NO944643L - Protein-kinase-C-hemmere - Google Patents

Protein-kinase-C-hemmere

Info

Publication number
NO944643L
NO944643L NO944643A NO944643A NO944643L NO 944643 L NO944643 L NO 944643L NO 944643 A NO944643 A NO 944643A NO 944643 A NO944643 A NO 944643A NO 944643 L NO944643 L NO 944643L
Authority
NO
Norway
Prior art keywords
protein kinase
inhibitors
indolemaleimide
mammals
chem
Prior art date
Application number
NO944643A
Other languages
English (en)
Other versions
NO308798B1 (no
NO944643D0 (no
Inventor
Jr William Francis Heath
Michael Robert Jirousek
Iii John Hampton Mcdonald
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO944643D0 publication Critical patent/NO944643D0/no
Publication of NO944643L publication Critical patent/NO944643L/no
Publication of NO308798B1 publication Critical patent/NO308798B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
NO944643A 1993-12-07 1994-12-02 Proteinkinase-C-hemmere, anvendelse av samme for fremstilling av farmasøytika samt farmasøytisk formulering omfattende samme NO308798B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16306093A 1993-12-07 1993-12-07
US31697394A 1994-10-03 1994-10-03

Publications (3)

Publication Number Publication Date
NO944643D0 NO944643D0 (no) 1994-12-02
NO944643L true NO944643L (no) 1995-06-08
NO308798B1 NO308798B1 (no) 2000-10-30

Family

ID=26859318

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944643A NO308798B1 (no) 1993-12-07 1994-12-02 Proteinkinase-C-hemmere, anvendelse av samme for fremstilling av farmasøytika samt farmasøytisk formulering omfattende samme

Country Status (31)

Country Link
US (1) US5698578A (no)
EP (1) EP0657458B1 (no)
JP (2) JP3581731B2 (no)
KR (1) KR100340159B1 (no)
CN (2) CN1050844C (no)
AT (1) ATE204579T1 (no)
AU (1) AU687909B2 (no)
BR (1) BR9404831A (no)
CA (1) CA2137203C (no)
CO (1) CO4340622A1 (no)
CY (1) CY2413B1 (no)
CZ (1) CZ291950B6 (no)
DE (1) DE69428025T2 (no)
DK (1) DK0657458T3 (no)
ES (1) ES2162843T3 (no)
FI (3) FI108138B (no)
GR (1) GR3037087T3 (no)
HK (1) HK1013827A1 (no)
HU (1) HU219709B (no)
IL (1) IL111850A (no)
MY (1) MY125587A (no)
NO (1) NO308798B1 (no)
NZ (1) NZ270048A (no)
PE (1) PE49195A1 (no)
PL (1) PL182124B1 (no)
PT (1) PT657458E (no)
RU (1) RU2147304C1 (no)
SG (1) SG63570A1 (no)
TW (1) TW425397B (no)
UA (1) UA44690C2 (no)
YU (1) YU49200B (no)

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ES2145978T3 (es) 1995-11-20 2000-07-16 Lilly Co Eli Intermedios y su uso para preparar bisindolilmaleimidas con un puente n,n'.
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UA54427C2 (uk) * 1996-05-01 2003-03-17 Елі Ліллі Енд Компані Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту
WO1997041127A1 (en) * 1996-05-01 1997-11-06 Eli Lilly And Company Halo-substituted protein kinase c inhibitors
US6093709A (en) * 1996-08-22 2000-07-25 Eli Lilly And Company Therapeutic treatment for sexual dysfunctions
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CN107778148A (zh) * 2016-08-30 2018-03-09 湖南华腾制药有限公司 一种溴化苄衍生物的合成方法
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
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EP3600440A1 (en) 2017-03-20 2020-02-05 Sienna Biopharmaceuticals, Inc. Reduced exposure conjugates modulating therapeutic targets
UA126158C2 (uk) 2017-07-28 2022-08-25 Тьорнінґ Поінт Терапьютикс, Інк. Макроциклічні сполуки і їх використання
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Also Published As

Publication number Publication date
NZ270048A (en) 1996-11-26
GR3037087T3 (en) 2002-01-31
HK1013827A1 (en) 1999-09-10
BR9404831A (pt) 1995-08-08
PT657458E (pt) 2002-02-28
CZ301894A3 (en) 1995-06-14
PL182124B1 (pl) 2001-11-30
EP0657458B1 (en) 2001-08-22
TW425397B (en) 2001-03-11
CN1050844C (zh) 2000-03-29
DK0657458T3 (da) 2001-10-29
JPH07215977A (ja) 1995-08-15
EP0657458A1 (en) 1995-06-14
YU70494A (sh) 1997-03-07
UA44690C2 (uk) 2002-03-15
CN1111247A (zh) 1995-11-08
HU9403468D0 (en) 1995-02-28
US5698578A (en) 1997-12-16
FI108138B (fi) 2001-11-30
JP2004269543A (ja) 2004-09-30
SG63570A1 (en) 1999-03-30
CZ291950B6 (cs) 2003-06-18
FI945706A (fi) 1995-06-08
NO308798B1 (no) 2000-10-30
HUT71130A (en) 1995-11-28
ATE204579T1 (de) 2001-09-15
ES2162843T3 (es) 2002-01-16
CN1220266A (zh) 1999-06-23
CY2413B1 (en) 2004-11-12
CA2137203C (en) 2006-11-28
AU7918894A (en) 1995-06-15
AU687909B2 (en) 1998-03-05
JP3581731B2 (ja) 2004-10-27
NO944643D0 (no) 1994-12-02
KR950018010A (ko) 1995-07-22
FI20000516A (fi) 2000-03-07
YU49200B (sh) 2004-09-03
FI20011109A (fi) 2001-05-28
RU94042922A (ru) 1996-12-27
IL111850A0 (en) 1995-03-15
MY125587A (en) 2006-08-30
HU219709B (hu) 2001-06-28
DE69428025D1 (de) 2001-09-27
FI945706A0 (fi) 1994-12-02
CO4340622A1 (es) 1996-07-30
CN1055089C (zh) 2000-08-02
KR100340159B1 (ko) 2002-11-23
IL111850A (en) 2002-11-10
DE69428025T2 (de) 2002-05-29
CA2137203A1 (en) 1995-06-08
RU2147304C1 (ru) 2000-04-10
PE49195A1 (es) 1996-01-06
PL306084A1 (en) 1995-06-12

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