ECSP088891A - Derivados bicíclicos como inhibidores de cetp - Google Patents
Derivados bicíclicos como inhibidores de cetpInfo
- Publication number
- ECSP088891A ECSP088891A EC2008008891A ECSP088891A ECSP088891A EC SP088891 A ECSP088891 A EC SP088891A EC 2008008891 A EC2008008891 A EC 2008008891A EC SP088891 A ECSP088891 A EC SP088891A EC SP088891 A ECSP088891 A EC SP088891A
- Authority
- EC
- Ecuador
- Prior art keywords
- cetp inhibitors
- present
- bicyclic derivatives
- compounds
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
La presente invención se refiere a novedosos compuestos de la Fórmula (I): o una composición farmacéutica de los mismos, estando todas las variables definidas en el texto. La presente invención se refiere además al uso de los compuestos de la presente para el tratamiento de, o demora de progreso para superar, las enfermedades en donde esté involucrada la proteína de transferencia de colesteril-éster.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0609268.8A GB0609268D0 (en) | 2006-05-10 | 2006-05-10 | Organic compounds |
US86648006P | 2006-11-20 | 2006-11-20 | |
US89614207P | 2007-03-21 | 2007-03-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP088891A true ECSP088891A (es) | 2008-12-30 |
Family
ID=38445602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008008891A ECSP088891A (es) | 2006-05-10 | 2008-11-10 | Derivados bicíclicos como inhibidores de cetp |
Country Status (17)
Country | Link |
---|---|
US (2) | US8232403B2 (es) |
EP (1) | EP2024356A1 (es) |
KR (1) | KR101172120B1 (es) |
AR (1) | AR060873A1 (es) |
AU (1) | AU2007247385B2 (es) |
CA (1) | CA2650954C (es) |
CL (1) | CL2007001325A1 (es) |
CR (1) | CR10420A (es) |
EC (1) | ECSP088891A (es) |
GT (1) | GT200800242A (es) |
IL (1) | IL195010A0 (es) |
MA (1) | MA30427B1 (es) |
MX (1) | MX2008014284A (es) |
NO (1) | NO20084912L (es) |
TN (1) | TNSN08444A1 (es) |
TW (1) | TW200813009A (es) |
WO (1) | WO2007128568A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007007919A (es) * | 2004-12-31 | 2008-01-22 | Reddy Us Therapeutics Inc | Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp). |
US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
JP2009522224A (ja) * | 2005-12-29 | 2009-06-11 | ノバルティス アクチエンゲゼルシャフト | コレステリルエステル輸送タンパク質(cetp)の阻害剤としてのピリジニルアミン誘導体 |
KR101172120B1 (ko) * | 2006-05-10 | 2012-08-10 | 노파르티스 아게 | Cetp 억제제로서의 바이시클릭 유도체 |
JP2009536609A (ja) * | 2006-05-11 | 2009-10-15 | ノバルティス アクチエンゲゼルシャフト | Cetp阻害剤としてのベンジルアミン誘導体 |
US7750019B2 (en) | 2006-08-11 | 2010-07-06 | Kowa Company, Ltd. | Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same |
US7790737B2 (en) | 2007-03-13 | 2010-09-07 | Kowa Company, Ltd. | Substituted pyrimidine compounds and their utility as CETP inhibitors |
JP5244095B2 (ja) | 2007-04-13 | 2013-07-24 | 興和株式会社 | 新規なジベンジルアミン構造を有するピリミジン化合物及びこれを含有する医薬 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2383253B1 (en) | 2008-11-28 | 2014-03-19 | Kowa Company, Ltd. | Method for manufacturing trans-{4-[(alkyl amino) methyl]cyclohexyl} acetic ester |
EA021275B9 (ru) * | 2009-09-03 | 2015-08-31 | Байоэнердженикс | Гетероциклические соединения, содержащая их фармацевтическая композиция и их применение для лечения pask-опосредованного заболевания |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
KR20140056258A (ko) * | 2011-07-08 | 2014-05-09 | 노파르티스 아게 | 높은 트리글리세리드 대상체에서의 아테롬성동맥경화증의 치료 방법 |
WO2013024358A2 (en) | 2011-08-18 | 2013-02-21 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors |
CN103958511A (zh) | 2011-09-27 | 2014-07-30 | 雷迪博士实验室有限公司 | 作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物 |
MX2015006223A (es) * | 2012-11-19 | 2015-09-25 | Reddys Lab Ltd Dr | Composiciones farmaceuticas de inhibidores cetp. |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
WO2014128564A2 (en) * | 2013-02-21 | 2014-08-28 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
TN2016000031A1 (en) | 2013-07-25 | 2017-07-05 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure |
CN105705167A (zh) | 2013-07-25 | 2016-06-22 | 诺华股份有限公司 | 合成的apelin多肽的生物缀合物 |
CN107406490A (zh) | 2015-01-23 | 2017-11-28 | 诺华股份有限公司 | 具有改善的半衰期的合成apelin脂肪酸缀合物 |
CA3159968A1 (en) * | 2019-12-11 | 2021-06-17 | Magdalena Izabela ZAWADZKA | Heterocyclic compounds as modulators of stimulator of interferon genes (sting) |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6451830B1 (en) * | 1999-09-23 | 2002-09-17 | G.D. Searle & Co. | Use of substituted N,N-disubstituted non-fused heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity |
MXPA03001186A (es) * | 2000-08-07 | 2004-04-20 | Neurogen Corp | Compuestos heterociclicos como ligandos del receptor acido gamma aminobutirico (gabaa). |
US7332514B2 (en) | 2002-08-30 | 2008-02-19 | Japan Tobacco Inc. | Dibenzylamine compound and medicinal use thereof |
WO2004043925A2 (en) | 2002-11-08 | 2004-05-27 | Neurogen Corporation | 3-substituted-6-aryl pyridined as ligands of c5a receptors |
MXPA05010456A (es) | 2003-03-28 | 2006-03-21 | Pfizer Prod Inc | Compuestos de quinolina y quinoxalina. |
US7371759B2 (en) * | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
JP4922924B2 (ja) | 2004-04-13 | 2012-04-25 | メルク・シャープ・エンド・ドーム・コーポレイション | Cetp阻害薬 |
CA2589322A1 (en) | 2004-11-23 | 2006-06-01 | Pfizer Products Inc. | Dibenzyl amine compounds and derivatives |
US7668830B2 (en) | 2004-11-29 | 2010-02-23 | Nokia Corporation | Access rights |
MX2007007919A (es) * | 2004-12-31 | 2008-01-22 | Reddy Us Therapeutics Inc | Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp). |
EP1834490A1 (en) | 2005-01-06 | 2007-09-19 | Thomson Licensing | Reducing rainbow artifacts in digital light projection systems |
EP1901057A1 (en) | 2005-07-07 | 2008-03-19 | Sony Corporation | Substance information acquisition method and substance information measurement device using evanescent light, and base arrangement decision method and device |
WO2007008899A2 (en) | 2005-07-11 | 2007-01-18 | University Of Florida Research Foundation, Inc. | Variable feathering field splitting for intensity modulated fields of large size |
EP1981342B1 (en) * | 2005-12-28 | 2016-11-30 | Dr. Reddy's Laboratories Ltd. | Selective benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors |
JP2009522224A (ja) * | 2005-12-29 | 2009-06-11 | ノバルティス アクチエンゲゼルシャフト | コレステリルエステル輸送タンパク質(cetp)の阻害剤としてのピリジニルアミン誘導体 |
UY30118A1 (es) * | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | Compueto amina trisustituido |
KR101172120B1 (ko) * | 2006-05-10 | 2012-08-10 | 노파르티스 아게 | Cetp 억제제로서의 바이시클릭 유도체 |
JP2009536609A (ja) * | 2006-05-11 | 2009-10-15 | ノバルティス アクチエンゲゼルシャフト | Cetp阻害剤としてのベンジルアミン誘導体 |
US20100076021A1 (en) * | 2006-11-15 | 2010-03-25 | Hidetomo Imase | Organic Compounds |
MX2009004982A (es) * | 2006-11-15 | 2009-05-20 | Novartis Ag | Derivados heterociclicos como inhibidores cetp. |
-
2007
- 2007-05-08 KR KR1020087030049A patent/KR101172120B1/ko not_active IP Right Cessation
- 2007-05-08 AR ARP070101992A patent/AR060873A1/es unknown
- 2007-05-08 CA CA2650954A patent/CA2650954C/en not_active Expired - Fee Related
- 2007-05-08 US US12/300,208 patent/US8232403B2/en not_active Expired - Fee Related
- 2007-05-08 AU AU2007247385A patent/AU2007247385B2/en not_active Ceased
- 2007-05-08 MX MX2008014284A patent/MX2008014284A/es active IP Right Grant
- 2007-05-08 EP EP07724982A patent/EP2024356A1/en not_active Withdrawn
- 2007-05-08 WO PCT/EP2007/004058 patent/WO2007128568A1/en active Application Filing
- 2007-05-09 TW TW096116482A patent/TW200813009A/zh unknown
- 2007-05-09 CL CL200701325A patent/CL2007001325A1/es unknown
-
2008
- 2008-10-30 CR CR10420A patent/CR10420A/es not_active Application Discontinuation
- 2008-10-30 IL IL195010A patent/IL195010A0/en unknown
- 2008-11-06 TN TNP2008000444A patent/TNSN08444A1/en unknown
- 2008-11-07 GT GT200800242A patent/GT200800242A/es unknown
- 2008-11-10 EC EC2008008891A patent/ECSP088891A/es unknown
- 2008-11-21 NO NO20084912A patent/NO20084912L/no not_active Application Discontinuation
- 2008-11-24 MA MA31408A patent/MA30427B1/fr unknown
-
2012
- 2012-05-17 US US13/473,649 patent/US8410275B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US8410275B2 (en) | 2013-04-02 |
AU2007247385A1 (en) | 2007-11-15 |
GT200800242A (es) | 2009-04-29 |
NO20084912L (no) | 2009-02-03 |
MA30427B1 (fr) | 2009-05-04 |
US20090227580A1 (en) | 2009-09-10 |
KR20090017580A (ko) | 2009-02-18 |
AU2007247385B2 (en) | 2011-07-14 |
CL2007001325A1 (es) | 2008-07-18 |
EP2024356A1 (en) | 2009-02-18 |
KR101172120B1 (ko) | 2012-08-10 |
TW200813009A (en) | 2008-03-16 |
WO2007128568A1 (en) | 2007-11-15 |
AR060873A1 (es) | 2008-07-16 |
CR10420A (es) | 2009-02-02 |
US8232403B2 (en) | 2012-07-31 |
IL195010A0 (en) | 2009-08-03 |
US20120225874A1 (en) | 2012-09-06 |
TNSN08444A1 (en) | 2010-04-14 |
CA2650954A1 (en) | 2007-11-15 |
MX2008014284A (es) | 2008-11-18 |
CA2650954C (en) | 2014-02-11 |
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