BR112014011055A2 - novos derivados de [1,2,3]triazolo[4,5-d]pirimidina - Google Patents

novos derivados de [1,2,3]triazolo[4,5-d]pirimidina

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Publication number
BR112014011055A2
BR112014011055A2 BR112014011055A BR112014011055A BR112014011055A2 BR 112014011055 A2 BR112014011055 A2 BR 112014011055A2 BR 112014011055 A BR112014011055 A BR 112014011055A BR 112014011055 A BR112014011055 A BR 112014011055A BR 112014011055 A2 BR112014011055 A2 BR 112014011055A2
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BR
Brazil
Prior art keywords
triazolo
new
pyrimidine derivatives
compound
formula
Prior art date
Application number
BR112014011055A
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English (en)
Other versions
BR112014011055B1 (pt
Inventor
Kimbara Atsushi
Bissantz Caterina
Adam Jean-Michel
Rogers-Evan Mark
Nettekoven Matthias
Roever Stephan
Grether Uwe
Original Assignee
Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014011055A2 publication Critical patent/BR112014011055A2/pt
Publication of BR112014011055B1 publication Critical patent/BR112014011055B1/pt

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    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

resumo novos derivados de [1,2,3]triazolo[4,5-d]pirimidina a invenção se refere a um composto da fórmula (i): (i) nnnnnar2r1 em que a, r1 e r2 são definidos como na descrição e nas reivindicações. o composto da fórmula (i) pode ser usado como um medicamento nos agonistas do receptor de canabinóide 2.
BR112014011055-7A 2011-11-08 2012-11-05 Novos derivados de [1,2,3]triazolo[4,5-d]pirimidina BR112014011055B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11188333.6 2011-11-08
EP11188333 2011-11-08
PCT/EP2012/071788 WO2013068306A1 (en) 2011-11-08 2012-11-05 [1, 2, 3] triazolo [4, 5 -d] pyrimidine derivatives as agonists of the cannabinoid receptor 2

Publications (2)

Publication Number Publication Date
BR112014011055A2 true BR112014011055A2 (pt) 2017-05-02
BR112014011055B1 BR112014011055B1 (pt) 2022-01-11

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BR112014011055-7A BR112014011055B1 (pt) 2011-11-08 2012-11-05 Novos derivados de [1,2,3]triazolo[4,5-d]pirimidina

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US (2) US8741906B2 (pt)
EP (1) EP2776442B1 (pt)
JP (1) JP6138141B2 (pt)
KR (1) KR102032337B1 (pt)
CN (1) CN103930426B (pt)
AR (1) AR088663A1 (pt)
AU (1) AU2012334173B2 (pt)
BR (1) BR112014011055B1 (pt)
CA (1) CA2850458C (pt)
CL (1) CL2014001174A1 (pt)
CO (1) CO6920295A2 (pt)
CY (1) CY1117147T1 (pt)
DK (1) DK2776442T3 (pt)
EA (1) EA023581B1 (pt)
ES (1) ES2553704T3 (pt)
HK (1) HK1194732A1 (pt)
HR (1) HRP20160052T1 (pt)
HU (1) HUE025543T2 (pt)
IL (1) IL231949A (pt)
MX (1) MX342309B (pt)
MY (1) MY170878A (pt)
PE (1) PE20141588A1 (pt)
PL (1) PL2776442T3 (pt)
PT (1) PT2776442E (pt)
RS (1) RS54436B1 (pt)
SG (1) SG11201402197UA (pt)
SI (1) SI2776442T1 (pt)
TW (2) TWI704150B (pt)
UA (1) UA111640C2 (pt)
WO (1) WO2013068306A1 (pt)
ZA (1) ZA201402905B (pt)

