MX339858B - Compuestos novedosos como ligandos del receptor h3 de la histamina. - Google Patents
Compuestos novedosos como ligandos del receptor h3 de la histamina.Info
- Publication number
- MX339858B MX339858B MX2013009683A MX2013009683A MX339858B MX 339858 B MX339858 B MX 339858B MX 2013009683 A MX2013009683 A MX 2013009683A MX 2013009683 A MX2013009683 A MX 2013009683A MX 339858 B MX339858 B MX 339858B
- Authority
- MX
- Mexico
- Prior art keywords
- novel compounds
- histamine
- receptor ligands
- formula
- pharmaceutically acceptable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 102000004384 Histamine H3 receptors Human genes 0.000 title abstract 2
- 108090000981 Histamine H3 receptors Proteins 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con compuestos novedosos de fórmula (I), y sus sales farmacéuticamente aceptables y composiciones que los contienen. (Ver Formula) La presente invención también se relaciona con un proceso para la preparación de los compuestos novedosos anteriores, y sus sales farmacéuticamente aceptables. Los compuestos de fórmula (I) son útiles en el tratamiento de varios trastornos que están relacionados con los receptores H3 de la Histamina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN520CH2011 | 2011-02-23 | ||
| PCT/IN2011/000380 WO2012114348A1 (en) | 2011-02-23 | 2011-06-07 | Novel compounds as histamine h3 receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013009683A MX2013009683A (es) | 2013-10-28 |
| MX339858B true MX339858B (es) | 2016-06-15 |
Family
ID=54290090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013009683A MX339858B (es) | 2011-02-23 | 2011-06-07 | Compuestos novedosos como ligandos del receptor h3 de la histamina. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9079888B2 (es) |
| EP (1) | EP2694492B1 (es) |
| JP (1) | JP5805792B2 (es) |
| KR (1) | KR101554407B1 (es) |
| CN (1) | CN103443093B (es) |
| AP (1) | AP3340A (es) |
| AU (1) | AU2011360550B2 (es) |
| BR (1) | BR112013021496B1 (es) |
| CA (1) | CA2827567C (es) |
| CY (1) | CY1116721T1 (es) |
| DK (1) | DK2694492T3 (es) |
| EA (1) | EA023260B1 (es) |
| ES (1) | ES2548284T3 (es) |
| HR (1) | HRP20151003T1 (es) |
| HU (1) | HUE025163T2 (es) |
| IL (1) | IL228019A (es) |
| ME (1) | ME02212B (es) |
| MX (1) | MX339858B (es) |
| NZ (1) | NZ614567A (es) |
| PL (1) | PL2694492T3 (es) |
| PT (1) | PT2694492E (es) |
| RS (1) | RS54248B1 (es) |
| SG (1) | SG192858A1 (es) |
| SI (1) | SI2694492T1 (es) |
| SM (1) | SMT201500238B (es) |
| WO (1) | WO2012114348A1 (es) |
| ZA (1) | ZA201306328B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP1300139A2 (en) * | 2013-03-06 | 2014-09-29 | Richter Gedeon Nyrt | Phenoxypiperidine h3 antagonists |
| BR112017002922B1 (pt) * | 2014-08-16 | 2023-01-03 | Suven Life Sciences Limited | Processo para a produção de dihidrocloreto de n-[4-(1-ciclobutil piperidin-4-iloxi) fenil]-2- (morfolin-4-il) acetamida |
| MA45988B1 (fr) * | 2016-08-18 | 2020-10-28 | Suven Life Sciences Ltd | Triple combinaison d'agonistes inverses du récepteur d'histamine-3, d'inhibiteurs de l'acétylcholinestérase et d'antagonistes du récepteurs nmda |
| RS60669B1 (sr) | 2016-08-18 | 2020-09-30 | Suven Life Sciences Ltd | Kombinacija inverznih agonista histamin-3 receptora sa inhibitorima acetilholinesteraze |
| SMT202500075T1 (it) | 2018-05-31 | 2025-05-12 | Suven Life Sciences Ltd | Metodo di trattamento con un agonista inverso del recettore dell’istamina-3 |
| WO2022113008A1 (en) | 2020-11-27 | 2022-06-02 | Richter Gedeon Nyrt. | Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder |
| EP4488263A2 (en) | 2022-03-02 | 2025-01-08 | Hangzhou Bio-Sincerity Pharma-tech Co., Ltd. | Phenylurea derivative and pharmaceutical use thereof |
| KR20250016079A (ko) | 2022-03-02 | 2025-02-03 | 항저우 바이오-신세리티 파마-테크 컴퍼니 리미티드 | 히스타민 h3 수용체 길항제 및 이의 약학적 용도 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725541D0 (en) * | 1997-12-02 | 1998-02-04 | Pharmacia & Upjohn Spa | Amino-benzothiazole derivatives |
| AU8112101A (en) * | 2000-08-08 | 2002-02-18 | Ortho Mcneil Pharm Inc | Non-imidazole aryloxypiperidines |
| CA2441080A1 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| ATE441417T1 (de) * | 2002-12-20 | 2009-09-15 | Glaxo Group Ltd | Benzoädüazepinderivate für die behandlung von neurologischen krankheiten |
| JP4777974B2 (ja) * | 2004-04-01 | 2011-09-21 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体作用物質、製剤および治療的使用 |
| US8008301B2 (en) * | 2004-04-01 | 2011-08-30 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| MX2007002274A (es) | 2004-08-23 | 2007-05-07 | Lilly Co Eli | Agentes del receptor de histamina h3. preparacion y usos terapeuticos. |
| CN101848903A (zh) | 2007-09-06 | 2010-09-29 | 葛兰素集团有限公司 | 对组胺h3受体具有亲和性的哌嗪衍生物 |
| CA2702933C (en) * | 2007-10-17 | 2012-12-18 | Sanofi-Aventis | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
| WO2009100120A2 (en) | 2008-02-04 | 2009-08-13 | Neurogen Corporation | Pyridinyl-substituted piperazinyl oxoethyl tetrahydropyrazolopyridines |
| CN102046624A (zh) | 2008-03-31 | 2011-05-04 | 埃沃特克股份有限公司 | 作为组胺h3受体拮抗剂的四氢萘啶及其氮杂衍生物 |
| EP2300422B1 (en) | 2008-05-08 | 2014-11-05 | Evotec AG | Azetidines as histamine h3 receptor antagonists |
| CA2739491A1 (en) * | 2008-10-16 | 2010-04-22 | Schering Corporation | Azine derivatives and methods of use thereof |
-
2011
- 2011-06-07 HR HRP20151003TT patent/HRP20151003T1/hr unknown
- 2011-06-07 CA CA2827567A patent/CA2827567C/en active Active
- 2011-06-07 EP EP11749555.6A patent/EP2694492B1/en active Active
- 2011-06-07 KR KR1020137024919A patent/KR101554407B1/ko active Active
- 2011-06-07 NZ NZ61456711A patent/NZ614567A/en unknown
- 2011-06-07 BR BR112013021496-1A patent/BR112013021496B1/pt active IP Right Grant
- 2011-06-07 SG SG2013063060A patent/SG192858A1/en unknown
- 2011-06-07 AP AP2013007088A patent/AP3340A/xx active
- 2011-06-07 AU AU2011360550A patent/AU2011360550B2/en active Active
- 2011-06-07 PL PL11749555T patent/PL2694492T3/pl unknown
- 2011-06-07 US US14/000,362 patent/US9079888B2/en active Active
- 2011-06-07 PT PT117495556T patent/PT2694492E/pt unknown
- 2011-06-07 SI SI201130601T patent/SI2694492T1/sl unknown
- 2011-06-07 HU HUE11749555A patent/HUE025163T2/en unknown
- 2011-06-07 RS RS20150610A patent/RS54248B1/sr unknown
- 2011-06-07 ME MEP-2015-151A patent/ME02212B/me unknown
- 2011-06-07 DK DK11749555.6T patent/DK2694492T3/en active
- 2011-06-07 EA EA201391211A patent/EA023260B1/ru unknown
- 2011-06-07 CN CN201180069505.8A patent/CN103443093B/zh active Active
- 2011-06-07 ES ES11749555.6T patent/ES2548284T3/es active Active
- 2011-06-07 WO PCT/IN2011/000380 patent/WO2012114348A1/en not_active Ceased
- 2011-06-07 JP JP2013554978A patent/JP5805792B2/ja active Active
- 2011-06-07 MX MX2013009683A patent/MX339858B/es active IP Right Grant
-
2013
- 2013-08-18 IL IL228019A patent/IL228019A/en active IP Right Grant
- 2013-08-22 ZA ZA2013/06328A patent/ZA201306328B/en unknown
-
2015
- 2015-09-28 CY CY20151100859T patent/CY1116721T1/el unknown
- 2015-10-02 SM SM201500238T patent/SMT201500238B/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |