CY2413B1 - Protein kinase C inhibitors. - Google Patents

Protein kinase C inhibitors.

Info

Publication number
CY2413B1
CY2413B1 CY0100035A CY0100035A CY2413B1 CY 2413 B1 CY2413 B1 CY 2413B1 CY 0100035 A CY0100035 A CY 0100035A CY 0100035 A CY0100035 A CY 0100035A CY 2413 B1 CY2413 B1 CY 2413B1
Authority
CY
Cyprus
Prior art keywords
protein kinase
inhibitors
indolemaleimide
mammals
chem
Prior art date
Application number
CY0100035A
Other languages
English (en)
Inventor
William Francis Heath Jr
Micheal Robert Jirousek
John Hampton Mcdonald Iii
Christopher John Rito
Original Assignee
Lelly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lelly Co Eli filed Critical Lelly Co Eli
Publication of CY2413B1 publication Critical patent/CY2413B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
CY0100035A 1993-12-07 2001-10-30 Protein kinase C inhibitors. CY2413B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16306093A 1993-12-07 1993-12-07
US31697394A 1994-10-03 1994-10-03

Publications (1)

Publication Number Publication Date
CY2413B1 true CY2413B1 (en) 2004-11-12

Family

ID=26859318

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0100035A CY2413B1 (en) 1993-12-07 2001-10-30 Protein kinase C inhibitors.

Country Status (31)

Country Link
US (1) US5698578A (no)
EP (1) EP0657458B1 (no)
JP (2) JP3581731B2 (no)
KR (1) KR100340159B1 (no)
CN (2) CN1050844C (no)
AT (1) ATE204579T1 (no)
AU (1) AU687909B2 (no)
BR (1) BR9404831A (no)
CA (1) CA2137203C (no)
CO (1) CO4340622A1 (no)
CY (1) CY2413B1 (no)
CZ (1) CZ291950B6 (no)
DE (1) DE69428025T2 (no)
DK (1) DK0657458T3 (no)
ES (1) ES2162843T3 (no)
FI (3) FI108138B (no)
GR (1) GR3037087T3 (no)
HK (1) HK1013827A1 (no)
HU (1) HU219709B (no)
IL (1) IL111850A (no)
MY (1) MY125587A (no)
NO (1) NO308798B1 (no)
NZ (1) NZ270048A (no)
PE (1) PE49195A1 (no)
PL (1) PL182124B1 (no)
PT (1) PT657458E (no)
RU (1) RU2147304C1 (no)
SG (1) SG63570A1 (no)
TW (1) TW425397B (no)
UA (1) UA44690C2 (no)
YU (1) YU49200B (no)

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UA56145C2 (uk) * 1995-11-20 2003-05-15 Елі Ліллі Енд Компані Нові проміжні продукти для одержання n,n'-місткових бісіндолілмалеімідів, спосіб отримання цих проміжних продуктів та фармацевтична композиція на їх основі
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UA54427C2 (uk) * 1996-05-01 2003-03-17 Елі Ліллі Енд Компані Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту
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US6093709A (en) * 1996-08-22 2000-07-25 Eli Lilly And Company Therapeutic treatment for sexual dysfunctions
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US8846712B2 (en) 2011-09-12 2014-09-30 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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Also Published As

Publication number Publication date
DK0657458T3 (da) 2001-10-29
HK1013827A1 (en) 1999-09-10
HUT71130A (en) 1995-11-28
DE69428025D1 (de) 2001-09-27
ES2162843T3 (es) 2002-01-16
BR9404831A (pt) 1995-08-08
YU70494A (sh) 1997-03-07
PT657458E (pt) 2002-02-28
GR3037087T3 (en) 2002-01-31
AU7918894A (en) 1995-06-15
CO4340622A1 (es) 1996-07-30
DE69428025T2 (de) 2002-05-29
AU687909B2 (en) 1998-03-05
HU219709B (hu) 2001-06-28
IL111850A0 (en) 1995-03-15
YU49200B (sh) 2004-09-03
JPH07215977A (ja) 1995-08-15
IL111850A (en) 2002-11-10
FI108138B (fi) 2001-11-30
UA44690C2 (uk) 2002-03-15
SG63570A1 (en) 1999-03-30
US5698578A (en) 1997-12-16
EP0657458A1 (en) 1995-06-14
FI945706A0 (fi) 1994-12-02
FI20000516A (fi) 2000-03-07
RU2147304C1 (ru) 2000-04-10
NO944643L (no) 1995-06-08
EP0657458B1 (en) 2001-08-22
CN1055089C (zh) 2000-08-02
PE49195A1 (es) 1996-01-06
PL306084A1 (en) 1995-06-12
HU9403468D0 (en) 1995-02-28
NO944643D0 (no) 1994-12-02
KR950018010A (ko) 1995-07-22
FI945706A (fi) 1995-06-08
TW425397B (en) 2001-03-11
CA2137203A1 (en) 1995-06-08
KR100340159B1 (ko) 2002-11-23
PL182124B1 (pl) 2001-11-30
JP3581731B2 (ja) 2004-10-27
CA2137203C (en) 2006-11-28
CZ291950B6 (cs) 2003-06-18
MY125587A (en) 2006-08-30
CN1050844C (zh) 2000-03-29
FI20011109A (fi) 2001-05-28
CZ301894A3 (en) 1995-06-14
CN1220266A (zh) 1999-06-23
RU94042922A (ru) 1996-12-27
CN1111247A (zh) 1995-11-08
NO308798B1 (no) 2000-10-30
NZ270048A (en) 1996-11-26
ATE204579T1 (de) 2001-09-15
JP2004269543A (ja) 2004-09-30

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