SMT201500238B - Nuovi composti come ligandi dei recettori H3 istaminergici - Google Patents

Nuovi composti come ligandi dei recettori H3 istaminergici

Info

Publication number
SMT201500238B
SMT201500238B SM201500238T SM201500238T SMT201500238B SM T201500238 B SMT201500238 B SM T201500238B SM 201500238 T SM201500238 T SM 201500238T SM 201500238 T SM201500238 T SM 201500238T SM T201500238 B SMT201500238 B SM T201500238B
Authority
SM
San Marino
Prior art keywords
ligands
new compounds
histaminergic receptors
histaminergic
receptors
Prior art date
Application number
SM201500238T
Other languages
English (en)
Italian (it)
Inventor
Ramakrishna Nirogi
Anil Karbhari Shinde
Ramasastri Kambhampati
Amol Dinakar Deshpande
Adi Reddy Dwarampudi
Narasimhareddy Gangadasari
Sangram Keshari Saraf
Vishwottam Nagaraj Kandikere
Pradeep Jayarajan
Ishtiyaque Ahmad
Mohmadsadik Abdulhamid Mulla
Venkateswarlu Jasti
Original Assignee
Suven Life Science Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Science Ltd filed Critical Suven Life Science Ltd
Publication of SMT201500238B publication Critical patent/SMT201500238B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SM201500238T 2011-02-23 2015-10-02 Nuovi composti come ligandi dei recettori H3 istaminergici SMT201500238B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN520CH2011 2011-02-23
PCT/IN2011/000380 WO2012114348A1 (en) 2011-02-23 2011-06-07 Novel compounds as histamine h3 receptor ligands

Publications (1)

Publication Number Publication Date
SMT201500238B true SMT201500238B (it) 2015-10-30

Family

ID=54290090

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201500238T SMT201500238B (it) 2011-02-23 2015-10-02 Nuovi composti come ligandi dei recettori H3 istaminergici

Country Status (28)

Country Link
US (1) US9079888B2 (es)
EP (1) EP2694492B1 (es)
JP (1) JP5805792B2 (es)
KR (1) KR101554407B1 (es)
CN (1) CN103443093B (es)
AP (1) AP3340A (es)
AU (1) AU2011360550B2 (es)
BR (1) BR112013021496B1 (es)
CA (1) CA2827567C (es)
CY (1) CY1116721T1 (es)
DK (1) DK2694492T3 (es)
EA (1) EA023260B1 (es)
ES (1) ES2548284T3 (es)
HK (1) HK1187613A1 (es)
HR (1) HRP20151003T1 (es)
HU (1) HUE025163T2 (es)
IL (1) IL228019A (es)
ME (1) ME02212B (es)
MX (1) MX339858B (es)
NZ (1) NZ614567A (es)
PL (1) PL2694492T3 (es)
PT (1) PT2694492E (es)
RS (1) RS54248B1 (es)
SG (1) SG192858A1 (es)
SI (1) SI2694492T1 (es)
SM (1) SMT201500238B (es)
WO (1) WO2012114348A1 (es)
ZA (1) ZA201306328B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP1300139A2 (en) * 2013-03-06 2014-09-29 Richter Gedeon Nyrt Phenoxypiperidine h3 antagonists
CA2957494C (en) * 2014-08-16 2018-08-28 Suven Life Sciences Limited Process for large scale production of n-[4-(1- cyclobutyl piperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide dihydrochloride
ME03812B (me) * 2016-08-18 2021-04-20 Suven Life Sciences Ltd Kombinacija inverznih agonista histamin-3 receptora sa inhibitorima acetilholinesteraze
JP6734469B2 (ja) * 2016-08-18 2020-08-05 スヴェン・ライフ・サイエンシーズ・リミテッドSuven Life Sciences Limited ヒスタミン−3受容体インバースアゴニスト、アセチルコリンエステラーゼ阻害剤及びnmda受容体アンタゴニストの3種組合せ
WO2019229509A1 (en) 2018-05-31 2019-12-05 Suven Life Sciences Limited Method of treatment with histamine-3 receptor inverse agonist
WO2022113008A1 (en) 2020-11-27 2022-06-02 Richter Gedeon Nyrt. Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder
CN116693446A (zh) * 2022-03-02 2023-09-05 杭州百诚医药科技股份有限公司 苯基脲类衍生物及其医药用途
WO2023166351A1 (zh) * 2022-03-02 2023-09-07 杭州百诚医药科技股份有限公司 组胺h3受体抑制剂及其医药用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
WO2002012190A2 (en) * 2000-08-08 2002-02-14 Ortho Mcneil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines as h3 receptor ligands
EP1379493A2 (en) * 2001-03-23 2004-01-14 Eli Lilly and Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
RU2423353C1 (ru) * 2002-12-20 2011-07-10 Глэксо Груп Лимитед Новые производные бензазепина
US8008301B2 (en) 2004-04-01 2011-08-30 Eli Lilly And Company Histamine H3 receptor agents, preparation and therapeutic uses
MXPA06011167A (es) * 2004-04-01 2007-01-25 Eli Lilli And Company Agentes del receptor h3 de histamina, preparacion y usos terapeuticos.
JP4942654B2 (ja) 2004-08-23 2012-05-30 イーライ リリー アンド カンパニー ヒスタミンh3受容体薬剤、製剤及び治療的使用
US20090170869A1 (en) 2007-09-06 2009-07-02 Desmond John Best Piperazine derivative having affinity for the histamine h3 receptor
EP2215058B1 (en) * 2007-10-17 2011-11-23 Sanofi Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof
US7799816B2 (en) 2008-02-04 2010-09-21 Roche Palo Alto Llc Imidazolinylmethyl aryl sulfonamide
CN102046624A (zh) 2008-03-31 2011-05-04 埃沃特克股份有限公司 作为组胺h3受体拮抗剂的四氢萘啶及其氮杂衍生物
US8691804B2 (en) 2008-05-08 2014-04-08 Evotec Ag Azetidines and cyclobutanes as histamine H3 receptor antagonists
WO2010045306A2 (en) 2008-10-16 2010-04-22 Schering Corporation Azine derivatives and methods of use thereof

Also Published As

Publication number Publication date
CA2827567A1 (en) 2012-08-30
KR101554407B1 (ko) 2015-09-18
MX2013009683A (es) 2013-10-28
PL2694492T3 (pl) 2015-12-31
EP2694492A1 (en) 2014-02-12
ZA201306328B (en) 2014-04-30
US20140135304A1 (en) 2014-05-15
MX339858B (es) 2016-06-15
AP2013007088A0 (en) 2013-08-31
AU2011360550B2 (en) 2015-04-09
US9079888B2 (en) 2015-07-14
HUE025163T2 (en) 2016-02-29
CA2827567C (en) 2015-10-27
ES2548284T3 (es) 2015-10-15
HRP20151003T1 (hr) 2015-10-23
EA023260B1 (ru) 2016-05-31
WO2012114348A1 (en) 2012-08-30
SG192858A1 (en) 2013-09-30
JP5805792B2 (ja) 2015-11-10
AP3340A (en) 2015-07-31
RS54248B1 (en) 2016-02-29
CN103443093A (zh) 2013-12-11
IL228019A0 (en) 2013-09-30
AU2011360550A1 (en) 2013-09-12
ME02212B (me) 2016-02-20
PT2694492E (pt) 2015-10-19
EP2694492B1 (en) 2015-07-29
CY1116721T1 (el) 2017-03-15
KR20130133270A (ko) 2013-12-06
HK1187613A1 (en) 2014-04-11
BR112013021496B1 (pt) 2021-10-13
CN103443093B (zh) 2015-02-25
SI2694492T1 (sl) 2015-11-30
DK2694492T3 (en) 2015-11-09
BR112013021496A2 (pt) 2019-08-06
NZ614567A (en) 2014-07-25
JP2014508761A (ja) 2014-04-10
IL228019A (en) 2015-11-30
EA201391211A1 (ru) 2014-06-30

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