FI945706A - Proteiinikinaasi C-inhibiittoreita - Google Patents
Proteiinikinaasi C-inhibiittoreita Download PDFInfo
- Publication number
- FI945706A FI945706A FI945706A FI945706A FI945706A FI 945706 A FI945706 A FI 945706A FI 945706 A FI945706 A FI 945706A FI 945706 A FI945706 A FI 945706A FI 945706 A FI945706 A FI 945706A
- Authority
- FI
- Finland
- Prior art keywords
- protein kinase
- inhibitors
- indolemaleimide
- mammals
- chem
- Prior art date
Links
- 229940123924 Protein kinase C inhibitor Drugs 0.000 title 1
- 239000003881 protein kinase C inhibitor Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16306093A | 1993-12-07 | 1993-12-07 | |
US16306093 | 1993-12-07 | ||
US31697394A | 1994-10-03 | 1994-10-03 | |
US31697394 | 1994-10-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI945706A0 FI945706A0 (fi) | 1994-12-02 |
FI945706A true FI945706A (fi) | 1995-06-08 |
FI108138B FI108138B (fi) | 2001-11-30 |
Family
ID=26859318
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI945706A FI108138B (fi) | 1993-12-07 | 1994-12-02 | Menetelmä uusien terapeuttisesti käyttökelpoisten 3,4-[(N,N'-1,1')-substituoitu alkyleeni)-bis(3,3'-indolyyli)]-1H-pyrroli-2,5-dionijohdannaisten valmistamiseksi |
FI20000516A FI20000516A (fi) | 1993-12-07 | 2000-03-07 | Bis-indolyylimaleimidijohdannaiset ja niiden valmistus |
FI20011109A FI20011109A (fi) | 1993-12-07 | 2001-05-28 | Bis-indolyylisukkiini-imidijohdannaiset ja niiden valmistus |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20000516A FI20000516A (fi) | 1993-12-07 | 2000-03-07 | Bis-indolyylimaleimidijohdannaiset ja niiden valmistus |
FI20011109A FI20011109A (fi) | 1993-12-07 | 2001-05-28 | Bis-indolyylisukkiini-imidijohdannaiset ja niiden valmistus |
Country Status (31)
Country | Link |
---|---|
US (1) | US5698578A (fi) |
EP (1) | EP0657458B1 (fi) |
JP (2) | JP3581731B2 (fi) |
KR (1) | KR100340159B1 (fi) |
CN (2) | CN1050844C (fi) |
AT (1) | ATE204579T1 (fi) |
AU (1) | AU687909B2 (fi) |
BR (1) | BR9404831A (fi) |
CA (1) | CA2137203C (fi) |
CO (1) | CO4340622A1 (fi) |
CY (1) | CY2413B1 (fi) |
CZ (1) | CZ291950B6 (fi) |
DE (1) | DE69428025T2 (fi) |
DK (1) | DK0657458T3 (fi) |
ES (1) | ES2162843T3 (fi) |
FI (3) | FI108138B (fi) |
GR (1) | GR3037087T3 (fi) |
HK (1) | HK1013827A1 (fi) |
HU (1) | HU219709B (fi) |
IL (1) | IL111850A (fi) |
MY (1) | MY125587A (fi) |
NO (1) | NO308798B1 (fi) |
NZ (1) | NZ270048A (fi) |
PE (1) | PE49195A1 (fi) |
PL (1) | PL182124B1 (fi) |
PT (1) | PT657458E (fi) |
RU (1) | RU2147304C1 (fi) |
SG (1) | SG63570A1 (fi) |
TW (1) | TW425397B (fi) |
UA (1) | UA44690C2 (fi) |
YU (1) | YU49200B (fi) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
UA56145C2 (uk) * | 1995-11-20 | 2003-05-15 | Елі Ліллі Енд Компані | Нові проміжні продукти для одержання n,n'-місткових бісіндолілмалеімідів, спосіб отримання цих проміжних продуктів та фармацевтична композиція на їх основі |
ATE172199T1 (de) * | 1995-11-20 | 1998-10-15 | Lilly Co Eli | Proteinkinase-c-inhibitor |
IL126272A0 (en) * | 1996-03-20 | 1999-05-09 | Lilly Co Eli | Synthesis of indolylmaleimides |
UA54427C2 (uk) * | 1996-05-01 | 2003-03-17 | Елі Ліллі Енд Компані | Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту |
EP0915698A4 (en) | 1996-05-01 | 1999-08-11 | Lilly Co Eli | TREATMENT PROCEDURE FOR VEGF-RELATED DISEASES |
BR9709301A (pt) * | 1996-05-01 | 1999-08-10 | Univ Mississipi | Inibidores da proteína quinase c halo-substituídos |
US6093709A (en) * | 1996-08-22 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for sexual dysfunctions |
IL128494A0 (en) * | 1996-08-30 | 2000-01-31 | Lilly Co Eli | Use of inhibitors of pkc for the manufacture of a medicament for the treatment of central nervous system diseases associated with hiv infection |
AU4250697A (en) * | 1996-08-30 | 1998-03-19 | Eli Lilly And Company | Use of inhibitors of pkc for the manufacture of a medicament for the treatment of central nervous system diseases associated with hiv infection |
US6107327A (en) * | 1996-08-30 | 2000-08-22 | Eli Lilly And Company | Therapeutic treatment for HIV infection |
US5962446A (en) * | 1996-08-30 | 1999-10-05 | Eli Lilly And Company | Therapetutic treatment for human T cell lymphotrophic virus type 1 infection |
US5721272A (en) * | 1996-11-18 | 1998-02-24 | Eli Lilly And Company | Intermediates and their use to prepare N,N'-bridged bisindolylmaleimides |
US6093740A (en) * | 1997-04-30 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for skin disorders |
JPH1135454A (ja) * | 1997-07-22 | 1999-02-09 | Meiji Milk Prod Co Ltd | 抗腫瘍剤 |
WO1999038828A1 (fr) * | 1998-01-30 | 1999-08-05 | Daiso Co., Ltd. | Procede de production d'un derive de butanetriol |
US6103713A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for autoimmune diseases |
US6291446B1 (en) | 1998-03-05 | 2001-09-18 | Eli Lilly And Company | Therapeutic treatment for cytomegalovirus infection |
US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
US6225301B1 (en) | 1998-03-05 | 2001-05-01 | Eli Lilly And Company | Therapeutic treatment for renal dysfunction |
WO1999047522A1 (en) * | 1998-03-13 | 1999-09-23 | The University Of British Columbia | Granulatimide derivatives for use in cancer treatment |
CA2245029A1 (en) | 1998-03-13 | 1999-09-13 | University Of British Columbia | Granulatimide compounds as g2 checkpoint inhibitors |
US6127401A (en) | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
US6492406B1 (en) * | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
AU2002227371B2 (en) * | 2000-12-08 | 2007-05-10 | Ortho-Mcneil Pharmaceutical, Inc. | Macroheterocylic compounds useful as kinase inhibitors |
DE10109280A1 (de) * | 2001-02-26 | 2002-09-05 | Peter Mayser | Indolderivate mit inhibitorischer Wirkung auf Proteinkinasen |
US20030119812A1 (en) * | 2001-11-08 | 2003-06-26 | Brazzell Romulus Kimbro | Method for decreasing capillary permeability in the retina |
EP1461070B1 (en) * | 2001-12-29 | 2007-01-24 | Novo Nordisk A/S | Combined use of a glp-1 compound and an aldose reductase inhibitor |
US6887864B2 (en) | 2002-03-12 | 2005-05-03 | Hoffmann-La Roche Inc. | Azepane derivatives |
US20030236246A1 (en) * | 2002-04-30 | 2003-12-25 | Brazzell Romulus Kimbro | Method for decreasing capillary permeability in the retina |
DE10233737A1 (de) * | 2002-07-24 | 2004-02-05 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Verwendung von Modulatoren des Signaltransduktionswegs über die Proteinkinase Fyn zur Behandlung von Tumorerkrankungen |
ES2338789T3 (es) | 2003-06-18 | 2010-05-12 | Tranzyme Pharma Inc. | Antagonistas macrociclicos del receptor de motilina. |
EP2305265A1 (en) | 2003-08-08 | 2011-04-06 | Novartis AG | Combinations comprising staurosporines |
CA2601278C (en) * | 2004-03-17 | 2014-06-10 | Lars Michael Larsen | Prevention of retinopathy by inhibition of the visual cycle |
JO3088B1 (ar) * | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
US8158586B2 (en) * | 2005-04-11 | 2012-04-17 | Pharmagap Inc. | Inhibitors of protein kinases and uses thereof |
JP2009529575A (ja) * | 2006-03-10 | 2009-08-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤としてのピリジン−含有大複素環式化合物 |
EP2181999A1 (en) | 2008-11-03 | 2010-05-05 | Zentiva, A.S. | Method of manufacturing ruboxistarin |
ES2385157B1 (es) * | 2010-02-25 | 2013-07-08 | Universidad Del País Vasco | Compuestos para el tratamiento de alzheimer. |
MX2012011341A (es) | 2010-03-30 | 2012-11-12 | Novartis Ag | Inhibidores de pkc para el tratamiento de linfoma de celulas-b que tenga señalizacion activa cronica de receptores de celulas-b. |
US8785648B1 (en) | 2010-08-10 | 2014-07-22 | The Regents Of The University Of California | PKC-epsilon inhibitors |
US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013167403A1 (en) | 2012-05-09 | 2013-11-14 | Sanofi | Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors |
PL2925366T3 (pl) | 2012-11-29 | 2018-08-31 | Novartis Ag | Kombinacje farmaceutyczne |
WO2014174478A1 (en) | 2013-04-26 | 2014-10-30 | Novartis Ag | Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor |
WO2016003450A1 (en) | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Pkc-epsilon inhibitors |
JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
WO2017004342A1 (en) | 2015-07-02 | 2017-01-05 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
DK3325488T3 (da) * | 2015-07-21 | 2020-09-14 | Turning Point Therapeutics Inc | Chiral diaryl-makrocyklus og anvendelse deraf til behandling af cancer |
CN106854141A (zh) * | 2015-12-08 | 2017-06-16 | 湖南华腾制药有限公司 | 一种4-氯甲苯化合物的合成方法 |
CN107778148A (zh) * | 2016-08-30 | 2018-03-09 | 湖南华腾制药有限公司 | 一种溴化苄衍生物的合成方法 |
TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
WO2018175340A1 (en) | 2017-03-20 | 2018-09-27 | Sienna Biopharmaceuticals, Inc. | Reduced exposure conjugates modulating therapeutic targets |
WO2018175302A1 (en) | 2017-03-20 | 2018-09-27 | Sienna Biopharmaceuticals, Inc. | Polymer conjugates targeting c-src with reduced exposure |
WO2019023417A1 (en) | 2017-07-28 | 2019-01-31 | Tp Therapeutics, Inc. | MACROCYCLIC COMPOUNDS AND USES THEREOF |
PL3728271T3 (pl) | 2017-12-19 | 2023-01-23 | Turning Point Therapeutics, Inc. | Związki makrocykliczne do leczenia chorób |
EP4201403A1 (en) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses |
US20230203017A1 (en) * | 2021-12-28 | 2023-06-29 | Kamal D. Mehta | Protein Kinase C Beta Inhibitors and Uses Thereof |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
US4808613A (en) * | 1986-11-21 | 1989-02-28 | Bristol-Myers Company | Rebeccamycin derivative containing pharmaceutical composition |
EP0303697B1 (en) * | 1987-03-09 | 1997-10-01 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance k-252 |
DE3803620A1 (de) * | 1988-02-06 | 1989-08-17 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
US5438050A (en) * | 1988-02-06 | 1995-08-01 | Godecke Aktiengesellschaft | Indolocarbazole derivatives, processes for their preparation and compositions containing them |
SK75289A3 (en) * | 1988-02-10 | 1998-05-06 | Hoffmann La Roche | Substituted pyrroles, their use for producing a drug, and the drug on their base |
MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
DE3914764A1 (de) * | 1989-05-05 | 1990-11-08 | Goedecke Ag | Maleinimid-derivate und deren verwendung als arzneimittel |
US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
DE3924538A1 (de) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
DE3942296A1 (de) * | 1989-12-21 | 1991-06-27 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung |
DE4005970A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
JPH04187686A (ja) * | 1990-11-20 | 1992-07-06 | Meiji Seika Kaisha Ltd | インドロカルバゾール誘導体 |
HUT70187A (en) * | 1991-04-11 | 1995-09-28 | Schering Corp | Process for preparing oxadiazepine derivatives condensed with indole and pharmaceutical compositions of anti-tumor and anti-psoriatic activity containing said compounds |
GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
WO1994007895A1 (en) * | 1992-09-25 | 1994-04-14 | Schering Corporation | Diindolo compounds and pharmaceutical compositions containing them |
DE4243321A1 (de) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
AU678435B2 (en) * | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
-
1994
- 1994-12-02 KR KR1019940032547A patent/KR100340159B1/ko not_active IP Right Cessation
- 1994-12-02 AT AT94308947T patent/ATE204579T1/de active
- 1994-12-02 ES ES94308947T patent/ES2162843T3/es not_active Expired - Lifetime
- 1994-12-02 EP EP94308947A patent/EP0657458B1/en not_active Expired - Lifetime
- 1994-12-02 IL IL11185094A patent/IL111850A/en not_active IP Right Cessation
- 1994-12-02 CZ CZ19943018A patent/CZ291950B6/cs not_active IP Right Cessation
- 1994-12-02 JP JP29939994A patent/JP3581731B2/ja not_active Expired - Fee Related
- 1994-12-02 HU HU9403468A patent/HU219709B/hu not_active IP Right Cessation
- 1994-12-02 DE DE69428025T patent/DE69428025T2/de not_active Expired - Lifetime
- 1994-12-02 AU AU79188/94A patent/AU687909B2/en not_active Ceased
- 1994-12-02 CA CA002137203A patent/CA2137203C/en not_active Expired - Fee Related
- 1994-12-02 RU RU94042922A patent/RU2147304C1/ru not_active IP Right Cessation
- 1994-12-02 TW TW083111226A patent/TW425397B/zh not_active IP Right Cessation
- 1994-12-02 PT PT94308947T patent/PT657458E/pt unknown
- 1994-12-02 FI FI945706A patent/FI108138B/fi not_active IP Right Cessation
- 1994-12-02 UA UA94129116A patent/UA44690C2/uk unknown
- 1994-12-02 SG SG1996003093A patent/SG63570A1/en unknown
- 1994-12-02 PE PE1994256342A patent/PE49195A1/es not_active Application Discontinuation
- 1994-12-02 PL PL94306084A patent/PL182124B1/pl not_active IP Right Cessation
- 1994-12-02 NZ NZ270048A patent/NZ270048A/en not_active IP Right Cessation
- 1994-12-02 CN CN94119362A patent/CN1050844C/zh not_active Expired - Fee Related
- 1994-12-02 YU YU70494A patent/YU49200B/sh unknown
- 1994-12-02 NO NO944643A patent/NO308798B1/no not_active IP Right Cessation
- 1994-12-02 BR BR9404831A patent/BR9404831A/pt not_active Application Discontinuation
- 1994-12-02 DK DK94308947T patent/DK0657458T3/da active
- 1994-12-05 CO CO94055192A patent/CO4340622A1/es unknown
- 1994-12-05 MY MYPI94003239A patent/MY125587A/en unknown
-
1996
- 1996-10-21 US US08/734,292 patent/US5698578A/en not_active Expired - Lifetime
-
1997
- 1997-12-09 CN CN97126094A patent/CN1055089C/zh not_active Expired - Fee Related
-
1998
- 1998-12-23 HK HK98115199A patent/HK1013827A1/xx not_active IP Right Cessation
-
2000
- 2000-03-07 FI FI20000516A patent/FI20000516A/fi unknown
-
2001
- 2001-05-28 FI FI20011109A patent/FI20011109A/fi unknown
- 2001-10-30 CY CY0100035A patent/CY2413B1/xx unknown
- 2001-10-31 GR GR20010401960T patent/GR3037087T3/el unknown
-
2004
- 2004-05-25 JP JP2004154808A patent/JP2004269543A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI945706A (fi) | Proteiinikinaasi C-inhibiittoreita | |
MX9707431A (es) | Inhibidores de la proteina cinasa c. | |
MY118068A (en) | Protein kinase c inhibitor | |
EA200300248A1 (ru) | Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции | |
ATE215954T1 (de) | Pyrazolo(4,3-d)pyrimidin-derivate und diese enthaltende pharmazeutische zubereitungen | |
ES2170918T3 (es) | Inhibidor de proteina quinasa c sustituidos con halo. | |
DK0916670T3 (da) | Pyrrolo[3,2-b]pyridiner og deres anvendelse som 5-HT1f-agonister | |
EA199800368A1 (ru) | Новые промежуточные продукты и их использование для получения n,n'-мостиковых бисиндолилмалеимидов | |
ECSP961937A (es) | Inhibidor de proteina quinasa "c" |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |