ATE448232T1 - Substituierte heterozyklen - Google Patents
Substituierte heterozyklenInfo
- Publication number
- ATE448232T1 ATE448232T1 AT04708731T AT04708731T ATE448232T1 AT E448232 T1 ATE448232 T1 AT E448232T1 AT 04708731 T AT04708731 T AT 04708731T AT 04708731 T AT04708731 T AT 04708731T AT E448232 T1 ATE448232 T1 AT E448232T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted heterocycles
- heterocycles
- substituted
- medicaments
- asthma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03003495 | 2003-02-14 | ||
| EP03007594 | 2003-04-02 | ||
| PCT/EP2004/001097 WO2004071382A2 (en) | 2003-02-14 | 2004-02-06 | Substituted heterocycles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE448232T1 true ATE448232T1 (de) | 2009-11-15 |
Family
ID=32870763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04708731T ATE448232T1 (de) | 2003-02-14 | 2004-02-06 | Substituierte heterozyklen |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20060229353A1 (de) |
| EP (1) | EP1597262B1 (de) |
| JP (1) | JP4795931B2 (de) |
| KR (1) | KR20050098928A (de) |
| CN (1) | CN1845925B (de) |
| AT (1) | ATE448232T1 (de) |
| AU (1) | AU2004212296B2 (de) |
| BR (1) | BRPI0407234A (de) |
| CA (1) | CA2515940C (de) |
| DE (1) | DE602004024037D1 (de) |
| ES (1) | ES2336562T3 (de) |
| HK (1) | HK1096392A1 (de) |
| IL (1) | IL169897A0 (de) |
| IN (1) | IN228043B (de) |
| MX (1) | MX272108B (de) |
| WO (1) | WO2004071382A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002047610A2 (en) | 2000-11-16 | 2002-06-20 | The Regents Of The University Of California | Marine actinomycete taxon for drug and fermentation product dicovery |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| JP2007523862A (ja) * | 2003-06-20 | 2007-08-23 | ネレアス ファーマシューティカルズ インコーポレイテッド | 癌、炎症及び感染性疾患の治療のための、［３．２．０］複素環式化合物およびそれらの類縁体の使用 |
| ZA200600473B (en) * | 2003-06-20 | 2007-04-25 | Univ California | Salinosporamides and methods for use thereof |
| WO2005099687A2 (en) * | 2004-04-09 | 2005-10-27 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
| EP2025679A3 (de) | 2004-04-30 | 2009-07-08 | Nereus Pharmaceuticals, Inc. | [3,2,0]-Heterocyclische Verbindungen und Verfahren zu Ihrer Verwendung |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| WO2006005551A1 (en) * | 2004-07-12 | 2006-01-19 | Bayer Cropscience Ag | Substituted 2-pyrrolidone derivatives as fungicides and insecticides |
| WO2006060676A1 (en) * | 2004-12-03 | 2006-06-08 | Dana Farber Cancer Institute | Compositions and methods for treating neoplastic diseases |
| MX2007006523A (es) * | 2004-12-03 | 2007-09-11 | Nereus Pharmaceuticals Inc | Metodos para utilizar compuestos heterociclicos [3.2.0] y sus analogos. |
| WO2006118973A2 (en) * | 2005-04-29 | 2006-11-09 | Nereus Pharmaceuticals, Inc. | Methods of using heterobyclic compounds for treatment of rectal cancer |
| US7465720B2 (en) | 2005-09-12 | 2008-12-16 | President And Fellows Of Harvard College | Proteasome inhibiting β-lactam compounds |
| CN102718776A (zh) | 2006-04-06 | 2012-10-10 | 尼瑞斯药品公司 | Salinosporamide a及其类似物的全合成 |
| US7824698B2 (en) | 2007-02-02 | 2010-11-02 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of Salinosporamide A |
| US20080280968A1 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
| US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| EP2088205A1 (de) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: Diagnosemarker und therapeutisches Target für chronische Abstoßung |
| EP2262812A2 (de) | 2008-03-07 | 2010-12-22 | Nereus Pharmaceuticals, Inc. | Totalsynthese von salinosporamid a und analoga davon |
| BRPI0912234A2 (pt) * | 2008-05-12 | 2015-10-06 | Nereus Pharmaceuticals Inc | derivados de salinosporamida como inibidores de proteassomas |
| EP2399129B1 (de) | 2009-02-20 | 2015-11-25 | Michael P. Lisanti | Verfahren zur diagnose bzw. prognose eines neoplasmas einschliesslich der bestimmung des expressionsgrads eines proteins in stromazellen neben dem neoplasma |
| US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
| CN104302180B (zh) | 2011-10-28 | 2017-05-17 | 米伦纽姆医药公司 | 对nedd8活化酶(nae)抑制剂的反应的生物标记 |
| WO2013071163A2 (en) | 2011-11-11 | 2013-05-16 | Millennium Pharamaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
| CN104204797B (zh) | 2012-01-24 | 2017-05-31 | 米伦纽姆医药公司 | 治疗癌症的方法 |
| US10085987B2 (en) | 2012-01-27 | 2018-10-02 | Thomas Jefferson University | MCT protein inhibitor-related prognostic and therapeutic methods |
| CA2886783A1 (en) | 2012-10-01 | 2014-04-10 | Millennium Pharmaceuticals, Inc. | Biomarkers and methods to predict response to inhibitors and uses thereof |
| EP2986290A4 (de) | 2013-04-19 | 2017-01-04 | Thomas Jefferson University | Caveolin-1-verwandte verfahren zur behandlung von glioblastom mit temozolomid |
| EP3339291A1 (de) | 2016-12-22 | 2018-06-27 | Vita Api | Proteasomhemmende ss-lactam-prodrugs, die zur behandlung von krebs und neurodegenerativen erkrankungen nützlich sind |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6335358B1 (en) * | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
| WO2002047610A2 (en) * | 2000-11-16 | 2002-06-20 | The Regents Of The University Of California | Marine actinomycete taxon for drug and fermentation product dicovery |
-
2004
- 2004-02-06 DE DE602004024037T patent/DE602004024037D1/de not_active Expired - Lifetime
- 2004-02-06 WO PCT/EP2004/001097 patent/WO2004071382A2/en active Application Filing
- 2004-02-06 MX MXPA05008478 patent/MX272108B/es active IP Right Grant
- 2004-02-06 ES ES04708731T patent/ES2336562T3/es not_active Expired - Lifetime
- 2004-02-06 IN IN3350DE2005 patent/IN228043B/en unknown
- 2004-02-06 AT AT04708731T patent/ATE448232T1/de not_active IP Right Cessation
- 2004-02-06 AU AU2004212296A patent/AU2004212296B2/en not_active Ceased
- 2004-02-06 KR KR1020057014935A patent/KR20050098928A/ko active IP Right Grant
- 2004-02-06 US US10/545,449 patent/US20060229353A1/en not_active Abandoned
- 2004-02-06 CA CA2515940A patent/CA2515940C/en not_active Expired - Fee Related
- 2004-02-06 CN CN2004800093759A patent/CN1845925B/zh not_active Expired - Fee Related
- 2004-02-06 JP JP2006501755A patent/JP4795931B2/ja not_active Expired - Fee Related
- 2004-02-06 EP EP04708731A patent/EP1597262B1/de not_active Expired - Lifetime
- 2004-02-06 BR BR0407234-0A patent/BRPI0407234A/pt not_active IP Right Cessation
-
2005
- 2005-07-26 IL IL169897A patent/IL169897A0/en unknown
-
2007
- 2007-03-30 HK HK07103474.2A patent/HK1096392A1/xx not_active IP Right Cessation
-
2009
- 2009-01-08 US US12/350,696 patent/US20110015248A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004212296A1 (en) | 2004-08-26 |
| ES2336562T3 (es) | 2010-04-14 |
| CN1845925A (zh) | 2006-10-11 |
| CA2515940A1 (en) | 2004-08-26 |
| MXPA05008478A (es) | 2005-10-18 |
| US20060229353A1 (en) | 2006-10-12 |
| IN2005DE03350A (de) | 2007-06-01 |
| JP2006517934A (ja) | 2006-08-03 |
| JP4795931B2 (ja) | 2011-10-19 |
| BRPI0407234A (pt) | 2006-01-31 |
| WO2004071382A2 (en) | 2004-08-26 |
| EP1597262A2 (de) | 2005-11-23 |
| HK1096392A1 (en) | 2007-06-01 |
| IN228043B (de) | 2009-02-13 |
| EP1597262B1 (de) | 2009-11-11 |
| AU2004212296B2 (en) | 2010-06-17 |
| IL169897A0 (en) | 2007-07-04 |
| WO2004071382A3 (en) | 2005-01-06 |
| CA2515940C (en) | 2011-12-06 |
| MX272108B (es) | 2009-11-25 |
| DE602004024037D1 (de) | 2009-12-24 |
| CN1845925B (zh) | 2010-11-03 |
| US20110015248A1 (en) | 2011-01-20 |
| KR20050098928A (ko) | 2005-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |