents

Isoindolin-verbindungen und deren verwendungen

Info

Publication number
DE602005027707D1
DE602005027707D1 DE602005027707T DE602005027707T DE602005027707D1 DE 602005027707 D1 DE602005027707 D1 DE 602005027707D1 DE 602005027707 T DE602005027707 T DE 602005027707T DE 602005027707 T DE602005027707 T DE 602005027707T DE 602005027707 D1 DE602005027707 D1 DE 602005027707D1
Authority
DE
Germany
Prior art keywords
isoindolin compounds
compounds
isoindolin
disorders
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005027707T
Other languages
English (en)
Inventor
George W Muller
Hon-Wah Man
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of DE602005027707D1 publication Critical patent/DE602005027707D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
DE602005027707T 2004-07-28 2005-07-27 Isoindolin-verbindungen und deren verwendungen Active DE602005027707D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/900,270 US7244759B2 (en) 2004-07-28 2004-07-28 Isoindoline compounds and methods of making and using the same
PCT/US2005/026680 WO2006025991A2 (en) 2004-07-28 2005-07-27 Isoindoline compounds and methods of making and using the same

Publications (1)

Publication Number Publication Date
DE602005027707D1 true DE602005027707D1 (de) 2011-06-09

Family

ID=35892540

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005027707T Active DE602005027707D1 (de) 2004-07-28 2005-07-27 Isoindolin-verbindungen und deren verwendungen

Country Status (15)

