AR070810A1 - Derivados de 1- bencil-3-hidroximetilindazol y su utilizacion en el tratamiento de enfermedades basadas en la expresion de mcp-1 cx3cr1 y p40 - Google Patents

Derivados de 1- bencil-3-hidroximetilindazol y su utilizacion en el tratamiento de enfermedades basadas en la expresion de mcp-1 cx3cr1 y p40

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Publication number
AR070810A1
AR070810A1 ARP090100800A ARP090100800A AR070810A1 AR 070810 A1 AR070810 A1 AR 070810A1 AR P090100800 A ARP090100800 A AR P090100800A AR P090100800 A ARP090100800 A AR P090100800A AR 070810 A1 AR070810 A1 AR 070810A1
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AR
Argentina
Prior art keywords
alkyl
hydrogen
different
same
alkoxy
Prior art date
Application number
ARP090100800A
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English (en)
Inventor
Angelo Guglielmotti
Guido Furlotti
Nicola Cazzolla
Giorgina Mangano
Barbara Garofalo
Original Assignee
Acraf
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Publication date
Application filed by Acraf filed Critical Acraf
Publication of AR070810A1 publication Critical patent/AR070810A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
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    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
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    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
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    • A61P35/00Antineoplastic agents
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    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

Derivados de 1-bencil-3-hidroximetilindazol segun la formula (1) descritos en las reivindicaciones y a una composicion farmacéutica que los comprende, junto con un vehiculo farmacéuticamente aceptable. Además, se refiere a la utilizacion de derivadas de 1-bencil-3-hidroximetilindazol para la preparacion de una composicion farmacéutica que es activa en el tratamiento de enfermedades basadas en la expresion de MCP-1, CX3CR1 y p40, y a su utilizacion para tratar o prevenir enfermedades basadas en la expresion de MCP-1 CX3CR1 y p40. Reivindicacion 1: Compuesto de formula (1) en la que: A puede ser -X1- o -X1-OC(R9)(R10)-, en los que X1 puede ser un grupo alquilo C1-5, opcionalmente sustituido con unto o más grupos alquilo C1-5 o uno o más grupos alcoxi C1-3, y R9 y R10, que pueden ser iguales o diferentes entre sí, pueden ser hidrogeno, alquilo C1-5, o alcoxi C1-3, Y es OH; R1 y R2, que pueden ser iguales o diferentes entre sí, pueden ser hidrogeno, alquilo C1-5, o alcoxi C1-3; R3, R4 y R8, que pueden ser iguales o diferentes entre sí, pueden ser hidrogeno, alquilo C1-5, alcoxi C1-3, un átomo de halogeno, -OH, -N(R')(Rö), -N(R')CORö, -CN, -CONR'Rö, -SO2NR'Rö, -SO2R', nitro y trifluorometilo; con R' y Rö, que pueden ser iguales o diferentes entre sí, representados por hidrogeno y un grupo alquilo C1-5, R5 puede ser hidrogeno, alquilo C1-5, alcoxi C1-3, un átomo de halogeno, -OH, -N(R')(Rö), -N(R')CORö, nitro y trifluorometilo, o R5 junto con uno de entre R6 y R7 forma un anillo que presenta 5 o 6 átomos de carbono; con R' y Rö, que pueden ser iguales o diferentes entre sí, representados por hidrogeno y un grupo alquilo C1-5, R6 y R7, que pueden ser iguales o diferentes entre sí, pueden ser hidrogeno, alquilo C1-5, o juntos forman un grupo C=O, o uno de entre R6 y R7, junto con R5, forma un anillo que presenta 5 o 6 átomos de carbono, con la condicion de que cuando Y sea -OH, A sea diferente de alquilo C1, opcionalmente sustituido con uno o más alquilo C1-5, o alternativamente por lo menos uno de los grupos de R1 a R8 es diferente de hidrogeno.
ARP090100800A 2008-03-07 2009-03-06 Derivados de 1- bencil-3-hidroximetilindazol y su utilizacion en el tratamiento de enfermedades basadas en la expresion de mcp-1 cx3cr1 y p40 AR070810A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08425139 2008-03-07

Publications (1)

Publication Number Publication Date
AR070810A1 true AR070810A1 (es) 2010-05-05

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ID=39671487

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP090100800A AR070810A1 (es) 2008-03-07 2009-03-06 Derivados de 1- bencil-3-hidroximetilindazol y su utilizacion en el tratamiento de enfermedades basadas en la expresion de mcp-1 cx3cr1 y p40
ARP090100801A AR070811A1 (es) 2008-03-07 2009-03-06 Derivados de 1- bencil-3- hidroximetilindazol y su utilizacion en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40

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US (3) US7919518B2 (es)
EP (3) EP3181551A1 (es)
JP (2) JP5509099B2 (es)
KR (2) KR101599867B1 (es)
CN (2) CN101945855B (es)
AR (2) AR070810A1 (es)
AU (2) AU2009221083B2 (es)
BR (2) BRPI0907976A2 (es)
CA (2) CA2712703C (es)
CY (2) CY1117584T1 (es)
DK (2) DK2254870T3 (es)
EA (2) EA019711B1 (es)
ES (2) ES2569330T3 (es)
GE (2) GEP20135912B (es)
HR (2) HRP20160462T1 (es)
HU (1) HUE027098T2 (es)
IL (3) IL206893A0 (es)
LT (1) LT2254869T (es)
MX (2) MX2010009623A (es)
PL (2) PL2254869T3 (es)
PT (1) PT2254869T (es)
SG (1) SG188177A1 (es)
SI (2) SI2254869T1 (es)
UA (2) UA103605C2 (es)
WO (2) WO2009109613A2 (es)

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CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法
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IL207131A0 (en) 2010-12-30
BRPI0907976A2 (pt) 2015-08-04
DK2254870T3 (en) 2016-05-17
HRP20171208T1 (hr) 2017-10-06
IL215579A0 (en) 2011-11-30
EP2254870A2 (en) 2010-12-01
IL206893A0 (en) 2010-12-30
US8283348B2 (en) 2012-10-09
GEP20135983B (en) 2013-12-10
IL207131A (en) 2013-02-28
GEP20135912B (en) 2013-08-26
AR070811A1 (es) 2010-05-05
EP2254869A2 (en) 2010-12-01
MX2010009623A (es) 2010-09-28
PL2254870T3 (pl) 2016-07-29
HRP20160462T1 (hr) 2016-06-03
US20110003874A1 (en) 2011-01-06
SG188177A1 (en) 2013-03-28
KR20100131432A (ko) 2010-12-15
UA103605C2 (en) 2013-11-11
CN101952256B (zh) 2016-03-16
KR101581828B1 (ko) 2015-12-31
MX2010009626A (es) 2010-12-20
CY1119252T1 (el) 2018-02-14
US20110160205A1 (en) 2011-06-30
CA2712703A1 (en) 2009-09-11
PL2254869T3 (pl) 2017-10-31
EP2254870B1 (en) 2016-02-24
PT2254869T (pt) 2017-07-18
CA2712703C (en) 2016-10-11
EA019711B1 (ru) 2014-05-30
US20100311744A1 (en) 2010-12-09
EP3181551A1 (en) 2017-06-21
AU2009221089B2 (en) 2013-12-05
AU2009221083B2 (en) 2013-11-28
KR101599867B1 (ko) 2016-03-04
JP5509101B2 (ja) 2014-06-04
CA2712403C (en) 2017-06-06
KR20100133957A (ko) 2010-12-22
EA201071040A1 (ru) 2011-02-28
JP2011513367A (ja) 2011-04-28
SI2254870T1 (sl) 2016-05-31
US8835481B2 (en) 2014-09-16
UA105170C2 (en) 2014-04-25
JP2011513365A (ja) 2011-04-28
SI2254869T1 (sl) 2017-10-30
WO2009109618A2 (en) 2009-09-11
HUE027098T2 (en) 2016-08-29
ES2569330T3 (es) 2016-05-10
DK2254869T3 (en) 2017-09-04
EA201071038A1 (ru) 2011-02-28
IL215579A (en) 2015-06-30
EP2254869B1 (en) 2017-05-31
AU2009221083A1 (en) 2009-09-11
BRPI0907977A2 (pt) 2015-08-04
CA2712403A1 (en) 2009-09-11
US7919518B2 (en) 2011-04-05
CN101952256A (zh) 2011-01-19
CY1117584T1 (el) 2017-04-26
WO2009109613A2 (en) 2009-09-11
CN101945855B (zh) 2014-12-17
JP5509099B2 (ja) 2014-06-04
AU2009221089A1 (en) 2009-09-11
ES2637009T3 (es) 2017-10-10
WO2009109613A3 (en) 2009-12-10
WO2009109618A3 (en) 2009-12-10
CN101945855A (zh) 2011-01-12
EA018241B1 (ru) 2013-06-28
LT2254869T (lt) 2017-08-10

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