NO20081034L - Pyrimidinforbindelser som serotoninreseptormodulatorer - Google Patents

Pyrimidinforbindelser som serotoninreseptormodulatorer

Info

Publication number
NO20081034L
NO20081034L NO20081034A NO20081034A NO20081034L NO 20081034 L NO20081034 L NO 20081034L NO 20081034 A NO20081034 A NO 20081034A NO 20081034 A NO20081034 A NO 20081034A NO 20081034 L NO20081034 L NO 20081034L
Authority
NO
Norway
Prior art keywords
receptor modulators
serotonin receptor
pyrimidine compounds
serotonin
pyrimidine
Prior art date
Application number
NO20081034A
Other languages
English (en)
Other versions
NO340744B1 (no
Inventor
Curt A Dvorak
Dale A Rudolph
Brock T Shireman
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20081034L publication Critical patent/NO20081034L/no
Publication of NO340744B1 publication Critical patent/NO340744B1/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)

Abstract

Visse pyrimidinholdige forbindelser representert ved formel (I) og (II) er serotoninreseptormodulatorer nyttige i behandlingen av serotoninmedierte sykdommer.
NO20081034A 2005-08-04 2008-02-27 Pyrimidinforbindelser som serotoninreseptormodulatorer NO340744B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70571905P 2005-08-04 2005-08-04
PCT/US2006/029437 WO2007019083A1 (en) 2005-08-04 2006-07-27 Pyrimidine compounds as serotonin receptor modulators

Publications (2)

Publication Number Publication Date
NO20081034L true NO20081034L (no) 2008-02-28
NO340744B1 NO340744B1 (no) 2017-06-12

Family

ID=37400981

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081034A NO340744B1 (no) 2005-08-04 2008-02-27 Pyrimidinforbindelser som serotoninreseptormodulatorer

Country Status (17)

Country Link
EP (1) EP1928461B1 (no)
JP (1) JP5066088B2 (no)
KR (1) KR101353268B1 (no)
CN (1) CN101277700B (no)
AT (1) ATE539753T1 (no)
AU (1) AU2006278759B2 (no)
BR (1) BRPI0614397A2 (no)
CA (1) CA2617760C (no)
CR (1) CR9791A (no)
EA (1) EA014495B1 (no)
HK (1) HK1118469A1 (no)
IL (2) IL189164A (no)
NO (1) NO340744B1 (no)
NZ (1) NZ565334A (no)
UA (1) UA95247C2 (no)
WO (1) WO2007019083A1 (no)
ZA (1) ZA200802010B (no)

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EA200801812A1 (ru) 2003-09-17 2009-06-30 Янссен Фармацевтика Н.В. Сопряженные гетероциклические соединения
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
MX2009010208A (es) 2007-03-23 2009-10-19 Pfizer Ltd Derivados de pirimido-[4,5-d]-azepina como agonistas de 5-ht2c.
US8288397B2 (en) 2007-12-17 2012-10-16 Janssen Pharmaceutica Nv Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
CN103002735B (zh) * 2010-05-21 2015-05-20 Abbvie公司 5-ht受体的调节剂和其使用方法
US9662333B2 (en) 2014-05-29 2017-05-30 Taiho Pharmaceutical Co., Ltd. Tetrahydropyridopyrimidine compound or salt thereof
CN107365314A (zh) * 2016-05-11 2017-11-21 国药集团国瑞药业有限公司 一种吡唑类化合物、其晶型及其制备方法
IL291029B2 (en) * 2016-11-15 2024-06-01 Univ Temple New modulators of 5-hydroxytryptamine receptor 7 and a method of using them
AU2018277520B2 (en) 2017-05-31 2022-03-17 Chemocentryx, Inc. 6-5 fused rings as C5a inhibitors
BR112020012270A2 (pt) * 2017-12-22 2020-11-24 Chemocentryx, Inc. compostos de anel 6,5-fundido substituído por diarila como inibidores de c5ar
AU2019255310B2 (en) 2018-04-18 2022-11-24 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
CA3100977A1 (en) 2018-05-21 2019-11-28 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
KR102282569B1 (ko) * 2019-02-08 2021-07-29 (주)퓨쳐켐 새로운 18F-표지된 친디엔체와 테트라진 화합물과의 IeDDA 반응을 이용한 18F-표지 방법
KR102483495B1 (ko) * 2019-09-02 2023-01-04 한양대학교 에리카산학협력단 2,4-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물
EP4058458A2 (en) * 2019-11-13 2022-09-21 Temple University - Of The Commonwealth System of Higher Education Novel functionalized lactones as modulators of the 5-hydroxytryptamine receptor 7 and their method of use

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US3969355A (en) * 1974-11-01 1976-07-13 Morton-Norwich Products, Inc. 5-Aminoethyl-2,4-diphenylpyrimidine dihydrobromide
JPH03148265A (ja) * 1989-11-01 1991-06-25 Sumitomo Chem Co Ltd ５，７―ジフェニル―４，６―ジアザインダン誘導体、その製造法およびそれを有効成分とする除草剤
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EA200801812A1 (ru) * 2003-09-17 2009-06-30 Янссен Фармацевтика Н.В. Сопряженные гетероциклические соединения

Also Published As

Publication number Publication date
CA2617760C (en) 2015-02-17
CA2617760A1 (en) 2007-02-15
AU2006278759A1 (en) 2007-02-15
NO340744B1 (no) 2017-06-12
JP5066088B2 (ja) 2012-11-07
CR9791A (es) 2010-05-27
IL213679A0 (en) 2011-07-31
KR101353268B1 (ko) 2014-02-06
CN101277700B (zh) 2013-02-20
NZ565334A (en) 2010-12-24
BRPI0614397A2 (pt) 2011-03-29
EA014495B1 (ru) 2010-12-30
ATE539753T1 (de) 2012-01-15
EP1928461A1 (en) 2008-06-11
KR20080033502A (ko) 2008-04-16
HK1118469A1 (en) 2009-02-13
WO2007019083A1 (en) 2007-02-15
ZA200802010B (en) 2009-09-30
EP1928461B1 (en) 2012-01-04
AU2006278759B2 (en) 2012-08-16
EA200800525A1 (ru) 2008-06-30
IL189164A (en) 2013-08-29
IL189164A0 (en) 2008-08-07
JP2009503076A (ja) 2009-01-29
UA95247C2 (ru) 2011-07-25
CN101277700A (zh) 2008-10-01

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