EP0562020A4 - A vaccine against cholesterol to prevent hypercholesterolemia and atherosclerosis - Google Patents

A vaccine against cholesterol to prevent hypercholesterolemia and atherosclerosis

Info

Publication number
EP0562020A4
EP0562020A4 EP19920903221 EP92903221A EP0562020A4 EP 0562020 A4 EP0562020 A4 EP 0562020A4 EP 19920903221 EP19920903221 EP 19920903221 EP 92903221 A EP92903221 A EP 92903221A EP 0562020 A4 EP0562020 A4 EP 0562020A4
Authority
EP
European Patent Office
Prior art keywords
atherosclerosis
vaccine against
against cholesterol
prevent hypercholesterolemia
hypercholesterolemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920903221
Other versions
EP0562020A1 (en
Inventor
Carl R. Alving
Glenn M. Swartz, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Casi Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0562020A1 publication Critical patent/EP0562020A1/en
Publication of EP0562020A4 publication Critical patent/EP0562020A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0012—Lipids; Lipoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/323—Arteriosclerosis, Stenosis
EP19920903221 1990-12-10 1991-12-10 A vaccine against cholesterol to prevent hypercholesterolemia and atherosclerosis Withdrawn EP0562020A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US624957 1984-06-27
US62495790A 1990-12-10 1990-12-10

Publications (2)

Publication Number Publication Date
EP0562020A1 EP0562020A1 (en) 1993-09-29
EP0562020A4 true EP0562020A4 (en) 1993-11-18

Family

ID=24504021

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920903221 Withdrawn EP0562020A4 (en) 1990-12-10 1991-12-10 A vaccine against cholesterol to prevent hypercholesterolemia and atherosclerosis

Country Status (5)

Country Link
EP (1) EP0562020A4 (en)
JP (1) JP3183665B2 (en)
AU (1) AU666473B2 (en)
CA (1) CA2098101A1 (en)
WO (1) WO1992010203A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589189A (en) * 1994-09-14 1996-12-31 Nexstar Pharmaceuticals, Inc. Liposome dispersion
GB9506863D0 (en) * 1995-04-03 1995-05-24 Smithkline Beecham Biolog Vaccines
US6410022B1 (en) 1995-05-01 2002-06-25 Avant Immunotherapeutics, Inc. Modulation of cholesteryl ester transfer protein (CETP) activity
WO1996039168A1 (en) 1995-06-06 1996-12-12 The Immune Response Corporation Method for increasing hdl cholesterol level
US6846808B1 (en) 1996-05-01 2005-01-25 Avant Immunotherapeutics, Inc. Plasmid-based vaccine for treating atherosclerosis
US6284533B1 (en) 1996-05-01 2001-09-04 Avant Immunotherapeutics, Inc. Plasmid-based vaccine for treating atherosclerosis
CN103908669B (en) 2004-04-15 2017-07-04 阿瑟拉生物技术公司 Phosphorylcholine conjugates and corresponding antibodies
EP2741770A4 (en) 2011-08-09 2014-12-31 Athera Biotechnologies Ab Antibodies binding to phosphorylcholine (pc) and/or pc conjugates
SI2742068T1 (en) 2011-08-09 2019-08-30 Athera Biotechnologies Ab New antibodies against phosphorylcholine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR704M (en) * 1960-10-10 1961-07-31
US4885256A (en) * 1986-06-17 1989-12-05 The United States Of America As Represented By The United States Army Monoclonal antibodies to cholesterol and methods
EP0356340A1 (en) * 1988-08-25 1990-02-28 The Liposome Company, Inc. Affinity associated vaccine
WO1992006709A1 (en) * 1990-10-22 1992-04-30 Alving Carl L Lipid a composition as immunogenic agents to prevent or treat gram-negative bacterial infections

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR704M (en) * 1960-10-10 1961-07-31
US4885256A (en) * 1986-06-17 1989-12-05 The United States Of America As Represented By The United States Army Monoclonal antibodies to cholesterol and methods
EP0356340A1 (en) * 1988-08-25 1990-02-28 The Liposome Company, Inc. Affinity associated vaccine
WO1992006709A1 (en) * 1990-10-22 1992-04-30 Alving Carl L Lipid a composition as immunogenic agents to prevent or treat gram-negative bacterial infections

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 83, no. 18, 1975, Columbus, Ohio, US; abstract no. 152332m, 'ANTICHOLESTEREMIC ANTIBODY' *
CRITICAL REVIEWS IN IMMUNOLOGY vol. 10, no. 5, 1991, pages 441 - 453 C.R. ALVING ET AL. 'ANTIBODIES TO CHOLESTEROL, CHOLESTEROL CONJUGATES, AND LIPOSOMES: IMPLICATIONS FOR ATHEROSCLEROSIS AND AUTOIMMUNITY' *
FR-M-704M (LABORATOIRES GUY HUE) 31 July 1961 *
PROG. CLIN. BIOL. RES. vol. 47, 1980, pages 339 - 355 C.R. ALVING ET AL. 'LIPOSOMES AS VEHICLES FOR VACCINES' *
See also references of WO9210203A1 *
STN FILE SUPPLIER, MEDLINE AN=78076339 'CHOLESTEROL METABOLISM IN RABBITS WITH RESISTANCE TO EXPERIMENTAL ATHEROSCLEROSIS ACQUIRED BY IMMUNOLOGICAL TREATMENT' *

Also Published As

Publication number Publication date
JPH06505714A (en) 1994-06-30
AU666473B2 (en) 1996-02-15
CA2098101A1 (en) 1992-06-10
WO1992010203A1 (en) 1992-06-25
AU9155691A (en) 1992-07-08
EP0562020A1 (en) 1993-09-29
JP3183665B2 (en) 2001-07-09

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