SG10201806965XA - 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer - Google Patents

3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer

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Publication number
SG10201806965XA
SG10201806965XA SG10201806965XA SG10201806965XA SG10201806965XA SG 10201806965X A SG10201806965X A SG 10201806965XA SG 10201806965X A SG10201806965X A SG 10201806965XA SG 10201806965X A SG10201806965X A SG 10201806965XA SG 10201806965X A SG10201806965X A SG 10201806965XA
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Singapore
Prior art keywords
cancer
inhibitors
aryl
treatment
stem cell
Prior art date
Application number
SG10201806965XA
Inventor
Chiang Li
Ji-Feng Liu
Wei Li
Amanda Gibeau
Harry Rogoff
Katsunori Tsuboi
Yosuke Takanashi
Shingo Tojo
Tomohiro Kodama
Katsumi Kubota
Toshio Kanai
Original Assignee
Boston Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Boston Biomedical Inc filed Critical Boston Biomedical Inc
Publication of SG10201806965XA publication Critical patent/SG10201806965XA/en

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Pyridine Compounds (AREA)

Abstract

3-(ARYL OR HETEROARYL) METHYLENEINDOLIN-2-ONE DERIVATIVES AS INHIBITORS OF CANCER STEM CELL PATHWAY KINASES FOR THE TREATMENT OF CANCER The invention provides compounds of Formula I as inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, wherein i.a. R 2 is an optionally substituted heterocycle or optionally substituted aryl; and one of R 4, R 5, R 6 and R 7 is a substituted heterocycle or substituted aryl. Y Z A X W U V T R4 R7 R1 R3 R2 R5 R6 (I)
SG10201806965XA 2013-03-13 2014-03-13 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer SG10201806965XA (en)

Applications Claiming Priority (2)

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US201361780248P 2013-03-13 2013-03-13
US201361780263P 2013-03-13 2013-03-13

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SG10201806965XA true SG10201806965XA (en) 2018-09-27

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SG10201806965XA SG10201806965XA (en) 2013-03-13 2014-03-13 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer
SG11201507346PA SG11201507346PA (en) 2013-03-13 2014-03-13 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer

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US (2) US20160031888A1 (en)
EP (1) EP2970206A1 (en)
JP (2) JP6378308B2 (en)
KR (1) KR20150127249A (en)
CN (1) CN105408320B (en)
AU (2) AU2014243869A1 (en)
BR (1) BR112015022431A2 (en)
CA (1) CA2904152A1 (en)
HK (1) HK1220184A1 (en)
IL (1) IL240960A0 (en)
MX (1) MX2015011456A (en)
RU (2) RU2019104092A (en)
SG (2) SG10201806965XA (en)
WO (1) WO2014160401A1 (en)

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MX2015011456A (en) 2016-05-31
AU2014243869A1 (en) 2015-09-24
CN105408320B (en) 2019-08-13
RU2015143526A (en) 2017-04-19
JP2016513656A (en) 2016-05-16
KR20150127249A (en) 2015-11-16
US20160031888A1 (en) 2016-02-04
IL240960A0 (en) 2015-11-30
RU2019104092A (en) 2019-03-20
AU2018233033A1 (en) 2018-10-11
JP2018168187A (en) 2018-11-01
US20190241569A1 (en) 2019-08-08
CN105408320A (en) 2016-03-16
JP6378308B2 (en) 2018-08-22
SG11201507346PA (en) 2015-10-29
WO2014160401A1 (en) 2014-10-02
CA2904152A1 (en) 2014-10-02
BR112015022431A2 (en) 2017-05-09
EP2970206A1 (en) 2016-01-20
HK1220184A1 (en) 2017-04-28

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