AR008177A1 - Nuevas bisindolilmaleimidas, sales de las mismas, procesos para su preparacion intermediarios, su uso para la fabricacion de medicamentos, metodode tratamiento y composicion farmaceutica. - Google Patents

Nuevas bisindolilmaleimidas, sales de las mismas, procesos para su preparacion intermediarios, su uso para la fabricacion de medicamentos, metodode tratamiento y composicion farmaceutica.

Info

Publication number
AR008177A1
AR008177A1 ARP970104132A ARP970104132A AR008177A1 AR 008177 A1 AR008177 A1 AR 008177A1 AR P970104132 A ARP970104132 A AR P970104132A AR P970104132 A ARP970104132 A AR P970104132A AR 008177 A1 AR008177 A1 AR 008177A1
Authority
AR
Argentina
Prior art keywords
alkyl
manufacture
processes
preparation
new
Prior art date
Application number
ARP970104132A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR008177A1 publication Critical patent/AR008177A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Nuevas bisindolilmaleimidas que comprenden la fórmula (I) R20-(CH2)n-R , en donde R20 es una porción de bisindolilmaleimida ligada al grupo -CH2- a travésde un indolil nitrógeno, n es 0 o 1, R es un anillo carbocíclico o heterocíclicoar omático de 5 o 6 miembros, conteniendo el anillo heterocíclicoN o S, R es sustituido por R1 y hasta cuatro de R2, R3, R4 y R5, en donde R1 es aminometilo, (N-(C1-4-alquil)amino)metilo, (N,N-di(C1-4-alquil)amino)metilo, opiridiniometilo, y R2, R3,y R 4, y R5 (si están presentes), que pueden ser iguales o diferentes, son cada uno hidrógeno, hidroxi, C1-6-alcoxi,C1-6-alquilo, tri(C1-4-alquil)silil(C1-4-alcoxi)(C1-4-alcoxi), o halógeno, o R2 cuando se encuentra en una posición contigua alenlac e que conecta R al grupo-(CH2)n-, y n es 1, puede, junto con el átomo 2 carbono en el indol al que el grupo -(CH2)n- está adherido, formar un anillo, y sales farmacéuticamenteaceptables de los mismos, que son inhibidoras de quinasa C deproteína (P KC), procesos para su preparación, intermediarios para los mismos, su uso en lafabricación de medicamentos y composiciones farmacéuticas que los comprenden.
ARP970104132A 1996-09-10 1997-09-10 Nuevas bisindolilmaleimidas, sales de las mismas, procesos para su preparacion intermediarios, su uso para la fabricacion de medicamentos, metodode tratamiento y composicion farmaceutica. AR008177A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9603283A SE9603283D0 (sv) 1996-09-10 1996-09-10 New compounds

Publications (1)

Publication Number Publication Date
AR008177A1 true AR008177A1 (es) 1999-12-09

Family

ID=20403828

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104132A AR008177A1 (es) 1996-09-10 1997-09-10 Nuevas bisindolilmaleimidas, sales de las mismas, procesos para su preparacion intermediarios, su uso para la fabricacion de medicamentos, metodode tratamiento y composicion farmaceutica.

Country Status (9)

Country Link
US (1) US6153641A (es)
EP (1) EP0925296A1 (es)
AR (1) AR008177A1 (es)
AU (1) AU718844B2 (es)
CA (1) CA2264236A1 (es)
NZ (1) NZ334201A (es)
SE (1) SE9603283D0 (es)
WO (1) WO1998011102A1 (es)
ZA (1) ZA977807B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
US6103712A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for asthma
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6346625B1 (en) 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
KR20040016828A (ko) 2000-12-08 2004-02-25 오르토-맥네일 파마슈티칼, 인코퍼레이티드 키나제 저해제로서 인다졸릴-치환된 피롤린 화합물
TWI335221B (en) 2001-09-27 2011-01-01 Alcon Inc Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
CN1639152A (zh) * 2002-03-08 2005-07-13 伊莱利利公司 吡咯－2,5－二酮衍生物及其作为gsk－3抑制剂的用途
MXPA04012188A (es) 2002-06-05 2005-07-25 Johnson & Johnson Derivados de bisindolil-maleimida como inhibidores de cinasa.
CA2488798A1 (en) 2002-06-05 2003-12-18 Janssen Pharmaceutica N.V. Substituted pyrrolines as kinase inhibitors
AU2004251178A1 (en) 2003-06-13 2005-01-06 Janssen Pharmaceutica N.V. Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors
US20070232658A1 (en) * 2004-04-08 2007-10-04 Jurgen Wagner Protein Kinase C Inhibitors for the Treatment of Autoimmune Diseases and of Transplant Rejiction
PT1846406E (pt) 2005-02-09 2010-12-10 Arqule Inc Derivados de maleimida, composições farmacêuticas e métodos para o tratamento do cancro
EP2173748B1 (en) * 2007-06-22 2011-08-31 ArQule, Inc. Indolyl pyrrolidines for the treatment of cancer
US8232285B2 (en) * 2007-06-22 2012-07-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
JP5425060B2 (ja) * 2007-06-22 2014-02-26 アークル インコーポレイテッド ピロリジノン、ピロリジン−２，５−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法
US8871807B2 (en) 2008-03-28 2014-10-28 Ecolab Usa Inc. Detergents capable of cleaning, bleaching, sanitizing and/or disinfecting textiles including sulfoperoxycarboxylic acids
WO2016008966A1 (en) 2014-07-17 2016-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CN106565517B (zh) * 2016-10-18 2018-08-17 湖南大学 一种由芳基甲烷衍生物和腈制备酰胺的方法

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Also Published As

Publication number Publication date
WO1998011102A1 (en) 1998-03-19
ZA977807B (en) 1998-03-10
US6153641A (en) 2000-11-28
AU4143197A (en) 1998-04-02
SE9603283D0 (sv) 1996-09-10
EP0925296A1 (en) 1999-06-30
NZ334201A (en) 2001-02-23
AU718844B2 (en) 2000-04-20
CA2264236A1 (en) 1998-03-19

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