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UA111640C2 (uk) * 2011-11-08 2016-05-25 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2
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EP2991988B1 (en) 2013-05-02 2017-05-31 F. Hoffmann-La Roche AG Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists
UA116395C2 (uk) * 2013-09-06 2018-03-12 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ ТРИАЗОЛ[4,5-b]ПІРИМІДИНУ
NZ766530A (en) 2014-08-04 2023-09-29 Nuevolution As Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
EA031735B1 (ru) * 2014-11-07 2019-02-28 Ф. Хоффманн-Ля Рош Аг ТРИАЗОЛО[4,5-d]ПИРИМИДИНЫ В КАЧЕСТВЕ АГОНИСТОВ КАННАБИНОИДНЫХ РЕЦЕПТОРОВ ТИПА 2
CN107743491B (zh) * 2015-05-08 2020-08-21 豪夫迈·罗氏有限公司 用于治疗和预防病毒感染的新的氧硫杂环戊烷甲酸及其衍生物
CN105541738B (zh) * 2016-01-21 2018-04-06 西北师范大学 一种三氮唑取代的苯乙酮类化合物的制备方法
SG11201809678VA (en) * 2016-06-23 2018-11-29 Hoffmann La Roche [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
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JP6964099B2 (ja) 2016-06-23 2021-11-10 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 新規[1,2,3]トリアゾロ[4,5−d]ピリミジン誘導体
CN109311895B (zh) 2016-06-23 2021-06-18 豪夫迈·罗氏有限公司 新型[1,2,3]三唑并[4,5-d]嘧啶衍生物
WO2022011171A1 (en) * 2020-07-08 2022-01-13 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
CN113164830B (zh) * 2018-08-20 2023-02-21 贝索制药有限责任公司 大麻素的制备方法
CA3138307A1 (en) 2019-05-13 2020-11-19 Ecolab Usa Inc. 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor
US11447479B2 (en) 2019-12-20 2022-09-20 Nuevolution A/S Compounds active towards nuclear receptors
WO2021198955A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors
CA3174176A1 (en) 2020-03-31 2021-10-07 Sanne Schroder Glad Compounds active towards nuclear receptors
KR20230112615A (ko) 2020-11-23 2023-07-27 에프. 호프만-라 로슈 아게 테트라졸 유도체의 제조를 위한 신규 방법
AR127456A1 (es) 2021-10-28 2024-01-24 Hoffmann La Roche Sintesis de [1,2,3]triazol[4,5-d]pirimidinas
WO2023237460A1 (en) 2022-06-07 2023-12-14 F. Hoffmann-La Roche Ag A process for preparing 1-[5-tert-butyl-3-[(1-methyltetrazol-5 -yl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol
WO2024047079A1 (en) 2022-09-01 2024-03-07 F. Hoffmann-La Roche Ag Anti-cb2 antibodies and their use in a flow cytometry assay to measure cell surface cb2 expression
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US9067943B2 (en) * 2011-11-25 2015-06-30 Hoffmann-La Roche Inc. [1,2,3]triazolo[4,5-D]pyrimidine derivatives

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CN103930426B (zh) 2016-05-11
JP6138141B2 (ja) 2017-05-31
HRP20160052T1 (hr) 2016-02-12
CA2850458C (en) 2016-10-25
CL2014001174A1 (es) 2014-09-12
US9056866B2 (en) 2015-06-16
CO6920295A2 (es) 2014-04-10
ES2553704T3 (es) 2015-12-11
EP2776442A1 (en) 2014-09-17
TW201825496A (zh) 2018-07-16
US20140288046A1 (en) 2014-09-25
MX342309B (es) 2016-09-26
US20130116236A1 (en) 2013-05-09
MX2014005184A (es) 2014-05-28
EP2776442B1 (en) 2015-10-21
BR112014011055B1 (pt) 2022-01-11
HUE025543T2 (en) 2016-03-29
TW201333011A (zh) 2013-08-16
IL231949A (en) 2016-02-29
AU2012334173A1 (en) 2014-04-03
CY1117147T1 (el) 2017-04-05
US8741906B2 (en) 2014-06-03
RS54436B1 (en) 2016-06-30
NZ622652A (en) 2015-08-28
UA111640C2 (uk) 2016-05-25
TWI639600B (zh) 2018-11-01
SI2776442T1 (sl) 2015-12-31
TWI704150B (zh) 2020-09-11
AU2012334173A8 (en) 2014-04-10
CN103930426A (zh) 2014-07-16
MY170878A (en) 2019-09-11
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