BR112014002929A2 - novos anticorpos contra fosforilcolina - Google Patents
novos anticorpos contra fosforilcolinaInfo
- Publication number
- BR112014002929A2 BR112014002929A2 BR112014002929A BR112014002929A BR112014002929A2 BR 112014002929 A2 BR112014002929 A2 BR 112014002929A2 BR 112014002929 A BR112014002929 A BR 112014002929A BR 112014002929 A BR112014002929 A BR 112014002929A BR 112014002929 A2 BR112014002929 A2 BR 112014002929A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies against
- new antibodies
- against phosphorylcholine
- phosphorylcholine
- new
- Prior art date
Links
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 title 1
- 229950004354 phosphorylcholine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521593P | 2011-08-09 | 2011-08-09 | |
| PCT/EP2012/065505 WO2013020995A1 (en) | 2011-08-09 | 2012-08-08 | New antibodies against phosphorylcholine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014002929A2 true BR112014002929A2 (pt) | 2017-03-28 |
| BR112014002929A8 BR112014002929A8 (pt) | 2021-09-28 |
Family
ID=46679261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014002929A BR112014002929A8 (pt) | 2011-08-09 | 2012-08-08 | Novos anticorpos contra fosforilcolina |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US9803028B2 (pt) |
| EP (1) | EP2742068B1 (pt) |
| JP (1) | JP6277125B2 (pt) |
| KR (1) | KR101947758B1 (pt) |
| CN (1) | CN104039832B (pt) |
| AR (1) | AR087485A1 (pt) |
| AU (1) | AU2012293646B2 (pt) |
| BR (1) | BR112014002929A8 (pt) |
| CA (1) | CA2843921A1 (pt) |
| CY (1) | CY1121950T1 (pt) |
| DK (1) | DK2742068T3 (pt) |
| ES (1) | ES2732838T3 (pt) |
| HK (1) | HK1200852A1 (pt) |
| HR (1) | HRP20190988T1 (pt) |
| HU (1) | HUE045163T2 (pt) |
| LT (1) | LT2742068T (pt) |
| MX (1) | MX364425B (pt) |
| PL (1) | PL2742068T3 (pt) |
| PT (1) | PT2742068T (pt) |
| RS (1) | RS58986B1 (pt) |
| RU (1) | RU2654584C2 (pt) |
| SG (1) | SG2014009344A (pt) |
| SI (1) | SI2742068T1 (pt) |
| TR (1) | TR201909072T4 (pt) |
| TW (1) | TWI707873B (pt) |
| WO (1) | WO2013020995A1 (pt) |
| ZA (1) | ZA201400665B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012294431B2 (en) | 2011-08-09 | 2017-03-30 | Athera Biotechnologies Ab | Antibodies binding to phosphorylcholine (PC) and/or PC conjugates |
| US9803028B2 (en) * | 2011-08-09 | 2017-10-31 | Athera Biotechnologies Ab | Antibodies against phosphorylcholine |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| AU2016229076B2 (en) | 2015-03-09 | 2022-01-20 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| AU2016287499B2 (en) | 2015-06-29 | 2022-08-04 | Caris Science, Inc. | Therapeutic oligonucleotides |
| AU2016298317B2 (en) | 2015-07-28 | 2021-02-18 | Caris Science, Inc. | Targeted oligonucleotides |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2402664A1 (fr) | 1977-09-07 | 1979-04-06 | Agronomique Inst Nat Rech | Produits de couplage phosphorylcholine, composes amines procede d'obtention et applications |
| US5955584A (en) | 1986-03-31 | 1999-09-21 | Charter Ventures | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
| ATE120233T1 (de) | 1986-08-06 | 1995-04-15 | Scripps Clinic Res | Monoklonale antikörper, b-spezifisch für apolipoprotein, die von zwei hybridomen erzeugt werden. |
| JPH02188532A (ja) | 1989-01-17 | 1990-07-24 | Otsuka Pharmaceut Co Ltd | リポソームワクチン |
| WO1990012632A1 (en) | 1989-04-19 | 1990-11-01 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Process for removing c-reactive protein and anti-phosphorylcholine antibodies from biological fluids |
| JP3283041B2 (ja) | 1990-07-13 | 2002-05-20 | 学校法人藤田学園 | 人工抗体 |
| EP0562020A4 (en) | 1990-12-10 | 1993-11-18 | Alving, Carl L. | A vaccine against cholesterol to prevent hypercholesterolemia and atherosclerosis |
| RU2014609C1 (ru) * | 1991-06-06 | 1994-06-15 | Московский институт тонкой химической технологии им.М.В.Ломоносова | Способ определения белков, специфичных к фосфорилхолину |
| CA2131150A1 (en) | 1992-03-03 | 1993-09-16 | Michel C. Nussenzweig | Receptor complexes with b29 (ig-beta or ig-gamma) and their uses |
| WO1994014454A1 (en) | 1992-12-29 | 1994-07-07 | Entremed, Inc. | Vaccines against sterols |
| CA2151742C (en) | 1993-02-22 | 1999-05-25 | Alfred A. Amkraut | Compositions for oral delivery of active agents |
| US5455032A (en) | 1993-07-29 | 1995-10-03 | The United States Of America As Represented By The Department Of Health And Human Services | Use of phosphocholine hapten conjugates in vaccines |
| WO1998021581A1 (en) | 1996-11-08 | 1998-05-22 | The Regents Of The University Of California | Methods and reagents for non-invasive imaging of atherosclerotic plaque |
| US6375925B1 (en) | 1996-11-08 | 2002-04-23 | The Regents Of The University Of California | Methods and reagents for non-invasive imaging of atherosclerotic plaque |
| US6225070B1 (en) | 1997-08-07 | 2001-05-01 | The Regents Of The University Of California | Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma |
| US20040185039A1 (en) | 2002-08-30 | 2004-09-23 | Heinz Kohler | Therapeutic applications of noncovalent dimerizing antibodies |
| US6300308B1 (en) | 1997-12-31 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions for inducing autoimmunity in the treatment of cancers |
| SE9802402D0 (sv) | 1998-07-03 | 1998-07-03 | Karolinska Innovations Ab | Method of diagnosing cardiovascular disease and early atherosclerosis |
| ES2205853T3 (es) | 1998-07-03 | 2004-05-01 | Athera Biotechnologies Ab | Metodo para diagnosticar la enfermedad cardiovascular y la aterosclerosis precoz. |
| WO2001032070A2 (en) | 1999-10-26 | 2001-05-10 | The Regents Of The University Of California | Reagents and methods for diagnosing, imaging and treating atherosclerotic disease |
| SE0000855D0 (sv) | 2000-03-15 | 2000-03-15 | Karolinska Innovations Ab | Antigenic composition useful as a vaccine against atherosclerosis |
| WO2001088547A2 (en) | 2000-05-12 | 2001-11-22 | The Regents Of The University Of California | Standardized oxidized ldl assay |
| DE10041515A1 (de) | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
| US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| SE0103754L (sv) | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
| WO2004091520A2 (en) | 2003-04-11 | 2004-10-28 | The Regents Of The University Of California | Methods and compositions for treating atherosclerosis |
| SI1735349T1 (sl) * | 2004-04-15 | 2010-12-31 | Athera Biotechnologies Ab | Postopek ocenitve tveganja ishemske kardiovaskularne bolezni z uporabo fosforilholinskih konjugatov |
| JP2008515774A (ja) | 2004-08-03 | 2008-05-15 | ダイアックス コーポレイション | ｈＫ１結合タンパク質 |
| EP1868651A4 (en) * | 2005-04-12 | 2010-10-06 | Univ Duke | METHOD FOR INDUCING ANTIBODIES THAT NEUTRALIZE THE HUMAN IMMUNODEFICIENCY VIRUS |
| US20080311122A1 (en) | 2005-11-28 | 2008-12-18 | Medimmune, Llc | Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof |
| US20090258005A1 (en) | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
| JP5122908B2 (ja) | 2007-10-17 | 2013-01-16 | 日泉化学株式会社 | 自動車の内装用部材の取り付け構造 |
| WO2010003602A1 (en) | 2008-07-07 | 2010-01-14 | Athera Biotechnologies Ab | New therapeutic and diagnostic methods for alzheimer's disease |
| WO2012010291A1 (en) | 2010-07-21 | 2012-01-26 | Athera Biotechnologies Ab | Diagnostic and therapeutic methods and compositions for metabolic disease |
| EP2661450A4 (en) * | 2011-01-06 | 2014-04-23 | Dyax Corp | PROTEINS BINDING TO PLASMA KALLIKREINE |
| US9803028B2 (en) * | 2011-08-09 | 2017-10-31 | Athera Biotechnologies Ab | Antibodies against phosphorylcholine |
| AU2012294431B2 (en) | 2011-08-09 | 2017-03-30 | Athera Biotechnologies Ab | Antibodies binding to phosphorylcholine (PC) and/or PC conjugates |
-
2012
- 2012-08-08 US US14/237,035 patent/US9803028B2/en active Active
- 2012-08-08 CN CN201280049552.0A patent/CN104039832B/zh not_active Expired - Fee Related
- 2012-08-08 PT PT12747915T patent/PT2742068T/pt unknown
- 2012-08-08 ES ES12747915T patent/ES2732838T3/es active Active
- 2012-08-08 WO PCT/EP2012/065505 patent/WO2013020995A1/en active Application Filing
- 2012-08-08 DK DK12747915.2T patent/DK2742068T3/da active
- 2012-08-08 TW TW101128575A patent/TWI707873B/zh not_active IP Right Cessation
- 2012-08-08 AR ARP120102895A patent/AR087485A1/es unknown
- 2012-08-08 BR BR112014002929A patent/BR112014002929A8/pt not_active Application Discontinuation
- 2012-08-08 KR KR1020147006274A patent/KR101947758B1/ko active IP Right Grant
- 2012-08-08 JP JP2014524371A patent/JP6277125B2/ja not_active Expired - Fee Related
- 2012-08-08 SI SI201231604T patent/SI2742068T1/sl unknown
- 2012-08-08 LT LTEP12747915.2T patent/LT2742068T/lt unknown
- 2012-08-08 EP EP12747915.2A patent/EP2742068B1/en active Active
- 2012-08-08 RU RU2014108815A patent/RU2654584C2/ru active
- 2012-08-08 CA CA2843921A patent/CA2843921A1/en not_active Abandoned
- 2012-08-08 SG SG2014009344A patent/SG2014009344A/en unknown
- 2012-08-08 RS RS20190807A patent/RS58986B1/sr unknown
- 2012-08-08 AU AU2012293646A patent/AU2012293646B2/en not_active Ceased
- 2012-08-08 PL PL12747915T patent/PL2742068T3/pl unknown
- 2012-08-08 MX MX2014001313A patent/MX364425B/es active IP Right Grant
- 2012-08-08 TR TR2019/09072T patent/TR201909072T4/tr unknown
- 2012-08-08 HU HUE12747915A patent/HUE045163T2/hu unknown
-
2014
- 2014-01-28 ZA ZA2014/00665A patent/ZA201400665B/en unknown
-
2015
- 2015-02-05 HK HK15101305.1A patent/HK1200852A1/xx unknown
-
2017
- 2017-09-28 US US15/719,520 patent/US20180086848A1/en not_active Abandoned
-
2019
- 2019-05-30 HR HRP20190988TT patent/HRP20190988T1/hr unknown
- 2019-06-28 CY CY20191100683T patent/CY1121950T1/el unknown
-
2021
- 2021-04-13 US US17/229,837 patent/US20210238311A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |