ZA200802010B - Pyrimidine compounds as serotonin receptor modulators - Google Patents
Pyrimidine compounds as serotonin receptor modulatorsInfo
- Publication number
- ZA200802010B ZA200802010B ZA200802010A ZA200802010A ZA200802010B ZA 200802010 B ZA200802010 B ZA 200802010B ZA 200802010 A ZA200802010 A ZA 200802010A ZA 200802010 A ZA200802010 A ZA 200802010A ZA 200802010 B ZA200802010 B ZA 200802010B
- Authority
- ZA
- South Africa
- Prior art keywords
- receptor modulators
- serotonin receptor
- pyrimidine compounds
- serotonin
- pyrimidine
- Prior art date
Links
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 title abstract 2
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70571905P | 2005-08-04 | 2005-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200802010B true ZA200802010B (en) | 2009-09-30 |
Family
ID=37400981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200802010A ZA200802010B (en) | 2005-08-04 | 2008-03-03 | Pyrimidine compounds as serotonin receptor modulators |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1928461B1 (xx) |
JP (1) | JP5066088B2 (xx) |
KR (1) | KR101353268B1 (xx) |
CN (1) | CN101277700B (xx) |
AT (1) | ATE539753T1 (xx) |
AU (1) | AU2006278759B2 (xx) |
BR (1) | BRPI0614397A2 (xx) |
CA (1) | CA2617760C (xx) |
CR (1) | CR9791A (xx) |
EA (1) | EA014495B1 (xx) |
HK (1) | HK1118469A1 (xx) |
IL (2) | IL189164A (xx) |
NO (1) | NO340744B1 (xx) |
NZ (1) | NZ565334A (xx) |
UA (1) | UA95247C2 (xx) |
WO (1) | WO2007019083A1 (xx) |
ZA (1) | ZA200802010B (xx) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2319539T3 (es) | 2003-09-17 | 2009-05-08 | Janssen Pharmaceutica Nv | Compuestos heterociclicos condensados como moduladores del receptor de serotonina. |
US7598255B2 (en) * | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
PE20080145A1 (es) * | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
MX2009010208A (es) * | 2007-03-23 | 2009-10-19 | Pfizer Ltd | Derivados de pirimido-[4,5-d]-azepina como agonistas de 5-ht2c. |
US8288397B2 (en) | 2007-12-17 | 2012-10-16 | Janssen Pharmaceutica Nv | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 |
RU2015140748A (ru) * | 2010-05-21 | 2018-12-26 | Эббви Инк. | Модуляторы 5-нт рецепторов и способы их применения |
RU2636310C1 (ru) | 2014-05-29 | 2017-11-22 | Тайхо Фармасьютикал Ко., Лтд. | Новое тетерагидропиримидиновое соединение или его соль |
CN107365314A (zh) * | 2016-05-11 | 2017-11-21 | 国药集团国瑞药业有限公司 | 一种吡唑类化合物、其晶型及其制备方法 |
KR20230148384A (ko) * | 2016-11-15 | 2023-10-24 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법 |
WO2018222598A1 (en) | 2017-05-31 | 2018-12-06 | Chemocentryx, Inc. | 6-5 FUSED RINGS AS C5a INHIBITORS |
EP3728203B1 (en) * | 2017-12-22 | 2024-03-13 | ChemoCentryx, Inc. | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS |
UA127357C2 (uk) | 2018-04-18 | 2023-07-26 | Констеллатіон Фармацеутікалс, Інк. | Модулятори метилмодифікуючих ферментів, композиції та їх використання |
EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
KR102282569B1 (ko) * | 2019-02-08 | 2021-07-29 | (주)퓨쳐켐 | 새로운 18F-표지된 친디엔체와 테트라진 화합물과의 IeDDA 반응을 이용한 18F-표지 방법 |
KR102483495B1 (ko) * | 2019-09-02 | 2023-01-04 | 한양대학교 에리카산학협력단 | 2,4-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물 |
BR112022009361A2 (pt) * | 2019-11-13 | 2022-08-09 | Univ Temple | Novas lactonas funcionalizadas como moduladores do receptor 7 de 5- hidroxitriptamina e seu método de uso |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3969355A (en) * | 1974-11-01 | 1976-07-13 | Morton-Norwich Products, Inc. | 5-Aminoethyl-2,4-diphenylpyrimidine dihydrobromide |
JPH03148265A (ja) * | 1989-11-01 | 1991-06-25 | Sumitomo Chem Co Ltd | 5,7―ジフェニル―4,6―ジアザインダン誘導体、その製造法およびそれを有効成分とする除草剤 |
US5137890A (en) * | 1990-02-14 | 1992-08-11 | Ortho Pharmaceutical Corporation | 4-phenyl tetrahydropyrido(4,3-d)pyrimidines |
ES2223049T3 (es) * | 1994-04-29 | 2005-02-16 | Pfizer Inc. | Amidas aciclicas y ciclicas novedosas como estimuladores de la liberacion de neurotransmisores. |
JP3531169B2 (ja) * | 1996-06-11 | 2004-05-24 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
WO2000059510A1 (en) * | 1999-04-01 | 2000-10-12 | Pfizer Products Inc. | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
DE60008550T2 (de) * | 1999-09-09 | 2004-08-05 | Kumiai Chemical Industry Co., Ltd. | Pyrimidinderivate und herbizide welche diese enthalten |
EP1264820A4 (en) * | 2000-03-14 | 2004-09-15 | Fujisawa Pharmaceutical Co | amide compounds |
DE10111842A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Antithrombotische Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
ES2319539T3 (es) * | 2003-09-17 | 2009-05-08 | Janssen Pharmaceutica Nv | Compuestos heterociclicos condensados como moduladores del receptor de serotonina. |
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2006
- 2006-07-27 AT AT06788808T patent/ATE539753T1/de active
- 2006-07-27 JP JP2008525054A patent/JP5066088B2/ja not_active Expired - Fee Related
- 2006-07-27 BR BRPI0614397-0A patent/BRPI0614397A2/pt not_active Application Discontinuation
- 2006-07-27 EP EP06788808A patent/EP1928461B1/en active Active
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- 2006-07-27 NZ NZ565334A patent/NZ565334A/en not_active IP Right Cessation
- 2006-07-27 EA EA200800525A patent/EA014495B1/ru unknown
- 2006-07-27 UA UAA200801682A patent/UA95247C2/ru unknown
- 2006-07-27 AU AU2006278759A patent/AU2006278759B2/en not_active Ceased
- 2006-07-27 CN CN2006800364302A patent/CN101277700B/zh not_active Expired - Fee Related
- 2006-07-27 CA CA2617760A patent/CA2617760C/en not_active Expired - Fee Related
- 2006-07-27 KR KR1020087005335A patent/KR101353268B1/ko active IP Right Grant
-
2008
- 2008-01-31 IL IL189164A patent/IL189164A/en active IP Right Grant
- 2008-02-27 NO NO20081034A patent/NO340744B1/no not_active IP Right Cessation
- 2008-03-03 ZA ZA200802010A patent/ZA200802010B/xx unknown
- 2008-03-04 CR CR9791A patent/CR9791A/es not_active Application Discontinuation
- 2008-09-10 HK HK08110066.0A patent/HK1118469A1/xx not_active IP Right Cessation
-
2011
- 2011-06-21 IL IL213679A patent/IL213679A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL213679A0 (en) | 2011-07-31 |
CN101277700B (zh) | 2013-02-20 |
EP1928461A1 (en) | 2008-06-11 |
NO20081034L (no) | 2008-02-28 |
IL189164A (en) | 2013-08-29 |
BRPI0614397A2 (pt) | 2011-03-29 |
IL189164A0 (en) | 2008-08-07 |
CA2617760C (en) | 2015-02-17 |
NZ565334A (en) | 2010-12-24 |
HK1118469A1 (en) | 2009-02-13 |
KR20080033502A (ko) | 2008-04-16 |
AU2006278759B2 (en) | 2012-08-16 |
UA95247C2 (ru) | 2011-07-25 |
EA200800525A1 (ru) | 2008-06-30 |
JP5066088B2 (ja) | 2012-11-07 |
WO2007019083A1 (en) | 2007-02-15 |
ATE539753T1 (de) | 2012-01-15 |
CN101277700A (zh) | 2008-10-01 |
CR9791A (es) | 2010-05-27 |
EA014495B1 (ru) | 2010-12-30 |
JP2009503076A (ja) | 2009-01-29 |
CA2617760A1 (en) | 2007-02-15 |
EP1928461B1 (en) | 2012-01-04 |
NO340744B1 (no) | 2017-06-12 |
AU2006278759A1 (en) | 2007-02-15 |
KR101353268B1 (ko) | 2014-02-06 |
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