BR9710648A - S¡ntese de indolilmaleimidas - Google Patents
S¡ntese de indolilmaleimidasInfo
- Publication number
- BR9710648A BR9710648A BR9710648A BR9710648A BR9710648A BR 9710648 A BR9710648 A BR 9710648A BR 9710648 A BR9710648 A BR 9710648A BR 9710648 A BR9710648 A BR 9710648A BR 9710648 A BR9710648 A BR 9710648A
- Authority
- BR
- Brazil
- Prior art keywords
- indolylmaleimides
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1373196P | 1996-03-20 | 1996-03-20 | |
| PCT/US1997/004416 WO1997034890A1 (en) | 1996-03-20 | 1997-03-20 | Synthesis of indolylmaleimides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9710648A true BR9710648A (pt) | 1999-08-17 |
Family
ID=21761453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9710648A BR9710648A (pt) | 1996-03-20 | 1997-03-20 | S¡ntese de indolilmaleimidas |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5919946A (pt) |
| EP (1) | EP0888339A4 (pt) |
| JP (1) | JP3258334B2 (pt) |
| KR (1) | KR20000064764A (pt) |
| CN (1) | CN1225634A (pt) |
| AU (1) | AU2217797A (pt) |
| BR (1) | BR9710648A (pt) |
| CA (1) | CA2249205A1 (pt) |
| IL (1) | IL126272A0 (pt) |
| WO (1) | WO1997034890A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| AU2003240517A1 (en) * | 2002-06-05 | 2003-12-22 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
| WO2003104222A1 (en) | 2002-06-05 | 2003-12-18 | Janssen Pharmaceutica N.V. | Bisindolyl-maleimid derivatives as kinase inhibitors |
| WO2006061212A1 (en) | 2004-12-08 | 2006-06-15 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
| ZA200706530B (en) | 2005-02-09 | 2009-01-28 | Arqule Inc | Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
| AU2008268613A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| CA2690782C (en) | 2007-06-22 | 2016-02-02 | Arqule, Inc. | Compositions and methods for treatment of cancer |
| CN101801961B (zh) | 2007-06-22 | 2014-09-24 | 艾科尔公司 | 吡咯烷酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺衍生物、组合物以及治疗癌症的方法 |
| EP2343291A1 (en) | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| CN105153126B (zh) * | 2015-09-10 | 2017-10-24 | 东华大学 | 一种双吲哚马来酰亚胺类化合物的制备方法 |
| EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| US11319320B2 (en) | 2017-11-06 | 2022-05-03 | Snap Bio, Inc. | PIM kinase inhibitor compositions, methods, and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4537902A (en) * | 1979-06-11 | 1985-08-27 | Merck & Co., Inc. | 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase |
| US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
| CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| AU678435B2 (en) * | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
| US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
| US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| IL111851A (en) * | 1993-12-07 | 1998-09-24 | Lilly Co Eli | Improved synthesis of bisindolylsimilides and process for its preparation |
| CN1050844C (zh) * | 1993-12-07 | 2000-03-29 | 伊莱利利公司 | 蛋白激酶ｃ抑制剂 |
| US5545636A (en) * | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| SI0817627T1 (pt) * | 1993-12-23 | 2005-08-31 | Lilly Co Eli | |
| US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5475110A (en) * | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
-
1997
- 1997-03-20 BR BR9710648A patent/BR9710648A/pt not_active Application Discontinuation
- 1997-03-20 JP JP53366997A patent/JP3258334B2/ja not_active Expired - Fee Related
- 1997-03-20 KR KR1019980707527A patent/KR20000064764A/ko not_active Application Discontinuation
- 1997-03-20 EP EP97915167A patent/EP0888339A4/en not_active Withdrawn
- 1997-03-20 CN CN97194663A patent/CN1225634A/zh active Pending
- 1997-03-20 WO PCT/US1997/004416 patent/WO1997034890A1/en not_active Application Discontinuation
- 1997-03-20 US US08/821,356 patent/US5919946A/en not_active Expired - Fee Related
- 1997-03-20 CA CA002249205A patent/CA2249205A1/en not_active Abandoned
- 1997-03-20 AU AU22177/97A patent/AU2217797A/en not_active Abandoned
- 1997-03-20 IL IL12627297A patent/IL126272A0/xx unknown
-
1999
- 1999-02-11 US US09/248,263 patent/US6037475A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3258334B2 (ja) | 2002-02-18 |
| JPH11511487A (ja) | 1999-10-05 |
| CN1225634A (zh) | 1999-08-11 |
| US6037475A (en) | 2000-03-14 |
| KR20000064764A (ko) | 2000-11-06 |
| AU2217797A (en) | 1997-10-10 |
| EP0888339A4 (en) | 2001-02-28 |
| EP0888339A1 (en) | 1999-01-07 |
| IL126272A0 (en) | 1999-05-09 |
| US5919946A (en) | 1999-07-06 |
| CA2249205A1 (en) | 1997-09-25 |
| WO1997034890A1 (en) | 1997-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |