KR100915483B1 - 태반 줄기 세포의 회수 방법 - Google Patents
태반 줄기 세포의 회수 방법Info
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- KR100915483B1 KR100915483B1 KR1020087015591A KR20087015591A KR100915483B1 KR 100915483 B1 KR100915483 B1 KR 100915483B1 KR 1020087015591 A KR1020087015591 A KR 1020087015591A KR 20087015591 A KR20087015591 A KR 20087015591A KR 100915483 B1 KR100915483 B1 KR 100915483B1
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- perfusate
- placental
- stem cells
- placenta
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Abstract
Description
WBC(1000/㎖) | Lym(%) | MID(%) | GRA(%) | 총 부피 | 세포수 | |
CB(제대혈) | 10.5 | 43.2 | 8 | 48.8 | 60㎖ | 6.3x108 |
PP(태반 관류액, 실온) | 12.0 | 62.9 | 18.2 | 18.9 | 15㎖ | 1.8x108 |
PP2(태반 관류액, 37℃) | 11.7 | 56.0 | 19.2 | 24.8 | 30㎖ | 3.5x108 |
PP 샘플은 피콜(Ficoll) 분리후에 얻은 것임.피콜 분리후 PP의 총 세포수는 5.3x108이고, 처리전 CB의 수는 6.3x108이다.Lym(%)는 림프구의 백분율이고; MID(%)는 중간범위 백혈구의 백분율이며; GRA(%)는 과립구의 백분율이다. |
Claims (16)
- 제대혈이 배출되고 관류되어 잔류 혈액이 제거된 산후 인간 태반을 관류 용액으로 관류시켜 상기 인간 태반으로부터의 태반 세포를 포함하는 관류액을 수득하고, 상기 관류액으로부터 상기 태반 세포를 분리하는 것에 의해 수득가능하며, CD34+ 태반 줄기 세포 또는 부착성 태반 줄기 세포를 포함하는, 분리된 태반 세포.
- 삭제
- 삭제
- 제 1 항에 있어서,SH2+, SH3+ 또는 SH4+인 줄기 세포를 포함하는, 분리된 태반 세포.
- 제 1 항에 있어서,CD34+ 태반 줄기 세포 및 부착성 태반 줄기 세포 둘 다를 포함하는, 분리된 태반 세포.
- 제 1 항에 있어서,상기 관류액이 태반 혈관계(vasculature)로부터 수집된 관류액으로 구성되는, 분리된 태반 세포.
- 제 1 항에 있어서,상기 관류액이 태반 혈관계로부터 수집된 관류액 및 태반의 모체측 부분으로부터 수집된 관류액을 포함하는, 분리된 태반 세포.
- 제대혈이 배출되고 관류되어 잔류 혈액이 제거된 산후 인간 태반을 관류 용액으로 관류시키고, 상기 태반으로부터 상기 관류 용액을 수집하여 분리된 관류액을 형성하는 것에 의해 생성되며, 태반 줄기 세포를 포함하는, 분리된 태반 관류액.
- 제 8 항에 있어서,상기 줄기 세포가 CD34+ 줄기 세포를 포함하는, 분리된 태반 관류액.
- 제 8 항에 있어서,상기 줄기 세포가 섬유아세포성 부착성 줄기 세포를 포함하는, 분리된 태반 관류액.
- 제 8 항에 있어서,상기 줄기 세포가 SH2+, SH3+ 또는 SH4+인 줄기 세포를 포함하는, 분리된 태반 관류액.
- 제 8 항에 있어서,상기 관류액이 CD34+ 태반 줄기 세포 및 섬유아세포성 부착성 줄기 세포 둘 다를 포함하는, 분리된 태반 관류액.
- 제 8 항에 있어서,상기 관류액이 태반의 모체측 부분으로부터 수집된 관류액을 포함하는, 분리된 태반 관류액.
- 제 8 항에 있어서,상기 관류액이 태반 혈관계로부터 수집된 관류액을 포함하는 분리된 태반 관류액.
- 제 8 항에 있어서,상기 관류액이 태반의 모체측 부분으로부터 수집된 관류액 및 태반 혈관계로부터 수집된 관류액 둘 다를 포함하는, 분리된 태반 관류액.
- 제 8 항에 있어서,상기 관류액이 순환된 관류액으로 구성되는, 분리된 태반 관류액.
Applications Claiming Priority (2)
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2015
- 2015-02-06 US US14/616,167 patent/US20150175959A1/en not_active Abandoned
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2016
- 2016-06-09 US US15/177,779 patent/US10113146B2/en not_active Expired - Lifetime
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2018
- 2018-09-26 HK HK18112337.7A patent/HK1252977A1/zh unknown
Non-Patent Citations (2)
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J. Immunol. Methods 209: 93-104 (1997) |
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