DK2742068T3 - Nye antistoffer mod phosphorylcholin - Google Patents
Nye antistoffer mod phosphorylcholin Download PDFInfo
- Publication number
- DK2742068T3 DK2742068T3 DK12747915.2T DK12747915T DK2742068T3 DK 2742068 T3 DK2742068 T3 DK 2742068T3 DK 12747915 T DK12747915 T DK 12747915T DK 2742068 T3 DK2742068 T3 DK 2742068T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibodies against
- new antibodies
- against phosphorylcholine
- phosphorylcholine
- new
- Prior art date
Links
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 title 1
- 229950004354 phosphorylcholine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521593P | 2011-08-09 | 2011-08-09 | |
| PCT/EP2012/065505 WO2013020995A1 (en) | 2011-08-09 | 2012-08-08 | New antibodies against phosphorylcholine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2742068T3 true DK2742068T3 (da) | 2019-06-11 |
Family
ID=46679261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12747915.2T DK2742068T3 (da) | 2011-08-09 | 2012-08-08 | Nye antistoffer mod phosphorylcholin |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US9803028B2 (da) |
| EP (1) | EP2742068B1 (da) |
| JP (1) | JP6277125B2 (da) |
| KR (1) | KR101947758B1 (da) |
| CN (1) | CN104039832B (da) |
| AR (1) | AR087485A1 (da) |
| AU (1) | AU2012293646B2 (da) |
| BR (1) | BR112014002929A8 (da) |
| CA (1) | CA2843921A1 (da) |
| CY (1) | CY1121950T1 (da) |
| DK (1) | DK2742068T3 (da) |
| ES (1) | ES2732838T3 (da) |
| HK (1) | HK1200852A1 (da) |
| HR (1) | HRP20190988T1 (da) |
| HU (1) | HUE045163T2 (da) |
| LT (1) | LT2742068T (da) |
| MX (1) | MX364425B (da) |
| PL (1) | PL2742068T3 (da) |
| PT (1) | PT2742068T (da) |
| RS (1) | RS58986B1 (da) |
| RU (1) | RU2654584C2 (da) |
| SG (1) | SG2014009344A (da) |
| SI (1) | SI2742068T1 (da) |
| TR (1) | TR201909072T4 (da) |
| TW (1) | TWI707873B (da) |
| WO (1) | WO2013020995A1 (da) |
| ZA (1) | ZA201400665B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI707873B (zh) * | 2011-08-09 | 2020-10-21 | 阿雷拉生物技術Ａｂ公司 | 新抗體 |
| AU2012294431B2 (en) | 2011-08-09 | 2017-03-30 | Athera Biotechnologies Ab | Antibodies binding to phosphorylcholine (PC) and/or PC conjugates |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| CA2979361A1 (en) | 2015-03-09 | 2016-09-15 | Caris Science, Inc. | Method of preparing oligonucleotide libraries |
| EP3314027A4 (en) | 2015-06-29 | 2019-07-03 | Caris Science, Inc. | THERAPEUTIC OLIGONUCLEOTIDES |
| WO2017019918A1 (en) | 2015-07-28 | 2017-02-02 | Caris Science, Inc. | Targeted oligonucleotides |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2402664A1 (fr) | 1977-09-07 | 1979-04-06 | Agronomique Inst Nat Rech | Produits de couplage phosphorylcholine, composes amines procede d'obtention et applications |
| US5955584A (en) | 1986-03-31 | 1999-09-21 | Charter Ventures | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
| ES2070820T3 (es) | 1986-08-06 | 1995-06-16 | Scripps Clinic Res | Anticuerpos monoclonales especificos de la apolipoproteina b, producidos por dos nuevos hibridomas. |
| JPH02188532A (ja) | 1989-01-17 | 1990-07-24 | Otsuka Pharmaceut Co Ltd | リポソームワクチン |
| AU5522390A (en) | 1989-04-19 | 1990-11-16 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Process for removing c-reactive protein and anti-phosphorylcholine antibodies from biological fluids |
| JP3283041B2 (ja) | 1990-07-13 | 2002-05-20 | 学校法人藤田学園 | 人工抗体 |
| AU666473B2 (en) | 1990-12-10 | 1996-02-15 | Entremed, Inc | A vaccine against cholesterol to prevent hypercholesterolemia and atherosclerosis |
| RU2014609C1 (ru) * | 1991-06-06 | 1994-06-15 | Московский институт тонкой химической технологии им.М.В.Ломоносова | Способ определения белков, специфичных к фосфорилхолину |
| JPH07504817A (ja) | 1992-03-03 | 1995-06-01 | ザ ロックフェラー ユニヴァーシティ | Ｂ２９（Ｉｇ‐βまたはＩｇ−γ）を含むレセプタ複合体およびその利用 |
| WO1994014454A1 (en) | 1992-12-29 | 1994-07-07 | Entremed, Inc. | Vaccines against sterols |
| WO1994018955A1 (en) | 1993-02-22 | 1994-09-01 | Alza Corporation | Compositions for oral delivery of active agents |
| US5455032A (en) | 1993-07-29 | 1995-10-03 | The United States Of America As Represented By The Department Of Health And Human Services | Use of phosphocholine hapten conjugates in vaccines |
| US6375925B1 (en) | 1996-11-08 | 2002-04-23 | The Regents Of The University Of California | Methods and reagents for non-invasive imaging of atherosclerotic plaque |
| WO1998021581A1 (en) | 1996-11-08 | 1998-05-22 | The Regents Of The University Of California | Methods and reagents for non-invasive imaging of atherosclerotic plaque |
| US6225070B1 (en) | 1997-08-07 | 2001-05-01 | The Regents Of The University Of California | Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma |
| US20040185039A1 (en) | 2002-08-30 | 2004-09-23 | Heinz Kohler | Therapeutic applications of noncovalent dimerizing antibodies |
| US6300308B1 (en) | 1997-12-31 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions for inducing autoimmunity in the treatment of cancers |
| ATE250228T1 (de) | 1998-07-03 | 2003-10-15 | Athera Biotechnologies Ab | Verfahren zur diagnose von gefässerkrankungen und früher atheriosklerose |
| SE9802402D0 (sv) | 1998-07-03 | 1998-07-03 | Karolinska Innovations Ab | Method of diagnosing cardiovascular disease and early atherosclerosis |
| MXPA02004244A (es) | 1999-10-26 | 2002-11-04 | Univ California | Reactivos y metodos para el diagnostico, la formacion de imagenes y el tratamiento del padecimiento de la ateroesclerosis.. |
| SE0000855D0 (sv) | 2000-03-15 | 2000-03-15 | Karolinska Innovations Ab | Antigenic composition useful as a vaccine against atherosclerosis |
| WO2001088547A2 (en) | 2000-05-12 | 2001-11-22 | The Regents Of The University Of California | Standardized oxidized ldl assay |
| DE10041515A1 (de) | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
| US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| SE0103754L (sv) | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
| WO2004091520A2 (en) | 2003-04-11 | 2004-10-28 | The Regents Of The University Of California | Methods and compositions for treating atherosclerosis |
| CA2562550C (en) | 2004-04-15 | 2013-09-24 | Athera Biotechnologies Ab | Phosphorylcholine conjugates and corresponding antibodies |
| JP2008515774A (ja) | 2004-08-03 | 2008-05-15 | ダイアックス コーポレイション | ｈＫ１結合タンパク質 |
| TW200726479A (en) * | 2005-04-12 | 2007-07-16 | Univ Duke | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| WO2007076200A2 (en) | 2005-11-28 | 2007-07-05 | Medimmune, Inc. | Antagonists of hmgb1 and/or rage and methods of use thereof |
| WO2008150485A2 (en) | 2007-05-29 | 2008-12-11 | Wyeth | Erbb2 binding proteins and use thereof |
| JP5122908B2 (ja) | 2007-10-17 | 2013-01-16 | 日泉化学株式会社 | 自動車の内装用部材の取り付け構造 |
| JP2011527016A (ja) * | 2008-07-07 | 2011-10-20 | アセラ・バイオテクノロジーズ・アーベー | アルツハイマー病についての新規の治療および診断方法 |
| WO2012010291A1 (en) | 2010-07-21 | 2012-01-26 | Athera Biotechnologies Ab | Diagnostic and therapeutic methods and compositions for metabolic disease |
| AU2012204202A1 (en) * | 2011-01-06 | 2013-07-11 | Dyax Corp. | Plasma kallikrein binding proteins |
| AU2012294431B2 (en) | 2011-08-09 | 2017-03-30 | Athera Biotechnologies Ab | Antibodies binding to phosphorylcholine (PC) and/or PC conjugates |
| TWI707873B (zh) * | 2011-08-09 | 2020-10-21 | 阿雷拉生物技術Ａｂ公司 | 新抗體 |
-
2012
- 2012-08-08 TW TW101128575A patent/TWI707873B/zh not_active IP Right Cessation
- 2012-08-08 US US14/237,035 patent/US9803028B2/en active Active
- 2012-08-08 EP EP12747915.2A patent/EP2742068B1/en active Active
- 2012-08-08 WO PCT/EP2012/065505 patent/WO2013020995A1/en active Application Filing
- 2012-08-08 AR ARP120102895A patent/AR087485A1/es unknown
- 2012-08-08 RU RU2014108815A patent/RU2654584C2/ru active
- 2012-08-08 ES ES12747915T patent/ES2732838T3/es active Active
- 2012-08-08 CA CA2843921A patent/CA2843921A1/en not_active Abandoned
- 2012-08-08 SI SI201231604T patent/SI2742068T1/sl unknown
- 2012-08-08 TR TR2019/09072T patent/TR201909072T4/tr unknown
- 2012-08-08 PL PL12747915T patent/PL2742068T3/pl unknown
- 2012-08-08 LT LTEP12747915.2T patent/LT2742068T/lt unknown
- 2012-08-08 HU HUE12747915A patent/HUE045163T2/hu unknown
- 2012-08-08 SG SG2014009344A patent/SG2014009344A/en unknown
- 2012-08-08 RS RS20190807A patent/RS58986B1/sr unknown
- 2012-08-08 MX MX2014001313A patent/MX364425B/es active IP Right Grant
- 2012-08-08 PT PT12747915T patent/PT2742068T/pt unknown
- 2012-08-08 JP JP2014524371A patent/JP6277125B2/ja not_active Expired - Fee Related
- 2012-08-08 KR KR1020147006274A patent/KR101947758B1/ko active IP Right Grant
- 2012-08-08 DK DK12747915.2T patent/DK2742068T3/da active
- 2012-08-08 CN CN201280049552.0A patent/CN104039832B/zh not_active Expired - Fee Related
- 2012-08-08 BR BR112014002929A patent/BR112014002929A8/pt not_active Application Discontinuation
- 2012-08-08 AU AU2012293646A patent/AU2012293646B2/en not_active Ceased
-
2014
- 2014-01-28 ZA ZA2014/00665A patent/ZA201400665B/en unknown
-
2015
- 2015-02-05 HK HK15101305.1A patent/HK1200852A1/xx unknown
-
2017
- 2017-09-28 US US15/719,520 patent/US20180086848A1/en not_active Abandoned
-
2019
- 2019-05-30 HR HRP20190988TT patent/HRP20190988T1/hr unknown
- 2019-06-28 CY CY20191100683T patent/CY1121950T1/el unknown
-
2021
- 2021-04-13 US US17/229,837 patent/US20210238311A1/en not_active Abandoned
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