ZA200802010B - Pyrimidine compounds as serotonin receptor modulators - Google Patents

Pyrimidine compounds as serotonin receptor modulators

Info

Publication number
ZA200802010B
ZA200802010B ZA200802010A ZA200802010A ZA200802010B ZA 200802010 B ZA200802010 B ZA 200802010B ZA 200802010 A ZA200802010 A ZA 200802010A ZA 200802010 A ZA200802010 A ZA 200802010A ZA 200802010 B ZA200802010 B ZA 200802010B
Authority
ZA
South Africa
Prior art keywords
receptor modulators
serotonin receptor
pyrimidine compounds
serotonin
pyrimidine
Prior art date
Application number
ZA200802010A
Other languages
English (en)
Inventor
Curt A Dvorak
Brock T Shireman
Dale A Rudolph
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA200802010B publication Critical patent/ZA200802010B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
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  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
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ZA200802010A 2005-08-04 2008-03-03 Pyrimidine compounds as serotonin receptor modulators ZA200802010B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70571905P 2005-08-04 2005-08-04

Publications (1)

Publication Number Publication Date
ZA200802010B true ZA200802010B (en) 2009-09-30

Family

ID=37400981

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200802010A ZA200802010B (en) 2005-08-04 2008-03-03 Pyrimidine compounds as serotonin receptor modulators

Country Status (17)

Country Link
EP (1) EP1928461B1 (ru)
JP (1) JP5066088B2 (ru)
KR (1) KR101353268B1 (ru)
CN (1) CN101277700B (ru)
AT (1) ATE539753T1 (ru)
AU (1) AU2006278759B2 (ru)
BR (1) BRPI0614397A2 (ru)
CA (1) CA2617760C (ru)
CR (1) CR9791A (ru)
EA (1) EA014495B1 (ru)
HK (1) HK1118469A1 (ru)
IL (2) IL189164A (ru)
NO (1) NO340744B1 (ru)
NZ (1) NZ565334A (ru)
UA (1) UA95247C2 (ru)
WO (1) WO2007019083A1 (ru)
ZA (1) ZA200802010B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ545836A (en) 2003-09-17 2009-09-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as serotonin receptor modulators
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
EP2139896A1 (en) 2007-03-23 2010-01-06 Pfizer Limited Pyrimido [4, 5-d]azepine derivatives as 5-ht2c agonists
PE20091102A1 (es) 2007-12-17 2009-07-25 Janssen Pharmaceutica Nv Moduladores imidazolo-, oxazolo-, y tiazolopirimidina del trpv1
CN103002735B (zh) * 2010-05-21 2015-05-20 Abbvie公司 5-ht受体的调节剂和其使用方法
JP5851663B1 (ja) 2014-05-29 2016-02-03 大鵬薬品工業株式会社 新規テトラヒドロピリドピリミジン化合物又はその塩
CN107365314A (zh) * 2016-05-11 2017-11-21 国药集团国瑞药业有限公司 一种吡唑类化合物、其晶型及其制备方法
WO2018093818A1 (en) * 2016-11-15 2018-05-24 Temple University-Of The Commonwealth System Of Higher Education Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use
AU2018277520B2 (en) 2017-05-31 2022-03-17 Chemocentryx, Inc. 6-5 fused rings as C5a inhibitors
US10828285B2 (en) * 2017-12-22 2020-11-10 Chemocentryx, Inc. Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
KR20210003160A (ko) 2018-04-18 2021-01-11 콘스텔레이션 파마슈티칼스, 인크. 메틸 변형 효소 조절제, 이의 조성물 및 용도
CN112262143A (zh) 2018-05-21 2021-01-22 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
KR102282569B1 (ko) * 2019-02-08 2021-07-29 (주)퓨쳐켐 새로운 18F-표지된 친디엔체와 테트라진 화합물과의 IeDDA 반응을 이용한 18F-표지 방법
KR102483495B1 (ko) * 2019-09-02 2023-01-04 한양대학교 에리카산학협력단 2,4-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물
JP2023501576A (ja) * 2019-11-13 2023-01-18 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクトンおよびその使用方法

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US3969355A (en) * 1974-11-01 1976-07-13 Morton-Norwich Products, Inc. 5-Aminoethyl-2,4-diphenylpyrimidine dihydrobromide
JPH03148265A (ja) * 1989-11-01 1991-06-25 Sumitomo Chem Co Ltd ５，７―ジフェニル―４，６―ジアザインダン誘導体、その製造法およびそれを有効成分とする除草剤
US5137890A (en) * 1990-02-14 1992-08-11 Ortho Pharmaceutical Corporation 4-phenyl tetrahydropyrido(4,3-d)pyrimidines
PT757685E (pt) * 1994-04-29 2004-10-29 Pfizer Novas amidas ciclicas como incrementadores de libertacao de neurotransmissores
AU2980797A (en) * 1996-06-11 1998-01-07 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and medicinal uses thereof
KR20020005653A (ko) * 1999-04-01 2002-01-17 실버스타인 아써 에이. 소르비톨 디하이드로게나제 저해제로서의 아미노피리미딘
CA2384354C (en) * 1999-09-09 2009-06-23 Kumiai Chemical Industry Co., Ltd. Pyrimidine derivatives and herbicides containing them
EP1264820A4 (en) * 2000-03-14 2004-09-15 Fujisawa Pharmaceutical Co amide compounds
DE10111842A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Antithrombotische Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
NZ545836A (en) * 2003-09-17 2009-09-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as serotonin receptor modulators

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BRPI0614397A2 (pt) 2011-03-29
EP1928461B1 (en) 2012-01-04
UA95247C2 (ru) 2011-07-25
EA014495B1 (ru) 2010-12-30
AU2006278759A1 (en) 2007-02-15
NO20081034L (no) 2008-02-28
ATE539753T1 (de) 2012-01-15
JP5066088B2 (ja) 2012-11-07
KR20080033502A (ko) 2008-04-16
CN101277700B (zh) 2013-02-20
NO340744B1 (no) 2017-06-12
CA2617760A1 (en) 2007-02-15
HK1118469A1 (en) 2009-02-13
EP1928461A1 (en) 2008-06-11
EA200800525A1 (ru) 2008-06-30
IL213679A0 (en) 2011-07-31
IL189164A (en) 2013-08-29
JP2009503076A (ja) 2009-01-29
CN101277700A (zh) 2008-10-01
AU2006278759B2 (en) 2012-08-16
CR9791A (es) 2010-05-27
WO2007019083A1 (en) 2007-02-15
CA2617760C (en) 2015-02-17
NZ565334A (en) 2010-12-24
IL189164A0 (en) 2008-08-07
KR101353268B1 (ko) 2014-02-06

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