Country Link
US (3) US7244759B2 (de)
EP (1) EP1778635B1 (de)
JP (1) JP5586830B2 (de)
KR (2) KR20070047808A (de)
CN (1) CN101031546A (de)
AT (1) ATE507204T1 (de)
AU (1) AU2005280499B2 (de)
BR (1) BRPI0513843A (de)
CA (1) CA2577222C (de)
DE (1) DE602005027707D1 (de)
ES (1) ES2362104T3 (de)
IL (1) IL180979A (de)
NZ (1) NZ553028A (de)
WO (1) WO2006025991A2 (de)
ZA (1) ZA200701661B (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8030343B2 (en) * 2000-06-08 2011-10-04 Celgene Corporation Pharmaceutically active isoindoline derivatives
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
KR100915483B1 (ko) 2000-12-06 2009-09-03 로버트 제이 하리리 태반 줄기 세포의 회수 방법
ES2629155T3 (es) 2001-02-14 2017-08-07 Anthrogenesis Corporation Matrices de tejido que comprenden células madre placentarias, y métodos para su preparación
US8460650B2 (en) 2007-02-12 2013-06-11 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
US7842691B2 (en) 2002-10-15 2010-11-30 Celgene Corporation Method for the treatment of myelodysplastic syndromes using cyclopropanecarboxylic acid {2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-OXO-2,3-dihydro-1 H-isoindol-4-yl}-amide
KR20050086780A (ko) * 2002-11-26 2005-08-30 안트로제네시스 코포레이션 세포요법제, 세포요법제 단위 및 이를 이용한 치료방법
US20050143344A1 (en) * 2003-12-30 2005-06-30 Zeldis Jerome B. Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
NZ550027A (en) * 2004-03-26 2009-03-31 Celgene Corp Systems and methods for providing a stem cell bank
US20080213213A1 (en) * 2004-04-14 2008-09-04 Zeldis Jerome B Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
AU2005316593A1 (en) * 2004-12-13 2006-06-22 Celgene Corporation Compositions comprising PDE4 modulators and their use for the treatment or prevention of airway inflammation
US20070038298A1 (en) * 2005-06-30 2007-02-15 Sulner Joseph W Repair of tympanic membrane using placenta derived collagen biofabric
PT2380887E (pt) 2005-06-30 2013-09-18 Celgene Corp Processos para a preparação de compostos de 4-amino-2-(2,6-dioxopiperidin-3-il)isoindolina-1,3-diona
WO2007009061A2 (en) * 2005-07-13 2007-01-18 Anthrogenesis Corporation Ocular plug formed from placenta derived collagen biofabric
EP1919500A2 (de) * 2005-07-13 2008-05-14 Anthrogenesis Corporation Behandlung von beingeschwüren mit kollagen-biogewebe aus plazenta
US20070066512A1 (en) * 2005-09-12 2007-03-22 Dominique Verhelle Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
US7878970B2 (en) 2005-09-28 2011-02-01 Boston Scientific Scimed, Inc. Apparatus and method for suspending a uterus
CA2624925C (en) * 2005-10-13 2014-09-30 Anthrogenesis Corporation Immunomodulation using placental stem cells
AU2006304274B2 (en) * 2005-10-13 2012-08-16 Celularity Inc. Production of oligodendrocytes from placenta-derived stem cells
JP5550235B2 (ja) 2005-12-29 2014-07-16 アントフロゲネシス コーポレーション 胎盤幹細胞集団
EP2412801A1 (de) * 2005-12-29 2012-02-01 Anthrogenesis Corporation Co-Kultivierung von Plazentastammzellen und Stammzellen aus einer zweiten Quelle
EP1974013A2 (de) * 2005-12-29 2008-10-01 Anthrogenesis Corporation Verbesserte zusammensetzung zum sammeln und zur konservierung von plazentastammzellen sowie verfahren zur verwendung der zusammensetzung
US9144483B2 (en) 2006-01-13 2015-09-29 Boston Scientific Scimed, Inc. Placing fixation devices
US9078727B2 (en) 2006-03-16 2015-07-14 Boston Scientific Scimed, Inc. System and method for treating tissue wall prolapse
US20080064876A1 (en) * 2006-05-16 2008-03-13 Muller George W Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
TW200806625A (en) * 2006-05-26 2008-02-01 Astrazeneca Ab Therapeutic compounds
US7993918B2 (en) 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
WO2008021391A1 (en) * 2006-08-15 2008-02-21 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US20080131522A1 (en) * 2006-10-03 2008-06-05 Qing Liu Use of placental biomaterial for ocular surgery
WO2008060377A2 (en) 2006-10-04 2008-05-22 Anthrogenesis Corporation Placental or umbilical cord tissue compositions
CA2665369C (en) * 2006-10-06 2023-01-10 Anthrogenesis Corporation Human placental collagen compositions, and methods of making and using the same
CN104099290A (zh) * 2006-10-23 2014-10-15 人类起源公司 用胎盘细胞群治疗骨缺损的方法和组合物
AU2008216748A1 (en) 2007-02-12 2008-08-21 Anthrogenesis Corporation Hepatocytes and chondrocytes from adherent placental stem cells; and CD34+, CD45- placental stem cell-enriched cell populations
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
WO2009045360A2 (en) 2007-09-28 2009-04-09 Celgene Cellular Therapeutics Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
US20090155207A1 (en) * 2007-11-29 2009-06-18 Hariri Robert J Use of Immunomodulatory Compounds for the Treatment of Transverse Myelitis, Multiple Sclerosis, and Other Disorders
CA2710196A1 (en) 2007-12-20 2009-07-09 Celgene Corporation Use of micro-rna as a biomarker of immunomodulatory drug activity
US8430807B2 (en) 2007-12-28 2013-04-30 Boston Scientific Scimed, Inc. Devices and methods for treating pelvic floor dysfunctions
US9078728B2 (en) 2007-12-28 2015-07-14 Boston Scientific Scimed, Inc. Devices and methods for delivering female pelvic floor implants
WO2009105256A2 (en) * 2008-02-20 2009-08-27 Celgene Corporation Method of treating cancer by administering an immunomodulatory compound in combination with a cd40 antibody or cd40 ligand
KR20210010648A (ko) 2008-08-20 2021-01-27 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
RU2011110736A (ru) 2008-08-22 2012-09-27 Антродженезис Корпорейшн (Us) Способы и композиции для лечения костных дефектов с помощью плацентарных клеточных популяций
RU2015130665A (ru) 2008-11-19 2018-12-24 Антродженезис Корпорейшн Амниотические адгезивные клетки
JP2012517441A (ja) 2009-02-10 2012-08-02 セルジーン コーポレイション 結核の治療、予防及び管理のためのｐｄｅ４モジュレーターの使用法及び含有組成物
PL2411506T3 (pl) 2009-03-25 2019-07-31 Celularity, Inc. Hamowanie nowotworu z użyciem ludzkich pochodzących z łożyska komórek nk pośrednich i związki immunomodulujące
US9125716B2 (en) 2009-04-17 2015-09-08 Boston Scientific Scimed, Inc. Delivery sleeve for pelvic floor implants
CN102448472A (zh) 2009-05-25 2012-05-09 国立大学法人东京工业大学 包含与中枢神经细胞的增殖和分化相关的核因子的药物组合物
AU2013263763B2 (en) * 2009-06-18 2016-05-19 Concert Pharmaceuticals, Inc. Deuterated isoindoline-1,3-dione derivatives as PDE4 and TNF-alpha inhibitors
US8124646B2 (en) 2009-06-18 2012-02-28 Concert Pharmaceuticals, Inc. Substituted isoindoline-1,3-dione derivatives
CA2767014C (en) 2009-07-02 2022-01-25 Anthrogenesis Corporation Method of producing erythrocytes without feeder cells
AR078581A1 (es) 2009-10-09 2011-11-16 Celgene Corp Procesos para la preparacion de compuestos 2-(1-feniletil)isoindolin-1-ona
EP2851070A1 (de) 2010-01-05 2015-03-25 Celgene Corporation Kombination von Lenalidomid und Artesunat/Artemison zur Behandlung von Krebs
KR20120115602A (ko) 2010-01-26 2012-10-18 안트로제네시스 코포레이션 태반 줄기 세포를 사용한 골 관련 암의 치료
RS59275B1 (sr) 2010-02-11 2019-10-31 Celgene Corp Derivati arilmetoksi izoindolina i kompozicije koje ih obuhvataju i postupci njihove primene
TW201703777A (zh) 2010-04-07 2017-02-01 安瑟吉納西斯公司 利用胎盤幹細胞之血管新生
CN102933221A (zh) 2010-04-08 2013-02-13 人类起源公司 使用胎盘干细胞治疗结节病
AU2011268450B2 (en) 2010-06-15 2015-07-16 Amgen (Europe) GmbH Biomarkers for the treatment of psoriasis
JP5996533B2 (ja) 2010-07-13 2016-09-21 アントフロゲネシス コーポレーション ナチュラルキラー細胞を生成させる方法
US8911348B2 (en) 2010-09-02 2014-12-16 Boston Scientific Scimed, Inc. Pelvic implants and methods of implanting the same
CN102558022B (zh) * 2010-12-22 2016-06-15 康塞特医药品有限公司 取代的异吲哚啉-1,3二酮衍生物
AU2011352036A1 (en) 2010-12-31 2013-07-18 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
US8853175B2 (en) 2011-01-10 2014-10-07 Celgene Corporation Phenethylsulfone isoindoline derivatives and their use
US9045417B2 (en) 2011-01-14 2015-06-02 Celgene Corporation Isotopologues of isoindole derivatives
MX2013012083A (es) 2011-04-18 2014-04-16 Celgene Corp Biomarcadores para el tratamiento de mieloma multiple.
JP6016892B2 (ja) 2011-04-29 2016-10-26 セルジーン コーポレイション セレブロンを予測因子として使用する癌及び炎症性疾患の治療方法
TWI602570B (zh) 2011-06-01 2017-10-21 安瑟吉納西斯公司 使用胎盤幹細胞之疼痛治療
US9938269B2 (en) 2011-06-30 2018-04-10 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
WO2013055476A1 (en) 2011-09-09 2013-04-18 Anthrogenesis Corporation Treatment of amyotrophic lateral sclerosis using placental stem cells
US9168120B2 (en) 2011-09-09 2015-10-27 Boston Scientific Scimed, Inc. Medical device and methods of delivering the medical device
JP6318152B2 (ja) 2012-06-29 2018-04-25 セルジーン コーポレイション セレブロン関連タンパク質を利用して薬物効能を決定する方法
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
JP5934658B2 (ja) * 2013-01-29 2016-06-15 Ｊｘエネルギー株式会社 イミド−ウレア化合物及びその製造方法、グリース用増ちょう剤並びにグリース組成物
EP2953635A4 (de) 2013-02-05 2016-10-26 Anthrogenesis Corp Natürliche killerzellen aus plazenta
US9814555B2 (en) 2013-03-12 2017-11-14 Boston Scientific Scimed, Inc. Medical device for pelvic floor repair and method of delivering the medical device
MX2015014596A (es) 2013-04-17 2016-03-03 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto imid para tratar cancer.
US9962251B2 (en) 2013-10-17 2018-05-08 Boston Scientific Scimed, Inc. Devices and methods for delivering implants
US20170087129A1 (en) 2014-05-16 2017-03-30 Celgene Corporation Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators
US10092555B2 (en) 2014-06-27 2018-10-09 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
US10682336B2 (en) 2015-10-21 2020-06-16 Amgen Inc. PDE4 modulators for treating and preventing immune reconstitution inflammatory syndrome (IRIS)
US10830762B2 (en) 2015-12-28 2020-11-10 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
WO2018102786A1 (en) 2016-12-03 2018-06-07 Juno Therapeutics, Inc. Methods for modulation of car-t cells
KR20200026805A (ko) 2017-05-01 2020-03-11 주노 쎄러퓨티크스 인코퍼레이티드 세포 요법 및 면역조절 화합물의 조합
CA3065120A1 (en) 2017-06-02 2018-12-06 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
CN111050545A (zh) 2017-06-29 2020-04-21 朱诺治疗学股份有限公司 评估与免疫疗法相关的毒性的小鼠模型
US20200246393A1 (en) 2017-09-28 2020-08-06 Celularity, Inc. Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody
US20210132042A1 (en) 2017-11-01 2021-05-06 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
SG11202003501XA (en) 2017-11-01 2020-05-28 Juno Therapeutics Inc Antibodies and chimeric antigen receptors specific for b-cell maturation antigen
MA51184A (fr) 2017-12-15 2020-10-21 Juno Therapeutics Inc Molécules de liaison à l'anti-cct5 et procédés d'utilisation associés
CA3089414A1 (en) * 2018-01-29 2019-08-01 Shijiazhuang Sagacity New Drug Development Company, Ltd. Crystal form of 1h-imidazo[4,5-b]pyridine-2(3h)-one compound and preparation process therefor
BR112020017053A2 (pt) 2018-02-21 2020-12-15 Celgene Corporation Anticorpos que se ligam ao bcma e usos dos mesmos
CA3117978A1 (en) 2018-11-08 2020-05-14 Juno Therapeutics, Inc. Methods and combinations for treatment and t cell modulation
MX2021005734A (es) 2018-11-16 2021-09-10 Juno Therapeutics Inc Metodos de dosificacion de celulas t modificadas para el tratamiento de malignidades de celulas b.
JP2022513685A (ja) 2018-11-30 2022-02-09 ジュノー セラピューティクス インコーポレイテッド 養子細胞療法を用いた処置のための方法
US20220096651A1 (en) 2019-01-29 2022-03-31 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1)
CN113527179B (zh) * 2020-04-13 2023-07-07 苏州璞正医药有限公司 链烃取代异吲哚啉-1,3-二酮类pde4抑制剂及其药物用途
CN113956190B (zh) * 2021-10-29 2023-05-02 大连理工大学 可激活肿瘤细胞焦亡的细胞器靶向光敏剂及其制备方法和应用
WO2023250400A1 (en) 2022-06-22 2023-12-28 Juno Therapeutics, Inc. Treatment methods for second line therapy of cd19-targeted car t cells

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173652A (en) 1976-12-18 1979-11-06 Akzona Incorporated Pharmaceutical hydroxamic acid compositions and uses thereof
SE434638B (sv) 1980-06-06 1984-08-06 Lekemedelsfabriken Medica Ab Nya terapeutiska verdefulla taurinderivat och deras framstellning
US4820828A (en) 1987-03-04 1989-04-11 Ortho Pharmaceutical Corporation Cinnamohydroxamic acids
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US5605914A (en) 1993-07-02 1997-02-25 Celgene Corporation Imides
US5801195A (en) 1994-12-30 1998-09-01 Celgene Corporation Immunotherapeutic aryl amides
US5703098A (en) 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
NZ305940A (en) 1995-07-26 1999-05-28 Pfizer N-(aroyl)glycine hydroxamic acid derivatives and related compounds that inhibit the production of tnf and are useful in treating asthma
US5728845A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic nitriles
US5728844A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic agents
US5658940A (en) 1995-10-06 1997-08-19 Celgene Corporation Succinimide and maleimide cytokine inhibitors
AU1529897A (en) 1996-01-02 1997-07-28 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds
KR100539030B1 (ko) 1996-08-12 2005-12-27 셀진 코포레이션 면역치료제 및 이를 이용하여 사이토카인 농도를 감소시키는 방법
US6020358A (en) * 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
US6667316B1 (en) * 1999-11-12 2003-12-23 Celgene Corporation Pharmaceutically active isoindoline derivatives
US6699899B1 (en) * 1999-12-21 2004-03-02 Celgene Corporation Substituted acylhydroxamic acids and method of reducing TNFα levels
ZA200505308B (en) * 2002-12-30 2006-10-25 Celgene Corp Fluoroalkoxy-substituted 1, 3-Dihydro-Isoindolyl compounds and their pharmaceutical uses
JP4713465B2 (ja) * 2003-03-12 2011-06-29 セルジーン コーポレイション ７−アミド−イソインドリル化合物およびその薬学的使用
WO2004080422A2 (en) * 2003-03-12 2004-09-23 Celgene Corporation N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses
US7405237B2 (en) * 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same

Also Published As

Publication number Publication date
BRPI0513843A (pt) 2008-05-06
ATE507204T1 (de) 2011-05-15
CN101031546A (zh) 2007-09-05
AU2005280499B2 (en) 2011-11-10
US8026269B2 (en) 2011-09-27
CA2577222C (en) 2013-07-16
JP2008508299A (ja) 2008-03-21
KR20070047808A (ko) 2007-05-07
WO2006025991A3 (en) 2006-08-24
WO2006025991A2 (en) 2006-03-09
IL180979A (en) 2013-07-31
EP1778635B1 (de) 2011-04-27
ZA200701661B (en) 2008-10-29
IL180979A0 (en) 2007-07-04
US20090148388A1 (en) 2009-06-11
KR20130097818A (ko) 2013-09-03
US7495112B2 (en) 2009-02-24
KR101564153B1 (ko) 2015-10-28
CA2577222A1 (en) 2006-03-09
JP5586830B2 (ja) 2014-09-10
US20070244183A1 (en) 2007-10-18
AU2005280499A1 (en) 2006-03-09
NZ553028A (en) 2011-02-25
US7244759B2 (en) 2007-07-17
US20060084815A1 (en) 2006-04-20
ES2362104T3 (es) 2011-06-28
EP1778635A2 (de) 2007-05-02

Similar Documents

Publication Publication Date Title
DE602005027707D1 (de) Isoindolin-verbindungen und deren verwendungen
MXPA05009595A (es) Compuestos 7-amino-isoindolilo y sus usos farmaceuticos.
LTPA2017009I1 (lt) Brutono tirozinkinazės inhibitoriai
MX2009006704A (es) Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa.
NO20055894L (no) Fremgangsmater og blandinger for behandling av amyloidrelatertere sykdommer
DE602005002562D1 (de) Pyrrolylsubstituierte pyridoä2,3-düpyrimidin-7-one und derivate davon als therapeutische mittel
CY1110965T1 (el) Επιπροσθετες ετεροπολυκυκλικες ενωσεις και η χρηση τους ως ανταγωνιστες μεταβολοτροπικου υποδοχεα γλουταμικου
EA200800100A1 (ru) Соединения азаиндазола и способы применения
EA200901166A1 (ru) Соединения и композиции в качестве модуляторов активности gpr 119
EA201690265A2 (ru) Фармацевтические композиции, содержащие замещенные ациланилиды
ATE475650T1 (de) Positive allosterische chinolon-m1- rezeptormodulatoren
MX2007009356A (es) Compuestos y composiciones como moduladores de ppar.
TW200716546A (en) Oxindole compounds and their uses as therapeutic agents
EA200901032A1 (ru) Соединения и композиции в качестве модуляторов активности gpr119
ATE530544T1 (de) Benzyl-substituierte positive allosterische chinolon-m1-rezeptormodulatoren
EA200701930A1 (ru) Производные пиримидина для лечения гиперпролиферативных нарушений
NO20075074L (no) Kinazolinon T-type-kalsiumkanalantagonister
ATE448232T1 (de) Substituierte heterozyklen
EA200801343A1 (ru) Иммуноглобулины, направленные против nogo
CY1115384T1 (el) Αντι-φλεγμονωδης συνθεση
FR2869540B1 (fr) Compositions pharmaceutiques contenant des derives de b-carboline, et leur utilisation pour le traitement des cancers
CY1111899T1 (el) Καινοφανη παραγωγα πυρρολης με δραστηριοτητα αναστολεα της απακετυλασης της ιστονης
NO20054723L (no) Behandling av proliferative sykdommer med epofilonderivater og straling
CY1116094T1 (el) Κυκλικες νιτρο-ενωσεις, φαρμακευτικες συνθεσεις εξ' αυτων και χρησεις εξ' αυτων
CY1114807T1 (el) Ενωσεις 2,4-πυριμιδινοδιαμινης για τη θεραπευτικη αντιμετωπιση ή την προληψη αυτοανοσων νοσων